WO2010012745A3 - Benzimidazoles - Google Patents

Benzimidazoles Download PDF

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Publication number
WO2010012745A3
WO2010012745A3 PCT/EP2009/059768 EP2009059768W WO2010012745A3 WO 2010012745 A3 WO2010012745 A3 WO 2010012745A3 EP 2009059768 W EP2009059768 W EP 2009059768W WO 2010012745 A3 WO2010012745 A3 WO 2010012745A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzimidazoles
medicament
excessive
preparing
treatment
Prior art date
Application number
PCT/EP2009/059768
Other languages
French (fr)
Other versions
WO2010012745A2 (en
Inventor
Darryl Mcconnell
Siegfried Schneider
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of WO2010012745A2 publication Critical patent/WO2010012745A2/en
Publication of WO2010012745A3 publication Critical patent/WO2010012745A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present invention encompasses compounds of general formula (1); wherein R1, R2 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
PCT/EP2009/059768 2008-07-29 2009-07-28 Benzimidazoles WO2010012745A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08161375 2008-07-29
EP08161375.4 2008-07-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/011,451 Continuation US20130344571A1 (en) 2007-07-27 2013-08-27 Microbial Bioreaction Process

Publications (2)

Publication Number Publication Date
WO2010012745A2 WO2010012745A2 (en) 2010-02-04
WO2010012745A3 true WO2010012745A3 (en) 2010-07-22

Family

ID=40010774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/059768 WO2010012745A2 (en) 2008-07-29 2009-07-28 Benzimidazoles

Country Status (1)

Country Link
WO (1) WO2010012745A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8415376B2 (en) 2008-05-30 2013-04-09 Amgen Inc. Inhibitors of PI3 kinase
WO2012026766A2 (en) * 2010-08-25 2012-03-01 (주)네오팜 Novel heterocyclic compound, and composition for treating inflammatory diseases using same
US9828348B2 (en) 2013-11-08 2017-11-28 Purdue Pharma L.P. Benzimidazole derivatives and use thereof
WO2018013430A2 (en) 2016-07-12 2018-01-18 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus infection
JOP20190086A1 (en) 2016-10-21 2019-04-18 Novartis Ag Naphthyridinone derivatives and their use in the treatment of arrhythmia
KR20200051626A (en) * 2017-08-07 2020-05-13 조인트 스탁 컴퍼니 "바이오케드" New heterocyclic compound as a CDK8 / 19 inhibitor
CN108456171B (en) * 2018-03-16 2021-07-27 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） FLT3/ITD mutant inhibitor and application thereof in tumor prevention and treatment medicines

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0330327A2 (en) * 1988-02-25 1989-08-30 Pfizer Limited Dihydropyridines, their preparation and their use as PAF-antagonists
WO1990011281A1 (en) * 1989-03-17 1990-10-04 Pfizer Limited Dihydropyrimidine antiallergy agents
WO1992000978A1 (en) * 1990-07-13 1992-01-23 Pfizer Limited Imidazopyridine paf antagonists
EP0706795A2 (en) * 1994-09-21 1996-04-17 Pfizer Inc. Catechol diether compounds as inhibitors of TNF release
EP0937722A1 (en) * 1998-02-11 1999-08-25 Pfizer Inc. Benzimidazole derivatives as cyclooxygenase-2 inhibitors
EP1020462A1 (en) * 1997-07-24 2000-07-19 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compounds and antitumor agent containing the same as active ingredient
EP1132387A1 (en) * 1998-11-17 2001-09-12 Kumiai Chemical Industry Co., Ltd. Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultura/horticultural bactericides
WO2003099811A1 (en) * 2002-05-23 2003-12-04 Cytopia Pty Ltd Kinase inhibitors
WO2004014899A1 (en) * 2002-08-08 2004-02-19 Smithkline Beecham Corporation Thiophene compounds

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0330327A2 (en) * 1988-02-25 1989-08-30 Pfizer Limited Dihydropyridines, their preparation and their use as PAF-antagonists
WO1990011281A1 (en) * 1989-03-17 1990-10-04 Pfizer Limited Dihydropyrimidine antiallergy agents
WO1992000978A1 (en) * 1990-07-13 1992-01-23 Pfizer Limited Imidazopyridine paf antagonists
EP0706795A2 (en) * 1994-09-21 1996-04-17 Pfizer Inc. Catechol diether compounds as inhibitors of TNF release
EP1020462A1 (en) * 1997-07-24 2000-07-19 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compounds and antitumor agent containing the same as active ingredient
EP0937722A1 (en) * 1998-02-11 1999-08-25 Pfizer Inc. Benzimidazole derivatives as cyclooxygenase-2 inhibitors
EP1132387A1 (en) * 1998-11-17 2001-09-12 Kumiai Chemical Industry Co., Ltd. Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultura/horticultural bactericides
WO2003099811A1 (en) * 2002-05-23 2003-12-04 Cytopia Pty Ltd Kinase inhibitors
WO2004014899A1 (en) * 2002-08-08 2004-02-19 Smithkline Beecham Corporation Thiophene compounds

Also Published As

Publication number Publication date
WO2010012745A2 (en) 2010-02-04

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