MX2011009989A - Metodos de tratamiento utilizando terapia de combinacion. - Google Patents
Metodos de tratamiento utilizando terapia de combinacion.Info
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- MX2011009989A MX2011009989A MX2011009989A MX2011009989A MX2011009989A MX 2011009989 A MX2011009989 A MX 2011009989A MX 2011009989 A MX2011009989 A MX 2011009989A MX 2011009989 A MX2011009989 A MX 2011009989A MX 2011009989 A MX2011009989 A MX 2011009989A
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| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| US20210292410A1 (en) | 2017-12-07 | 2021-09-23 | Morphosys Ag | Treatment paradigm for an anti-cd19 antibody and venetoclax combination treatment |
| KR101954370B1 (ko) | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| BR112021016522A2 (pt) | 2019-02-22 | 2021-10-26 | Hanmi Pharm. Co., Ltd. | Composição farmacêutica para o tratamento da leucemia mieloide aguda |
| TW202045174A (zh) | 2019-02-28 | 2020-12-16 | 日商富士軟片股份有限公司 | 組合醫藥 |
| EP3991733A4 (en) * | 2019-06-27 | 2023-07-05 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition for treating acute myeloid leukemia, containing flt3 inhibitor and chemotherapeutic agents |
| KR102694140B1 (ko) * | 2020-12-31 | 2024-08-12 | 울산대학교 산학협력단 | 소라페닙의 간암에 대한 활성 증진용 조성물 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1050899A (enExample) * | 1963-12-22 | |||
| DE2012888C3 (de) * | 1970-03-14 | 1981-04-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden |
| US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
| US4751221A (en) * | 1985-10-18 | 1988-06-14 | Sloan-Kettering Institute For Cancer Research | 2-fluoro-arabinofuranosyl purine nucleosides |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5384310A (en) * | 1989-05-23 | 1995-01-24 | Southern Research Institute | 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| JP3178843B2 (ja) * | 1995-03-13 | 2001-06-25 | 日研化学株式会社 | イミダゾチアゾール化合物 |
| AU2002254342A1 (en) * | 2001-03-23 | 2002-10-08 | The Board Of Trustees Of The University Of Illinois | Compounds capable of modulating the activity of multidrug transporters and therapeutic use of the same |
| ATE394409T1 (de) * | 2001-08-02 | 2008-05-15 | Ilex Oncology Inc | Verfahren zur herstellung von purinnukleosiden |
| US7038038B2 (en) * | 2003-03-17 | 2006-05-02 | Pharmion Corporation | Synthesis of 5-azacytidine |
| US6887855B2 (en) * | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
| US7192781B2 (en) * | 2004-04-13 | 2007-03-20 | Pharmion Corporation | Methods for stabilizing 5-azacytidine in plasma |
| US20070006613A1 (en) | 2005-06-20 | 2007-01-11 | Hirsch Victoria H | Coil beaded fashion accessory with attached key ring |
| KR101449057B1 (ko) * | 2006-03-17 | 2014-10-10 | 암비트 바이오사이언시즈 코포레이션 | 질환 치료용 이미다졸로티아졸 화합물 |
| WO2008028193A2 (en) * | 2006-09-01 | 2008-03-06 | Pharmion Corporation | Colon-targeted oral formulations of cytidine analogs |
| BRPI0816904B8 (pt) | 2007-09-19 | 2021-12-07 | Ambit Biosciences Corp | Forma cristalna b da forma sólida do sal de bis-hcl, composição farmacêutica, e, uso de uma forma sólida |
| AU2008325141B2 (en) | 2007-11-08 | 2014-03-20 | Ambit Biosciences Corp. | Methods of administering N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea to treat proliferative disease |
| US8551963B2 (en) | 2008-11-06 | 2013-10-08 | Ambit Biosciences Corporation | Imidazolothiazole compounds and methods of use thereof |
| CN102438588B (zh) * | 2009-03-23 | 2015-04-01 | 埃姆比特生物科学公司 | 使用联合治疗法治疗疾病的方法 |
| SMT202000092T1 (it) | 2009-05-14 | 2020-05-08 | Ambit Biosciences Corp | Formulazione essiccata a spruzzo o liofilizzata di ac220 |
| CN104447801A (zh) | 2009-11-05 | 2015-03-25 | 埃姆比特生物科学公司 | 用于制备咪唑并[2,1-b][1,3]苯并噻唑衍生物的方法 |
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| RU2543348C2 (ru) | 2015-02-27 |
| KR20120000567A (ko) | 2012-01-02 |
| US20100292177A1 (en) | 2010-11-18 |
| EP2410987A1 (en) | 2012-02-01 |
| CA2755976C (en) | 2020-04-07 |
| WO2010111172A1 (en) | 2010-09-30 |
| KR101755725B1 (ko) | 2017-07-07 |
| AU2010228982A1 (en) | 2011-10-20 |
| US8357690B2 (en) | 2013-01-22 |
| FR24C1013I1 (fr) | 2024-05-24 |
| JP6033678B2 (ja) | 2016-11-30 |
| EP2410987B1 (en) | 2018-05-16 |
| AU2010228982B2 (en) | 2015-05-14 |
| ES2681529T3 (es) | 2018-09-13 |
| CN102438588A (zh) | 2012-05-02 |
| IL215131A0 (en) | 2011-12-29 |
| US20130137650A1 (en) | 2013-05-30 |
| US8836218B2 (en) | 2014-09-16 |
| ZA201106730B (en) | 2012-11-28 |
| JP2012521435A (ja) | 2012-09-13 |
| FR24C1013I2 (fr) | 2025-03-28 |
| BRPI1013698A2 (pt) | 2016-04-26 |
| CN102438588B (zh) | 2015-04-01 |
| IL215131A (en) | 2015-08-31 |
| SG174419A1 (en) | 2011-11-28 |
| RU2011142750A (ru) | 2013-04-27 |
| CA2755976A1 (en) | 2010-09-30 |
| NZ595382A (en) | 2014-02-28 |
| JP2015212268A (ja) | 2015-11-26 |
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