MX2011007065A - Analogos de dicetopiperazina substituida para usarse como agentes de suministro de farmaco. - Google Patents
Analogos de dicetopiperazina substituida para usarse como agentes de suministro de farmaco.Info
- Publication number
- MX2011007065A MX2011007065A MX2011007065A MX2011007065A MX2011007065A MX 2011007065 A MX2011007065 A MX 2011007065A MX 2011007065 A MX2011007065 A MX 2011007065A MX 2011007065 A MX2011007065 A MX 2011007065A MX 2011007065 A MX2011007065 A MX 2011007065A
- Authority
- MX
- Mexico
- Prior art keywords
- drug delivery
- delivery agents
- substituted diketopiperazine
- analogs
- delivery
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se describen sistemas de suministro de fármaco para el suministro de fármacos de molécula pequeña y macromoleculares. Más particularmente. Se describen análogos substituidos de 3,6- di(alquil-4-aminobutil)-2,5-dicetopiperazina (la cual también puede ser denominada como DKP), su uso en la formulación de fármacos tanto de molécula pequeña como macromoleculares incluyendo agentes terapéuticos, profilácticos y de diagnóstico, agentes de estabilización y sistemas para su suministro.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14120708P | 2008-12-29 | 2008-12-29 | |
PCT/US2009/069745 WO2010078373A1 (en) | 2008-12-29 | 2009-12-29 | Substituted diketopiperazine analogs for use as drug delivery agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011007065A true MX2011007065A (es) | 2011-08-03 |
Family
ID=41694085
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011007065A MX2011007065A (es) | 2008-12-29 | 2009-12-29 | Analogos de dicetopiperazina substituida para usarse como agentes de suministro de farmaco. |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP2862854A1 (es) |
JP (2) | JP5788806B2 (es) |
CA (1) | CA2748490C (es) |
DK (1) | DK2379511T3 (es) |
ES (1) | ES2531009T3 (es) |
MX (1) | MX2011007065A (es) |
PT (1) | PT2379511E (es) |
SI (1) | SI2379511T1 (es) |
WO (1) | WO2010078373A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
CA2479751C (en) | 2002-03-20 | 2008-06-03 | Trent Poole | Inhalation apparatus |
KR101273120B1 (ko) | 2004-08-20 | 2013-06-13 | 맨카인드 코포레이션 | 다이케토피페라진 합성의 촉매 작용 |
KR101644250B1 (ko) | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
KR101486397B1 (ko) | 2005-09-14 | 2015-01-28 | 맨카인드 코포레이션 | 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법 |
BRPI0707991B8 (pt) | 2006-02-22 | 2021-05-25 | Mannkind Corp | métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
CN104491962B (zh) | 2008-06-13 | 2018-10-23 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
ES2421385T3 (es) | 2008-06-20 | 2013-09-02 | Mannkind Corp | Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación |
TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
KR101734955B1 (ko) | 2008-11-07 | 2017-05-12 | 메사추세츠 인스티튜트 오브 테크놀로지 | 아미노알콜 리피도이드 및 그의 용도 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
MX2011007065A (es) * | 2008-12-29 | 2011-08-03 | Mannkind Corp | Analogos de dicetopiperazina substituida para usarse como agentes de suministro de farmaco. |
CA2754595C (en) | 2009-03-11 | 2017-06-27 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
US8734845B2 (en) | 2009-06-12 | 2014-05-27 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
US9016147B2 (en) | 2009-11-03 | 2015-04-28 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
EP2582421A1 (en) | 2010-06-21 | 2013-04-24 | MannKind Corporation | Dry powder drug delivery system and methods |
WO2012135025A2 (en) | 2011-03-28 | 2012-10-04 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
SG10201606220QA (en) | 2011-04-01 | 2016-09-29 | Mannkind Corp | Blister package for pharmaceutical cartridges |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
KR20140095483A (ko) | 2011-10-24 | 2014-08-01 | 맨카인드 코포레이션 | 통증을 치료하기 위한 방법 및 조성물 |
JP6151707B2 (ja) | 2011-10-27 | 2017-06-21 | マサチューセッツ インスティテュート オブ テクノロジー | 薬物内包微小球の形成が可能なn−末端で官能基化されたアミノ酸誘導体 |
WO2013142969A1 (en) * | 2012-03-28 | 2013-10-03 | Jian Ping Gao | Urethanes and ureas and processes |
KR20150023315A (ko) * | 2012-04-27 | 2015-03-05 | 맨카인드 코포레이션 | 에틸푸마레이트의 합성방법 및 중간체로서의 이들의 용도 |
JP6312262B2 (ja) | 2012-07-12 | 2018-04-18 | マンカインド コーポレイション | 乾燥粉末薬物送達システム |
WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
SG11201507564PA (en) | 2013-03-15 | 2015-10-29 | Mannkind Corp | Microcrystalline diketopiperazine compositions and methods |
AU2014290438B2 (en) | 2013-07-18 | 2019-11-07 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
WO2016004202A1 (en) | 2014-07-02 | 2016-01-07 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
AU2016278970B2 (en) | 2015-06-19 | 2020-10-29 | Massachusetts Institute Of Technology | Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell |
AU2020351154A1 (en) * | 2019-09-17 | 2022-03-31 | Cass Pharmaceuticals, Inc. | Subcutaneously injectable insulin formulations and methods of administration |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6331318B1 (en) | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
US5352461A (en) | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
US6509006B1 (en) | 1992-07-08 | 2003-01-21 | Inhale Therapeutic Systems, Inc. | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments |
US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
CA2190502A1 (en) | 1994-05-18 | 1995-11-23 | Robert M. Platz | Methods and compositions for the dry powder formulation of interferons |
US6428771B1 (en) | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
WO1998029140A1 (en) | 1996-12-31 | 1998-07-09 | Inhale Therapeutic Systems | Processes and compositions for spray drying hydrophobic drugs in organic solvent suspensions of hydrophilic excipients |
US7464706B2 (en) | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
GB2382346B (en) * | 2000-08-04 | 2004-08-11 | Dmi Biosciences Inc | Method of synthesizing diketopiperazines |
TWI283182B (en) | 2000-08-07 | 2007-07-01 | Nektar Therapeutics | Inhalable spray dried 4-helix bundle protein powders having minimized aggregation |
ES2281458T3 (es) | 2000-12-21 | 2007-10-01 | Nektar Therapeutics | Composiciones de polvo estables en almacenamiento del receptor de interleucina 4. |
JP4663906B2 (ja) * | 2001-04-26 | 2011-04-06 | 富士フイルム株式会社 | セルロースアシレートフイルム |
CN1314445C (zh) | 2001-05-21 | 2007-05-09 | 耐科塔医药公司 | 化学修饰胰岛素的肺部给药 |
CA2575684A1 (en) | 2004-08-23 | 2006-03-02 | Mannkind Corporation | Pulmonary delivery of inhibitors of phosphodiesterase type 5 |
KR101644250B1 (ko) | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
KR101486397B1 (ko) | 2005-09-14 | 2015-01-28 | 맨카인드 코포레이션 | 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법 |
BRPI0707991B8 (pt) | 2006-02-22 | 2021-05-25 | Mannkind Corp | métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco |
EA018548B1 (ru) * | 2006-08-04 | 2013-08-30 | Манус Фармасьютикалз (Канада) Лтд. | Полифункциональные биологически активные соединения |
MX2011007065A (es) * | 2008-12-29 | 2011-08-03 | Mannkind Corp | Analogos de dicetopiperazina substituida para usarse como agentes de suministro de farmaco. |
-
2009
- 2009-12-29 MX MX2011007065A patent/MX2011007065A/es active IP Right Grant
- 2009-12-29 EP EP20140192154 patent/EP2862854A1/en not_active Withdrawn
- 2009-12-29 SI SI200931126T patent/SI2379511T1/sl unknown
- 2009-12-29 DK DK09803976.1T patent/DK2379511T3/en active
- 2009-12-29 EP EP09803976.1A patent/EP2379511B1/en active Active
- 2009-12-29 ES ES09803976T patent/ES2531009T3/es active Active
- 2009-12-29 JP JP2011543723A patent/JP5788806B2/ja active Active
- 2009-12-29 PT PT98039761T patent/PT2379511E/pt unknown
- 2009-12-29 WO PCT/US2009/069745 patent/WO2010078373A1/en active Application Filing
- 2009-12-29 CA CA2748490A patent/CA2748490C/en active Active
-
2015
- 2015-07-30 JP JP2015150379A patent/JP2016006082A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2016006082A (ja) | 2016-01-14 |
DK2379511T3 (en) | 2015-01-12 |
JP2012514008A (ja) | 2012-06-21 |
ES2531009T3 (es) | 2015-03-09 |
EP2379511A1 (en) | 2011-10-26 |
JP5788806B2 (ja) | 2015-10-07 |
CA2748490A1 (en) | 2010-07-08 |
WO2010078373A1 (en) | 2010-07-08 |
EP2862854A1 (en) | 2015-04-22 |
PT2379511E (pt) | 2015-02-27 |
EP2379511B1 (en) | 2014-12-17 |
CA2748490C (en) | 2016-10-04 |
SI2379511T1 (sl) | 2015-03-31 |
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