MX2011007065A - Analogos de dicetopiperazina substituida para usarse como agentes de suministro de farmaco. - Google Patents

Analogos de dicetopiperazina substituida para usarse como agentes de suministro de farmaco.

Info

Publication number
MX2011007065A
MX2011007065A MX2011007065A MX2011007065A MX2011007065A MX 2011007065 A MX2011007065 A MX 2011007065A MX 2011007065 A MX2011007065 A MX 2011007065A MX 2011007065 A MX2011007065 A MX 2011007065A MX 2011007065 A MX2011007065 A MX 2011007065A
Authority
MX
Mexico
Prior art keywords
drug delivery
delivery agents
substituted diketopiperazine
analogs
delivery
Prior art date
Application number
MX2011007065A
Other languages
English (en)
Inventor
Kelly Sullivan Kraft
Original Assignee
Mannkind Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mannkind Corp filed Critical Mannkind Corp
Publication of MX2011007065A publication Critical patent/MX2011007065A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Se describen sistemas de suministro de fármaco para el suministro de fármacos de molécula pequeña y macromoleculares. Más particularmente. Se describen análogos substituidos de 3,6- di(alquil-4-aminobutil)-2,5-dicetopiperazina (la cual también puede ser denominada como DKP), su uso en la formulación de fármacos tanto de molécula pequeña como macromoleculares incluyendo agentes terapéuticos, profilácticos y de diagnóstico, agentes de estabilización y sistemas para su suministro.
MX2011007065A 2008-12-29 2009-12-29 Analogos de dicetopiperazina substituida para usarse como agentes de suministro de farmaco. MX2011007065A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14120708P 2008-12-29 2008-12-29
PCT/US2009/069745 WO2010078373A1 (en) 2008-12-29 2009-12-29 Substituted diketopiperazine analogs for use as drug delivery agents

Publications (1)

Publication Number Publication Date
MX2011007065A true MX2011007065A (es) 2011-08-03

Family

ID=41694085

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011007065A MX2011007065A (es) 2008-12-29 2009-12-29 Analogos de dicetopiperazina substituida para usarse como agentes de suministro de farmaco.

Country Status (9)

Country Link
EP (2) EP2862854A1 (es)
JP (2) JP5788806B2 (es)
CA (1) CA2748490C (es)
DK (1) DK2379511T3 (es)
ES (1) ES2531009T3 (es)
MX (1) MX2011007065A (es)
PT (1) PT2379511E (es)
SI (1) SI2379511T1 (es)
WO (1) WO2010078373A1 (es)

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AU2009259883B2 (en) 2008-06-20 2015-02-05 Mannkind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
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EP2862854A1 (en) * 2008-12-29 2015-04-22 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
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WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CA2852536A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
KR102272498B1 (ko) * 2011-10-27 2021-07-06 메사추세츠 인스티튜트 오브 테크놀로지 약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체
CN104284918B (zh) * 2012-03-28 2017-03-29 高剑萍 氨酯型和脲酯型化合物及其制备方法
EP2841422B1 (en) * 2012-04-27 2019-08-28 MannKind Corporation Methods for the synthesis of ethylfumarates and their use as intermediates
WO2014012069A2 (en) * 2012-07-12 2014-01-16 Mannkind Corporation Dry powder drug delivery systems and methods
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
EP3587404B1 (en) 2013-03-15 2022-07-13 MannKind Corporation Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
BR112016000937A8 (pt) 2013-07-18 2021-06-22 Mannkind Corp formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
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EP2862854A1 (en) * 2008-12-29 2015-04-22 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents

Also Published As

Publication number Publication date
SI2379511T1 (sl) 2015-03-31
WO2010078373A1 (en) 2010-07-08
JP2012514008A (ja) 2012-06-21
ES2531009T3 (es) 2015-03-09
EP2379511B1 (en) 2014-12-17
CA2748490A1 (en) 2010-07-08
CA2748490C (en) 2016-10-04
DK2379511T3 (en) 2015-01-12
JP5788806B2 (ja) 2015-10-07
EP2379511A1 (en) 2011-10-26
EP2862854A1 (en) 2015-04-22
PT2379511E (pt) 2015-02-27
JP2016006082A (ja) 2016-01-14

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