MX2011005147A - Derivados de cromenona como antagonistas de trpv3. - Google Patents
Derivados de cromenona como antagonistas de trpv3.Info
- Publication number
- MX2011005147A MX2011005147A MX2011005147A MX2011005147A MX2011005147A MX 2011005147 A MX2011005147 A MX 2011005147A MX 2011005147 A MX2011005147 A MX 2011005147A MX 2011005147 A MX2011005147 A MX 2011005147A MX 2011005147 A MX2011005147 A MX 2011005147A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- unsubstituted
- compound
- pain
- alkyl
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title description 6
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical class C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 title description 4
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- 125000000217 alkyl group Chemical group 0.000 claims description 42
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzenecarbonitrile Natural products N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims description 42
- 125000003118 aryl group Chemical group 0.000 claims description 32
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- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 21
- 239000001257 hydrogen Substances 0.000 claims description 20
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- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 6
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- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 26
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 24
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- 239000002904 solvent Substances 0.000 description 21
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2420MU2008 | 2008-11-17 | ||
| US13845608P | 2008-12-17 | 2008-12-17 | |
| IN664MU2009 | 2009-03-23 | ||
| US17126509P | 2009-04-21 | 2009-04-21 | |
| PCT/IB2009/007353 WO2010055384A1 (en) | 2008-11-17 | 2009-11-06 | Chromenone derivatives as trpv3 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011005147A true MX2011005147A (es) | 2011-08-29 |
Family
ID=42169675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011005147A MX2011005147A (es) | 2008-11-17 | 2009-11-06 | Derivados de cromenona como antagonistas de trpv3. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20110237659A1 (enExample) |
| EP (1) | EP2367810A4 (enExample) |
| JP (1) | JP2012508790A (enExample) |
| AU (1) | AU2009315363A1 (enExample) |
| CA (1) | CA2743276A1 (enExample) |
| EA (1) | EA201190003A1 (enExample) |
| GE (1) | GEP20146025B (enExample) |
| MX (1) | MX2011005147A (enExample) |
| NZ (1) | NZ595779A (enExample) |
| WO (1) | WO2010055384A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160127749A (ko) | 2014-03-20 | 2016-11-04 | 니폰 조키 세야쿠 가부시키가이샤 | 쿠마린 유도체를 유효 성분으로서 함유하는 치료·예방제 |
| CN112694392B (zh) * | 2020-12-21 | 2022-11-22 | 青岛大学 | 一种trpv3抑制剂及其制备方法 |
| WO2024140431A1 (en) * | 2022-12-26 | 2024-07-04 | Iongen Therapeutics Co., Ltd. | Compounds comprising heteroaryl rings and compositions and methods thereof |
| WO2025255092A1 (en) * | 2024-06-03 | 2025-12-11 | Artax Biopharma Inc. | Combination of a chromene derivative tcr inhibitor and a tyk2 inhibitor |
| CN121021448B (zh) * | 2025-08-26 | 2026-05-08 | 江西金丰药业有限公司 | 一种2-烃基-3-碘色酮类化合物的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4033845A (en) * | 1975-11-20 | 1977-07-05 | Warner-Lambert Company | [2-(4-Oxo-4H-1-benzopyran-2-yl)ethenyl]benzonitriles and benzoic acids |
| AU508350B2 (en) * | 1976-06-16 | 1980-03-20 | Farmitalia Carlo Erba S.P.A. | Substicuted 2-vinyl-chromones |
| US4183945A (en) * | 1976-06-16 | 1980-01-15 | Carlo Erba S.P.A. | Substituted 2-vinyl-chromones and process for their preparation |
| JP4431638B2 (ja) * | 1996-01-29 | 2010-03-17 | アメリカ合衆国 | ジヒドロピリジン―、ピリジン―、ベンゾピラン―オン―およびトリアゾロキナゾリン誘導体、それらの製造およびそれらのアデノシン受容体アンタゴニストとしての用途 |
| DE10031809A1 (de) * | 2000-07-04 | 2002-01-17 | Basf Ag | Neue Flavonoide und ihre Verwendung in kosmetischen und dermatologischen Zubereitungen |
| US20040009537A1 (en) * | 2002-01-11 | 2004-01-15 | Jack Roos | Methods of modulating and of identifying agents that modulate intracellular calcium |
| GB0412768D0 (en) * | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
| EP2392328A1 (en) * | 2005-05-09 | 2011-12-07 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 Function |
| US20100152209A1 (en) * | 2005-11-04 | 2010-06-17 | Hydra Biosciences Inc. | Compounds for Modulating TRPV3 Function |
| CA2652307A1 (en) * | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
-
2009
- 2009-11-06 JP JP2011543830A patent/JP2012508790A/ja active Pending
- 2009-11-06 NZ NZ595779A patent/NZ595779A/xx not_active IP Right Cessation
- 2009-11-06 CA CA2743276A patent/CA2743276A1/en not_active Abandoned
- 2009-11-06 MX MX2011005147A patent/MX2011005147A/es not_active Application Discontinuation
- 2009-11-06 US US13/126,003 patent/US20110237659A1/en not_active Abandoned
- 2009-11-06 EP EP09825816A patent/EP2367810A4/en not_active Withdrawn
- 2009-11-06 WO PCT/IB2009/007353 patent/WO2010055384A1/en not_active Ceased
- 2009-11-06 GE GEAP200912253A patent/GEP20146025B/en unknown
- 2009-11-06 EA EA201190003A patent/EA201190003A1/ru unknown
- 2009-11-06 AU AU2009315363A patent/AU2009315363A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009315363A1 (en) | 2012-01-19 |
| EP2367810A1 (en) | 2011-09-28 |
| AU2009315363A2 (en) | 2012-04-12 |
| CA2743276A1 (en) | 2010-05-20 |
| WO2010055384A1 (en) | 2010-05-20 |
| JP2012508790A (ja) | 2012-04-12 |
| NZ595779A (en) | 2013-08-30 |
| EP2367810A4 (en) | 2012-06-13 |
| GEP20146025B (en) | 2014-01-27 |
| EA201190003A1 (ru) | 2012-05-30 |
| US20110237659A1 (en) | 2011-09-29 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |