NZ595779A - Chromenone derivatives as trpv3 antagonists - Google Patents
Chromenone derivatives as trpv3 antagonistsInfo
- Publication number
- NZ595779A NZ595779A NZ595779A NZ59577909A NZ595779A NZ 595779 A NZ595779 A NZ 595779A NZ 595779 A NZ595779 A NZ 595779A NZ 59577909 A NZ59577909 A NZ 59577909A NZ 595779 A NZ595779 A NZ 595779A
- Authority
- NZ
- New Zealand
- Prior art keywords
- pain
- disease
- chromenyl
- benzonitrile
- ethenyl
- Prior art date
Links
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical class C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title 1
- 208000002193 Pain Diseases 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 2
- 208000004296 neuralgia Diseases 0.000 abstract 2
- NHNKEBWFQXTVRR-BUHFOSPRSA-N 4-[2-[(e)-2-(2-cyclopentyloxy-3-methoxyphenyl)ethenyl]-6,7-difluoro-4-oxochromen-3-yl]benzonitrile Chemical compound C1CCCC1OC=1C(OC)=CC=CC=1\C=C\C=1OC2=CC(F)=C(F)C=C2C(=O)C=1C1=CC=C(C#N)C=C1 NHNKEBWFQXTVRR-BUHFOSPRSA-N 0.000 abstract 1
- KHJBISIYEJBUOX-DTQAZKPQSA-N 4-[2-[(e)-2-(2-cyclopentyloxy-3-methoxyphenyl)ethenyl]-7-fluoro-4-oxochromen-3-yl]benzonitrile Chemical compound C1CCCC1OC=1C(OC)=CC=CC=1\C=C\C=1OC2=CC(F)=CC=C2C(=O)C=1C1=CC=C(C#N)C=C1 KHJBISIYEJBUOX-DTQAZKPQSA-N 0.000 abstract 1
- PNPREJPSLFEKKY-NTCAYCPXSA-N 4-[2-[(e)-2-[2-(2,2-dimethylpropoxy)-3-methoxyphenyl]ethenyl]-7-fluoro-4-oxochromen-3-yl]benzonitrile Chemical compound COC1=CC=CC(\C=C\C2=C(C(=O)C3=CC=C(F)C=C3O2)C=2C=CC(=CC=2)C#N)=C1OCC(C)(C)C PNPREJPSLFEKKY-NTCAYCPXSA-N 0.000 abstract 1
- QEWYWOPMTTVSQP-ACCUITESSA-N 4-[6-fluoro-2-[(e)-2-[3-methoxy-2-(2-methylpropoxy)phenyl]ethenyl]-4-oxochromen-3-yl]benzonitrile Chemical compound COC1=CC=CC(\C=C\C2=C(C(=O)C3=CC(F)=CC=C3O2)C=2C=CC(=CC=2)C#N)=C1OCC(C)C QEWYWOPMTTVSQP-ACCUITESSA-N 0.000 abstract 1
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006820 Arthralgia Diseases 0.000 abstract 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- 206010058019 Cancer Pain Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 208000015943 Coeliac disease Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- 208000012661 Dyskinesia Diseases 0.000 abstract 1
- 208000004232 Enteritis Diseases 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 206010020559 Hyperacusis Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 208000027530 Meniere disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000007101 Muscle Cramp Diseases 0.000 abstract 1
- 208000028389 Nerve injury Diseases 0.000 abstract 1
- 208000001294 Nociceptive Pain Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 208000004550 Postoperative Pain Diseases 0.000 abstract 1
- 208000017442 Retinal disease Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 208000005392 Spasm Diseases 0.000 abstract 1
- 208000009205 Tinnitus Diseases 0.000 abstract 1
- 206010060875 Uraemic pruritus Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 208000003728 Vulvodynia Diseases 0.000 abstract 1
- 206010069055 Vulvovaginal pain Diseases 0.000 abstract 1
- 208000009621 actinic keratosis Diseases 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000003925 brain function Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 1
- 208000009326 ileitis Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- 230000008764 nerve damage Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
- 208000037916 non-allergic rhinitis Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000001823 pruritic effect Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 231100000886 tinnitus Toxicity 0.000 abstract 1
- 230000001052 transient effect Effects 0.000 abstract 1
- 206010044652 trigeminal neuralgia Diseases 0.000 abstract 1
- 210000003932 urinary bladder Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
- C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
-
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2420MU2008 | 2008-11-17 | ||
| US13845608P | 2008-12-17 | 2008-12-17 | |
| IN664MU2009 | 2009-03-23 | ||
| US17126509P | 2009-04-21 | 2009-04-21 | |
| PCT/IB2009/007353 WO2010055384A1 (en) | 2008-11-17 | 2009-11-06 | Chromenone derivatives as trpv3 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ595779A true NZ595779A (en) | 2013-08-30 |
Family
ID=42169675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ595779A NZ595779A (en) | 2008-11-17 | 2009-11-06 | Chromenone derivatives as trpv3 antagonists |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20110237659A1 (enExample) |
| EP (1) | EP2367810A4 (enExample) |
| JP (1) | JP2012508790A (enExample) |
| AU (1) | AU2009315363A1 (enExample) |
| CA (1) | CA2743276A1 (enExample) |
| EA (1) | EA201190003A1 (enExample) |
| GE (1) | GEP20146025B (enExample) |
| MX (1) | MX2011005147A (enExample) |
| NZ (1) | NZ595779A (enExample) |
| WO (1) | WO2010055384A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160127749A (ko) | 2014-03-20 | 2016-11-04 | 니폰 조키 세야쿠 가부시키가이샤 | 쿠마린 유도체를 유효 성분으로서 함유하는 치료·예방제 |
| CN112694392B (zh) * | 2020-12-21 | 2022-11-22 | 青岛大学 | 一种trpv3抑制剂及其制备方法 |
| WO2024140431A1 (en) * | 2022-12-26 | 2024-07-04 | Iongen Therapeutics Co., Ltd. | Compounds comprising heteroaryl rings and compositions and methods thereof |
| WO2025255092A1 (en) * | 2024-06-03 | 2025-12-11 | Artax Biopharma Inc. | Combination of a chromene derivative tcr inhibitor and a tyk2 inhibitor |
| CN121021448B (zh) * | 2025-08-26 | 2026-05-08 | 江西金丰药业有限公司 | 一种2-烃基-3-碘色酮类化合物的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4033845A (en) * | 1975-11-20 | 1977-07-05 | Warner-Lambert Company | [2-(4-Oxo-4H-1-benzopyran-2-yl)ethenyl]benzonitriles and benzoic acids |
| AU508350B2 (en) * | 1976-06-16 | 1980-03-20 | Farmitalia Carlo Erba S.P.A. | Substicuted 2-vinyl-chromones |
| US4183945A (en) * | 1976-06-16 | 1980-01-15 | Carlo Erba S.P.A. | Substituted 2-vinyl-chromones and process for their preparation |
| JP4431638B2 (ja) * | 1996-01-29 | 2010-03-17 | アメリカ合衆国 | ジヒドロピリジン―、ピリジン―、ベンゾピラン―オン―およびトリアゾロキナゾリン誘導体、それらの製造およびそれらのアデノシン受容体アンタゴニストとしての用途 |
| DE10031809A1 (de) * | 2000-07-04 | 2002-01-17 | Basf Ag | Neue Flavonoide und ihre Verwendung in kosmetischen und dermatologischen Zubereitungen |
| US20040009537A1 (en) * | 2002-01-11 | 2004-01-15 | Jack Roos | Methods of modulating and of identifying agents that modulate intracellular calcium |
| GB0412768D0 (en) * | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
| EP2392328A1 (en) * | 2005-05-09 | 2011-12-07 | Hydra Biosciences, Inc. | Compounds for modulating TRPV3 Function |
| US20100152209A1 (en) * | 2005-11-04 | 2010-06-17 | Hydra Biosciences Inc. | Compounds for Modulating TRPV3 Function |
| CA2652307A1 (en) * | 2006-04-10 | 2007-10-18 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
-
2009
- 2009-11-06 JP JP2011543830A patent/JP2012508790A/ja active Pending
- 2009-11-06 NZ NZ595779A patent/NZ595779A/xx not_active IP Right Cessation
- 2009-11-06 CA CA2743276A patent/CA2743276A1/en not_active Abandoned
- 2009-11-06 MX MX2011005147A patent/MX2011005147A/es not_active Application Discontinuation
- 2009-11-06 US US13/126,003 patent/US20110237659A1/en not_active Abandoned
- 2009-11-06 EP EP09825816A patent/EP2367810A4/en not_active Withdrawn
- 2009-11-06 WO PCT/IB2009/007353 patent/WO2010055384A1/en not_active Ceased
- 2009-11-06 GE GEAP200912253A patent/GEP20146025B/en unknown
- 2009-11-06 EA EA201190003A patent/EA201190003A1/ru unknown
- 2009-11-06 AU AU2009315363A patent/AU2009315363A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009315363A1 (en) | 2012-01-19 |
| EP2367810A1 (en) | 2011-09-28 |
| AU2009315363A2 (en) | 2012-04-12 |
| CA2743276A1 (en) | 2010-05-20 |
| MX2011005147A (es) | 2011-08-29 |
| WO2010055384A1 (en) | 2010-05-20 |
| JP2012508790A (ja) | 2012-04-12 |
| EP2367810A4 (en) | 2012-06-13 |
| GEP20146025B (en) | 2014-01-27 |
| EA201190003A1 (ru) | 2012-05-30 |
| US20110237659A1 (en) | 2011-09-29 |
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