EA201890402A1 - 5-htрецепторные агонисты и композиции и способы применения - Google Patents
5-htрецепторные агонисты и композиции и способы примененияInfo
- Publication number
- EA201890402A1 EA201890402A1 EA201890402A EA201890402A EA201890402A1 EA 201890402 A1 EA201890402 A1 EA 201890402A1 EA 201890402 A EA201890402 A EA 201890402A EA 201890402 A EA201890402 A EA 201890402A EA 201890402 A1 EA201890402 A1 EA 201890402A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- disorders
- caused
- addiction
- sleep
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Addiction (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
В некоторых вариантах осуществления обеспечивают соединения формулы A, как определено в настоящем изобретении, которые модулируют активность 5-HTрецептора.В некоторых вариантах осуществления также обеспечивают способы, такие как коррекция веса, стимулирование чувства насыщения и снижение потребления пищи, и предотвращение и лечение ожирения, набора веса, вызванного антипсихотическими средствами, диабета 2 типа, синдрома Прадера-Вилли, зависимости от табака/никотина, наркотической зависимости, алкогольной зависимости, патологического влечения к азартным играм, синдрома дефицита значимости и сексуальной зависимости, заболеваний обсессивно-компульсивного спектра и расстройств контроля над побуждениями (включая привычку грызть ногти и онихофагию), расстройств сна (включая бессонницу, структуру фрагментированного сна и нарушения медленноволнового сна), недержания мочи, психических заболеваний (включая шизофрению, нервную анорексию и нервную булимию), болезни Альцгеймера, сексуальной дисфункции, эректильной дисфункции, эпилепсии, нарушений движения (включая паркинсонизм и нарушение движения, вызванное антипсихотическими средствами), гипертензии, дислипидемии, неалкогольного жирового заболевания печени, заболевания почек, вызванного ожирением, и апноэ во время сна.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562199382P | 2015-07-31 | 2015-07-31 | |
PCT/US2016/044426 WO2017023679A1 (en) | 2015-07-31 | 2016-07-28 | 5-ht2c receptor agonists and compositions and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201890402A1 true EA201890402A1 (ru) | 2018-09-28 |
EA039412B1 EA039412B1 (ru) | 2022-01-25 |
Family
ID=56684262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201890402A EA039412B1 (ru) | 2015-07-31 | 2016-07-28 | 5-ht2c рецепторные агонисты и композиции и способы применения |
Country Status (14)
Country | Link |
---|---|
US (4) | US10272094B2 (ru) |
EP (1) | EP3328835B1 (ru) |
JP (1) | JP6789578B2 (ru) |
KR (1) | KR20180031035A (ru) |
CN (1) | CN108137508B (ru) |
AU (1) | AU2016302755B2 (ru) |
BR (1) | BR112018001707A2 (ru) |
CA (1) | CA3002525A1 (ru) |
EA (1) | EA039412B1 (ru) |
HK (1) | HK1255850A1 (ru) |
IL (1) | IL257107B (ru) |
MA (1) | MA42527A (ru) |
MX (1) | MX2018001380A (ru) |
WO (1) | WO2017023679A1 (ru) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3002525A1 (en) * | 2015-07-31 | 2017-02-09 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
JPWO2019131902A1 (ja) | 2017-12-27 | 2020-12-10 | 武田薬品工業株式会社 | 腹圧性尿失禁および便失禁の治療薬 |
CN110668951B (zh) * | 2018-12-21 | 2022-09-30 | 安徽贝克生物制药有限公司 | 一种盐酸司来吉兰的合成工艺 |
CN110642721B (zh) * | 2018-12-21 | 2022-09-30 | 安徽贝克生物制药有限公司 | 盐酸司来吉兰的制备方法 |
CN113993523A (zh) | 2019-04-17 | 2022-01-28 | 指南针探路者有限公司 | 用赛洛西宾治疗抑郁症和其他各种病症 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1919592A (en) | 1991-04-16 | 1992-11-17 | National Institutes Of Health | Method of treating trichotillomania and onychophagia |
US6953787B2 (en) * | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
WO2003086303A2 (en) | 2002-04-12 | 2003-10-23 | The University Of Chicago | Farnesoid x-activated receptor agonists |
TW200307682A (en) * | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
NZ578503A (en) * | 2003-06-17 | 2011-02-25 | Arena Pharm Inc | Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases |
JP4773969B2 (ja) * | 2003-10-08 | 2011-09-14 | イーライ リリー アンド カンパニー | 脂質代謝異常の治療ための化合物及び方法 |
JP6198715B2 (ja) * | 2012-03-06 | 2017-09-20 | 武田薬品工業株式会社 | 三環性化合物 |
CA3002525A1 (en) | 2015-07-31 | 2017-02-09 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
-
2016
- 2016-07-28 CA CA3002525A patent/CA3002525A1/en not_active Abandoned
- 2016-07-28 AU AU2016302755A patent/AU2016302755B2/en not_active Ceased
- 2016-07-28 EP EP16751083.3A patent/EP3328835B1/en active Active
- 2016-07-28 CN CN201680058247.6A patent/CN108137508B/zh active Active
- 2016-07-28 KR KR1020187005698A patent/KR20180031035A/ko not_active Application Discontinuation
- 2016-07-28 JP JP2018504658A patent/JP6789578B2/ja active Active
- 2016-07-28 MX MX2018001380A patent/MX2018001380A/es active IP Right Grant
- 2016-07-28 US US15/748,205 patent/US10272094B2/en active Active
- 2016-07-28 WO PCT/US2016/044426 patent/WO2017023679A1/en active Application Filing
- 2016-07-28 BR BR112018001707A patent/BR112018001707A2/pt active Search and Examination
- 2016-07-28 MA MA042527A patent/MA42527A/fr unknown
- 2016-07-28 EA EA201890402A patent/EA039412B1/ru unknown
-
2018
- 2018-01-23 IL IL257107A patent/IL257107B/en active IP Right Grant
- 2018-11-22 HK HK18114926.0A patent/HK1255850A1/zh unknown
-
2019
- 2019-03-12 US US16/299,880 patent/US10624900B2/en active Active
-
2020
- 2020-04-14 US US16/848,013 patent/US11395824B2/en active Active
-
2022
- 2022-06-10 US US17/837,622 patent/US20230055376A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US11395824B2 (en) | 2022-07-26 |
MX2018001380A (es) | 2018-06-15 |
AU2016302755A1 (en) | 2018-03-15 |
HK1255850A1 (zh) | 2019-08-30 |
US20200078368A1 (en) | 2020-03-12 |
EA039412B1 (ru) | 2022-01-25 |
AU2016302755B2 (en) | 2020-09-10 |
BR112018001707A2 (pt) | 2018-09-18 |
US10624900B2 (en) | 2020-04-21 |
CN108137508B (zh) | 2021-08-27 |
IL257107B (en) | 2021-03-25 |
CN108137508A (zh) | 2018-06-08 |
MA42527A (fr) | 2021-04-07 |
EP3328835B1 (en) | 2022-10-12 |
US10272094B2 (en) | 2019-04-30 |
NZ739883A (en) | 2021-03-26 |
KR20180031035A (ko) | 2018-03-27 |
WO2017023679A1 (en) | 2017-02-09 |
US20200383993A1 (en) | 2020-12-10 |
EP3328835A1 (en) | 2018-06-06 |
IL257107A (en) | 2018-03-29 |
US20180214455A1 (en) | 2018-08-02 |
JP6789578B2 (ja) | 2020-11-25 |
US20230055376A1 (en) | 2023-02-23 |
CA3002525A1 (en) | 2017-02-09 |
JP2018522025A (ja) | 2018-08-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201890402A1 (ru) | 5-htрецепторные агонисты и композиции и способы применения | |
BR112017023088A2 (pt) | agonistas do receptor 5-ht2c e composições e métodos de uso | |
EA201990527A1 (ru) | Агонисты рецептора 5-htи композиции, а также способ их применения | |
MX2020002060A (es) | Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos. | |
TN2017000119A1 (en) | Indole carboxamides compounds useful as kinase inhibitors | |
PH12015501208A1 (en) | Amine derivative compounds for treating ophthalmic diseases and disorders | |
NZ629198A (en) | Oxazolidin- 2 -one compounds and uses thereof as pi3ks inhibitors | |
EA200901159A1 (ru) | Производные 3-циано-4-(4-фенилпиперидин-1-ил)пиридин-2-она | |
PH12015501942A1 (en) | Susbtituted 3-phenylpropylamine derivatives for the treatment of opthalmic diseases and disorders | |
EA200800430A1 (ru) | Замещённые тетрагидро-1н-пиридо[4,3,b] индолы как агонисты и антагонисты серотониновых рецепторов | |
EA201000006A1 (ru) | Способы и композиции для лечения аллергических заболеваний | |
NZ595625A (en) | Substituted 2-mercaptoquinoline-3-carboxamides as kcnq2/3 modulators | |
EA200901162A1 (ru) | Производные 1,4-дизамещённого 3-цианопиридона и их применение в качестве положительных модуляторов рецептора mglur2 | |
TN2011000463A1 (en) | Composition and methods for increasing muscle growth | |
EA200901160A1 (ru) | Производные 3-циано-4-(4-тетрагидропиранфенил)пиридин-2-она | |
EA200970583A1 (ru) | Способ получения пиперазиниловых и диазепаниловых производных бензамида | |
TN2017000158A1 (en) | Carbazole derivatives | |
EA201590406A1 (ru) | Мочевинные и амидные производные аминоалкилпиперазинов и их применение | |
PE20081373A1 (es) | Derivados de 5-fenil-nicotinamida | |
BR112017000160A2 (pt) | derivados de azetidina substituidos como ligantes de taar | |
JP2014532063A5 (ru) | ||
DE602005016836D1 (de) | Chotischer und anxiolytischer aktivität | |
MX2014003883A (es) | Inhibidores de monoacilglicerol lipasa para el tratamiento de enfermedades metabolicas y transtornos relacionados. | |
MX2016001080A (es) | Derivados de pirroloquinolina como antagonistas de 5-ht6, metodo de preparacion y uso de los mismos. | |
MX2015012459A (es) | Polimorfos y sales de un compuesto. |