MX2010007887A - Tratamiento y prevencion de condiciones cardiacas utilizando dos o mas isoformas del factor de crecimiento de hepatocitos. - Google Patents
Tratamiento y prevencion de condiciones cardiacas utilizando dos o mas isoformas del factor de crecimiento de hepatocitos.Info
- Publication number
- MX2010007887A MX2010007887A MX2010007887A MX2010007887A MX2010007887A MX 2010007887 A MX2010007887 A MX 2010007887A MX 2010007887 A MX2010007887 A MX 2010007887A MX 2010007887 A MX2010007887 A MX 2010007887A MX 2010007887 A MX2010007887 A MX 2010007887A
- Authority
- MX
- Mexico
- Prior art keywords
- isoforms
- growth factor
- hepatocyte growth
- prevention
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1833—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Abstract
La presente invención se relaciona con métodos para tratar o prevenir condiciones cardíacas en un sujeto, que comprende administrar al sujeto dos o más isoformas de fractor de crecimiento de hepatocito (HGF). La presente invención se relaciona además con métodos para promover el crecimiento de célula endotelial en un vaso sanguíneo que comprende administrar al vaso sanguíneo dos o más isoformas de factor de crecimiento de hpatocito (HGF). En una modalidad las dos o más isoformas de HGF se administran como uno o más polinucleótidos que codifican las isoformas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2375608P | 2008-01-25 | 2008-01-25 | |
| PCT/KR2009/000406 WO2009093880A2 (en) | 2008-01-25 | 2009-01-28 | Treatment and prevention of cardiac conditions using two or more isoforms of hepatocyte growth factor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010007887A true MX2010007887A (es) | 2010-08-10 |
Family
ID=40901564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010007887A MX2010007887A (es) | 2008-01-25 | 2009-01-28 | Tratamiento y prevencion de condiciones cardiacas utilizando dos o mas isoformas del factor de crecimiento de hepatocitos. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090202606A1 (es) |
| EP (1) | EP2252321B1 (es) |
| JP (1) | JP5563991B2 (es) |
| KR (1) | KR101325674B1 (es) |
| CN (1) | CN101925362A (es) |
| AU (1) | AU2009206869B2 (es) |
| BR (1) | BRPI0907624A2 (es) |
| CA (1) | CA2712078C (es) |
| DK (1) | DK2252321T3 (es) |
| ES (1) | ES2537971T3 (es) |
| MX (1) | MX2010007887A (es) |
| PT (1) | PT2252321E (es) |
| RU (1) | RU2448159C1 (es) |
| WO (1) | WO2009093880A2 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8409214B2 (en) * | 2009-01-22 | 2013-04-02 | Meditech Development Incorporated | Portable regulated vacuum pump for medical procedures |
| KR100562824B1 (ko) | 2002-03-20 | 2006-03-23 | 주식회사 바이로메드 | 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자 |
| AU2009234598C1 (en) * | 2008-04-09 | 2012-08-23 | Viromed Co., Ltd. | Lyophilized DNA formulations for enhanced expression of plasmid DNA |
| AU2012333408B2 (en) | 2011-11-03 | 2016-05-26 | Viromed Co., Ltd. | Gene therapy for diabetic neuropathy using an HGF isoform |
| US10639351B2 (en) | 2013-10-22 | 2020-05-05 | Helixmith Co., Ltd. | Method for treating amyotrophic lateral sclerosis with a polynucleotide encoding two or more isoforms of hepatocyte growth factor |
| CN103519900A (zh) * | 2013-10-24 | 2014-01-22 | 河南科技大学第一附属医院 | 一种心胸外科护肺膜 |
| KR101567954B1 (ko) * | 2013-11-25 | 2015-11-11 | 인하대학교 산학협력단 | Hgf 단백질 또는 그 유전자를 포함하는 발기부전 예방 또는 치료용 조성물 및 그의 용도 |
| WO2015192020A1 (en) | 2014-06-13 | 2015-12-17 | Children's Medical Center Corporation | Products and methods to isolate mitochondria |
| JP6532141B2 (ja) * | 2014-09-26 | 2019-06-19 | ヘリックスミス カンパニー リミテッド | 肝細胞増殖因子及びストローマ細胞由来因子１αを用いた末梢動脈疾患の予防または治療用組成物 |
| JP6944875B2 (ja) | 2015-01-21 | 2021-10-06 | ユニヴェルシテ デ シアンス エ テクノロジーズ ド リール １Ｕｎｉｖｅｒｓｉｔｅ Ｄｅｓ Ｓｃｉｅｎｃｅｓ Ｅｔ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｄｅ Ｌｉｌｌｅ １ | Ｍｅｔ受容体アゴニストタンパク質 |
| WO2018167447A1 (en) * | 2017-03-14 | 2018-09-20 | University Of Sheffield | Low dose aspirin (1-50 mg) together with antiplatelets such as ticagrelor of anticoagulants |
| CN109771642B (zh) | 2017-11-13 | 2022-09-20 | 同济大学苏州研究院 | c-MET激动型抗体及其用途 |
| KR20210052443A (ko) | 2018-07-17 | 2021-05-10 | 뉴로마이언 주식회사 | Igf-1 이형체를 발현하는 dna 컨스트럭트를 이용한 신경병증의 치료 |
| WO2020018969A1 (en) | 2018-07-19 | 2020-01-23 | Helixmith Co., Ltd. | Lyophilized pharmaceutical compositions for naked dna gene therapy |
| CA3130213A1 (en) * | 2019-02-15 | 2020-08-20 | Children's Medical Center Corporation | Treating heart failure |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ232813A (en) * | 1989-03-10 | 1992-08-26 | Snow Brand Milk Products Co Ltd | Human fibroblast glycoprotein, cell differentiation, blood vessel endothelial cell growth factor, cellular immunology inforcing factor of 78 or 74 thousand daltons plus or minus two thousand daltons |
| US6673776B1 (en) * | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5693622A (en) * | 1989-03-21 | 1997-12-02 | Vical Incorporated | Expression of exogenous polynucleotide sequences cardiac muscle of a mammal |
| CA2022752C (en) * | 1989-08-11 | 1998-07-07 | Naomi Kitamura | Hepatic parenchymal cell growth factor, gene encoding the same, process for producing the factor, and transformants producing the factor |
| US6706694B1 (en) * | 1990-03-21 | 2004-03-16 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate |
| ATE178354T1 (de) * | 1990-07-13 | 1999-04-15 | Snow Brand Milk Products Co Ltd | Plasmid das für die aminosäuresequenz von tcf-ii kodierende dns enthalt, transformierte zelle und produktion einer physiologisch aktiven substanz mit ihrer verwendung |
| US5661133B1 (en) * | 1991-11-12 | 1999-06-01 | Univ Michigan | Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein |
| US5837676A (en) * | 1993-10-18 | 1998-11-17 | Long Island Jewish Medical Center | Use of scatter factor to enhance angiogenesis |
| US6498144B1 (en) * | 1993-10-18 | 2002-12-24 | North Shore - Long Island Jewish Research Institute | Use of scatter factor to enhance angiogenesis |
| US5652225A (en) * | 1994-10-04 | 1997-07-29 | St. Elizabeth's Medical Center Of Boston, Inc. | Methods and products for nucleic acid delivery |
| US20030148968A1 (en) * | 1995-02-28 | 2003-08-07 | Hammond H. Kirk | Techniques and compositions for treating cardiovascular disease by in vivo gene delivery |
| CN100478033C (zh) * | 1995-08-29 | 2009-04-15 | 安增生摩祺株式会社 | 含有hgf基因的药物 |
| US5830879A (en) * | 1995-10-02 | 1998-11-03 | St. Elizabeth's Medical Center Of Boston, Inc. | Treatment of vascular injury using vascular endothelial growth factor |
| US6121246A (en) * | 1995-10-20 | 2000-09-19 | St. Elizabeth's Medical Center Of Boston, Inc. | Method for treating ischemic tissue |
| JPH11246433A (ja) * | 1998-03-03 | 1999-09-14 | Sumitomo Pharmaceut Co Ltd | 心筋梗塞治療剤 |
| US20040228834A1 (en) * | 1998-03-09 | 2004-11-18 | Jeffrey Isner | Compositions and methods for modulating vascularization |
| CN1222310C (zh) * | 1998-08-05 | 2005-10-12 | 住友制药株式会社 | 肝实质细胞增殖因子药用制剂 |
| KR20000046969A (ko) | 1998-12-31 | 2000-07-25 | 이선경 | 이종 유전자 유래의 유전자 발현 조절요소를 포함하는 강력한전사 활성을 가진 진핵세포 발현벡더 |
| AU778826B2 (en) * | 1999-10-29 | 2004-12-23 | Anges Mg, Inc. | Gene therapy for diabetic ischemic disease |
| CA2413768A1 (en) * | 2000-06-27 | 2002-01-03 | Anges Mg, Inc. | Pharmaceutical compositions for angiogenic therapy |
| WO2002064157A2 (en) * | 2001-01-23 | 2002-08-22 | Boston Scientific Corporation | Localized myocardial injection method for treating ischemic myocardium |
| EP1234583A1 (en) * | 2001-02-23 | 2002-08-28 | F. Hoffmann-La Roche Ag | PEG-conjugates of HGF-NK4 |
| KR100562824B1 (ko) * | 2002-03-20 | 2006-03-23 | 주식회사 바이로메드 | 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자 |
| AU2006244639A1 (en) * | 2005-03-31 | 2006-11-16 | Mytogen, Inc. | Treatment for heart disease |
| US20070212390A1 (en) * | 2005-09-22 | 2007-09-13 | Ludwig Institute For Cancer Research | Protease-resistant forms of VEGF-D, method of making and method of use |
| EP1954714A2 (en) * | 2005-11-10 | 2008-08-13 | Receptor Biologix, Inc. | Hepatocyte growth factor intron fusion proteins |
| AU2009234598C1 (en) * | 2008-04-09 | 2012-08-23 | Viromed Co., Ltd. | Lyophilized DNA formulations for enhanced expression of plasmid DNA |
-
2009
- 2009-01-23 US US12/359,137 patent/US20090202606A1/en not_active Abandoned
- 2009-01-28 CA CA2712078A patent/CA2712078C/en not_active Expired - Fee Related
- 2009-01-28 WO PCT/KR2009/000406 patent/WO2009093880A2/en active Application Filing
- 2009-01-28 BR BRPI0907624A patent/BRPI0907624A2/pt not_active Application Discontinuation
- 2009-01-28 KR KR1020107018680A patent/KR101325674B1/ko active IP Right Grant
- 2009-01-28 RU RU2010135532/10A patent/RU2448159C1/ru not_active IP Right Cessation
- 2009-01-28 PT PT97046601T patent/PT2252321E/pt unknown
- 2009-01-28 JP JP2010544236A patent/JP5563991B2/ja active Active
- 2009-01-28 AU AU2009206869A patent/AU2009206869B2/en not_active Ceased
- 2009-01-28 DK DK09704660.1T patent/DK2252321T3/en active
- 2009-01-28 ES ES09704660.1T patent/ES2537971T3/es active Active
- 2009-01-28 CN CN2009801030779A patent/CN101925362A/zh active Pending
- 2009-01-28 EP EP20090704660 patent/EP2252321B1/en active Active
- 2009-01-28 MX MX2010007887A patent/MX2010007887A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009093880A3 (en) | 2009-10-29 |
| PT2252321E (pt) | 2015-07-07 |
| BRPI0907624A2 (pt) | 2016-08-16 |
| ES2537971T3 (es) | 2015-06-16 |
| EP2252321A2 (en) | 2010-11-24 |
| EP2252321A4 (en) | 2012-09-05 |
| RU2448159C1 (ru) | 2012-04-20 |
| EP2252321B1 (en) | 2015-04-29 |
| CA2712078C (en) | 2015-02-24 |
| KR101325674B1 (ko) | 2013-11-06 |
| RU2010135532A (ru) | 2012-02-27 |
| KR20100126316A (ko) | 2010-12-01 |
| AU2009206869A1 (en) | 2009-07-30 |
| JP5563991B2 (ja) | 2014-07-30 |
| AU2009206869B2 (en) | 2012-04-19 |
| JP2011510069A (ja) | 2011-03-31 |
| US20090202606A1 (en) | 2009-08-13 |
| DK2252321T3 (en) | 2015-05-26 |
| CN101925362A (zh) | 2010-12-22 |
| CA2712078A1 (en) | 2009-07-30 |
| WO2009093880A2 (en) | 2009-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |