MX357071B - Medicamentos que comprenden apolipoproteína a-iv no glicosilada para el tratamiento de diabetes. - Google Patents

Medicamentos que comprenden apolipoproteína a-iv no glicosilada para el tratamiento de diabetes.

Info

Publication number
MX357071B
MX357071B MX2014008829A MX2014008829A MX357071B MX 357071 B MX357071 B MX 357071B MX 2014008829 A MX2014008829 A MX 2014008829A MX 2014008829 A MX2014008829 A MX 2014008829A MX 357071 B MX357071 B MX 357071B
Authority
MX
Mexico
Prior art keywords
methods
subject
need
expression system
glycosylated apolipoprotein
Prior art date
Application number
MX2014008829A
Other languages
English (en)
Other versions
MX2014008829A (es
Inventor
Fei Wang
Patrick Tso
Sean Davidson
Original Assignee
Univ Cincinnati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2012/021802 external-priority patent/WO2012100010A1/en
Application filed by Univ Cincinnati filed Critical Univ Cincinnati
Publication of MX2014008829A publication Critical patent/MX2014008829A/es
Publication of MX357071B publication Critical patent/MX357071B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a una proteína apolipoproteína A-IV no glicosilada, o u n análogo o fragmento biológicamente activo de la misa: a) que tiene al menos 905 de identidad a la proteína apolipoproteína A-IV, para usarse en : i) el tratamiento de la diabetes tipo 2 en un sujeto; ii) la reducción del nivel de glucosa en la sangre en un suejto; o iii) la restauración substancialmente de la tolerancia a la glucosa en un sjeto a un nivel normal; en donde la proteína apolipoproteína A-IV no glicosilada, o el análogo o fragmento biológicamente activo de la misma, se produce utilizando un sistema de expresión de proteínas.
MX2014008829A 2012-01-19 2012-11-21 Medicamentos que comprenden apolipoproteína a-iv no glicosilada para el tratamiento de diabetes. MX357071B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2012/021802 WO2012100010A1 (en) 2011-01-19 2012-01-19 Apolipoprotein aiv as an antidiabetic peptide
US201261675692P 2012-07-25 2012-07-25
PCT/US2012/066314 WO2013109342A1 (en) 2012-01-19 2012-11-21 Method of treating diabetes using non-glycosylated apolipoprotein a-iv

Publications (2)

Publication Number Publication Date
MX2014008829A MX2014008829A (es) 2014-10-24
MX357071B true MX357071B (es) 2018-06-22

Family

ID=48799573

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014008829A MX357071B (es) 2012-01-19 2012-11-21 Medicamentos que comprenden apolipoproteína a-iv no glicosilada para el tratamiento de diabetes.

Country Status (13)

Country Link
US (1) US9951120B2 (es)
EP (1) EP2804618B1 (es)
JP (1) JP6310398B2 (es)
KR (1) KR20140117565A (es)
CN (1) CN104066436B (es)
AU (1) AU2012366182B2 (es)
BR (1) BR112014017141A2 (es)
CA (1) CA2860782A1 (es)
EA (1) EA028230B1 (es)
HK (1) HK1203823A1 (es)
IL (1) IL233351A (es)
MX (1) MX357071B (es)
WO (1) WO2013109342A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX342020B (es) 2011-01-19 2016-09-08 Univ Cincinnati Apolipoproteina a-iv como un peptido antidiabetico.
WO2013109342A1 (en) 2012-01-19 2013-07-25 University Of Cincinnati Method of treating diabetes using non-glycosylated apolipoprotein a-iv
CA2878695A1 (en) 2012-07-25 2014-01-30 University Of Cincinnati Method of treating type i diabetes using apolipoprotein aiv
CA2878684A1 (en) 2012-07-25 2014-01-30 University Of Cincinnati Method of treating hyperglycemic disorders using apolipoprotein aiv
JP6629725B2 (ja) * 2014-06-23 2020-01-15 東亞合成株式会社 新規合成ペプチドおよびその利用
CN112546201A (zh) * 2019-09-26 2021-03-26 中国科学院生物物理研究所 人工脂蛋白颗粒apoA-Ⅳ脂肪体在治疗和/或预防糖尿病中的应用
CN112891561A (zh) * 2021-03-09 2021-06-04 百码科技(深圳)有限公司 一种基因治疗脂肪肝的生物药剂及其制备方法
CN113018459A (zh) * 2021-03-09 2021-06-25 百码科技(深圳)有限公司 一种基因治疗减肥的生物药剂及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
FR2686605B1 (fr) * 1992-01-27 1994-03-11 Rhone Poulenc Rorer Sa Nouveaux polypeptides, leur preparation et leur utilisation.
AU7242394A (en) 1993-05-28 1994-12-20 Merck & Co., Inc. Method to control appetite and treat obesity
US6729075B2 (en) * 2000-10-19 2004-05-04 Wenger Corporation Audience seating system
WO2003097696A1 (en) 2002-05-17 2003-11-27 Esperion Therapeutics, Inc. Methods and copositions for the treatment of ischemic reperfusion
US20080015265A1 (en) * 2006-07-11 2008-01-17 Byron Rubin Methods of treating obesity using satiety factors
US20100267052A1 (en) 2006-09-01 2010-10-21 American Type Culture Collection Compositions and methods for diagnosis and treatment of type 2 diabetes
WO2009116861A2 (en) * 2008-03-21 2009-09-24 Podiceps B.V. Diagnostic of pre-symptomatic metabolic syndrome
CN103788043B (zh) 2008-11-28 2016-02-03 中国医学科学院药物研究所 硝克柳胺化合物晶iv型、其制法和其药物组合物与用途
ES2558751T3 (es) * 2010-08-30 2016-02-08 F. Hoffmann-La Roche Ag Alimento alcalino
MX342020B (es) 2011-01-19 2016-09-08 Univ Cincinnati Apolipoproteina a-iv como un peptido antidiabetico.
WO2013109342A1 (en) 2012-01-19 2013-07-25 University Of Cincinnati Method of treating diabetes using non-glycosylated apolipoprotein a-iv
CA2878684A1 (en) 2012-07-25 2014-01-30 University Of Cincinnati Method of treating hyperglycemic disorders using apolipoprotein aiv
CA2878695A1 (en) 2012-07-25 2014-01-30 University Of Cincinnati Method of treating type i diabetes using apolipoprotein aiv

Also Published As

Publication number Publication date
AU2012366182B2 (en) 2017-08-17
BR112014017141A2 (pt) 2019-09-24
US20150011469A1 (en) 2015-01-08
IL233351A0 (en) 2014-08-31
HK1203823A1 (en) 2015-11-06
WO2013109342A8 (en) 2014-09-04
KR20140117565A (ko) 2014-10-07
IL233351A (en) 2016-12-29
EP2804618B1 (en) 2018-03-07
EP2804618A1 (en) 2014-11-26
US9951120B2 (en) 2018-04-24
CN104066436B (zh) 2016-12-14
EA028230B1 (ru) 2017-10-31
CN104066436A (zh) 2014-09-24
AU2012366182A8 (en) 2015-06-18
CA2860782A1 (en) 2013-07-25
JP2015506942A (ja) 2015-03-05
EA201491369A1 (ru) 2015-03-31
WO2013109342A1 (en) 2013-07-25
JP6310398B2 (ja) 2018-04-11
MX2014008829A (es) 2014-10-24
AU2012366182A1 (en) 2014-08-07

Similar Documents

Publication Publication Date Title
MX357071B (es) Medicamentos que comprenden apolipoproteína a-iv no glicosilada para el tratamiento de diabetes.
IN2014DN09782A (es)
PH12014502449A1 (en) Methods for the treatment of diabetic retinopathy and other ophthalmic diseases
MX2015008114A (es) Derivados de exendina-4.
MX2013004699A (es) Combinaciones farmaceuticas para el tratamiento de trastornos metabolicos.
NZ707139A (en) Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level
MX2020010004A (es) Composicion farmaceutica que comprende empagliflozina, metodos para tratamiento y sus usos.
WO2013186240A3 (en) Exendin-4 peptide analogues
EA201490377A1 (ru) Лечение рассеянного склероза комбинацией лаквинимода и глатирамера ацетата
NZ703597A (en) Mutant fragments of ospa and methods and uses relating thereto
MX2019005435A (es) Composicion farmaceutica, metodos para tratamiento y sus usos.
MA40057A (fr) Traitement thérapeutique de maladie cutanée au moyen de micro-organismes cutanés commensaux recombinants
BR112014027087A2 (pt) tablete, método para fabricação de um tablete de mesilato de bromocriptina, método para fabricação de um tablete de mesilato de bromocriptina e método de tratamento para melhorar o controle glicêmico de diabetes do tipo 2 em um paciente
WO2013022740A3 (en) Gpr35 ligands and the uses thereof
WO2010025321A3 (en) Method for treating multiple sclerosis patients with anti-il2r antibodies
MX343931B (es) Tratamiento de la esclerosis lateral amiotrofica con el uso de celulas derivadas del cordon umbilical.
WO2012012278A3 (en) Compositions and methods for the treatment of pathological condition(s) related to gpr35 and/or gpr35-herg complex
EA201691420A1 (ru) Композиции енолазы 1 (eno1) и их применение
PH12015500653B1 (en) Combination drug comprising gemigliptin and metformin, and method for the preparation thereof
EA201391063A1 (ru) Аполипопротеин a-iv в качестве антидиабетического пептида
MA32416B1 (fr) 7-sulfanylmethyl-, 7-sulfinymethyl-et 7-sulfonylmethyl-indoles substitues et leur utilisation
WO2014018763A3 (en) Method of treating type i diabetes using apolipoprotein aiv
NZ702666A (en) A method of weight reduction
MX2023005014A (es) Metodos de tratamiento de enfermedades inflamatorias cronicas.
WO2013090319A3 (en) Treatment of type i and type ii diabetes

Legal Events

Date Code Title Description
FG Grant or registration