MX357071B - Medicamentos que comprenden apolipoproteína a-iv no glicosilada para el tratamiento de diabetes. - Google Patents

Medicamentos que comprenden apolipoproteína a-iv no glicosilada para el tratamiento de diabetes.

Info

Publication number
MX357071B
MX357071B MX2014008829A MX2014008829A MX357071B MX 357071 B MX357071 B MX 357071B MX 2014008829 A MX2014008829 A MX 2014008829A MX 2014008829 A MX2014008829 A MX 2014008829A MX 357071 B MX357071 B MX 357071B
Authority
MX
Mexico
Prior art keywords
methods
subject
need
expression system
glycosylated apolipoprotein
Prior art date
Application number
MX2014008829A
Other languages
English (en)
Other versions
MX2014008829A (es
Inventor
Fei Wang
Patrick Tso
Sean Davidson
Original Assignee
Univ Cincinnati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2012/021802 external-priority patent/WO2012100010A1/en
Application filed by Univ Cincinnati filed Critical Univ Cincinnati
Publication of MX2014008829A publication Critical patent/MX2014008829A/es
Publication of MX357071B publication Critical patent/MX357071B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a una proteína apolipoproteína A-IV no glicosilada, o u n análogo o fragmento biológicamente activo de la misa: a) que tiene al menos 905 de identidad a la proteína apolipoproteína A-IV, para usarse en : i) el tratamiento de la diabetes tipo 2 en un sujeto; ii) la reducción del nivel de glucosa en la sangre en un suejto; o iii) la restauración substancialmente de la tolerancia a la glucosa en un sjeto a un nivel normal; en donde la proteína apolipoproteína A-IV no glicosilada, o el análogo o fragmento biológicamente activo de la misma, se produce utilizando un sistema de expresión de proteínas.
MX2014008829A 2012-01-19 2012-11-21 Medicamentos que comprenden apolipoproteína a-iv no glicosilada para el tratamiento de diabetes. MX357071B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2012/021802 WO2012100010A1 (en) 2011-01-19 2012-01-19 Apolipoprotein aiv as an antidiabetic peptide
US201261675692P 2012-07-25 2012-07-25
PCT/US2012/066314 WO2013109342A1 (en) 2012-01-19 2012-11-21 Method of treating diabetes using non-glycosylated apolipoprotein a-iv

Publications (2)

Publication Number Publication Date
MX2014008829A MX2014008829A (es) 2014-10-24
MX357071B true MX357071B (es) 2018-06-22

Family

ID=48799573

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014008829A MX357071B (es) 2012-01-19 2012-11-21 Medicamentos que comprenden apolipoproteína a-iv no glicosilada para el tratamiento de diabetes.

Country Status (13)

Country Link
US (1) US9951120B2 (es)
EP (1) EP2804618B1 (es)
JP (1) JP6310398B2 (es)
KR (1) KR20140117565A (es)
CN (1) CN104066436B (es)
AU (1) AU2012366182B2 (es)
BR (1) BR112014017141A2 (es)
CA (1) CA2860782A1 (es)
EA (1) EA028230B1 (es)
HK (1) HK1203823A1 (es)
IL (1) IL233351A (es)
MX (1) MX357071B (es)
WO (1) WO2013109342A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140071272A (ko) 2011-01-19 2014-06-11 유니버시티 오브 신시내티 항 당뇨병 펩타이드로서의 아포리포프로테인 ａｉｖ
CN104066436B (zh) 2012-01-19 2016-12-14 辛辛那提大学 使用非糖基化载脂蛋白a‑iv治疗糖尿病的方法
JP2015524808A (ja) * 2012-07-25 2015-08-27 ユニバーシティ・オブ・シンシナティ アポリポタンパク質ａｉｖを用いたｉ型糖尿病の治療法
JP6033433B2 (ja) 2012-07-25 2016-11-30 ユニバーシティ・オブ・シンシナティ アポリポタンパク質ａｉｖを用いて高血糖障害を治療する方法
US10138469B2 (en) * 2014-06-23 2018-11-27 Toagosei Co., Ltd. Synthetic peptide and use thereof
CN112546201A (zh) * 2019-09-26 2021-03-26 中国科学院生物物理研究所 人工脂蛋白颗粒apoA-Ⅳ脂肪体在治疗和/或预防糖尿病中的应用
CN112891561A (zh) * 2021-03-09 2021-06-04 百码科技(深圳)有限公司 一种基因治疗脂肪肝的生物药剂及其制备方法
CN113018459A (zh) * 2021-03-09 2021-06-25 百码科技(深圳)有限公司 一种基因治疗减肥的生物药剂及其制备方法

Family Cites Families (16)

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US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
FR2686605B1 (fr) 1992-01-27 1994-03-11 Rhone Poulenc Rorer Sa Nouveaux polypeptides, leur preparation et leur utilisation.
WO1994027629A1 (en) 1993-05-28 1994-12-08 Merck & Co., Inc. Method to control appetite and treat obesity
US6729075B2 (en) * 2000-10-19 2004-05-04 Wenger Corporation Audience seating system
CA2485989A1 (en) 2002-05-17 2003-11-27 Esperion Therapeutics, Inc. Methods and compositions for the treatment of ischemic reperfusion
CA2657578A1 (en) * 2006-07-11 2008-01-17 Harkness Pharmaceuticals, Inc. Methods of treating obesity using satiety factors
US20100267052A1 (en) 2006-09-01 2010-10-21 American Type Culture Collection Compositions and methods for diagnosis and treatment of type 2 diabetes
WO2009116861A2 (en) 2008-03-21 2009-09-24 Podiceps B.V. Diagnostic of pre-symptomatic metabolic syndrome
CN103833712B (zh) 2008-11-28 2016-02-03 中国医学科学院药物研究所 硝克柳胺化合物晶ii型、其制法和其药物组合物与用途
JP5798193B2 (ja) * 2010-08-30 2015-10-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ アルカリ性フィード
KR20140071272A (ko) 2011-01-19 2014-06-11 유니버시티 오브 신시내티 항 당뇨병 펩타이드로서의 아포리포프로테인 ａｉｖ
CN104066436B (zh) 2012-01-19 2016-12-14 辛辛那提大学 使用非糖基化载脂蛋白a‑iv治疗糖尿病的方法
JP6033433B2 (ja) 2012-07-25 2016-11-30 ユニバーシティ・オブ・シンシナティ アポリポタンパク質ａｉｖを用いて高血糖障害を治療する方法
JP2015524808A (ja) 2012-07-25 2015-08-27 ユニバーシティ・オブ・シンシナティ アポリポタンパク質ａｉｖを用いたｉ型糖尿病の治療法

Also Published As

Publication number Publication date
CA2860782A1 (en) 2013-07-25
WO2013109342A1 (en) 2013-07-25
KR20140117565A (ko) 2014-10-07
MX2014008829A (es) 2014-10-24
BR112014017141A2 (pt) 2019-09-24
CN104066436A (zh) 2014-09-24
JP6310398B2 (ja) 2018-04-11
WO2013109342A8 (en) 2014-09-04
EA201491369A1 (ru) 2015-03-31
US9951120B2 (en) 2018-04-24
AU2012366182B2 (en) 2017-08-17
US20150011469A1 (en) 2015-01-08
AU2012366182A8 (en) 2015-06-18
IL233351A (en) 2016-12-29
AU2012366182A1 (en) 2014-08-07
IL233351A0 (en) 2014-08-31
EP2804618A1 (en) 2014-11-26
HK1203823A1 (en) 2015-11-06
EA028230B1 (ru) 2017-10-31
CN104066436B (zh) 2016-12-14
EP2804618B1 (en) 2018-03-07
JP2015506942A (ja) 2015-03-05

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