MX2010000474A - Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral. - Google Patents

Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral.

Info

Publication number
MX2010000474A
MX2010000474A MX2010000474A MX2010000474A MX2010000474A MX 2010000474 A MX2010000474 A MX 2010000474A MX 2010000474 A MX2010000474 A MX 2010000474A MX 2010000474 A MX2010000474 A MX 2010000474A MX 2010000474 A MX2010000474 A MX 2010000474A
Authority
MX
Mexico
Prior art keywords
akt
compound
subject invention
cell
pkb
Prior art date
Application number
MX2010000474A
Other languages
English (en)
Spanish (es)
Inventor
Said M Sebti
Jin Q Cheng
Mei Sun
Original Assignee
Univ South Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ South Florida filed Critical Univ South Florida
Publication of MX2010000474A publication Critical patent/MX2010000474A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MX2010000474A 2007-07-12 2008-07-14 Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral. MX2010000474A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94936507P 2007-07-12 2007-07-12
PCT/US2008/069974 WO2009009793A2 (en) 2007-07-12 2008-07-14 Inhibitors of akt/pkb with anti-tumor activity

Publications (1)

Publication Number Publication Date
MX2010000474A true MX2010000474A (es) 2010-06-23

Family

ID=40229514

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010000474A MX2010000474A (es) 2007-07-12 2008-07-14 Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral.

Country Status (10)

Country Link
US (2) US8183249B2 (enExample)
EP (1) EP2173352B1 (enExample)
JP (1) JP5568471B2 (enExample)
KR (1) KR101618037B1 (enExample)
CN (1) CN101743007B (enExample)
AU (1) AU2008274956B2 (enExample)
BR (1) BRPI0815563A2 (enExample)
CA (1) CA2695330C (enExample)
MX (1) MX2010000474A (enExample)
WO (1) WO2009009793A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20110834T1 (hr) * 2004-09-03 2011-12-31 Merck Serono Sa Piridin metilen azolidinoni i njihova uporaba kao inhibitora fosfoinozitida
WO2009009793A2 (en) * 2007-07-12 2009-01-15 University Of South Florida Inhibitors of akt/pkb with anti-tumor activity
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
CA2810844C (en) 2010-09-07 2017-03-21 Dmi Acquisition Corp. Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions
WO2012158197A2 (en) * 2010-11-11 2012-11-22 Lyndor Biosciences L.L.C. Compounds useful as akt/pkb modulators and uses thereof
WO2012135759A1 (en) 2011-04-01 2012-10-04 Genentech, Inc. Combinations of akt inhibitor compounds and abiraterone, and methods of use
KR102016182B1 (ko) * 2011-04-01 2019-08-29 제넨테크, 인크. 암 치료에 대한 감수성을 예측하기 위한 바이오마커
CN102225067B (zh) * 2011-04-29 2012-10-03 济南环肽医药科技有限公司 一种治疗胃癌的药物组合物
MX2014003856A (es) 2011-10-10 2015-01-16 Ampio Pharmaceuticals Inc Dispositivos medicos implantables con tolerancia inmune incrementada y metodos para hacerlos e implantarlos.
EP2766029B1 (en) 2011-10-10 2020-03-25 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease
SG11201400283RA (en) 2011-10-28 2014-03-28 Ampio Pharmaceuticals Inc Treatment of rhinitis
GB201207722D0 (en) * 2012-05-02 2012-06-13 Bergenbio As Method
KR101461626B1 (ko) * 2012-08-02 2014-11-28 서울대학교산학협력단 Ａｋｔ１ 억제제 및 소수성 항암제를 포함하는 항암용 약학적 조성물
WO2014074883A1 (en) * 2012-11-08 2014-05-15 Lyndor Biosciences L.L.C. Novel synthesis of ld101
AU2014232728B2 (en) 2013-03-15 2019-02-21 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
KR20160104612A (ko) 2013-07-26 2016-09-05 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조성물
US9986375B2 (en) * 2014-02-12 2018-05-29 Google Llc Energy-efficient location determination
EP3183240A4 (en) 2014-08-18 2018-06-27 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
FR3033499A1 (fr) * 2015-03-11 2016-09-16 Centre Leon-Berard Composition pour le traitement des tumeurs neuroendocrines pancreatiques
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
CN116650645A (zh) * 2020-12-04 2023-08-29 周清华 Akt/stat3作为免疫检查点抑制剂的靶点的用途
WO2023168291A1 (en) * 2022-03-02 2023-09-07 Terremoto Biosciences, Inc. Covalent modifiers of akt1 and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US5167649A (en) 1988-08-22 1992-12-01 Zook Gerald P Drug delivery system for the removal of dermal lesions
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
JP4407008B2 (ja) * 2000-05-11 2010-02-03 パナソニック株式会社 カラー画像形成装置
UA72612C2 (en) 2000-07-06 2005-03-15 Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
CA2484921A1 (en) 2002-05-06 2003-11-13 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis c virus infection
LT2574341T (lt) * 2004-03-29 2017-09-11 University Of South Florida Navikų ir vėžio efektyvus gydymas triciribino fosfatu
US8828451B2 (en) * 2006-10-04 2014-09-09 University Of South Florida Akt sensitization of cancer cells
WO2009009793A2 (en) 2007-07-12 2009-01-15 University Of South Florida Inhibitors of akt/pkb with anti-tumor activity

Also Published As

Publication number Publication date
US9359347B2 (en) 2016-06-07
WO2009009793A3 (en) 2009-03-26
EP2173352A2 (en) 2010-04-14
KR101618037B1 (ko) 2016-05-04
BRPI0815563A2 (pt) 2015-02-18
CA2695330A1 (en) 2009-01-15
CA2695330C (en) 2017-06-13
US8183249B2 (en) 2012-05-22
CN101743007B (zh) 2015-04-08
CN101743007A (zh) 2010-06-16
AU2008274956B2 (en) 2014-08-21
JP2010533206A (ja) 2010-10-21
JP5568471B2 (ja) 2014-08-06
KR20100066438A (ko) 2010-06-17
EP2173352A4 (en) 2011-07-27
AU2008274956A1 (en) 2009-01-15
US20090028855A1 (en) 2009-01-29
EP2173352B1 (en) 2016-09-07
US20130034598A1 (en) 2013-02-07
WO2009009793A2 (en) 2009-01-15

Similar Documents

Publication Publication Date Title
MX2010000474A (es) Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral.
UA110697C2 (uk) ЗАСТОСУВАННЯ ІНГІБІТОРІВ TOR-КІНАЗИ ДЛЯ ЛІКУВАННЯ ПУХЛИННИХ ЗАХВОРЮВАНЬ У ПАЦІЄНТА ЗІ ЗНИЖЕНИМ РІВНЕМ БІЛКА pAMPK ТА/АБО АКТИВНОСТІ AMPK
EA201100119A1 (ru) Химические соединения 251
MX2009012066A (es) Imidazopirinas sustituidas como inhibidoras de cinasa de lipido p13k.
ATE525375T1 (de) Hemmer von janus-kinasen und/oder 3- phosphoinositid-abhängiger protein-kinase 1
MX2009009304A (es) Inhibidores de cinasa pim y metodos para su uso.
MX2009004623A (es) Imidazopiridazinas como inhibidores de la lipido cinasa pi3k.
EA200870048A1 (ru) ГЕТЕРОАРИЛ-ЗЕМЕЩЕННЫЕ ПИРРОЛО[2,3-b]ПИРИДИНЫ И ПИРРОЛО[2,3-b]ПИРИМИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ
TW200626576A (en) Bicyclic amides as kinase inhibitors
TW200801008A (en) Protein kinase inhibitors
EA201100425A1 (ru) Производные пиколинамида в качестве ингибиторов киназы
MY152948A (en) 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors
IL174965A0 (en) SUBSTITUTED BENZAZOLES AND USE THEREOF AS INHIBITORS OF Raf KINASE
EP4047001A3 (en) Bicyclic urea kinase inhibitors and uses thereof
EA200600689A1 (ru) Замещённые бензазолы и их применение в качестве ингибиторов raf киназы
IL191832A (en) Pyridiazinone compounds and their use in the preparation of drugs for the treatment of tumors
EA201070611A1 (ru) Ингибиторы человеческой фосфатидилинозитол-3-киназы дельта
PH12020552135A1 (en) Kdm1a inhibitors for the treatment of disease
ECSP055911A (es) Compuestos tricíclicos inhibidores de proteína quinasa para mejorar la eficacia de agentes antineoplásicos y terapia de radiación
MX2009006688A (es) Compuestos y metodos para modulacion de cinasas, e indicaciones para ello.
MX2021008667A (es) Derivado de pirrolopirimidina y composición farmacéutica para prevenir o tratar enfermedades relacionadas con la proteína quinasa que comprende el mismo como principio activo.
PH12012502070A1 (en) Inhibitors of protein tyrosine kinase activity and use thereof to treat ophthalmic disorders
UA84954C2 (ru) Конденсированные пиримидоны, пригодные для лечения и профилактики злокачественного новообразования
EA201071422A1 (ru) Способы лечения заболеваний, связанных с мейотическим кинезином
WO2007080457A3 (en) Use of inhibitors of scinderin and/or of ephrin-a1 for treating tumors

Legal Events

Date Code Title Description
FG Grant or registration