CN101743007B - 具有抗肿瘤活性的akt/pkb抑制剂 - Google Patents

具有抗肿瘤活性的akt/pkb抑制剂 Download PDF

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Publication number
CN101743007B
CN101743007B CN200880024470.4A CN200880024470A CN101743007B CN 101743007 B CN101743007 B CN 101743007B CN 200880024470 A CN200880024470 A CN 200880024470A CN 101743007 B CN101743007 B CN 101743007B
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China
Prior art keywords
akt
api
compound
cells
cancer
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Expired - Fee Related
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CN200880024470.4A
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English (en)
Chinese (zh)
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CN101743007A (zh
Inventor
J·Q·程
孙梅
S·M·瑟布逖
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University of South Florida St Petersburg
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University of South Florida St Petersburg
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
CN200880024470.4A 2007-07-12 2008-07-14 具有抗肿瘤活性的akt/pkb抑制剂 Expired - Fee Related CN101743007B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94936507P 2007-07-12 2007-07-12
US60/949,365 2007-07-12
PCT/US2008/069974 WO2009009793A2 (en) 2007-07-12 2008-07-14 Inhibitors of akt/pkb with anti-tumor activity

Publications (2)

Publication Number Publication Date
CN101743007A CN101743007A (zh) 2010-06-16
CN101743007B true CN101743007B (zh) 2015-04-08

Family

ID=40229514

Family Applications (1)

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CN200880024470.4A Expired - Fee Related CN101743007B (zh) 2007-07-12 2008-07-14 具有抗肿瘤活性的akt/pkb抑制剂

Country Status (10)

Country Link
US (2) US8183249B2 (enExample)
EP (1) EP2173352B1 (enExample)
JP (1) JP5568471B2 (enExample)
KR (1) KR101618037B1 (enExample)
CN (1) CN101743007B (enExample)
AU (1) AU2008274956B2 (enExample)
BR (1) BRPI0815563A2 (enExample)
CA (1) CA2695330C (enExample)
MX (1) MX2010000474A (enExample)
WO (1) WO2009009793A2 (enExample)

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US7842698B2 (en) * 2004-09-03 2010-11-30 Merck Serono S.A. Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors
MX2010000474A (es) * 2007-07-12 2010-06-23 Univ South Florida Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral.
US8217047B2 (en) 2008-05-27 2012-07-10 Dmi Acquisition Corp. Therapeutic methods and compounds
CA2810844C (en) 2010-09-07 2017-03-21 Dmi Acquisition Corp. Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions
WO2012158197A2 (en) * 2010-11-11 2012-11-22 Lyndor Biosciences L.L.C. Compounds useful as akt/pkb modulators and uses thereof
CN103841975A (zh) 2011-04-01 2014-06-04 基因泰克公司 Akt抑制剂化合物和厄洛替尼的组合以及使用方法
CN103858007B (zh) * 2011-04-01 2017-03-29 基因泰克公司 用于预测对癌症治疗的敏感性的生物标记
CN102225067B (zh) * 2011-04-29 2012-10-03 济南环肽医药科技有限公司 一种治疗胃癌的药物组合物
CA2846598C (en) 2011-10-10 2019-12-10 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease
EP2765968A4 (en) 2011-10-10 2015-01-21 Ampio Pharmaceuticals Inc IMPLANTABLE MEDICINE PRODUCTS WITH INCREASED IMMUNO TOLERANCE AND PROCESSING AND IMPLANTATION METHODS
HK1198812A1 (en) 2011-10-28 2015-06-12 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
GB201207722D0 (en) * 2012-05-02 2012-06-13 Bergenbio As Method
KR101461626B1 (ko) * 2012-08-02 2014-11-28 서울대학교산학협력단 Ａｋｔ１ 억제제 및 소수성 항암제를 포함하는 항암용 약학적 조성물
WO2014074883A1 (en) * 2012-11-08 2014-05-15 Lyndor Biosciences L.L.C. Novel synthesis of ld101
EA201500943A1 (ru) 2013-03-15 2016-08-31 Ампио Фармасьютикалс, Инк. Составы для мобилизации, хоуминга, размножения и дифференцировки стволовых клеток и способы применения составов
CA2938626A1 (en) 2013-07-26 2015-01-29 John Rothman Compositions to improve the therapeutic benefit of bisantrene
US9986375B2 (en) * 2014-02-12 2018-05-29 Google Llc Energy-efficient location determination
CA2958080A1 (en) 2014-08-18 2016-02-25 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
FR3033499A1 (fr) * 2015-03-11 2016-09-16 Centre Leon-Berard Composition pour le traitement des tumeurs neuroendocrines pancreatiques
US11389512B2 (en) 2015-06-22 2022-07-19 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
CN116650645A (zh) * 2020-12-04 2023-08-29 周清华 Akt/stat3作为免疫检查点抑制剂的靶点的用途
EP4486390A1 (en) * 2022-03-02 2025-01-08 Terremoto Biosciences, Inc Covalent modifiers of akt1 and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1653077A (zh) * 2002-05-06 2005-08-10 健亚生物科技公司 治疗c型肝炎病毒感染的核苷衍生物
US20060247188A1 (en) * 2004-03-29 2006-11-02 University Of South Florida Effective treatment of tumors and cancer with triciribine and related compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4559157A (en) * 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) * 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4820508A (en) 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) * 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US5167649A (en) * 1988-08-22 1992-12-01 Zook Gerald P Drug delivery system for the removal of dermal lesions
US4938949A (en) * 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
JP4407008B2 (ja) * 2000-05-11 2010-02-03 パナソニック株式会社 カラー画像形成装置
UA72612C2 (en) 2000-07-06 2005-03-15 Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
US8828451B2 (en) * 2006-10-04 2014-09-09 University Of South Florida Akt sensitization of cancer cells
MX2010000474A (es) * 2007-07-12 2010-06-23 Univ South Florida Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1653077A (zh) * 2002-05-06 2005-08-10 健亚生物科技公司 治疗c型肝炎病毒感染的核苷衍生物
US20060247188A1 (en) * 2004-03-29 2006-11-02 University Of South Florida Effective treatment of tumors and cancer with triciribine and related compounds

Also Published As

Publication number Publication date
EP2173352A2 (en) 2010-04-14
CA2695330C (en) 2017-06-13
CA2695330A1 (en) 2009-01-15
US8183249B2 (en) 2012-05-22
JP5568471B2 (ja) 2014-08-06
KR101618037B1 (ko) 2016-05-04
AU2008274956B2 (en) 2014-08-21
BRPI0815563A2 (pt) 2015-02-18
CN101743007A (zh) 2010-06-16
EP2173352B1 (en) 2016-09-07
AU2008274956A1 (en) 2009-01-15
WO2009009793A2 (en) 2009-01-15
MX2010000474A (es) 2010-06-23
US20130034598A1 (en) 2013-02-07
EP2173352A4 (en) 2011-07-27
US20090028855A1 (en) 2009-01-29
KR20100066438A (ko) 2010-06-17
JP2010533206A (ja) 2010-10-21
WO2009009793A3 (en) 2009-03-26
US9359347B2 (en) 2016-06-07

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Granted publication date: 20150408