MX2009012906A - Anticuerpos monoclonales contra claudin-18 para tratamiento de cancer. - Google Patents

Anticuerpos monoclonales contra claudin-18 para tratamiento de cancer.

Info

Publication number
MX2009012906A
MX2009012906A MX2009012906A MX2009012906A MX2009012906A MX 2009012906 A MX2009012906 A MX 2009012906A MX 2009012906 A MX2009012906 A MX 2009012906A MX 2009012906 A MX2009012906 A MX 2009012906A MX 2009012906 A MX2009012906 A MX 2009012906A
Authority
MX
Mexico
Prior art keywords
cancer
treatment
monoclonal antibodies
antibodies against
against claudin
Prior art date
Application number
MX2009012906A
Other languages
English (en)
Inventor
Ugur Sahin
Oezlem Tuereci
Dirk Usener
Gunda Brandenburg
Original Assignee
Ganymed Pharmaceuticals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ganymed Pharmaceuticals Ag filed Critical Ganymed Pharmaceuticals Ag
Publication of MX2009012906A publication Critical patent/MX2009012906A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Abstract

La presente invención proporciona anticuerpos útiles como terapéuticos para el tratamiento y/o prevención de enfermedades asociadas con células que expresan CLD18, entre las que se incluyen enfermedades relacionadas con tumores, tales como cáncer gástrico, cáncer esofágico, cáncer pancreático, cáncer pulmonar, cáncer ovárico, cáncer de colon, cáncer hepático, cáncer de cabeza-cuello, cáncer de la vesícula biliar, y metástasis de los mismos.
MX2009012906A 2007-05-29 2008-05-27 Anticuerpos monoclonales contra claudin-18 para tratamiento de cancer. MX2009012906A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93209907P 2007-05-29 2007-05-29
EP07010622A EP1997832A1 (en) 2007-05-29 2007-05-29 Monoclonal antibodies against Claudin-18 for treatment of cancer
PCT/EP2008/004197 WO2008145338A2 (en) 2007-05-29 2008-05-27 Monoclonal antibodies against claudin-18 for treatment of cancer

Publications (1)

Publication Number Publication Date
MX2009012906A true MX2009012906A (es) 2010-01-25

Family

ID=38650052

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012906A MX2009012906A (es) 2007-05-29 2008-05-27 Anticuerpos monoclonales contra claudin-18 para tratamiento de cancer.

Country Status (24)

Country Link
US (1) US8425902B2 (es)
EP (4) EP1997832A1 (es)
JP (3) JP5816431B2 (es)
KR (3) KR101585990B1 (es)
CN (2) CN103694353B (es)
BR (1) BRPI0811907A2 (es)
CA (1) CA2687206C (es)
DK (1) DK3401334T3 (es)
ES (2) ES2675375T3 (es)
FI (1) FI3401334T3 (es)
HR (1) HRP20230282T3 (es)
HU (1) HUE061795T2 (es)
IL (3) IL201666A (es)
LT (1) LT3401334T (es)
MX (1) MX2009012906A (es)
NZ (1) NZ581365A (es)
PL (1) PL3401334T3 (es)
PT (1) PT3401334T (es)
RS (1) RS64065B1 (es)
RU (2) RU2682285C2 (es)
SG (1) SG183773A1 (es)
SI (1) SI3401334T1 (es)
WO (1) WO2008145338A2 (es)
ZA (1) ZA200907675B (es)

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