EP2152754B8 - Monoclonal antibodies against claudin-18 for treatment of cancer - Google Patents
Monoclonal antibodies against claudin-18 for treatment of cancer Download PDFInfo
- Publication number
- EP2152754B8 EP2152754B8 EP08758782.0A EP08758782A EP2152754B8 EP 2152754 B8 EP2152754 B8 EP 2152754B8 EP 08758782 A EP08758782 A EP 08758782A EP 2152754 B8 EP2152754 B8 EP 2152754B8
- Authority
- EP
- European Patent Office
- Prior art keywords
- cancer
- treatment
- monoclonal antibodies
- antibodies against
- against claudin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK18168460.6T DK3401334T3 (en) | 2007-05-29 | 2008-05-27 | MONOCLONAL ANTIBODIES AGAINST CLAUDIN-18 FOR CANCER TREATMENT |
EP23155995.6A EP4242236A3 (en) | 2007-05-29 | 2008-05-27 | Monoclonal antibodies against claudin-18 for treatment of cancer |
EP18168460.6A EP3401334B1 (en) | 2007-05-29 | 2008-05-27 | Monoclonal antibodies against claudin-18 for treatment of cancer |
EP08758782.0A EP2152754B8 (en) | 2007-05-29 | 2008-05-27 | Monoclonal antibodies against claudin-18 for treatment of cancer |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93209907P | 2007-05-29 | 2007-05-29 | |
EP07010622A EP1997832A1 (en) | 2007-05-29 | 2007-05-29 | Monoclonal antibodies against Claudin-18 for treatment of cancer |
PCT/EP2008/004197 WO2008145338A2 (en) | 2007-05-29 | 2008-05-27 | Monoclonal antibodies against claudin-18 for treatment of cancer |
EP08758782.0A EP2152754B8 (en) | 2007-05-29 | 2008-05-27 | Monoclonal antibodies against claudin-18 for treatment of cancer |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18168460.6A Division EP3401334B1 (en) | 2007-05-29 | 2008-05-27 | Monoclonal antibodies against claudin-18 for treatment of cancer |
EP18168460.6A Division-Into EP3401334B1 (en) | 2007-05-29 | 2008-05-27 | Monoclonal antibodies against claudin-18 for treatment of cancer |
EP23155995.6A Division EP4242236A3 (en) | 2007-05-29 | 2008-05-27 | Monoclonal antibodies against claudin-18 for treatment of cancer |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2152754A2 EP2152754A2 (en) | 2010-02-17 |
EP2152754B1 EP2152754B1 (en) | 2018-04-25 |
EP2152754B8 true EP2152754B8 (en) | 2018-07-04 |
Family
ID=38650052
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07010622A Withdrawn EP1997832A1 (en) | 2007-05-29 | 2007-05-29 | Monoclonal antibodies against Claudin-18 for treatment of cancer |
EP18168460.6A Active EP3401334B1 (en) | 2007-05-29 | 2008-05-27 | Monoclonal antibodies against claudin-18 for treatment of cancer |
EP08758782.0A Active EP2152754B8 (en) | 2007-05-29 | 2008-05-27 | Monoclonal antibodies against claudin-18 for treatment of cancer |
EP23155995.6A Pending EP4242236A3 (en) | 2007-05-29 | 2008-05-27 | Monoclonal antibodies against claudin-18 for treatment of cancer |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07010622A Withdrawn EP1997832A1 (en) | 2007-05-29 | 2007-05-29 | Monoclonal antibodies against Claudin-18 for treatment of cancer |
EP18168460.6A Active EP3401334B1 (en) | 2007-05-29 | 2008-05-27 | Monoclonal antibodies against claudin-18 for treatment of cancer |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP23155995.6A Pending EP4242236A3 (en) | 2007-05-29 | 2008-05-27 | Monoclonal antibodies against claudin-18 for treatment of cancer |
Country Status (24)
Country | Link |
---|---|
US (1) | US8425902B2 (en) |
EP (4) | EP1997832A1 (en) |
JP (3) | JP5816431B2 (en) |
KR (3) | KR101585990B1 (en) |
CN (2) | CN103694353B (en) |
BR (1) | BRPI0811907A2 (en) |
CA (1) | CA2687206C (en) |
DK (1) | DK3401334T3 (en) |
ES (2) | ES2675375T3 (en) |
FI (1) | FI3401334T3 (en) |
HR (1) | HRP20230282T3 (en) |
HU (1) | HUE061795T2 (en) |
IL (3) | IL201666A (en) |
LT (1) | LT3401334T (en) |
MX (1) | MX2009012906A (en) |
NZ (1) | NZ581365A (en) |
PL (1) | PL3401334T3 (en) |
PT (1) | PT3401334T (en) |
RS (1) | RS64065B1 (en) |
RU (2) | RU2571923C2 (en) |
SG (1) | SG183773A1 (en) |
SI (1) | SI3401334T1 (en) |
WO (1) | WO2008145338A2 (en) |
ZA (1) | ZA200907675B (en) |
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