CN115715202A - 抗体药物缀合物及其制备方法和用途 - Google Patents

抗体药物缀合物及其制备方法和用途 Download PDF

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CN115715202A
CN115715202A CN202180032620.1A CN202180032620A CN115715202A CN 115715202 A CN115715202 A CN 115715202A CN 202180032620 A CN202180032620 A CN 202180032620A CN 115715202 A CN115715202 A CN 115715202A
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antibody
cancer
seq
tumor
drug conjugate
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肖亮
薛彤彤
王晶翼
王成
刘登念
田强
宋帅
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Sichuan Kelun Biotech Biopharmaceutical Co Ltd
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Sichuan Kelun Biotech Biopharmaceutical Co Ltd
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68037—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a camptothecin [CPT] or derivatives
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    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6863—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from stomach or intestines cancer cell
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    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
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Abstract

一种抗CLDN18.2抗体‑药物缀合物及其制备方法和用途，该抗体‑药物缀合物及含有该缀合物的组合物能够有效结合CLDN18.2并抑制Claudin18.2阳性肿瘤生长。进一步涉及包含该抗体‑药物缀合物或组合物的药物组合物，以及该药物组合物在制备预防和/或治疗肿瘤药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (24)

  1. PCT国内申请，权利要求书已公开。
CN202180032620.1A 2020-05-15 2021-05-12 抗体药物缀合物及其制备方法和用途 Pending CN115715202A (zh)

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CN202010410633 2020-05-15
CN2020104106335 2020-05-15
PCT/CN2021/093348 WO2021228141A1 (zh) 2020-05-15 2021-05-12 抗体药物缀合物及其制备方法和用途

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KR (1) KR20230012000A (zh)
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AU (1) AU2021270940A1 (zh)
CA (1) CA3178406A1 (zh)
CL (1) CL2022003170A1 (zh)
CO (1) CO2022016208A2 (zh)
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CN117327182A (zh) * 2023-09-19 2024-01-02 上海交通大学医学院附属仁济医院 Cldn18.2单域抗体探针的制备方法及应用
CN117327182B (zh) * 2023-09-19 2024-06-04 上海交通大学医学院附属仁济医院 Cldn18.2单域抗体探针的制备方法及应用

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WO2023098515A1 (zh) * 2021-12-02 2023-06-08 四川科伦博泰生物医药股份有限公司 一种药物-接头偶联物的制备方法
WO2023143208A1 (zh) * 2022-01-26 2023-08-03 苏州宜联生物医药有限公司 一种药物连接体偶联物的制备方法
TW202404647A (zh) * 2022-07-14 2024-02-01 大陸商蘇州宜聯生物醫藥有限公司 抗體藥物偶聯物及其製備方法和用途
WO2024027708A1 (zh) * 2022-08-02 2024-02-08 诺纳生物（苏州）有限公司 Msln抗体药物偶联物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117327182A (zh) * 2023-09-19 2024-01-02 上海交通大学医学院附属仁济医院 Cldn18.2单域抗体探针的制备方法及应用
CN117327182B (zh) * 2023-09-19 2024-06-04 上海交通大学医学院附属仁济医院 Cldn18.2单域抗体探针的制备方法及应用

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EP4151235A1 (en) 2023-03-22
WO2021228141A1 (zh) 2021-11-18
JP2024037960A (ja) 2024-03-19
DOP2022000251A (es) 2023-04-16
CO2022016208A2 (es) 2023-02-27
MX2022014332A (es) 2022-12-13
CL2022003170A1 (es) 2023-05-19
CR20220580A (es) 2023-04-11
PE20230373A1 (es) 2023-03-06
JP7407973B2 (ja) 2024-01-04
AU2021270940A1 (en) 2022-12-15
JP2023525120A (ja) 2023-06-14
CA3178406A1 (en) 2021-11-18
KR20230012000A (ko) 2023-01-25
US20230338565A1 (en) 2023-10-26
ECSP22089507A (es) 2023-02-28

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