MX2009012369A - Proceso para preparar un agonista del receptor de adenosina-a2a y sus polimorfos. - Google Patents

Proceso para preparar un agonista del receptor de adenosina-a2a y sus polimorfos.

Info

Publication number
MX2009012369A
MX2009012369A MX2009012369A MX2009012369A MX2009012369A MX 2009012369 A MX2009012369 A MX 2009012369A MX 2009012369 A MX2009012369 A MX 2009012369A MX 2009012369 A MX2009012369 A MX 2009012369A MX 2009012369 A MX2009012369 A MX 2009012369A
Authority
MX
Mexico
Prior art keywords
polymorphs
receptor agonist
adenosine receptor
preparing
isolating
Prior art date
Application number
MX2009012369A
Other languages
English (en)
Inventor
Jeff Zablocki
Elfatih Elzein
Original Assignee
Cv Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38543556&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009012369(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cv Therapeutics Inc filed Critical Cv Therapeutics Inc
Publication of MX2009012369A publication Critical patent/MX2009012369A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describe una síntesis adecuada para la fabricación a gran escala de un agonista del receptor de adenosina-A2A, y también se refiere a sus polimorfos del compuesto, y a métodos para aislar un polimorfo específico.
MX2009012369A 2007-05-17 2007-05-17 Proceso para preparar un agonista del receptor de adenosina-a2a y sus polimorfos. MX2009012369A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/069190 WO2008143667A1 (en) 2007-05-17 2007-05-17 Process for preparing an a2a-adenosine receptor agonist and its polymorphs

Publications (1)

Publication Number Publication Date
MX2009012369A true MX2009012369A (es) 2009-12-01

Family

ID=38543556

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012369A MX2009012369A (es) 2007-05-17 2007-05-17 Proceso para preparar un agonista del receptor de adenosina-a2a y sus polimorfos.

Country Status (15)

Country Link
EP (1) EP2158208B1 (es)
JP (1) JP5349461B2 (es)
KR (2) KR20140041965A (es)
CN (1) CN101668768B (es)
AU (1) AU2007353780B2 (es)
CA (1) CA2685589C (es)
ES (1) ES2537959T3 (es)
HK (1) HK1140771A1 (es)
IL (1) IL201856A (es)
MX (1) MX2009012369A (es)
NO (1) NO341758B1 (es)
NZ (1) NZ580940A (es)
PT (1) PT2158208E (es)
WO (1) WO2008143667A1 (es)
ZA (1) ZA200907565B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US20020012946A1 (en) 2000-02-23 2002-01-31 Luiz Belardinelli Method of identifying partial agonists of the A2A receptor
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
US7732595B2 (en) 2006-02-03 2010-06-08 Gilead Palo Alto, Inc. Process for preparing an A2A-adenosine receptor agonist and its polymorphs
CZ308577B6 (cs) * 2011-08-18 2020-12-16 Farmak, A. S. Způsob přípravy 2-(4-methoxykarbonylpyrazol-1-yl)adenosinu a 2-(4-ethoxykarbonylpyrazol-1-yl)adenosinu
CZ304053B6 (cs) 2011-08-22 2013-09-04 Farmak, A. S. Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
WO2014022577A1 (en) 2012-08-01 2014-02-06 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as a2a agonists
US9822141B2 (en) 2012-08-01 2017-11-21 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists
CZ305213B6 (cs) 2013-04-29 2015-06-10 Farmak, A. S. Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
WO2014207758A2 (en) 2013-05-30 2014-12-31 Biophore India Pharmaceuticals Pvt. Ltd. Novel polymorph of regadenoson
CN104744540A (zh) * 2013-12-26 2015-07-01 上海紫源制药有限公司 一种制备瑞加德松的方法
CN105085593A (zh) * 2014-04-21 2015-11-25 上海紫源制药有限公司 瑞加德松的晶型及其制备方法
CN105198950B (zh) * 2014-06-17 2018-10-02 上海紫源制药有限公司 一种瑞加德松晶型e的制备方法
CN105315284A (zh) * 2014-07-23 2016-02-10 上海医药工业研究院 阿拉格列汀中间体的制备方法
WO2016126734A1 (en) 2015-02-06 2016-08-11 Apicore Us Llc Process of making regadenoson and novel polymorph thereof
CN106397442B (zh) * 2015-07-28 2020-03-27 国药集团国瑞药业有限公司 一种瑞加德松的纯化方法
WO2017042837A2 (en) * 2015-09-11 2017-03-16 Sun Pharmaceutical Industries Limited Stable crystalline form of regadenoson
US10392417B2 (en) * 2016-11-04 2019-08-27 Apicore Us Llc Polymorph of regadenoson and process for preparation thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403567B1 (en) * 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
NZ538590A (en) * 2002-08-15 2006-10-27 Cv Therapeutics Inc Partial and full agonists of A1 adenosine receptors
EP1883646A1 (en) * 2005-05-19 2008-02-06 Cv Therapeutics, Inc. A1 adenosine receptor agonists
US7732595B2 (en) * 2006-02-03 2010-06-08 Gilead Palo Alto, Inc. Process for preparing an A2A-adenosine receptor agonist and its polymorphs

Also Published As

Publication number Publication date
CA2685589C (en) 2014-09-16
ZA200907565B (en) 2011-10-26
NZ580940A (en) 2012-02-24
JP2010527351A (ja) 2010-08-12
HK1140771A1 (en) 2010-10-22
KR20140041965A (ko) 2014-04-04
ES2537959T3 (es) 2015-06-16
ES2537959T8 (es) 2016-08-19
CN101668768B (zh) 2012-08-29
NO20093543L (no) 2009-12-16
AU2007353780B2 (en) 2013-11-14
PT2158208E (pt) 2015-06-11
KR101464794B1 (ko) 2014-11-27
NO341758B1 (no) 2018-01-15
JP5349461B2 (ja) 2013-11-20
WO2008143667A1 (en) 2008-11-27
EP2158208A1 (en) 2010-03-03
EP2158208B1 (en) 2015-04-08
IL201856A0 (en) 2010-06-16
KR20100021462A (ko) 2010-02-24
IL201856A (en) 2013-07-31
AU2007353780A1 (en) 2008-11-27
CA2685589A1 (en) 2008-11-27
CN101668768A (zh) 2010-03-10

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Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: GILEAD SCIENCES, INC.

HC Change of company name or juridical status

Owner name: GILEAD SCIENCES, INC.

FG Grant or registration