MX2009010211A - Proceso de intermediarios para la sintesis de compuestos 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-d iaza-espiro[4.5]decan-2-ona. - Google Patents

Proceso de intermediarios para la sintesis de compuestos 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-d iaza-espiro[4.5]decan-2-ona.

Info

Publication number
MX2009010211A
MX2009010211A MX2009010211A MX2009010211A MX2009010211A MX 2009010211 A MX2009010211 A MX 2009010211A MX 2009010211 A MX2009010211 A MX 2009010211A MX 2009010211 A MX2009010211 A MX 2009010211A MX 2009010211 A MX2009010211 A MX 2009010211A
Authority
MX
Mexico
Prior art keywords
decan
pheny
diaza
trifluoromethyl
ethoxy
Prior art date
Application number
MX2009010211A
Other languages
English (en)
Inventor
Sunil Paliwal
Neng-Yang Shih
Ingrid Mergelsberg
Dominik Hermann Scherer
Monika Erika Huttenloch
Hon-Chung Tsui
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2009010211A publication Critical patent/MX2009010211A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/38—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Abstract

La presente solicitud revela un proceso novedoso para sintetizar compuestos de 8-[{1-(3,5-Bis-(trifluorometil)fenil)-etoxi}-metil}- 8-fenil-1,7-diaza-espiro[4,5]decan-2-ona, los cuales se pueden utilizar, por ejemplo, como compuestos inhibidores de NK-1 en preparaciones farmacéuticas.
MX2009010211A 2007-03-22 2008-03-20 Proceso de intermediarios para la sintesis de compuestos 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-d iaza-espiro[4.5]decan-2-ona. MX2009010211A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91966607P 2007-03-22 2007-03-22
PCT/US2008/003640 WO2008118328A2 (en) 2007-03-22 2008-03-20 Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds

Publications (1)

Publication Number Publication Date
MX2009010211A true MX2009010211A (es) 2009-10-19

Family

ID=39789180

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009010211A MX2009010211A (es) 2007-03-22 2008-03-20 Proceso de intermediarios para la sintesis de compuestos 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-d iaza-espiro[4.5]decan-2-ona.

Country Status (11)

Country Link
US (3) US8552191B2 (es)
EP (2) EP2137151B1 (es)
JP (2) JP5451404B2 (es)
CN (2) CN101679257B (es)
AR (1) AR066191A1 (es)
CA (1) CA2682221C (es)
ES (1) ES2579771T3 (es)
HK (1) HK1136297A1 (es)
MX (1) MX2009010211A (es)
SG (1) SG182226A1 (es)
WO (1) WO2008118328A2 (es)

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SG10201500028RA (en) 2006-04-05 2015-02-27 Opko Health Inc Pharmaceutical formulations: salts of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and treatment methods using the same
AR060353A1 (es) 2006-04-05 2008-06-11 Schering Corp Sales de hidrocloruro de 8 - [( 1- (3,5 -bis- (trifluorometil) fenil) -etoxi) -metil] -8-fenil-1,7 -diaza- spiro [4.5] decan -2-ona. composiciones farmaceuticas
AR066191A1 (es) 2007-03-22 2009-08-05 Schering Corp Proceso e intermediarios para la sintesis de compuestos 8- [ ( 1- (3,5- bis- ( trifluorometil) fenil) - etoxi ) - metil]- 8 fenil - 1,7- diaza - espiro (4, 5) decan -2 ona
HUE026148T2 (en) * 2008-09-05 2016-05-30 Opko Health Inc 8 - ({1- [3,5-bis (trifluoromethyl) phenyl] ethoxy} methyl) -8-phenyl-1,7-diaza-spiro [4,5] decane-on-compounds intermediates
ES2609640T3 (es) * 2009-08-14 2017-04-21 Opko Health, Inc Formulaciones intravenosas de rolapitant
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HUE026148T2 (en) 2008-09-05 2016-05-30 Opko Health Inc 8 - ({1- [3,5-bis (trifluoromethyl) phenyl] ethoxy} methyl) -8-phenyl-1,7-diaza-spiro [4,5] decane-on-compounds intermediates
ES2609640T3 (es) 2009-08-14 2017-04-21 Opko Health, Inc Formulaciones intravenosas de rolapitant

Also Published As

Publication number Publication date
CN101679257B (zh) 2015-01-07
AR066191A1 (es) 2009-08-05
EP2137151B1 (en) 2016-05-11
US8552191B2 (en) 2013-10-08
WO2008118328A2 (en) 2008-10-02
JP5451404B2 (ja) 2014-03-26
US20170008893A1 (en) 2017-01-12
CN104447510B (zh) 2018-03-30
US10000493B2 (en) 2018-06-19
WO2008118328A3 (en) 2009-03-05
US9260428B2 (en) 2016-02-16
CA2682221A1 (en) 2008-10-02
EP2137151A2 (en) 2009-12-30
HK1136297A1 (es) 2010-06-25
CN101679257A (zh) 2010-03-24
JP2014144951A (ja) 2014-08-14
ES2579771T3 (es) 2016-08-16
CN104447510A (zh) 2015-03-25
SG182226A1 (en) 2012-07-30
US20140024834A1 (en) 2014-01-23
US20100087426A1 (en) 2010-04-08
JP2010522171A (ja) 2010-07-01
CA2682221C (en) 2017-04-25
EP3138836A1 (en) 2017-03-08

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Owner name: OPKO HEALTH, INC.

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