MX2009008170A - Nuevos biomateriales para la distribucion de farmaco ocular y metodo para hacerlos y utilizarlos. - Google Patents

Nuevos biomateriales para la distribucion de farmaco ocular y metodo para hacerlos y utilizarlos.

Info

Publication number
MX2009008170A
MX2009008170A MX2009008170A MX2009008170A MX2009008170A MX 2009008170 A MX2009008170 A MX 2009008170A MX 2009008170 A MX2009008170 A MX 2009008170A MX 2009008170 A MX2009008170 A MX 2009008170A MX 2009008170 A MX2009008170 A MX 2009008170A
Authority
MX
Mexico
Prior art keywords
drug delivery
making
same
ocular drug
novel biomaterials
Prior art date
Application number
MX2009008170A
Other languages
English (en)
Spanish (es)
Inventor
James N Chang
Ronald E Utecht
Kaia L Kloster
Therese M Downey
Barbara R Haberer
Patrick D Youso
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of MX2009008170A publication Critical patent/MX2009008170A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/722Chitin, chitosan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/00272-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/16Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Birds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
MX2009008170A 2007-01-31 2008-01-31 Nuevos biomateriales para la distribucion de farmaco ocular y metodo para hacerlos y utilizarlos. MX2009008170A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88755907P 2007-01-31 2007-01-31
PCT/US2008/001301 WO2008094659A2 (en) 2007-01-31 2008-01-31 Novel biomaterials for ocular drug delivery and a method for making and using same

Publications (1)

Publication Number Publication Date
MX2009008170A true MX2009008170A (es) 2009-08-12

Family

ID=39409833

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008170A MX2009008170A (es) 2007-01-31 2008-01-31 Nuevos biomateriales para la distribucion de farmaco ocular y metodo para hacerlos y utilizarlos.

Country Status (9)

Country Link
US (5) US9855337B2 (enExample)
EP (2) EP2425816A3 (enExample)
JP (2) JP5541926B2 (enExample)
KR (1) KR20090108723A (enExample)
AU (1) AU2008211083B2 (enExample)
BR (1) BRPI0807065A2 (enExample)
CA (1) CA2676919C (enExample)
MX (1) MX2009008170A (enExample)
WO (2) WO2008094659A2 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3144324A1 (en) 2006-06-02 2017-03-22 Synedgen, Inc. Chitosan-derivative compounds and methods of controlling microbial populations
US20080248508A1 (en) * 2006-08-17 2008-10-09 Shenda Baker Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials
BRPI0807065A2 (pt) * 2007-01-31 2017-03-21 Allergan Inc biomateriais novos para liberação de fármaco ocular e um método para fazer e usar os mesmos
AU2008219065B2 (en) 2007-02-19 2014-01-30 Marine Polymer Technologies, Inc. Hemostatic compositions and therapeutic regimens
US20100009009A1 (en) * 2008-07-10 2010-01-14 Micropure, Inc. Method and composition for prevention and treatment of oral fungal infections
CN101780105B (zh) * 2009-01-20 2011-09-28 沈阳兴齐制药有限公司 小牛血去蛋白提取物的滴眼液
US20100233101A1 (en) 2009-02-13 2010-09-16 Micropure, Inc. Composition and method for the oxidative consumption of salivary biomolecules
EP2477617B1 (en) 2009-09-18 2018-01-31 Bioinspire Technologies Inc. Free-standing biodegradable patch
US9271925B2 (en) 2013-03-11 2016-03-01 Bioinspire Technologies, Inc. Multi-layer biodegradable device having adjustable drug release profile
CN101695583B (zh) * 2009-10-29 2012-12-26 中国人民解放军第三军医大学第一附属医院 一种用于组织修复的颗粒状生物材料及其制备方法
BR112012025844A2 (pt) 2010-04-15 2017-07-18 Marine Polymer Tech Inc uso de nanofibras snag
WO2012061803A2 (en) * 2010-11-06 2012-05-10 Marine Polymer Technologies, Inc. Compositions and methods for nanopolymer-based nucleic acid delivery
CN103459368B (zh) * 2011-02-14 2016-06-08 阿勒根公司 比马前列素组合物的酯衍生物和方法
CA2832859C (en) 2011-04-15 2020-06-16 Marine Polymer Technologies, Inc. Treatment of disease with poly-n-acetylglucosamine nanofibers
US9962401B2 (en) * 2011-09-27 2018-05-08 Purdue Research Foundation Chitosan derivatives for inactivation of endotoxins and surface protection of nanoparticles
CA2849192C (en) * 2011-10-12 2019-09-24 Ascendis Pharma Ophthalmology Division A/S Prevention and treatment of ocular conditions
US8968790B2 (en) * 2011-12-09 2015-03-03 Shaker A. Mousa Nanoformulation of vitamin D derivatives and/or vitamin D metabolites
US9956291B2 (en) * 2012-07-10 2018-05-01 Shaker A. Mousa Nanoformulation and methods of use of thyroid receptor beta1 agonists for liver targeting
EP2928501B1 (en) * 2012-12-07 2020-05-06 Ascendis Pharma A/S Carrier-linked prostanoid prodrugs
TWI485189B (zh) 2012-12-28 2015-05-21 Ind Tech Res Inst 固體製劑及其製造方法
EP3569262A1 (en) 2013-03-14 2019-11-20 Tricol Biomedical, Inc. Biocompatible and bioabsorbable derivatized chitosan compositions
GB201309788D0 (en) * 2013-05-31 2013-07-17 Medtrade Products Ltd Process for the removal of contamination from a raw material
EP3139903B1 (en) 2014-05-07 2019-07-03 Croma-Pharma Gesellschaft m.b.H. Aqueous ophthalmic solution and method for treating dry eye syndrome
US10449272B2 (en) 2015-10-16 2019-10-22 Industrial Technology Research Institute Hydrogel composition and method for using the same
RU2741912C2 (ru) 2015-10-30 2021-01-29 Крома-Фарма Гезелльшафт М.Б.Х. Применение в терапии стерильного водного офтальмологического раствора
KR20180066240A (ko) 2015-10-30 2018-06-18 크로마-파르마 게젤샤프트 엠.베.하. 무균 수성 안과용 액제의 치료적 용도
US9833469B2 (en) * 2015-12-28 2017-12-05 Alumend, Llc Compositions and methods to affect skin irritation
PT3500255T (pt) 2016-08-19 2023-01-10 Orasis Pharmaceuticals Ltd Composições farmacêuticas oftálmicas e utilizações relacionadas com estas
CA3020197C (en) 2017-09-01 2024-06-04 Micropure, Inc. Aliphatic anionic compounds and oxidative compounds with improved stability and efficacy for use in pharmaceutical compositions
CN110343263A (zh) * 2018-04-02 2019-10-18 中国海洋大学 一种基于氢氧化钾和低温溶解壳聚糖的方法
US11344507B2 (en) 2019-01-08 2022-05-31 Alumend, Llc Topical compositions containing low molecular weight chitosan derivatives
GB2604239A (en) 2019-07-26 2022-08-31 Pandorum Tech Private Limited Bioengineered formulation, process for preparing and implementations thereof
KR102119693B1 (ko) * 2019-10-31 2020-06-05 경희대학교 산학협력단 숙신화 콜라겐-피브리노겐 하이드로겔의 제조방법
CN115697265A (zh) * 2020-04-03 2023-02-03 组织技术公司 使用脐带产物治疗眼部表面病症的方法
CA3209420A1 (en) 2021-02-24 2022-09-01 Peter Jarrett Intracanalicular depot inserter device
CN113440643B (zh) * 2021-06-10 2022-04-29 武汉大学 一种可吸收外科材料的表面抗菌处理方法
CN113881070B (zh) * 2021-11-09 2022-11-15 中北大学 具有光-应力双重响应的碳量子点/壳聚糖衍生物水凝胶的制备方法及应用
WO2025090805A1 (en) * 2023-10-25 2025-05-01 The Board Of Trustees Of The Leland Stanford Junior University Antimicrobial irrigation solutions for endourological procedures

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001477A1 (en) * 1990-07-26 1992-02-06 G.D. Searle & Co. Polymeric drug delivery system
FR2707878A1 (fr) * 1993-07-21 1995-01-27 Imedex Nouvelles compositions adhésives à usage chirurgical.
US5422116A (en) * 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system
US5510102A (en) 1995-01-23 1996-04-23 The Regents Of The University Of California Plasma and polymer containing surgical hemostatic adhesives
TW389694B (en) * 1995-08-17 2000-05-11 Novartis Ag Compositions including o-carboxyalkyl chitosan and methods of use in ophthalmics
US6015474A (en) 1997-06-20 2000-01-18 Protein Polymer Technologies Methods of using primer molecules for enhancing the mechanical performance of tissue adhesives and sealants
US6200595B1 (en) 1998-04-24 2001-03-13 Kuraray Co., Ltd. Medical adhesive
JP2000288079A (ja) 1999-04-07 2000-10-17 Toyobo Co Ltd 生体組織用接着剤
EP1223986A2 (en) * 1999-06-11 2002-07-24 Shearwater Corporation Hydrogels derived from chitosan and poly(ethylene glycol)
US6310188B1 (en) 2000-01-24 2001-10-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method for producing chitin or chitosan
US6991652B2 (en) 2000-06-13 2006-01-31 Burg Karen J L Tissue engineering composite
US20040047892A1 (en) * 2000-11-15 2004-03-11 Desrosiers Eric Andre Filler composition for soft tissue augmentation and reconstructive surgery
US6756363B1 (en) * 2000-11-17 2004-06-29 Wound Healing Of Oklahoma, Inc. Solutions and films of glycated chitosan
KR100507968B1 (ko) * 2001-08-18 2005-08-17 한국과학기술연구원 자기집합체를 형성하는 항암제-키토산 복합체 및 그의제조방법
ATA13842001A (de) * 2001-08-31 2002-10-15 Mucobiomer Biotechnologische F Chitosan-thio-alkyl-amidin konjugate und deren kosmetische sowie pharmazeutische verwendung
CA2586320A1 (en) * 2003-11-05 2005-05-19 Photobiomed Corporation Bonding tissues and cross-linking proteins with naphthalimide compounds
ES2609105T3 (es) 2004-05-20 2017-04-18 Mentor Worldwide Llc Método de enlance covalente de ácido hialurónico y quitosano
US20050283004A1 (en) * 2004-06-18 2005-12-22 Hopax Chemicals Manufacturing Co., Ltd. Alkylsulfonated polyaminosaccharides
KR100578382B1 (ko) * 2004-07-16 2006-05-11 나재운 항암제의 전달체용 수용성 키토산 나노입자 및 그 제조방법
AU2005304035B2 (en) * 2004-11-09 2010-07-22 Santen Sas Ophthalmic oil-in-water type emulsion with stable positive zeta potential
GB0615834D0 (en) * 2006-08-09 2006-09-20 Univ Glasgow Polymeric micellar clusters and their uses in formulating drugs
BRPI0807065A2 (pt) * 2007-01-31 2017-03-21 Allergan Inc biomateriais novos para liberação de fármaco ocular e um método para fazer e usar os mesmos

Also Published As

Publication number Publication date
US9855337B2 (en) 2018-01-02
WO2008094659A3 (en) 2009-05-14
BRPI0807065A2 (pt) 2017-03-21
EP2114370B1 (en) 2012-10-03
US20160175449A1 (en) 2016-06-23
WO2008094675A2 (en) 2008-08-07
EP2425816A2 (en) 2012-03-07
JP2014129408A (ja) 2014-07-10
EP2425816A3 (en) 2014-04-30
JP2010516814A (ja) 2010-05-20
WO2008094659A2 (en) 2008-08-07
US20180344859A1 (en) 2018-12-06
US20080207561A1 (en) 2008-08-28
US20180344858A1 (en) 2018-12-06
WO2008094675A3 (en) 2009-11-26
AU2008211083B2 (en) 2013-08-01
CA2676919C (en) 2013-01-29
AU2008211083A1 (en) 2008-08-07
US9884121B2 (en) 2018-02-06
KR20090108723A (ko) 2009-10-16
EP2114370A2 (en) 2009-11-11
CA2676919A1 (en) 2008-08-07
US20080200948A1 (en) 2008-08-21
US8252771B2 (en) 2012-08-28
JP5541926B2 (ja) 2014-07-09

Similar Documents

Publication Publication Date Title
MX2009008170A (es) Nuevos biomateriales para la distribucion de farmaco ocular y metodo para hacerlos y utilizarlos.
CY1122687T1 (el) Συνθεσεις και μεθοδοι για την τροποποιηση της smn2 συναρμογης σε ενα υποκειμενο
EP2226074A3 (en) Pharmaceutical compositions and their methods of use
EP4364795A3 (en) Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
WO2012056111A3 (en) Drug delivery compositions
AR061446A1 (es) Utilizacion de la 1,7 -dimetilxantina para la fabricacion de un medicamento psicoanaleptico no ansiogeno destinado al tratamiento de un trastorno neuropsiquiatrico
WO2010078486A3 (en) Opioid-containing oral pharmaceutical compositions and methods
BR112012030818A2 (pt) "derivados de ácido c-3 betulínico modificado como inibidores da maturação do hiv"
CY1109606T1 (el) Βιοδιασπωμενο υμενιο για την απελευθερωση φαρμακου στον οφθαλμο
SG170087A1 (en) Pharmaceutical compositions
CY1111454T1 (el) Παραγωγα φαινυλο-πυραζολιου ως συνδετες υποδοχεα μη στεροειδων γλυκοκορτικοειδων
BRPI0812064A2 (pt) Formulação farmacêutica, tabletes, e, processo para a produção de uma formulação farmacêutica
NO20081592L (no) Dipeptidylpeptidaseinhibitorer for behandling av diabetes
NO20091700L (no) Florizinanaloger som inhibitorer av glukose-ko-transporter 2
WO2008000731A3 (en) Pharmaceutical composition for the oral administration of omega polyenoic fatty acids
CY1111954T1 (el) Παραγωγα τετραϋδροναφθαλινιου, μεθοδοι για την παραγωγη αυτων και η χρηση αυτων ως αντιφλεγμονωδη
CY1113551T1 (el) Υποκατεστημενες ενωσεις νικοτιναμιδιου και η χρησιμοποιηση τους σε φαρμακα
NO20080133L (no) Azolopyridin-2-on derivater som lipase og fosfolipaseinhibitorer
WO2008101173A3 (en) Biodegradable compositions and materials
NO20080035L (no) Benzooksazol-2-on derivater som lipase og fosfolipaseinhibitorer
WO2009116078A3 (en) Oral dosage form containing a pyridinol derivative
DE602006018467D1 (de) Schnell lösliche Formulierung von nichtsteroidalen Antiphlogistika
ATE425961T1 (de) Salze substituierter allophansaureester und deren verwendung in arzneimitteln
WO2010017265A3 (en) Injectable extended release compositions containing an ion channel blocker for the treatment of arthritis
IL205044A (en) Derivatives of (5-acetylamino-biphenyl-3-yl) acetic acid, pharmaceutical preparations containing them and their use in the preparation of a drug for the treatment of mammals for the modulation of gamma-secretase and for the treatment of mammals in diseases associated with high levels of beta-42

Legal Events

Date Code Title Description
FG Grant or registration