MX2009007801A - Composicion farmaceutica de oxaliplatino con regulador basado en azucar alcoholico. - Google Patents

Composicion farmaceutica de oxaliplatino con regulador basado en azucar alcoholico.

Info

Publication number
MX2009007801A
MX2009007801A MX2009007801A MX2009007801A MX2009007801A MX 2009007801 A MX2009007801 A MX 2009007801A MX 2009007801 A MX2009007801 A MX 2009007801A MX 2009007801 A MX2009007801 A MX 2009007801A MX 2009007801 A MX2009007801 A MX 2009007801A
Authority
MX
Mexico
Prior art keywords
acids
oxaliplatinum
pharmaceutical composition
solution
metal hydroxide
Prior art date
Application number
MX2009007801A
Other languages
English (en)
Inventor
Borek Zaludek
Libuse Zatloukalova
Frantisek Zak
Bozena Matejkova
Hana Tkadleckova
Original Assignee
Pliva Lachema As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CZ20070049A external-priority patent/CZ300665B6/cs
Priority claimed from CZ20070048A external-priority patent/CZ300664B6/cs
Application filed by Pliva Lachema As filed Critical Pliva Lachema As
Publication of MX2009007801A publication Critical patent/MX2009007801A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Una composición farmacéutica, prevista particularmente para administración potencial y para tratamiento de enfermedades tumorales sensibles al oxaliplatino, comprende oxaliplatino como el compuesto activo, un solvente acuoso aceptable farmacéuticamente y un agente estabilizante en una cantidad efectiva estabilizantemente. El agente estabilizante incluye al menos un compuesto seleccionado del grupo que consiste de ácidos derivados de azúcares alcohólicos neutros, lactonas de estos ácidos y sales de estos ácidos. En un método para producir una composición farmacéutica tal, que el oxaliplatino es disuelto en un solvente acuoso, luego a la solución de oxaliplatino obtenida se añade al menos un ácido derivado de un azúcar alcohólico neutro y/o al menos una lactona de estos ácidos y/o al menos una sal de estos ácidos, y opcionalmente el valor de pH de la solución es ajustado por adición de un hidróxido de metal alcalino y/o un hidróxido de metal alcalino térreo a pH de 3.5 a 6.5, luego la solución obtenida es esterilizada y llenada en unidades de empaque individuales y opcionalmente inerciada con nitrógeno o argón.
MX2009007801A 2007-01-22 2008-01-10 Composicion farmaceutica de oxaliplatino con regulador basado en azucar alcoholico. MX2009007801A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CZ20070049A CZ300665B6 (cs) 2007-01-22 2007-01-22 Sterilní kapalná farmaceutická kompozice a zpusob její výroby
CZ20070048A CZ300664B6 (cs) 2007-01-22 2007-01-22 Sterilní kapalná farmaceutická kompozice a zpusob její výroby
PCT/CZ2008/000006 WO2008089709A2 (en) 2007-01-22 2008-01-10 Oxaliplatin pharmaceutical composition with alcoholic sugar-based buffer

Publications (1)

Publication Number Publication Date
MX2009007801A true MX2009007801A (es) 2009-10-08

Family

ID=39272761

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009007801A MX2009007801A (es) 2007-01-22 2008-01-10 Composicion farmaceutica de oxaliplatino con regulador basado en azucar alcoholico.

Country Status (9)

Country Link
US (1) US20100093849A1 (es)
EP (1) EP2124886A2 (es)
JP (1) JP2010516717A (es)
KR (1) KR20090102844A (es)
BR (1) BRPI0806728A2 (es)
CA (1) CA2675788A1 (es)
MX (1) MX2009007801A (es)
RU (1) RU2009131757A (es)
WO (1) WO2008089709A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2712611A1 (en) * 2012-09-27 2014-04-02 B. Braun Melsungen AG Stabilized aqueous compositions of neuromuscular blocking agents
EP3286137A4 (en) 2015-04-23 2019-01-30 Lawrence Carlson STABLE ELECTROLYTE MATERIAL THEREWITH
JP5963156B1 (ja) * 2016-03-23 2016-08-03 テバ製薬株式会社 オキサリプラチンを含む水性医薬組成物の製造方法及び安定化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9804013D0 (en) * 1998-02-25 1998-04-22 Sanofi Sa Formulations
FR2840923B1 (fr) * 2002-06-17 2007-07-06 Centre Nat Rech Scient Agent anti-resistance a l'oxaliplatine
GB2441445B (en) * 2003-08-28 2008-04-23 Mayne Pharma Ltd Acid containing oxaliplatin formulation
CZ300795B6 (cs) * 2003-09-02 2009-08-12 Pliva-Lachema A. S. Farmaceutická kompozice a zpusob její výroby
US20060275331A1 (en) * 2004-08-31 2006-12-07 Borek Zaludek Pharmaceutical composition, method of manufacturing and therapeutic use thereof
US20060063833A1 (en) * 2004-09-22 2006-03-23 Edgar Schridde Ready-to-use oxaliplatin solutions

Also Published As

Publication number Publication date
EP2124886A2 (en) 2009-12-02
RU2009131757A (ru) 2011-02-27
BRPI0806728A2 (pt) 2011-09-13
CA2675788A1 (en) 2008-07-31
WO2008089709A2 (en) 2008-07-31
WO2008089709A3 (en) 2009-06-18
KR20090102844A (ko) 2009-09-30
US20100093849A1 (en) 2010-04-15
JP2010516717A (ja) 2010-05-20

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal