MX2009007668A - 1,3-dioxanos sustituidos y sus usos. - Google Patents

1,3-dioxanos sustituidos y sus usos.

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Publication number
MX2009007668A
MX2009007668A MX2009007668A MX2009007668A MX2009007668A MX 2009007668 A MX2009007668 A MX 2009007668A MX 2009007668 A MX2009007668 A MX 2009007668A MX 2009007668 A MX2009007668 A MX 2009007668A MX 2009007668 A MX2009007668 A MX 2009007668A
Authority
MX
Mexico
Prior art keywords
compounds
dioxanes
substituted
pharmaceutical compositions
compositions
Prior art date
Application number
MX2009007668A
Other languages
English (en)
Inventor
Jean-Philippe Meyer
Alexandra Santana Sorensen
Peteris Alberts
Mainkar S Prathama
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IB2007/002542 external-priority patent/WO2007138485A2/en
Application filed by Evolva Sa filed Critical Evolva Sa
Priority claimed from PCT/US2008/051523 external-priority patent/WO2008089463A2/en
Publication of MX2009007668A publication Critical patent/MX2009007668A/es

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    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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Abstract

La presente invención se relaciona con compuestos que contienen una porción de 1,3-dioxano, composiciones farmacéuticas de los mismos, y el uso de los compuestos y composiciones para la modulación del tromboxano A2 o un receptor activado por proliferador de perosixoma. Los compuestos, análogos, y sales farmacéuticamente aceptables de los mismos, así como composiciones farmacéuticas pueden utilizarse en el tratamiento y prevención del cáncer.
MX2009007668A 2007-01-18 2008-01-18 1,3-dioxanos sustituidos y sus usos. MX2009007668A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/IB2007/002542 WO2007138485A2 (en) 2006-01-18 2007-01-18 Ppar modulators
US98980507P 2007-11-21 2007-11-21
US98980807P 2007-11-21 2007-11-21
US98980607P 2007-11-21 2007-11-21
PCT/US2008/051523 WO2008089463A2 (en) 2007-01-18 2008-01-18 Substituted 1,3-dioxanes and their uses

Publications (1)

Publication Number Publication Date
MX2009007668A true MX2009007668A (es) 2011-12-08

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MX2009007667A MX2009007667A (es) 2007-01-18 2008-01-18 Profarmacos de 1,3-dioxanos sustituidos y sus usos.
MX2009007669A MX2009007669A (es) 2007-01-18 2008-01-18 1,3,-dioxanos sustituidos y sus usos.
MX2009007668A MX2009007668A (es) 2007-01-18 2008-01-18 1,3-dioxanos sustituidos y sus usos.
MX2009007670A MX2009007670A (es) 2007-01-18 2008-01-18 1,3-dioxanos sustituidos utiles como moduladores de paar.

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EP (1) EP2120567A4 (es)
JP (6) JP2010516701A (es)
CN (1) CN101641009A (es)
CA (4) CA2676437A1 (es)
ES (1) ES2609825T3 (es)
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WO (1) WO2008089464A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2676437A1 (en) 2007-01-18 2008-07-24 Evolva Sa Substituted 1,3-dioxanes and their uses
US8486994B2 (en) 2007-01-18 2013-07-16 Evolva Sa Prodrugs of substituted 1,3-dioxanes and their uses
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
DE102010015123A1 (de) 2010-04-16 2011-10-20 Sanofi-Aventis Deutschland Gmbh Benzylamidische Diphenylazetidinone, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013068486A1 (en) 2011-11-08 2013-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of male infertility
CN111886008B (zh) * 2017-10-18 2024-05-31 港大科桥有限公司 用于抗mers-冠状病毒治疗的组合物和方法
EP4000615B1 (en) 2020-11-13 2022-10-19 Serodus ASA Dual tnfr1 antagonists and tnfr2 agonists for use in renal diseases

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8310407D0 (en) 1982-05-12 1983-05-25 Ici Plc 1 3 - dioxan -5- ylalkenoic acids
GB8330120D0 (en) 1983-11-11 1983-12-21 Ici Plc Chemical process
GB8417314D0 (en) * 1984-07-06 1984-08-08 Ici Plc Carboxylic acid derivatives
JPS61215584A (ja) * 1985-03-20 1986-09-25 株式会社日立製作所 表示制御装置
GB8511896D0 (en) * 1985-05-10 1985-06-19 Ici Plc Alkenes
GB8511892D0 (en) * 1985-05-10 1985-06-19 Ici Plc Fluoralkane derivatives
GB8511890D0 (en) * 1985-05-10 1985-06-19 Ici Plc Benzene derivatives
GB8511891D0 (en) * 1985-05-10 1985-06-19 Ici Plc Alkenoic acids
GR861209B (en) 1985-05-10 1986-08-29 Ici Plc Process for preparing novel alkene derivatives
GB8626297D0 (en) * 1986-11-04 1986-12-03 Ici Plc Pharmaceutical compositions
GB8709794D0 (en) * 1987-04-24 1987-05-28 Ici Plc Heterocyclic acids
US5248780A (en) 1988-02-16 1993-09-28 Imperial Chemical Industries, Plc Pyridyl substituted alkenoic acid derivatives
GB8901201D0 (en) * 1988-02-16 1989-03-15 Ici Plc Pyridine derivatives
GB8808599D0 (en) 1988-04-12 1988-05-11 Glaxo Group Ltd Medicaments
IE81170B1 (en) * 1988-10-21 2000-05-31 Zeneca Ltd Pyridine derivatives
US5128359A (en) 1990-02-16 1992-07-07 Laboratoires Upsa Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation
ZA911453B (en) 1990-03-19 1991-11-27 Squibb & Sons Inc Method of protecting against and/or treating ulcerative gastrointestinal conditions using a thromoboxane,a2 receptor antagonist and combination useful in preventing and/or treating ulcers and/or inflammation
DE4225488A1 (de) 1992-07-30 1994-02-03 Schering Ag Neue Bicyclo[3.3.0]octan-Derivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
GB9313649D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Medicaments
US5462726A (en) 1993-12-17 1995-10-31 Bristol-Myers Squibb Company Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
US5801195A (en) 1994-12-30 1998-09-01 Celgene Corporation Immunotherapeutic aryl amides
AU6263996A (en) 1995-06-07 1996-12-30 Ligand Pharmaceuticals Incorporated Method for screening for receptor agonists and antagonists
US6028052A (en) 1995-09-18 2000-02-22 Ligand Pharmaceuticals Incorporated Treating NIDDM with RXR agonists
GB9600464D0 (en) 1996-01-09 1996-03-13 Smithkline Beecham Plc Novel method
AU1856997A (en) 1996-02-02 1997-08-22 Merck & Co., Inc. Method for raising hdl cholesterol levels
AU6773598A (en) 1997-03-26 1998-10-20 Institut Pasteur Treatment of gastrointestinal disease with ppar modulators
US5981586A (en) 1997-05-23 1999-11-09 Pershadsingh; Harrihar A. Methods for treating proliferative and inflammatory skin diseases
US6410245B1 (en) 1998-04-01 2002-06-25 Affymax, Inc. Compositions and methods for detecting ligand-dependent nuclear receptor and coactivator interactions
US6277884B1 (en) 1998-06-01 2001-08-21 Nitromed, Inc. Treatment of sexual dysfunction with N-hydroxyguanidine compounds
US6436997B1 (en) 1998-06-01 2002-08-20 Nitromed, Inc. Endogenous nitric oxide synthesis under conditions of low oxygen tension
EP1028113A4 (en) 1998-08-04 2004-10-13 Toray Industries HETEROCYCLIC DERIVATIVES OF BENZENE IN FUSION AND THEIR USE
US6509348B1 (en) 1998-11-03 2003-01-21 Bristol-Myers Squibb Company Combination of an ADP-receptor blocking antiplatelet drug and a thromboxane A2 receptor antagonist and a method for inhibiting thrombus formation employing such combination
WO2000030683A1 (fr) 1998-11-19 2000-06-02 Shionogi & C0., Ltd. Composes prophylactiques et/ou therapeutiques destines a des maladies du systeme nerveux central et possedant des composes antagonistes du recepteur de txa2 et/ou inhibiteurs de la txa2 synthase
US6291496B1 (en) 1999-12-27 2001-09-18 Andrew J. Dannenberg Treating cancers associated with overexpression of class I family of receptor tyrosine kinases
WO2001089519A1 (en) 2000-05-22 2001-11-29 Nitromed, Inc. Thromboxane inhibitors, compositions and methods of use related applications
US6284790B1 (en) 2000-06-15 2001-09-04 Sachin Gupte Methods of potentiating organic nitrates having vasodilating activity and formulations for the same
EP1267171A1 (en) 2001-06-14 2002-12-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Cofactor-based screening method for nuclear receptor modulators
AU2003299648A1 (en) 2002-12-12 2004-06-30 Janssen Pharmaceutica, N.V. Substituted 4-phenyl-(1,3)-dioxanes
AU2003300867A1 (en) 2002-12-19 2004-07-29 Synaptic Pharmaceutical Corporation Uses of the snorf207 receptor
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
GB0314130D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
ATE386725T1 (de) 2003-10-24 2008-03-15 Glaxo Group Ltd Heterocyclylverbindungen
US20070105847A1 (en) * 2004-01-09 2007-05-10 Lohray Braj B 1,3-Dioxane derivatives and analogues thereof useful in the treatment of i.a. obesity and diabetes
ES2603856T3 (es) * 2004-03-29 2017-03-01 Les Laboratoires Servier Procedimiento para preparar una composición farmacéutica sólida
ES2739493T3 (es) * 2004-05-05 2020-01-31 Pfizer Prod Inc Formas de sal de de atorvastatina con benetamina
US20070037797A1 (en) 2005-08-15 2007-02-15 Hellstrom Harold R Method of reducing the risk of adverse cardiovascular (CV) events associated with the administration of pharmaceutical agents which favor CV events
IN2015DN00502A (es) * 2006-01-18 2015-06-26 Evolva Sa
US8486994B2 (en) * 2007-01-18 2013-07-16 Evolva Sa Prodrugs of substituted 1,3-dioxanes and their uses
CA2676437A1 (en) 2007-01-18 2008-07-24 Evolva Sa Substituted 1,3-dioxanes and their uses
WO2009089098A1 (en) 2008-01-03 2009-07-16 Musc Foundation For Research Development Methods for the treatment of cancers

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Publication number Publication date
MX2009007669A (es) 2011-12-08
EP2120567A4 (en) 2011-11-09
WO2008089464A1 (en) 2008-07-24
US20130197030A1 (en) 2013-08-01
EP2120567A1 (en) 2009-11-25
CA2676435A1 (en) 2008-07-24
US20150158838A1 (en) 2015-06-11
CA2676444C (en) 2013-07-30
MX2009007667A (es) 2011-12-08
JP2014159487A (ja) 2014-09-04
US20120142766A1 (en) 2012-06-07
US20100168169A1 (en) 2010-07-01
US20120252836A1 (en) 2012-10-04
MX2009007670A (es) 2011-11-18
CN101641009A (zh) 2010-02-03
US8536196B2 (en) 2013-09-17
JP5662682B2 (ja) 2015-02-04
JP2010516701A (ja) 2010-05-20
CA2676437A1 (en) 2008-07-24
CA2676439A1 (en) 2008-07-24
CA2676444A1 (en) 2008-07-24
JP2010516699A (ja) 2010-05-20
ES2609825T3 (es) 2017-04-24
JP2014240409A (ja) 2014-12-25
JP2010516702A (ja) 2010-05-20
JP2010516700A (ja) 2010-05-20
CA2676435C (en) 2015-03-24

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