MX2009007139A - Metodos y vectores para generar inmunoglobulinas no sialiladas. - Google Patents
Metodos y vectores para generar inmunoglobulinas no sialiladas.Info
- Publication number
- MX2009007139A MX2009007139A MX2009007139A MX2009007139A MX2009007139A MX 2009007139 A MX2009007139 A MX 2009007139A MX 2009007139 A MX2009007139 A MX 2009007139A MX 2009007139 A MX2009007139 A MX 2009007139A MX 2009007139 A MX2009007139 A MX 2009007139A
- Authority
- MX
- Mexico
- Prior art keywords
- asialylated
- immunoglobulins
- vectors
- generating
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
Abstract
Las propiedades de una proteína que contiene Fc, por ejemplo un anticuerpo, se controlan alterando la sialilación de los oligosacáridos de la región Fc, transfectando la línea celular que expresa la proteína que contiene Fc con una secuencia de vector que codifica una sialidasa; las proteínas que contienen Fc modificadas tienen utilidad terapéutica en enfermedades o condiciones en las que es deseable controlar la afinidad por uno o más de los receptores Fc?RI, Fc?RIIA y Fc?RIIIA, la actividad de ADCC, la activación de macrófagos o monocitos, la vida media en el suero, y la avidez.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88230106P | 2006-12-28 | 2006-12-28 | |
PCT/US2007/088809 WO2008083150A2 (en) | 2006-12-28 | 2007-12-26 | Methods and vectors for generating asialylated immunoglobulins |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009007139A true MX2009007139A (es) | 2009-10-08 |
Family
ID=39589190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009007139A MX2009007139A (es) | 2006-12-28 | 2007-12-26 | Metodos y vectores para generar inmunoglobulinas no sialiladas. |
Country Status (12)
Country | Link |
---|---|
US (3) | US8540992B2 (es) |
EP (1) | EP2115151B1 (es) |
JP (1) | JP2010514448A (es) |
KR (1) | KR101667981B1 (es) |
CN (2) | CN101646775B (es) |
BR (1) | BRPI0720861A2 (es) |
CA (1) | CA2674239C (es) |
DK (1) | DK2115151T3 (es) |
ES (1) | ES2474940T3 (es) |
MX (1) | MX2009007139A (es) |
RU (1) | RU2466189C2 (es) |
WO (1) | WO2008083150A2 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012002562A1 (en) * | 2010-06-30 | 2012-01-05 | Tokyo University Of Science Educational Foundation Administrative Organization | Modified protein therapeutics |
AU2012204241A1 (en) * | 2011-01-06 | 2013-06-06 | The Johns Hopkins University | Method of production of recombinant glycoproteins with increased circulatory half-life in mammalian cells |
EP2702077A2 (en) * | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
ES2692539T3 (es) * | 2011-12-19 | 2018-12-04 | The Rockefeller University | Polipéptidos antiinflamatorios no sialilados |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
US9512214B2 (en) * | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
US20150252108A1 (en) * | 2012-09-26 | 2015-09-10 | Momenta Pharmaceuticals, Inc. | Glycoprotein preparations |
EP3572090B1 (en) * | 2012-12-24 | 2022-12-14 | Coagulant Therapeutics Corporation | Short-acting factor vii polypeptides |
ES2755181T3 (es) | 2013-02-13 | 2020-04-21 | Lab Francais Du Fractionnement | Anticuerpos anti-TNF-alfa altamente galactosilados y usos de los mismos |
WO2014143205A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
TWI670279B (zh) | 2013-03-15 | 2019-09-01 | 美商艾爾德生物製藥股份有限公司 | 抗體純化及純度監測 |
CN105263960B (zh) * | 2013-04-18 | 2020-05-22 | 国家医疗保健研究所 | 具有降低的免疫原性的组合物 |
CA2910877C (en) * | 2013-05-03 | 2021-08-03 | Fujifilm Diosynth Biotechnologies Uk Limited | Expression process |
WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
CN104004727B (zh) * | 2014-06-09 | 2016-02-17 | 东北师范大学 | 一种具有唾液酸水解酶活性的蛋白质的制备方法 |
JP2017528468A (ja) * | 2014-09-10 | 2017-09-28 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ガラクトース操作型免疫グロブリン1抗体 |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
JP2018500934A (ja) | 2014-12-22 | 2018-01-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Cmp依存性シアリダーゼ活性 |
TWI717333B (zh) * | 2015-01-30 | 2021-02-01 | 中央研究院 | 增進抗體功效之通用糖型組合物及方法 |
CN107847586A (zh) | 2015-03-04 | 2018-03-27 | 洛克菲勒大学 | 抗炎多肽 |
KR102512608B1 (ko) * | 2016-01-15 | 2023-03-22 | 버클리 라잇츠, 인크. | 환자 특이적인 항암 치료제의 제조 방법 및 그 치료 방법 |
PL3512876T3 (pl) * | 2016-09-13 | 2022-02-14 | Coagulant Therapeutics Corporation | Glikoformy czynnika viia |
WO2018092078A1 (en) * | 2016-11-18 | 2018-05-24 | Biocon Limited | Rapid and efficient de-glycosylation of glycoproteins |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
CN108956979B (zh) * | 2018-08-02 | 2021-07-27 | 上海细胞治疗集团有限公司 | 一种细胞毒性检测试剂组合 |
KR20210142002A (ko) | 2019-03-14 | 2021-11-23 | 얀센 바이오테크 인코포레이티드 | 항-tnf 항체 조성물을 생성하기 위한 제조 방법 |
KR20210141990A (ko) | 2019-03-14 | 2021-11-23 | 얀센 바이오테크 인코포레이티드 | 항-il12/il23 항체 조성물을 생성하기 위한 제조 방법 |
CA3133388A1 (en) | 2019-03-14 | 2020-09-17 | Janssen Biotech, Inc. | Methods for producing anti-tnf antibody compositions |
JP7343890B2 (ja) * | 2019-04-26 | 2023-09-13 | 国立大学法人東海国立大学機構 | シアリダーゼ活性を有する酵素剤及びその利用 |
CN110894494B (zh) * | 2019-11-22 | 2022-09-27 | 广西梧州制药(集团)股份有限公司 | 一种大规模高密度悬浮培养293细胞高产腺病毒的方法 |
WO2024079711A1 (en) | 2022-10-14 | 2024-04-18 | Janssen Research & Development, Llc | Method for detection of antibody-dependent cellular phagocytosis |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2726898B2 (ja) | 1988-05-02 | 1998-03-11 | 丸金醤油株式会社 | ノイラミニダーゼ・アイソザイムl及びガングリオシド類の製造法 |
ES2340112T3 (es) * | 1998-04-20 | 2010-05-28 | Glycart Biotechnology Ag | Ingenieria de glicosilacion de anticuerpos para la mejora de la citotoxicidad celular dependiente de anticuerpos. |
CN1505682A (zh) * | 2000-06-26 | 2004-06-16 | ��ѧ�о��� | 用于同时糖化发酵的方法和组合物 |
JP2006507228A (ja) | 2002-07-01 | 2006-03-02 | ザ ケネス エス.ウォーレン インスティテュート,インコーポレーテッド | 応答性の細胞、組織および器官を保護、回復ならびに増強するための組換え型組織保護サイトカインおよびそれをコードする核酸 |
CN1729013B (zh) | 2002-11-22 | 2012-10-03 | 耐百生物制药有限公司 | 广谱抗病毒化合物、药物制剂及其用途 |
US7785594B2 (en) * | 2003-08-14 | 2010-08-31 | Life Sciences Research Partners Vzw | Factor VIII inhibitory antibodies with reduced glycosylation |
-
2007
- 2007-12-26 WO PCT/US2007/088809 patent/WO2008083150A2/en active Application Filing
- 2007-12-26 CA CA2674239A patent/CA2674239C/en active Active
- 2007-12-26 KR KR1020097015810A patent/KR101667981B1/ko active IP Right Grant
- 2007-12-26 CN CN200780051802.3A patent/CN101646775B/zh not_active Expired - Fee Related
- 2007-12-26 CN CN201510535932.0A patent/CN105056231A/zh active Pending
- 2007-12-26 ES ES07869893.3T patent/ES2474940T3/es active Active
- 2007-12-26 BR BRPI0720861-8A2A patent/BRPI0720861A2/pt not_active Application Discontinuation
- 2007-12-26 RU RU2009128960/10A patent/RU2466189C2/ru active
- 2007-12-26 EP EP07869893.3A patent/EP2115151B1/en active Active
- 2007-12-26 JP JP2009544246A patent/JP2010514448A/ja active Pending
- 2007-12-26 US US12/521,417 patent/US8540992B2/en active Active
- 2007-12-26 DK DK07869893.3T patent/DK2115151T3/en active
- 2007-12-26 MX MX2009007139A patent/MX2009007139A/es active IP Right Grant
-
2013
- 2013-08-23 US US13/974,655 patent/US8975040B2/en active Active
-
2015
- 2015-02-10 US US14/618,185 patent/US20150291946A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2466189C2 (ru) | 2012-11-10 |
CN105056231A (zh) | 2015-11-18 |
BRPI0720861A2 (pt) | 2014-02-25 |
US20140057319A1 (en) | 2014-02-27 |
CA2674239A1 (en) | 2008-07-10 |
EP2115151A4 (en) | 2011-01-26 |
RU2009128960A (ru) | 2011-02-10 |
CN101646775B (zh) | 2016-08-24 |
DK2115151T3 (en) | 2015-01-05 |
ES2474940T3 (es) | 2014-07-10 |
KR101667981B1 (ko) | 2016-10-20 |
US20100172911A1 (en) | 2010-07-08 |
KR20090096740A (ko) | 2009-09-14 |
WO2008083150A3 (en) | 2009-04-30 |
JP2010514448A (ja) | 2010-05-06 |
US8975040B2 (en) | 2015-03-10 |
CA2674239C (en) | 2018-01-23 |
US8540992B2 (en) | 2013-09-24 |
US20150291946A1 (en) | 2015-10-15 |
WO2008083150A2 (en) | 2008-07-10 |
EP2115151B1 (en) | 2014-05-07 |
EP2115151A2 (en) | 2009-11-11 |
CN101646775A (zh) | 2010-02-10 |
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