MX2009003142A - Derivados de indazolilo utiles como agentes moduladores del canal de potasio. - Google Patents
Derivados de indazolilo utiles como agentes moduladores del canal de potasio.Info
- Publication number
- MX2009003142A MX2009003142A MX2009003142A MX2009003142A MX2009003142A MX 2009003142 A MX2009003142 A MX 2009003142A MX 2009003142 A MX2009003142 A MX 2009003142A MX 2009003142 A MX2009003142 A MX 2009003142A MX 2009003142 A MX2009003142 A MX 2009003142A
- Authority
- MX
- Mexico
- Prior art keywords
- disease
- spasms
- modulating agents
- potassium channel
- channel modulating
- Prior art date
Links
- 102000004257 Potassium Channel Human genes 0.000 title abstract 3
- 108020001213 potassium channel Proteins 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 206010010904 Convulsion Diseases 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010003225 Arteriospasm coronary Diseases 0.000 abstract 1
- 206010003591 Ataxia Diseases 0.000 abstract 1
- 206010003805 Autism Diseases 0.000 abstract 1
- 208000020706 Autistic disease Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 206010048994 Bladder spasm Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 208000003890 Coronary Vasospasm Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010022562 Intermittent claudication Diseases 0.000 abstract 1
- 206010026749 Mania Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000008238 Muscle Spasticity Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 206010036600 Premature labour Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 206010047163 Vasospasm Diseases 0.000 abstract 1
- 208000028311 absence seizure Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 201000011634 coronary artery vasospasm Diseases 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 abstract 1
- 230000003676 hair loss Effects 0.000 abstract 1
- 230000008629 immune suppression Effects 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 208000021156 intermittent vascular claudication Diseases 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 230000003274 myotonic effect Effects 0.000 abstract 1
- 201000003631 narcolepsy Diseases 0.000 abstract 1
- 208000030761 polycystic kidney disease Diseases 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000018198 spasticity Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000009529 traumatic brain injury Effects 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Pregnancy & Childbirth (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82794006P | 2006-10-03 | 2006-10-03 | |
| DKPA200601280 | 2006-10-03 | ||
| PCT/EP2007/060493 WO2008040753A1 (en) | 2006-10-03 | 2007-10-03 | Indazolyl derivatives useful as potassium channel modulating agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009003142A true MX2009003142A (es) | 2009-04-06 |
Family
ID=38959688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009003142A MX2009003142A (es) | 2006-10-03 | 2007-10-03 | Derivados de indazolilo utiles como agentes moduladores del canal de potasio. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8222262B2 (enExample) |
| EP (1) | EP2074113A1 (enExample) |
| JP (1) | JP2010505794A (enExample) |
| AU (1) | AU2007304195A1 (enExample) |
| CA (1) | CA2665398A1 (enExample) |
| MX (1) | MX2009003142A (enExample) |
| WO (1) | WO2008040753A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT4193B (en) | 1994-04-01 | 1997-07-25 | Microcide Pharmaceuticals Inc | Cephalosporin antibiotics |
| WO2008028935A2 (en) * | 2006-09-07 | 2008-03-13 | Neurosearch A/S | Pyridinyl-pyrimidine derivatives useful as potassium channel modulating agents |
| JP2010517970A (ja) * | 2007-02-02 | 2010-05-27 | ノイロサーチ アクティーゼルスカブ | ピリジニル−ピラゾール誘導体及びカリウムチャネル調節剤としてのそれらの使用 |
| WO2008116911A1 (en) | 2007-03-28 | 2008-10-02 | Neurosearch A/S | Purinyl derivatives and their use as potassium channel modulators |
| US8415358B2 (en) | 2007-09-17 | 2013-04-09 | Neurosearch A/S | Pyrazine derivatives and their use as potassium channel modulators |
| AU2009272034B2 (en) * | 2008-07-17 | 2011-10-13 | Asahi Kasei Pharma Corporation | Nitrogenated bicyclic heterocyclic compound |
| WO2010026087A1 (en) * | 2008-09-02 | 2010-03-11 | Neurosearch A/S | Pyrazolyl-pyrimidine derivatives and their use as potassium channel modulators |
| EP2344501A1 (en) * | 2008-09-26 | 2011-07-20 | NeuroSearch A/S | Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators |
| WO2010034707A1 (en) | 2008-09-26 | 2010-04-01 | Neurosearch A/S | Substituted purinyl-pyrazol derivatives and their use as potassium channel modulators |
| EP2373317B1 (en) * | 2008-11-25 | 2016-12-14 | Merck Sharp & Dohme Corp. | 4-amino-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one or 4-amino-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one derivatives as activators of the soluble guanylat cyclase for the treatment of cardiovascular diseases |
| WO2011119518A1 (en) | 2010-03-25 | 2011-09-29 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| CA2800541C (en) | 2010-05-27 | 2016-03-22 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| US8895583B2 (en) | 2010-10-28 | 2014-11-25 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| WO2014001282A1 (en) | 2012-06-26 | 2014-01-03 | Aniona Aps | A phenyl triazole derivative and its use for modulating the gabaa receptor complex |
| DK2922828T3 (da) * | 2012-11-21 | 2020-08-31 | Ptc Therapeutics Inc | 4,6-diamino-pyrimidin-derivater som bmi-1-inhibitorer til at behandle cancer |
| US9802904B2 (en) | 2012-12-28 | 2017-10-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inhibitors of the USP1/UAF1 deubiquitinase complex and uses thereof |
| CA2922657C (en) | 2013-08-30 | 2022-04-12 | Ptc Therapeutics, Inc. | Substituted pyrimidine bmi-1 inhibitors |
| US10584115B2 (en) | 2013-11-21 | 2020-03-10 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine BMI-1 inhibitors |
| TW201605832A (zh) * | 2013-12-10 | 2016-02-16 | 克立弗生物科學公司 | 作為ｐ９７錯合物之抑制劑之單環嘧啶／吡啶化合物 |
| KR101922317B1 (ko) | 2014-01-20 | 2018-11-26 | 클리브 바이오사이언스 인코포레이티드 (클리브) | p97 복합체의 저해제로서 융합된 피리미딘 |
| WO2017133664A1 (en) * | 2016-02-05 | 2017-08-10 | Savira Pharmaceuticals Gmbh | Bicyclic pyridine and pyrimidine derivatives and their use in the treatment， amelioration or prevention of influenza |
| WO2017148995A1 (en) | 2016-03-04 | 2017-09-08 | Bayer Pharma Aktiengesellschaft | 1-(pyrimidin-2-yl)-1h-indazoles having bub1 kinase inhibiting activity |
| AU2017275657B2 (en) | 2016-06-02 | 2021-08-19 | Novartis Ag | Potassium channel modulators |
| EP3571193B1 (en) | 2017-01-23 | 2021-12-01 | Cadent Therapeutics, Inc. | Potassium channel modulators |
| WO2019074809A1 (en) * | 2017-10-11 | 2019-04-18 | Merck Sharp & Dohme Corp. | INDAZOLYL-SPIRO [2.2] PENTANE-CARBONITRILE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF |
| EP3694331B1 (en) | 2017-10-11 | 2022-11-16 | Merck Sharp & Dohme LLC | Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof |
| BR112021002630A2 (pt) | 2018-08-17 | 2021-05-11 | Ptc Therapeutics, Inc. | método para tratar câncer pancreático |
| EP3870291A1 (en) | 2018-10-22 | 2021-09-01 | Cadent Therapeutics, Inc. | Crystalline forms of potassium channel modulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20032475A3 (cs) * | 2001-03-15 | 2003-12-17 | Basf Aktiengesellschaft | 5-Fenylpyrimidiny, způsob jejich přípravy, meziprodukty pro jejich přípravu a jejich použití pro kontrolu škodlivých hub |
| CL2004000409A1 (es) | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
| GB2423083B (en) * | 2003-12-03 | 2007-07-11 | Cytopia Res Pty Ltd | Azole-based kinase inhibitors |
| MX2007010991A (es) | 2005-03-14 | 2007-11-07 | Neurosearch As | Agentes que modulan el canal de potasio y su uso medico. |
| JP2008534472A (ja) | 2005-03-22 | 2008-08-28 | ノイロサーチ アクティーゼルスカブ | カリウムチャンネル調節剤としてのピラゾリル−ピリミジン及びその医学的使用 |
| WO2007042571A1 (en) * | 2005-10-14 | 2007-04-19 | Neurosearch A/S | Novel pyrimidine-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
| EP1966184B1 (en) * | 2005-12-20 | 2010-08-25 | NeuroSearch A/S | Pyridinyl-quinazoline derivatives and their medical use |
-
2007
- 2007-10-03 WO PCT/EP2007/060493 patent/WO2008040753A1/en not_active Ceased
- 2007-10-03 MX MX2009003142A patent/MX2009003142A/es active IP Right Grant
- 2007-10-03 AU AU2007304195A patent/AU2007304195A1/en not_active Abandoned
- 2007-10-03 JP JP2009530875A patent/JP2010505794A/ja not_active Abandoned
- 2007-10-03 US US12/444,344 patent/US8222262B2/en active Active
- 2007-10-03 CA CA002665398A patent/CA2665398A1/en not_active Abandoned
- 2007-10-03 EP EP07820871A patent/EP2074113A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2665398A1 (en) | 2008-04-10 |
| US8222262B2 (en) | 2012-07-17 |
| JP2010505794A (ja) | 2010-02-25 |
| AU2007304195A1 (en) | 2008-04-10 |
| US20090325989A1 (en) | 2009-12-31 |
| WO2008040753A1 (en) | 2008-04-10 |
| EP2074113A1 (en) | 2009-07-01 |
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