MX2009002972A - Moleculas de union. - Google Patents
Moleculas de union.Info
- Publication number
- MX2009002972A MX2009002972A MX2009002972A MX2009002972A MX2009002972A MX 2009002972 A MX2009002972 A MX 2009002972A MX 2009002972 A MX2009002972 A MX 2009002972A MX 2009002972 A MX2009002972 A MX 2009002972A MX 2009002972 A MX2009002972 A MX 2009002972A
- Authority
- MX
- Mexico
- Prior art keywords
- domains
- locus
- binding molecules
- solubilising
- incorporation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Processing Of Solid Wastes (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
La presente invención se refiere a métodos para diseñar dominio VH para mejorar su solubilidad y estabilidad; la invención provee la incorporación de sustituciones de aminoácido definidas basadas en la información estructural tridimensional en los segmentos V de un locus de cadena pesada expresando el locus en un mamífero no humano y seleccionando dominios VH solubles; pueden introducirse otras mutaciones de estabilización o solubilización como resultado de maduración por afinidad durante la maduración de células B in vivo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0618345.3A GB0618345D0 (en) | 2006-09-18 | 2006-09-18 | Binding molecules |
PCT/IB2007/003647 WO2008035216A2 (en) | 2006-09-18 | 2007-09-18 | Generation of heavy-chain only antibodies in transgenic animals |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009002972A true MX2009002972A (es) | 2009-05-11 |
Family
ID=37310122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009002972A MX2009002972A (es) | 2006-09-18 | 2007-09-18 | Moleculas de union. |
Country Status (13)
Country | Link |
---|---|
US (1) | US20090271880A1 (es) |
EP (1) | EP2079759A2 (es) |
JP (1) | JP2010503659A (es) |
KR (1) | KR20090114350A (es) |
CN (1) | CN101573378A (es) |
AU (1) | AU2007298661A1 (es) |
BR (1) | BRPI0717020A2 (es) |
CA (1) | CA2663828A1 (es) |
GB (1) | GB0618345D0 (es) |
MX (1) | MX2009002972A (es) |
RU (1) | RU2009114691A (es) |
WO (1) | WO2008035216A2 (es) |
ZA (1) | ZA200901815B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101443473B1 (ko) * | 2004-07-22 | 2014-09-22 | 에라스무스 유니버시티 메디컬 센터 로테르담 | Vh 결합 영역의 분리 방법 |
WO2009013620A2 (en) * | 2007-06-11 | 2009-01-29 | Erasmus University Medical Center Rotterdam | Homologous recombination |
US20110123527A1 (en) | 2008-05-23 | 2011-05-26 | Hiroaki Shizuya | Method of generating single vl domain antibodies in transgenic animals |
ES2613730T3 (es) | 2008-12-18 | 2017-05-25 | Erasmus University Medical Center Rotterdam | Animales transgénicos no humanos que expresan anticuerpos humanizados y su uso |
GB0905023D0 (en) * | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
SG181477A1 (en) | 2009-12-10 | 2012-07-30 | Regeneron Pharma | Mice that make heavy chain antibodies |
RU2750219C2 (ru) * | 2010-08-02 | 2021-06-24 | Ридженерон Фармасьютикалз, Инк. | Мыши, у которых вырабатываются связывающие белки, содержащие vl-домены |
CA2859408C (en) | 2011-12-20 | 2020-06-16 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
PL2967012T3 (pl) | 2013-03-14 | 2021-04-19 | Erasmus University Medical Center Rotterdam | Transgeniczne ssaki inne niż człowiek do wytwarzania przeciwciał |
US10993420B2 (en) | 2013-03-15 | 2021-05-04 | Erasmus University Medical Center | Production of heavy chain only antibodies in transgenic mammals |
ES2762640T3 (es) | 2014-03-21 | 2020-05-25 | Regeneron Pharma | Proteínas VL de unión a antígeno que exhiben diferentes características de unión |
WO2015143414A2 (en) | 2014-03-21 | 2015-09-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
WO2016062989A1 (en) * | 2014-10-22 | 2016-04-28 | Crescendo Biologics Limited | Human vh domain scaffolds |
EP3209699A1 (en) * | 2014-10-22 | 2017-08-30 | Crescendo Biologics Limited | Vh scaffold |
CN107438622A (zh) | 2015-03-19 | 2017-12-05 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
CN108486125B (zh) * | 2018-03-27 | 2024-01-05 | 重庆金迈博生物科技有限公司 | 一种核酸分子及其在制备人源单域抗体中的应用 |
CN114134144A (zh) * | 2020-09-04 | 2022-03-04 | 北京仁源欣生生物科技有限公司 | 一种非人哺乳动物或其子代的制备方法及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7129084B2 (en) * | 2000-08-03 | 2006-10-31 | Therapeutic Human Polyclonals, Inc. | Production of humanized antibodies in transgenic animals |
GB0110029D0 (en) * | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
GB0228210D0 (en) * | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
KR101443473B1 (ko) * | 2004-07-22 | 2014-09-22 | 에라스무스 유니버시티 메디컬 센터 로테르담 | Vh 결합 영역의 분리 방법 |
-
2006
- 2006-09-18 GB GBGB0618345.3A patent/GB0618345D0/en not_active Ceased
-
2007
- 2007-09-18 AU AU2007298661A patent/AU2007298661A1/en not_active Abandoned
- 2007-09-18 MX MX2009002972A patent/MX2009002972A/es not_active Application Discontinuation
- 2007-09-18 US US12/441,581 patent/US20090271880A1/en not_active Abandoned
- 2007-09-18 EP EP07825742A patent/EP2079759A2/en not_active Withdrawn
- 2007-09-18 WO PCT/IB2007/003647 patent/WO2008035216A2/en active Application Filing
- 2007-09-18 CA CA002663828A patent/CA2663828A1/en not_active Abandoned
- 2007-09-18 KR KR1020097007769A patent/KR20090114350A/ko not_active Application Discontinuation
- 2007-09-18 JP JP2009527923A patent/JP2010503659A/ja not_active Withdrawn
- 2007-09-18 CN CNA2007800428188A patent/CN101573378A/zh active Pending
- 2007-09-18 BR BRPI0717020-3A patent/BRPI0717020A2/pt not_active IP Right Cessation
- 2007-09-18 RU RU2009114691/10A patent/RU2009114691A/ru unknown
- 2007-09-18 ZA ZA200901815A patent/ZA200901815B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US20090271880A1 (en) | 2009-10-29 |
WO2008035216A9 (en) | 2008-10-02 |
KR20090114350A (ko) | 2009-11-03 |
CN101573378A (zh) | 2009-11-04 |
EP2079759A2 (en) | 2009-07-22 |
BRPI0717020A2 (pt) | 2013-10-08 |
AU2007298661A1 (en) | 2008-03-27 |
ZA200901815B (en) | 2010-06-30 |
JP2010503659A (ja) | 2010-02-04 |
CA2663828A1 (en) | 2008-03-27 |
WO2008035216A3 (en) | 2009-05-14 |
GB0618345D0 (en) | 2006-10-25 |
RU2009114691A (ru) | 2010-10-27 |
WO2008035216A2 (en) | 2008-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |