MX2009000770A - Formulaciones para eteres de piridilo de bencimidazolilo. - Google Patents

Info

Publication number

MX2009000770A

MX2009000770A MX2009000770A MX2009000770A MX2009000770A MX 2009000770 A MX2009000770 A MX 2009000770A MX 2009000770 A MX2009000770 A MX 2009000770A MX 2009000770 A MX2009000770 A MX 2009000770A MX 2009000770 A MX2009000770 A MX 2009000770A

Authority

MX

Mexico

Prior art keywords

formulation

mixture

compound

formulation according

fatty acid

Prior art date

2006-07-21

Links

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• 239000000203 mixture Substances 0.000 title claims abstract description 466
• 238000009472 formulation Methods 0.000 title claims abstract description 322
• SYLABBNLHCTJEF-UHFFFAOYSA-N 2-pyridin-2-yloxy-1h-benzimidazole Chemical class N=1C2=CC=CC=C2NC=1OC1=CC=CC=N1 SYLABBNLHCTJEF-UHFFFAOYSA-N 0.000 title description 7
• 150000001875 compounds Chemical class 0.000 claims abstract description 90
• 239000002904 solvent Substances 0.000 claims abstract description 89
• 238000000034 method Methods 0.000 claims abstract description 72
• 150000003839 salts Chemical class 0.000 claims abstract description 58
• 239000007787 solid Substances 0.000 claims abstract description 45
• 239000003995 emulsifying agent Substances 0.000 claims abstract description 31
• 239000004615 ingredient Substances 0.000 claims abstract description 26
• 239000007788 liquid Substances 0.000 claims abstract description 9
• 239000002775 capsule Substances 0.000 claims description 92
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 69
• -1 fatty acid ester Chemical class 0.000 claims description 64
• 239000000194 fatty acid Substances 0.000 claims description 59
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 53
• 235000014113 dietary fatty acids Nutrition 0.000 claims description 53
• 229930195729 fatty acid Natural products 0.000 claims description 53
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 32
• 229920001223 polyethylene glycol Polymers 0.000 claims description 32
• WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 27
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 25
• 229920000642 polymer Polymers 0.000 claims description 25
• 229920002675 Polyoxyl Polymers 0.000 claims description 24
• 150000004665 fatty acids Chemical group 0.000 claims description 23
• 239000002202 Polyethylene glycol Substances 0.000 claims description 22
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 21
• 239000012669 liquid formulation Substances 0.000 claims description 20
• 239000003981 vehicle Substances 0.000 claims description 20
• 239000008187 granular material Substances 0.000 claims description 17
• 229920000858 Cyclodextrin Polymers 0.000 claims description 16
• 239000002253 acid Substances 0.000 claims description 16
• 239000003086 colorant Substances 0.000 claims description 16
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 16
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 16
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 16
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 15
• 150000002148 esters Chemical class 0.000 claims description 15
• 239000007903 gelatin capsule Substances 0.000 claims description 15
• 239000004359 castor oil Substances 0.000 claims description 14
• 235000019438 castor oil Nutrition 0.000 claims description 14
• 150000005690 diesters Chemical class 0.000 claims description 14
• 235000003599 food sweetener Nutrition 0.000 claims description 14
• ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 14
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 14
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 14
• 239000003765 sweetening agent Substances 0.000 claims description 14
• 239000003963 antioxidant agent Substances 0.000 claims description 13
• 235000006708 antioxidants Nutrition 0.000 claims description 13
• 239000007887 hard shell capsule Substances 0.000 claims description 13
• 229940069328 povidone Drugs 0.000 claims description 13
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
• 229960000913 crospovidone Drugs 0.000 claims description 12
• 239000000796 flavoring agent Substances 0.000 claims description 12
• 235000013355 food flavoring agent Nutrition 0.000 claims description 12
• 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 12
• 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims description 12
• 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims description 12
• 125000005456 glyceride group Chemical group 0.000 claims description 11
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 11
• 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 10
• 230000003078 antioxidant effect Effects 0.000 claims description 10
• 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 10
• 239000008108 microcrystalline cellulose Substances 0.000 claims description 10
• 229940016286 microcrystalline cellulose Drugs 0.000 claims description 10
• 239000003755 preservative agent Substances 0.000 claims description 10
• 235000000346 sugar Nutrition 0.000 claims description 10
• 150000005691 triesters Chemical class 0.000 claims description 10
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 9
• JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 8
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 8
• VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 8
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 8
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 8
• 239000005642 Oleic acid Substances 0.000 claims description 8
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 8
• 229920001214 Polysorbate 60 Polymers 0.000 claims description 8
• 229920002472 Starch Polymers 0.000 claims description 8
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 8
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 8
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 8
• 229940049964 oleate Drugs 0.000 claims description 8
• 229960001866 silicon dioxide Drugs 0.000 claims description 8
• 235000019698 starch Nutrition 0.000 claims description 8
• 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 claims description 7
• 229920001213 Polysorbate 20 Polymers 0.000 claims description 7
• 239000003463 adsorbent Substances 0.000 claims description 7
• 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 7
• 235000019477 peppermint oil Nutrition 0.000 claims description 7
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 7
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 7
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 7
• 229920000053 polysorbate 80 Polymers 0.000 claims description 7
• 230000002335 preservative effect Effects 0.000 claims description 7
• 239000008107 starch Substances 0.000 claims description 7
• 229940032147 starch Drugs 0.000 claims description 7
• ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims description 6
• 229920002785 Croscarmellose sodium Polymers 0.000 claims description 6
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 6
• 229930006000 Sucrose Natural products 0.000 claims description 6
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 6
• WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 6
• 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 6
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 6
• 229920000193 polymethacrylate Polymers 0.000 claims description 6
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 6
• 229940068977 polysorbate 20 Drugs 0.000 claims description 6
• 229940068968 polysorbate 80 Drugs 0.000 claims description 6
• 239000000377 silicon dioxide Substances 0.000 claims description 6
• 235000012239 silicon dioxide Nutrition 0.000 claims description 6
• 235000011069 sorbitan monooleate Nutrition 0.000 claims description 6
• 239000001593 sorbitan monooleate Substances 0.000 claims description 6
• 229940035049 sorbitan monooleate Drugs 0.000 claims description 6
• 239000005720 sucrose Substances 0.000 claims description 6
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
• 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 5
• 235000021355 Stearic acid Nutrition 0.000 claims description 5
• 239000002671 adjuvant Substances 0.000 claims description 5
• 229920001577 copolymer Polymers 0.000 claims description 5
• 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 5
• 235000011187 glycerol Nutrition 0.000 claims description 5
• 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 5
• 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 5
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 5
• 150000003904 phospholipids Chemical class 0.000 claims description 5
• 239000000600 sorbitol Substances 0.000 claims description 5
• 235000010356 sorbitol Nutrition 0.000 claims description 5
• 239000008117 stearic acid Substances 0.000 claims description 5
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 5
• 239000000454 talc Substances 0.000 claims description 5
• 235000012222 talc Nutrition 0.000 claims description 5
• 229910052623 talc Inorganic materials 0.000 claims description 5
• OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims description 4
• 239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 claims description 4
• RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 claims description 4
• XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims description 4
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
• 235000001815 DL-alpha-tocopherol Nutrition 0.000 claims description 4
• 239000011627 DL-alpha-tocopherol Substances 0.000 claims description 4
• LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims description 4
• 229920000881 Modified starch Polymers 0.000 claims description 4
• SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 4
• 229920001219 Polysorbate 40 Polymers 0.000 claims description 4
• 235000019485 Safflower oil Nutrition 0.000 claims description 4
• 239000004147 Sorbitan trioleate Substances 0.000 claims description 4
• PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 4
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
• 150000005215 alkyl ethers Chemical class 0.000 claims description 4
• 239000002285 corn oil Substances 0.000 claims description 4
• 235000005687 corn oil Nutrition 0.000 claims description 4
• 235000012343 cottonseed oil Nutrition 0.000 claims description 4
• 239000002385 cottonseed oil Substances 0.000 claims description 4
• 229940097362 cyclodextrins Drugs 0.000 claims description 4
• 125000004494 ethyl ester group Chemical group 0.000 claims description 4
• FMMOOAYVCKXGMF-MURFETPASA-N ethyl linoleate Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OCC FMMOOAYVCKXGMF-MURFETPASA-N 0.000 claims description 4
• 229940031016 ethyl linoleate Drugs 0.000 claims description 4
• LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims description 4
• 229940093471 ethyl oleate Drugs 0.000 claims description 4
• 229940075507 glyceryl monostearate Drugs 0.000 claims description 4
• FMMOOAYVCKXGMF-UHFFFAOYSA-N linoleic acid ethyl ester Natural products CCCCCC=CCC=CCCCCCCCC(=O)OCC FMMOOAYVCKXGMF-UHFFFAOYSA-N 0.000 claims description 4
• 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 4
• RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 claims description 4
• 235000021313 oleic acid Nutrition 0.000 claims description 4
• 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 claims description 4
• 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 claims description 4
• 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 4
• 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 4
• 229940101027 polysorbate 40 Drugs 0.000 claims description 4
• 229940113124 polysorbate 60 Drugs 0.000 claims description 4
• 235000005713 safflower oil Nutrition 0.000 claims description 4
• 239000003813 safflower oil Substances 0.000 claims description 4
• 239000008159 sesame oil Substances 0.000 claims description 4
• 235000011803 sesame oil Nutrition 0.000 claims description 4
• 229940035044 sorbitan monolaurate Drugs 0.000 claims description 4
• 235000019337 sorbitan trioleate Nutrition 0.000 claims description 4
• 229960000391 sorbitan trioleate Drugs 0.000 claims description 4
• 239000003549 soybean oil Substances 0.000 claims description 4
• 235000012424 soybean oil Nutrition 0.000 claims description 4
• OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 claims description 3
• WITKSCOBOCOGSC-UHFFFAOYSA-N 2-dodecanoyloxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(C)OC(=O)CCCCCCCCCCC WITKSCOBOCOGSC-UHFFFAOYSA-N 0.000 claims description 3
• 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 3
• 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
• 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
• 235000019483 Peanut oil Nutrition 0.000 claims description 3
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
• SJLAFUFWXUJDDR-KTKRTIGZSA-N [3-[3-(2,3-dihydroxypropoxy)-2-hydroxypropoxy]-2-hydroxypropyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)COCC(O)COCC(O)CO SJLAFUFWXUJDDR-KTKRTIGZSA-N 0.000 claims description 3
• 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 3
• 229960001681 croscarmellose sodium Drugs 0.000 claims description 3
• 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims description 3
• 229940049654 glyceryl behenate Drugs 0.000 claims description 3
• FETSQPAGYOVAQU-UHFFFAOYSA-N glyceryl palmitostearate Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O FETSQPAGYOVAQU-UHFFFAOYSA-N 0.000 claims description 3
• 229940046813 glyceryl palmitostearate Drugs 0.000 claims description 3
• 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
• 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims description 3
• 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims description 3
• 229920003145 methacrylic acid copolymer Polymers 0.000 claims description 3
• IWVKTOUOPHGZRX-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.COC(=O)C(C)=C IWVKTOUOPHGZRX-UHFFFAOYSA-N 0.000 claims description 3
• 229920000609 methyl cellulose Polymers 0.000 claims description 3
• 235000010981 methylcellulose Nutrition 0.000 claims description 3
• 239000001923 methylcellulose Substances 0.000 claims description 3
• 229960002900 methylcellulose Drugs 0.000 claims description 3
• 238000000465 moulding Methods 0.000 claims description 3
• 239000004006 olive oil Substances 0.000 claims description 3
• 235000008390 olive oil Nutrition 0.000 claims description 3
• 239000000312 peanut oil Substances 0.000 claims description 3
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 3
• 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 3
• 229920003109 sodium starch glycolate Polymers 0.000 claims description 3
• 239000008109 sodium starch glycolate Substances 0.000 claims description 3
• 229940079832 sodium starch glycolate Drugs 0.000 claims description 3
• PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims description 2
• TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims description 2
• CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 claims description 2
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
• 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 2
• JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims description 2
• ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims description 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
• 229930195725 Mannitol Natural products 0.000 claims description 2
• 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
• YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims description 2
• SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical group [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 2
• 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
• 239000001506 calcium phosphate Substances 0.000 claims description 2
• NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 2
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