MX2008007358A - Dimeros de trioxano que tienen altas actividades anticancer y antimalaricas de la larga duracion. - Google Patents

Dimeros de trioxano que tienen altas actividades anticancer y antimalaricas de la larga duracion.

Info

Publication number
MX2008007358A
MX2008007358A MX2008007358A MX2008007358A MX2008007358A MX 2008007358 A MX2008007358 A MX 2008007358A MX 2008007358 A MX2008007358 A MX 2008007358A MX 2008007358 A MX2008007358 A MX 2008007358A MX 2008007358 A MX2008007358 A MX 2008007358A
Authority
MX
Mexico
Prior art keywords
substituted
unsubstituted
mmol
compound according
nmr
Prior art date
Application number
MX2008007358A
Other languages
English (en)
Spanish (es)
Inventor
Kristina Borstnik
Wonsuk Chang
Ikhyeon Paik
Sandra Sinishtaj
William Anthony Maio
John Gaetano D Angelo
Lauren Elaine Woodard
Alvin Soloman Kalinda
Aimee R Usera
Lindsey Catherine Hess
Andrew Scott Rosenthal
Seongho Oh
Astrid C Baege
Original Assignee
Johns Hopkins Universty
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins Universty filed Critical Johns Hopkins Universty
Publication of MX2008007358A publication Critical patent/MX2008007358A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MX2008007358A 2005-12-08 2006-11-17 Dimeros de trioxano que tienen altas actividades anticancer y antimalaricas de la larga duracion. MX2008007358A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74854805P 2005-12-08 2005-12-08
US76512506P 2006-02-03 2006-02-03
US79481106P 2006-04-25 2006-04-25
PCT/US2006/044845 WO2007067333A2 (en) 2005-12-08 2006-11-17 Trioxane dimers having high anticancer and long-lasting antimalarial activities

Publications (1)

Publication Number Publication Date
MX2008007358A true MX2008007358A (es) 2008-11-10

Family

ID=38123365

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008007358A MX2008007358A (es) 2005-12-08 2006-11-17 Dimeros de trioxano que tienen altas actividades anticancer y antimalaricas de la larga duracion.

Country Status (10)

Country Link
US (1) US20090291923A1 (enExample)
EP (1) EP1962596A4 (enExample)
JP (1) JP2009518397A (enExample)
KR (1) KR20080081310A (enExample)
AU (1) AU2006323040A1 (enExample)
BR (1) BRPI0619759A2 (enExample)
CA (1) CA2632200A1 (enExample)
IL (1) IL191597A0 (enExample)
MX (1) MX2008007358A (enExample)
WO (1) WO2007067333A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2141499A1 (en) * 2008-07-02 2010-01-06 Apoptec AG COPD diagnosis
US8592611B2 (en) 2008-07-17 2013-11-26 The Johns Hopkins University Trioxane dimer sulfur compounds
WO2010032165A2 (en) * 2008-09-19 2010-03-25 North-West University Prodrugs of artemisinin
US8884032B2 (en) 2009-05-19 2014-11-11 The Johns Hopkins University Trioxane monomers and dimers
IN2012DN05028A (enExample) 2009-12-07 2015-10-23 Univ Johns Hopkins
CA2782110A1 (en) * 2009-12-07 2011-06-16 Johns Hopkins University N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives
US9493480B2 (en) 2011-04-15 2016-11-15 The Johns Hopkins University Monomeric trioxane amide sulfur compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL121749A0 (en) * 1997-09-11 1998-02-22 Yeda Res & Dev 2,3-dioxabicycloÚ3.3.1¾nonane derivatives and antimalarial pharmaceutical compositions comprising them
US6160004A (en) * 1997-12-30 2000-12-12 Hauser, Inc. C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities
US20050240034A1 (en) * 2002-05-07 2005-10-27 Mitchell Avery Artemisinin-based peroxide compounds as broad spectrum anti-infective agents
US7417156B2 (en) * 2002-09-27 2008-08-26 Johns Hopkins University Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers

Also Published As

Publication number Publication date
EP1962596A2 (en) 2008-09-03
WO2007067333A3 (en) 2008-01-31
KR20080081310A (ko) 2008-09-09
JP2009518397A (ja) 2009-05-07
BRPI0619759A2 (pt) 2011-10-18
US20090291923A1 (en) 2009-11-26
EP1962596A4 (en) 2010-09-22
CA2632200A1 (en) 2007-06-14
AU2006323040A1 (en) 2007-06-14
WO2007067333A2 (en) 2007-06-14
IL191597A0 (en) 2009-02-11

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Legal Events

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