MX2008002089A - Nuevos derivados de triazol como ligandos analogos de ghrelin de receptores secretagogos de hormonas del crecimiento. - Google Patents

Nuevos derivados de triazol como ligandos analogos de ghrelin de receptores secretagogos de hormonas del crecimiento.

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Publication number
MX2008002089A
MX2008002089A MX2008002089A MX2008002089A MX2008002089A MX 2008002089 A MX2008002089 A MX 2008002089A MX 2008002089 A MX2008002089 A MX 2008002089A MX 2008002089 A MX2008002089 A MX 2008002089A MX 2008002089 A MX2008002089 A MX 2008002089A
Authority
MX
Mexico
Prior art keywords
receptors
growth hormone
triazole derivatives
hormone secretagogue
ghrelin
Prior art date
Application number
MX2008002089A
Other languages
English (en)
Inventor
Daniel Perrissoud
Jean Martinez
Aline Moulin
Jean-Alain Fehrentz
Damien Boeglin
Luc Demange
Original Assignee
Aeterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35589641&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2008002089(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Publication of MX2008002089A publication Critical patent/MX2008002089A/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

La presente invención proporciona nuevos derivados de triazol como ligandos análogos de ghrelin de receptores secretagogos de hormona del crecimiento de acuerdo a la fórmula (I), que son útiles en el tratamiento o profilaxis de condiciones fisiológicas y/o patofisiológicas en mamíferos, preferentemente humanos, que son mediadas por receptores de GHS. La presente invención proporciona además antagonistas y agonistas del receptor de GHS que se pueden utilizar para la modulación de estos receptores y son útiles para tratar las condiciones anteriores, en particular retardo del crecimiento, caquexia, regulación del balance energético a corto, mediano y/o a largo plazo; regulación (estimulación y/o inhibición) del consumo de alimento a corto, mediano y/o a largo plazo; adipogénesis, adiposidad y/u obesidad; aumento y/o reducción del peso corporal, diabetes, diabetes tipo I, diabetes tipo II, proliferación de células tumorales, inflamación, efectos inflamatorios, íleo postoperativo gástrico, íleo postoperativo y/o gastrectomía (terapia de reemplazo de ghrelin).
MX2008002089A 2005-08-15 2006-08-11 Nuevos derivados de triazol como ligandos analogos de ghrelin de receptores secretagogos de hormonas del crecimiento. MX2008002089A (es)

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US70794105P 2005-08-15 2005-08-15
EP05017732A EP1757290A1 (en) 2005-08-16 2005-08-16 Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors
US78754306P 2006-03-31 2006-03-31
PCT/EP2006/007945 WO2007020013A2 (en) 2005-08-15 2006-08-11 Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors

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WO2007020013A2 (en) 2007-02-22
EP1757290A1 (en) 2007-02-28
CN101272782A (zh) 2008-09-24
WO2007020013A3 (en) 2007-04-19
EP1915149A2 (en) 2008-04-30
US7829724B2 (en) 2010-11-09
KR20080059145A (ko) 2008-06-26
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CA2620280A1 (en) 2007-02-22
US20070208061A2 (en) 2007-09-06
JP5284091B2 (ja) 2013-09-11
AR059026A1 (es) 2008-03-12
US8710089B2 (en) 2014-04-29
AU2006281594A1 (en) 2007-02-22
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JP2009504697A (ja) 2009-02-05
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