MX2007014588A - Derivados de morfinano 7-carbamoil-sustituidos 6,7-insaturados. - Google Patents

Derivados de morfinano 7-carbamoil-sustituidos 6,7-insaturados.

Info

Publication number
MX2007014588A
MX2007014588A MX2007014588A MX2007014588A MX2007014588A MX 2007014588 A MX2007014588 A MX 2007014588A MX 2007014588 A MX2007014588 A MX 2007014588A MX 2007014588 A MX2007014588 A MX 2007014588A MX 2007014588 A MX2007014588 A MX 2007014588A
Authority
MX
Mexico
Prior art keywords
optionally substituted
compound
lower alkyl
pharmaceutically acceptable
solvate
Prior art date
Application number
MX2007014588A
Other languages
English (en)
Spanish (es)
Inventor
Nobuhiro Haga
Tsuyoshi Hasegawa
Masanao Inagaki
Shin-Ichiro Hara
Yoshinori Tamura
Yoshihisa Goto
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of MX2007014588A publication Critical patent/MX2007014588A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MX2007014588A 2005-05-25 2006-05-25 Derivados de morfinano 7-carbamoil-sustituidos 6,7-insaturados. MX2007014588A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2005151864 2005-05-25
JP2006065762 2006-03-10
PCT/JP2006/310231 WO2006126529A1 (ja) 2005-05-25 2006-05-23 ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
PCT/JP2006/310454 WO2006126637A1 (ja) 2005-05-25 2006-05-25 ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体

Publications (1)

Publication Number Publication Date
MX2007014588A true MX2007014588A (es) 2008-01-24

Family

ID=37451954

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007014588A MX2007014588A (es) 2005-05-25 2006-05-25 Derivados de morfinano 7-carbamoil-sustituidos 6,7-insaturados.

Country Status (20)

Country Link
US (4) US8084460B2 (index.php)
EP (1) EP1889848B8 (index.php)
JP (1) JP4323547B2 (index.php)
KR (1) KR100912782B1 (index.php)
CN (1) CN101228172B (index.php)
AU (1) AU2006250390B2 (index.php)
BE (1) BE2019C533I2 (index.php)
BR (1) BRPI0610343B8 (index.php)
CA (1) CA2609733C (index.php)
DK (1) DK1889848T3 (index.php)
ES (1) ES2525215T3 (index.php)
FR (1) FR19C1042I2 (index.php)
HU (1) HUS1900034I1 (index.php)
MX (1) MX2007014588A (index.php)
NL (1) NL300996I2 (index.php)
PL (1) PL1889848T3 (index.php)
PT (1) PT1889848E (index.php)
RU (1) RU2403255C2 (index.php)
TW (1) TWI311056B (index.php)
WO (2) WO2006126529A1 (index.php)

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WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
JP5714910B2 (ja) * 2008-01-09 2015-05-07 チャールストン ラボラトリーズ，インコーポレイテッド 薬学的組成物
JP5252391B2 (ja) * 2008-02-21 2013-07-31 学校法人北里研究所 オキサビシクロ［２．２．２］オクタンを有するモルヒナン誘導体およびその医薬用途
EP3342427A1 (en) * 2008-09-16 2018-07-04 Nektar Therapeutics Pegylated opioids with low potential for abuse
BR112012006069A8 (pt) * 2009-09-18 2017-10-10 Adolor Corp Método para tratar ou prevenir constipação induzida e disfunção intestinal induzida por opióide em um humano, e, uso de uma quantidade terapeuticamente efetiva de composto
CN102906099A (zh) * 2010-05-13 2013-01-30 株式会社绿十字 作为神经保护剂的基于(+)-3-羟基吗啡喃的多环衍生物
EP2639234B1 (en) 2010-11-12 2019-07-03 Shionogi&Co., Ltd. Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same
WO2013172297A1 (ja) 2012-05-14 2013-11-21 塩野義製薬株式会社 ６，７－不飽和－７－カルバモイルモルヒナン誘導体含有製剤
WO2018124062A1 (ja) 2016-12-26 2018-07-05 塩野義製薬株式会社 含量均一性を改善した製剤の製造方法
US10759756B2 (en) 2018-04-12 2020-09-01 Morphic Therapeutic, Inc. Antagonists of human integrin α4β7
KR102201609B1 (ko) 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
UA130059C2 (uk) 2019-10-16 2025-10-29 Морфік Терапьютік, Інк. ІНГІБУВАННЯ ІНТЕГРИНУ <font face="Symbol">a<sub></font>4</sub><font face="Symbol">b<sub></font>7</sub> ЛЮДИНИ
WO2021100728A1 (ja) 2019-11-20 2021-05-27 塩野義製薬株式会社 ６，７－不飽和－７－カルバモイルモルヒナン誘導体含有固形製剤
CN111905111B (zh) * 2020-09-16 2023-03-31 地奥集团成都药业股份有限公司 一种评价复方谷氨酰胺组方对腹泻型肠易激综合征疗效的方法
IT202300009864A1 (it) * 2023-05-16 2024-11-16 Procos Spa Processo per la preparazione di naldemedina

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US4275205A (en) 1980-05-05 1981-06-23 Miles Laboratories, Inc. 7,7-Ditosyloxymethyl-4,5α-epoxy-morphinan-6-ols
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DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
CN1288158C (zh) 2002-07-11 2006-12-06 东丽株式会社 用于预防恶心和呕吐的治疗剂或预防剂
WO2004026819A2 (en) 2002-09-18 2004-04-01 The Curators Of The University Of Missouri OPIATE ANALOGS SELECTIVE FOR THE delta-OPIOID RECEPTOR
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EP2639234B1 (en) 2010-11-12 2019-07-03 Shionogi&Co., Ltd. Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same

Also Published As

Publication number Publication date
EP1889848B1 (en) 2014-10-15
AU2006250390B2 (en) 2010-07-08
US20120135978A1 (en) 2012-05-31
EP1889848B8 (en) 2014-12-17
NL300996I1 (nl) 2019-07-03
CA2609733A1 (en) 2006-11-30
CA2609733C (en) 2011-07-19
BRPI0610343B8 (pt) 2021-05-25
TWI311056B (en) 2009-06-21
NL300996I2 (nl) 2019-07-30
FR19C1042I2 (fr) 2020-06-19
WO2006126637A1 (ja) 2006-11-30
JPWO2006126637A1 (ja) 2008-12-25
JP4323547B2 (ja) 2009-09-02
CN101228172B (zh) 2013-04-03
PL1889848T3 (pl) 2015-04-30
PT1889848E (pt) 2014-12-09
RU2403255C2 (ru) 2010-11-10
EP1889848A1 (en) 2008-02-20
BE2019C533I2 (index.php) 2025-12-10
HUS1900034I1 (hu) 2019-07-29
US8084460B2 (en) 2011-12-27
ES2525215T3 (es) 2014-12-19
AU2006250390A1 (en) 2006-11-30
USRE46365E1 (en) 2017-04-11
US8536192B2 (en) 2013-09-17
TW200726470A (en) 2007-07-16
US20090203723A1 (en) 2009-08-13
WO2006126529A1 (ja) 2006-11-30
EP1889848A4 (en) 2011-08-10
KR100912782B1 (ko) 2009-08-18
RU2007148412A (ru) 2009-06-27
USRE46375E1 (en) 2017-04-25
DK1889848T3 (en) 2014-12-01
CN101228172A (zh) 2008-07-23
FR19C1042I1 (index.php) 2019-08-09
KR20080014791A (ko) 2008-02-14
BRPI0610343B1 (pt) 2020-03-10
BRPI0610343A2 (pt) 2010-06-15

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