MX2007013760A - Uso novedoso de spiegelmers. - Google Patents
Uso novedoso de spiegelmers.Info
- Publication number
- MX2007013760A MX2007013760A MX2007013760A MX2007013760A MX2007013760A MX 2007013760 A MX2007013760 A MX 2007013760A MX 2007013760 A MX2007013760 A MX 2007013760A MX 2007013760 A MX2007013760 A MX 2007013760A MX 2007013760 A MX2007013760 A MX 2007013760A
- Authority
- MX
- Mexico
- Prior art keywords
- helix
- section
- nucleic acid
- hmga
- binding
- Prior art date
Links
- 102000039446 nucleic acids Human genes 0.000 claims description 365
- 108020004707 nucleic acids Proteins 0.000 claims description 365
- 150000007523 nucleic acids Chemical class 0.000 claims description 363
- 239000002773 nucleotide Substances 0.000 claims description 223
- 102000009012 HMGA Proteins Human genes 0.000 claims description 209
- 108010049069 HMGA Proteins Proteins 0.000 claims description 209
- 230000027455 binding Effects 0.000 claims description 209
- 125000003729 nucleotide group Chemical group 0.000 claims description 205
- NPOAOTPXWNWTSH-UHFFFAOYSA-N 3-hydroxy-3-methylglutaric acid Chemical compound OC(=O)CC(O)(C)CC(O)=O NPOAOTPXWNWTSH-UHFFFAOYSA-N 0.000 claims description 202
- 108091027076 Spiegelmer Proteins 0.000 claims description 156
- 206010028980 Neoplasm Diseases 0.000 claims description 103
- 238000000034 method Methods 0.000 claims description 67
- 239000000693 micelle Substances 0.000 claims description 65
- 201000011510 cancer Diseases 0.000 claims description 60
- 230000003834 intracellular effect Effects 0.000 claims description 55
- 102100029009 High mobility group protein HMG-I/HMG-Y Human genes 0.000 claims description 49
- 101000986380 Homo sapiens High mobility group protein HMG-I/HMG-Y Proteins 0.000 claims description 49
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 48
- 102000027411 intracellular receptors Human genes 0.000 claims description 48
- 108091008582 intracellular receptors Proteins 0.000 claims description 48
- 201000010099 disease Diseases 0.000 claims description 46
- 239000000203 mixture Substances 0.000 claims description 46
- 229920002873 Polyethylenimine Polymers 0.000 claims description 45
- 102000005962 receptors Human genes 0.000 claims description 37
- 239000003981 vehicle Substances 0.000 claims description 37
- 108020003175 receptors Proteins 0.000 claims description 36
- 238000009396 hybridization Methods 0.000 claims description 34
- 108700039143 HMGA2 Proteins 0.000 claims description 29
- 101150073387 Hmga2 gene Proteins 0.000 claims description 28
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 28
- 239000000556 agonist Substances 0.000 claims description 26
- 238000001514 detection method Methods 0.000 claims description 24
- 239000005557 antagonist Substances 0.000 claims description 23
- 238000011282 treatment Methods 0.000 claims description 22
- 230000015572 biosynthetic process Effects 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 19
- 239000002253 acid Substances 0.000 claims description 18
- 239000000543 intermediate Substances 0.000 claims description 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 17
- 102000040945 Transcription factor Human genes 0.000 claims description 16
- 108091023040 Transcription factor Proteins 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 230000004048 modification Effects 0.000 claims description 15
- 238000012986 modification Methods 0.000 claims description 15
- 238000012360 testing method Methods 0.000 claims description 15
- 102000004190 Enzymes Human genes 0.000 claims description 14
- 108090000790 Enzymes Proteins 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- -1 HMGA nucleic acid Chemical class 0.000 claims description 12
- 230000001404 mediated effect Effects 0.000 claims description 12
- 229920001184 polypeptide Polymers 0.000 claims description 12
- 102000018802 High Mobility Group Proteins Human genes 0.000 claims description 11
- 108010052512 High Mobility Group Proteins Proteins 0.000 claims description 11
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 11
- 150000001720 carbohydrates Chemical class 0.000 claims description 11
- 235000014633 carbohydrates Nutrition 0.000 claims description 11
- 210000004072 lung Anatomy 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 206010027476 Metastases Diseases 0.000 claims description 10
- 150000002632 lipids Chemical class 0.000 claims description 9
- 102000052510 DNA-Binding Proteins Human genes 0.000 claims description 8
- 108700020911 DNA-Binding Proteins Proteins 0.000 claims description 8
- 230000009401 metastasis Effects 0.000 claims description 8
- 239000002105 nanoparticle Substances 0.000 claims description 8
- 210000000496 pancreas Anatomy 0.000 claims description 8
- 206010024612 Lipoma Diseases 0.000 claims description 7
- 108010006519 Molecular Chaperones Proteins 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 7
- 238000011534 incubation Methods 0.000 claims description 7
- 208000032839 leukemia Diseases 0.000 claims description 7
- 201000008806 mesenchymal cell neoplasm Diseases 0.000 claims description 7
- 230000002265 prevention Effects 0.000 claims description 7
- 201000009030 Carcinoma Diseases 0.000 claims description 6
- 206010025323 Lymphomas Diseases 0.000 claims description 6
- 210000001072 colon Anatomy 0.000 claims description 6
- 239000000032 diagnostic agent Substances 0.000 claims description 6
- 229940039227 diagnostic agent Drugs 0.000 claims description 6
- 230000012202 endocytosis Effects 0.000 claims description 6
- 230000002503 metabolic effect Effects 0.000 claims description 6
- 208000009091 myxoma Diseases 0.000 claims description 6
- 208000004333 pleomorphic adenoma Diseases 0.000 claims description 6
- 210000003079 salivary gland Anatomy 0.000 claims description 6
- 210000001685 thyroid gland Anatomy 0.000 claims description 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 5
- 208000036142 Viral infection Diseases 0.000 claims description 5
- 208000016160 chondroid hamartoma Diseases 0.000 claims description 5
- 238000004520 electroporation Methods 0.000 claims description 5
- 208000016018 endometrial polyp Diseases 0.000 claims description 5
- 201000010260 leiomyoma Diseases 0.000 claims description 5
- 210000001672 ovary Anatomy 0.000 claims description 5
- 230000035939 shock Effects 0.000 claims description 5
- 210000002784 stomach Anatomy 0.000 claims description 5
- 206010046811 uterine polyp Diseases 0.000 claims description 5
- 230000009385 viral infection Effects 0.000 claims description 5
- 206010029260 Neuroblastoma Diseases 0.000 claims description 4
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 4
- 210000000481 breast Anatomy 0.000 claims description 4
- 210000003679 cervix uteri Anatomy 0.000 claims description 4
- 230000000799 fusogenic effect Effects 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000020816 lung neoplasm Diseases 0.000 claims description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 4
- 210000002307 prostate Anatomy 0.000 claims description 4
- 210000000664 rectum Anatomy 0.000 claims description 4
- 201000000849 skin cancer Diseases 0.000 claims description 4
- 239000007790 solid phase Substances 0.000 claims description 4
- 206010046798 Uterine leiomyoma Diseases 0.000 claims description 3
- 208000020719 chondrogenic neoplasm Diseases 0.000 claims description 3
- 239000000412 dendrimer Substances 0.000 claims description 3
- 229920000736 dendritic polymer Polymers 0.000 claims description 3
- 239000002502 liposome Substances 0.000 claims description 3
- 201000007954 uterine fibroid Diseases 0.000 claims description 3
- 206010003571 Astrocytoma Diseases 0.000 claims description 2
- 208000011691 Burkitt lymphomas Diseases 0.000 claims description 2
- 208000021994 Diffuse astrocytoma Diseases 0.000 claims description 2
- 208000037062 Polyps Diseases 0.000 claims description 2
- 210000000038 chest Anatomy 0.000 claims description 2
- 201000001169 fibrillary astrocytoma Diseases 0.000 claims description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims description 2
- 238000002604 ultrasonography Methods 0.000 claims description 2
- 102100028999 High mobility group protein HMGI-C Human genes 0.000 claims 6
- 229910018509 Al—N Inorganic materials 0.000 claims 1
- 208000001715 Osteoblastoma Diseases 0.000 claims 1
- 230000008485 antagonism Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 abstract description 19
- 210000004027 cell Anatomy 0.000 description 161
- 108090000623 proteins and genes Proteins 0.000 description 72
- 241000282414 Homo sapiens Species 0.000 description 67
- 108700039142 HMGA1a Proteins 0.000 description 56
- 102000049983 HMGA1a Human genes 0.000 description 56
- 235000018102 proteins Nutrition 0.000 description 45
- 230000014509 gene expression Effects 0.000 description 44
- 102000004169 proteins and genes Human genes 0.000 description 44
- 238000004458 analytical method Methods 0.000 description 42
- 108091023037 Aptamer Proteins 0.000 description 34
- 230000000694 effects Effects 0.000 description 33
- 229920001223 polyethylene glycol Polymers 0.000 description 32
- 210000001519 tissue Anatomy 0.000 description 30
- 239000002202 Polyethylene glycol Substances 0.000 description 29
- 108020004414 DNA Proteins 0.000 description 27
- 239000000872 buffer Substances 0.000 description 25
- 230000003993 interaction Effects 0.000 description 25
- 102000049982 HMGA2 Human genes 0.000 description 23
- 230000035755 proliferation Effects 0.000 description 22
- 108700020796 Oncogene Proteins 0.000 description 21
- 239000000243 solution Substances 0.000 description 20
- 210000000170 cell membrane Anatomy 0.000 description 19
- 150000001875 compounds Chemical class 0.000 description 19
- 108010054147 Hemoglobins Proteins 0.000 description 18
- 102000001554 Hemoglobins Human genes 0.000 description 18
- 108010029485 Protein Isoforms Proteins 0.000 description 18
- 102000001708 Protein Isoforms Human genes 0.000 description 18
- 238000009826 distribution Methods 0.000 description 18
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 17
- 101100184710 Xenopus laevis cdc25-1-a gene Proteins 0.000 description 17
- 230000005764 inhibitory process Effects 0.000 description 17
- 230000008569 process Effects 0.000 description 17
- 241001465754 Metazoa Species 0.000 description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 16
- 230000006870 function Effects 0.000 description 16
- 239000000523 sample Substances 0.000 description 15
- SVUJNSGGPUCLQZ-FQQAACOVSA-N tenofovir alafenamide fumarate Chemical compound OC(=O)\C=C\C(O)=O.O([P@@](=O)(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)N[C@@H](C)C(=O)OC(C)C)C1=CC=CC=C1.O([P@@](=O)(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)N[C@@H](C)C(=O)OC(C)C)C1=CC=CC=C1 SVUJNSGGPUCLQZ-FQQAACOVSA-N 0.000 description 15
- 238000013518 transcription Methods 0.000 description 15
- 230000035897 transcription Effects 0.000 description 15
- 101710088194 Dehydrogenase Proteins 0.000 description 14
- 238000003745 diagnosis Methods 0.000 description 14
- 210000002381 plasma Anatomy 0.000 description 14
- 239000000499 gel Substances 0.000 description 13
- 230000032258 transport Effects 0.000 description 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
- 241000700605 Viruses Species 0.000 description 12
- 210000000172 cytosol Anatomy 0.000 description 12
- 210000001163 endosome Anatomy 0.000 description 12
- 239000012528 membrane Substances 0.000 description 12
- 238000001890 transfection Methods 0.000 description 12
- 102000004357 Transferases Human genes 0.000 description 11
- 108090000992 Transferases Proteins 0.000 description 11
- 229940024606 amino acid Drugs 0.000 description 11
- 235000001014 amino acid Nutrition 0.000 description 11
- 150000001413 amino acids Chemical class 0.000 description 11
- 230000033228 biological regulation Effects 0.000 description 11
- 230000012010 growth Effects 0.000 description 11
- 238000004904 shortening Methods 0.000 description 11
- 230000004614 tumor growth Effects 0.000 description 11
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 10
- 101001093899 Homo sapiens Retinoic acid receptor RXR-alpha Proteins 0.000 description 10
- 229920001213 Polysorbate 20 Polymers 0.000 description 10
- 102100035178 Retinoic acid receptor RXR-alpha Human genes 0.000 description 10
- 230000000875 corresponding effect Effects 0.000 description 10
- 230000008878 coupling Effects 0.000 description 10
- 238000010168 coupling process Methods 0.000 description 10
- 238000005859 coupling reaction Methods 0.000 description 10
- 229940088598 enzyme Drugs 0.000 description 10
- 229910052757 nitrogen Inorganic materials 0.000 description 10
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 10
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 10
- 230000002441 reversible effect Effects 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- 230000004568 DNA-binding Effects 0.000 description 9
- 101100189471 Mus musculus Pbx1 gene Proteins 0.000 description 9
- 101710163270 Nuclease Proteins 0.000 description 9
- 102000004316 Oxidoreductases Human genes 0.000 description 9
- 108090000854 Oxidoreductases Proteins 0.000 description 9
- 230000008859 change Effects 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 9
- 210000000056 organ Anatomy 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 101000595993 Phyllomedusa sauvagei Phylloseptin-S1 Proteins 0.000 description 8
- 108010090804 Streptavidin Proteins 0.000 description 8
- 230000000295 complement effect Effects 0.000 description 8
- 239000012634 fragment Substances 0.000 description 8
- 108020004999 messenger RNA Proteins 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 239000011780 sodium chloride Substances 0.000 description 8
- 239000000758 substrate Substances 0.000 description 8
- 102000053602 DNA Human genes 0.000 description 7
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 7
- 108091034117 Oligonucleotide Proteins 0.000 description 7
- 230000022131 cell cycle Effects 0.000 description 7
- 238000011835 investigation Methods 0.000 description 7
- 210000004940 nucleus Anatomy 0.000 description 7
- 238000004806 packaging method and process Methods 0.000 description 7
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 6
- 102100036220 PC4 and SFRS1-interacting protein Human genes 0.000 description 6
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 6
- 230000000692 anti-sense effect Effects 0.000 description 6
- 239000011575 calcium Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 238000009510 drug design Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 108020001507 fusion proteins Proteins 0.000 description 6
- 102000037865 fusion proteins Human genes 0.000 description 6
- 239000011777 magnesium Substances 0.000 description 6
- 239000002609 medium Substances 0.000 description 6
- 238000001556 precipitation Methods 0.000 description 6
- 239000002243 precursor Substances 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 102100032912 CD44 antigen Human genes 0.000 description 5
- 102000006786 Chloride-Bicarbonate Antiporters Human genes 0.000 description 5
- 229920000858 Cyclodextrin Polymers 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 5
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 5
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 5
- 101000736088 Homo sapiens PC4 and SFRS1-interacting protein Proteins 0.000 description 5
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 5
- 101150069805 MAFG gene Proteins 0.000 description 5
- 108010074633 Mixed Function Oxygenases Proteins 0.000 description 5
- 102000008109 Mixed Function Oxygenases Human genes 0.000 description 5
- 102100025725 Mothers against decapentaplegic homolog 4 Human genes 0.000 description 5
- 101710143112 Mothers against decapentaplegic homolog 4 Proteins 0.000 description 5
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 5
- 229910019142 PO4 Inorganic materials 0.000 description 5
- 102100029904 Signal transducer and activator of transcription 1-alpha/beta Human genes 0.000 description 5
- 102100023132 Transcription factor Jun Human genes 0.000 description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
- 229960002685 biotin Drugs 0.000 description 5
- 235000020958 biotin Nutrition 0.000 description 5
- 239000011616 biotin Substances 0.000 description 5
- 239000006143 cell culture medium Substances 0.000 description 5
- 230000002860 competitive effect Effects 0.000 description 5
- 238000010494 dissociation reaction Methods 0.000 description 5
- 230000005593 dissociations Effects 0.000 description 5
- 231100000673 dose–response relationship Toxicity 0.000 description 5
- 210000003527 eukaryotic cell Anatomy 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 230000002068 genetic effect Effects 0.000 description 5
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 5
- 239000003102 growth factor Substances 0.000 description 5
- 238000005470 impregnation Methods 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 239000002853 nucleic acid probe Substances 0.000 description 5
- 230000002018 overexpression Effects 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
- 239000010452 phosphate Substances 0.000 description 5
- 150000003904 phospholipids Chemical class 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 239000011701 zinc Substances 0.000 description 5
- 229910052725 zinc Inorganic materials 0.000 description 5
- 101100026251 Caenorhabditis elegans atf-2 gene Proteins 0.000 description 4
- 102000004031 Carboxy-Lyases Human genes 0.000 description 4
- 108090000489 Carboxy-Lyases Proteins 0.000 description 4
- 208000005623 Carcinogenesis Diseases 0.000 description 4
- 101100352278 Danio rerio pitx2 gene Proteins 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 108010068377 Hemoglobin M Proteins 0.000 description 4
- 102100022103 Histone-lysine N-methyltransferase 2A Human genes 0.000 description 4
- 101150107737 Hmga1 gene Proteins 0.000 description 4
- 101001045846 Homo sapiens Histone-lysine N-methyltransferase 2A Proteins 0.000 description 4
- 101000572976 Homo sapiens POU domain, class 2, transcription factor 3 Proteins 0.000 description 4
- 102000001947 MafK Transcription Factor Human genes 0.000 description 4
- 108010040548 MafK Transcription Factor Proteins 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 102100026466 POU domain, class 2, transcription factor 3 Human genes 0.000 description 4
- 108091000080 Phosphotransferase Proteins 0.000 description 4
- 102100023606 Retinoic acid receptor alpha Human genes 0.000 description 4
- 108091006260 SLC4A2 Proteins 0.000 description 4
- 108010044012 STAT1 Transcription Factor Proteins 0.000 description 4
- 108010017324 STAT3 Transcription Factor Proteins 0.000 description 4
- 102100024040 Signal transducer and activator of transcription 3 Human genes 0.000 description 4
- 241000700584 Simplexvirus Species 0.000 description 4
- 102100024026 Transcription factor E2F1 Human genes 0.000 description 4
- 241000405115 Zela Species 0.000 description 4
- 230000005856 abnormality Effects 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 4
- 210000004899 c-terminal region Anatomy 0.000 description 4
- 230000036952 cancer formation Effects 0.000 description 4
- 231100000504 carcinogenesis Toxicity 0.000 description 4
- 210000003855 cell nucleus Anatomy 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 230000002759 chromosomal effect Effects 0.000 description 4
- 229940097362 cyclodextrins Drugs 0.000 description 4
- 239000000975 dye Substances 0.000 description 4
- 230000008030 elimination Effects 0.000 description 4
- 238000003379 elimination reaction Methods 0.000 description 4
- 230000007717 exclusion Effects 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000007850 fluorescent dye Substances 0.000 description 4
- 238000001415 gene therapy Methods 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000010189 intracellular transport Effects 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000012856 packing Methods 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 102000020233 phosphotransferase Human genes 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 108091008726 retinoic acid receptors α Proteins 0.000 description 4
- 238000003757 reverse transcription PCR Methods 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 150000003384 small molecules Chemical class 0.000 description 4
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 4
- 230000003612 virological effect Effects 0.000 description 4
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 3
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 3
- 239000005695 Ammonium acetate Substances 0.000 description 3
- 101000986346 Chironomus tentans High mobility group protein I Proteins 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 101150089759 HOXB8 gene Proteins 0.000 description 3
- 101000756346 Homo sapiens RE1-silencing transcription factor Proteins 0.000 description 3
- 101001050288 Homo sapiens Transcription factor Jun Proteins 0.000 description 3
- 108090000769 Isomerases Proteins 0.000 description 3
- 102000004195 Isomerases Human genes 0.000 description 3
- 101150026829 JUNB gene Proteins 0.000 description 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 3
- 102000004317 Lyases Human genes 0.000 description 3
- 108090000856 Lyases Proteins 0.000 description 3
- 102100022819 MHC class II regulatory factor RFX1 Human genes 0.000 description 3
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 3
- 101710135898 Myc proto-oncogene protein Proteins 0.000 description 3
- 108010074852 NF-kappa B p52 Subunit Proteins 0.000 description 3
- 102000008125 NF-kappa B p52 Subunit Human genes 0.000 description 3
- 101150006407 NRF1 gene Proteins 0.000 description 3
- 108010077850 Nuclear Localization Signals Proteins 0.000 description 3
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 3
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 3
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 3
- 102100022940 RE1-silencing transcription factor Human genes 0.000 description 3
- 239000012980 RPMI-1640 medium Substances 0.000 description 3
- 108010030933 Regulatory Factor X1 Proteins 0.000 description 3
- 101150063267 STAT5B gene Proteins 0.000 description 3
- 206010039491 Sarcoma Diseases 0.000 description 3
- 102100024474 Signal transducer and activator of transcription 5B Human genes 0.000 description 3
- 210000001744 T-lymphocyte Anatomy 0.000 description 3
- 239000006180 TBST buffer Substances 0.000 description 3
- 108010048992 Transcription Factor 4 Proteins 0.000 description 3
- 102100023489 Transcription factor 4 Human genes 0.000 description 3
- 101710150448 Transcriptional regulator Myc Proteins 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- 108700005077 Viral Genes Proteins 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 229940043376 ammonium acetate Drugs 0.000 description 3
- 235000019257 ammonium acetate Nutrition 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 238000005349 anion exchange Methods 0.000 description 3
- 230000001745 anti-biotin effect Effects 0.000 description 3
- 230000001093 anti-cancer Effects 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 230000008033 biological extinction Effects 0.000 description 3
- 239000000090 biomarker Substances 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 238000009833 condensation Methods 0.000 description 3
- 230000005494 condensation Effects 0.000 description 3
- 230000009260 cross reactivity Effects 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 210000000232 gallbladder Anatomy 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 239000011859 microparticle Substances 0.000 description 3
- 230000001613 neoplastic effect Effects 0.000 description 3
- 229910052759 nickel Inorganic materials 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 239000002751 oligonucleotide probe Substances 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000004393 prognosis Methods 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- 238000012552 review Methods 0.000 description 3
- 229920002477 rna polymer Polymers 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 230000006641 stabilisation Effects 0.000 description 3
- 238000011105 stabilization Methods 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000010254 subcutaneous injection Methods 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
- 238000001262 western blot Methods 0.000 description 3
- 239000002023 wood Substances 0.000 description 3
- HCUOEKSZWPGJIM-YBRHCDHNSA-N (e,2e)-2-hydroxyimino-6-methoxy-4-methyl-5-nitrohex-3-enamide Chemical compound COCC([N+]([O-])=O)\C(C)=C\C(=N/O)\C(N)=O HCUOEKSZWPGJIM-YBRHCDHNSA-N 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- 102000004899 14-3-3 Proteins Human genes 0.000 description 2
- 108091006112 ATPases Proteins 0.000 description 2
- 108010085238 Actins Proteins 0.000 description 2
- 102000057234 Acyl transferases Human genes 0.000 description 2
- 108700016155 Acyl transferases Proteins 0.000 description 2
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 2
- 108090001008 Avidin Proteins 0.000 description 2
- LCFVJGUPQDGYKZ-UHFFFAOYSA-N Bisphenol A diglycidyl ether Chemical compound C=1C=C(OCC2OC2)C=CC=1C(C)(C)C(C=C1)=CC=C1OCC1CO1 LCFVJGUPQDGYKZ-UHFFFAOYSA-N 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 2
- 101000850966 Cavia porcellus Eosinophil granule major basic protein 1 Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 108010077544 Chromatin Proteins 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 2
- 102000016736 Cyclin Human genes 0.000 description 2
- 108050006400 Cyclin Proteins 0.000 description 2
- 108010068192 Cyclin A Proteins 0.000 description 2
- 108010068106 Cyclin T Proteins 0.000 description 2
- 102100025191 Cyclin-A2 Human genes 0.000 description 2
- 239000003298 DNA probe Substances 0.000 description 2
- 102100022812 DNA-binding protein RFX2 Human genes 0.000 description 2
- 102100020986 DNA-binding protein RFX5 Human genes 0.000 description 2
- 102100035078 ETS-related transcription factor Elf-2 Human genes 0.000 description 2
- 102100035079 ETS-related transcription factor Elf-3 Human genes 0.000 description 2
- 102100031702 Endoplasmic reticulum membrane sensor NFE2L1 Human genes 0.000 description 2
- 108010041356 Estrogen Receptor beta Proteins 0.000 description 2
- 102100038595 Estrogen receptor Human genes 0.000 description 2
- 101710196141 Estrogen receptor Proteins 0.000 description 2
- 102100029951 Estrogen receptor beta Human genes 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 102100035134 Forkhead box protein J2 Human genes 0.000 description 2
- 102100023374 Forkhead box protein M1 Human genes 0.000 description 2
- 101150096607 Fosl2 gene Proteins 0.000 description 2
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 description 2
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 description 2
- 102100033840 General transcription factor IIF subunit 1 Human genes 0.000 description 2
- 102100032863 General transcription factor IIH subunit 3 Human genes 0.000 description 2
- 208000002966 Giant Cell Tumor of Bone Diseases 0.000 description 2
- 102100033295 Glial cell line-derived neurotrophic factor Human genes 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 108700039144 HMGA1b Proteins 0.000 description 2
- 102000000849 HMGB Proteins Human genes 0.000 description 2
- 108010001860 HMGB Proteins Proteins 0.000 description 2
- 101150021904 HMGB1 gene Proteins 0.000 description 2
- 108010044429 HMGN Proteins Proteins 0.000 description 2
- 102000006491 HMGN Proteins Human genes 0.000 description 2
- 101150032268 HOXB7 gene Proteins 0.000 description 2
- 102100032606 Heat shock factor protein 1 Human genes 0.000 description 2
- 102100027489 Helicase-like transcription factor Human genes 0.000 description 2
- 102100022846 Histone acetyltransferase KAT2B Human genes 0.000 description 2
- 108050002855 Histone-lysine N-methyltransferase 2A Proteins 0.000 description 2
- 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 description 2
- 102100032742 Histone-lysine N-methyltransferase SETD2 Human genes 0.000 description 2
- 102100030339 Homeobox protein Hox-A10 Human genes 0.000 description 2
- 102100029240 Homeobox protein Hox-B5 Human genes 0.000 description 2
- 102100029394 Homeobox protein PKNOX1 Human genes 0.000 description 2
- 101000882335 Homo sapiens Alpha-enolase Proteins 0.000 description 2
- 101000756799 Homo sapiens DNA-binding protein RFX2 Proteins 0.000 description 2
- 101001075432 Homo sapiens DNA-binding protein RFX5 Proteins 0.000 description 2
- 101000877377 Homo sapiens ETS-related transcription factor Elf-2 Proteins 0.000 description 2
- 101000907578 Homo sapiens Forkhead box protein M1 Proteins 0.000 description 2
- 101000666405 Homo sapiens General transcription factor IIH subunit 1 Proteins 0.000 description 2
- 101000655398 Homo sapiens General transcription factor IIH subunit 2 Proteins 0.000 description 2
- 101000655391 Homo sapiens General transcription factor IIH subunit 3 Proteins 0.000 description 2
- 101000655406 Homo sapiens General transcription factor IIH subunit 4 Proteins 0.000 description 2
- 101000655402 Homo sapiens General transcription factor IIH subunit 5 Proteins 0.000 description 2
- 101100395337 Homo sapiens HMGA2 gene Proteins 0.000 description 2
- 101000867525 Homo sapiens Heat shock factor protein 1 Proteins 0.000 description 2
- 101001081105 Homo sapiens Helicase-like transcription factor Proteins 0.000 description 2
- 101001047006 Homo sapiens Histone acetyltransferase KAT2B Proteins 0.000 description 2
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 description 2
- 101000654725 Homo sapiens Histone-lysine N-methyltransferase SETD2 Proteins 0.000 description 2
- 101001083164 Homo sapiens Homeobox protein Hox-A10 Proteins 0.000 description 2
- 101000840553 Homo sapiens Homeobox protein Hox-B5 Proteins 0.000 description 2
- 101001125957 Homo sapiens Homeobox protein PKNOX1 Proteins 0.000 description 2
- 101000614841 Homo sapiens Myocyte-specific enhancer factor 2A Proteins 0.000 description 2
- 101000588302 Homo sapiens Nuclear factor erythroid 2-related factor 2 Proteins 0.000 description 2
- 101000588303 Homo sapiens Nuclear factor erythroid 2-related factor 3 Proteins 0.000 description 2
- 101001109689 Homo sapiens Nuclear receptor subfamily 4 group A member 3 Proteins 0.000 description 2
- 101000572986 Homo sapiens POU domain, class 3, transcription factor 2 Proteins 0.000 description 2
- 101001094741 Homo sapiens POU domain, class 4, transcription factor 1 Proteins 0.000 description 2
- 101000612089 Homo sapiens Pancreas/duodenum homeobox protein 1 Proteins 0.000 description 2
- 101000611663 Homo sapiens Prolargin Proteins 0.000 description 2
- 101000598778 Homo sapiens Protein OSCP1 Proteins 0.000 description 2
- 101000665894 Homo sapiens Replication initiator 1 Proteins 0.000 description 2
- 101000640876 Homo sapiens Retinoic acid receptor RXR-beta Proteins 0.000 description 2
- 101000666775 Homo sapiens T-box transcription factor TBX3 Proteins 0.000 description 2
- 101000879604 Homo sapiens Transcription factor E4F1 Proteins 0.000 description 2
- 101000723923 Homo sapiens Transcription factor HIVEP2 Proteins 0.000 description 2
- 101000756787 Homo sapiens Transcription factor RFX3 Proteins 0.000 description 2
- 101000671637 Homo sapiens Upstream stimulatory factor 1 Proteins 0.000 description 2
- 101000818569 Homo sapiens Zinc finger and BTB domain-containing protein 24 Proteins 0.000 description 2
- 101000964706 Homo sapiens Zinc finger protein 398 Proteins 0.000 description 2
- 101000723920 Homo sapiens Zinc finger protein 40 Proteins 0.000 description 2
- 101000730643 Homo sapiens Zinc finger protein PLAGL1 Proteins 0.000 description 2
- 101000788690 Homo sapiens Zinc fingers and homeoboxes protein 1 Proteins 0.000 description 2
- 102000003839 Human Proteins Human genes 0.000 description 2
- 108090000144 Human Proteins Proteins 0.000 description 2
- 206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 description 2
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 description 2
- 206010061598 Immunodeficiency Diseases 0.000 description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- 102100026720 Interferon beta Human genes 0.000 description 2
- 108090000467 Interferon-beta Proteins 0.000 description 2
- 101150021395 JUND gene Proteins 0.000 description 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
- 102000016397 Methyltransferase Human genes 0.000 description 2
- 108060004795 Methyltransferase Proteins 0.000 description 2
- 102100025751 Mothers against decapentaplegic homolog 2 Human genes 0.000 description 2
- 101710143123 Mothers against decapentaplegic homolog 2 Proteins 0.000 description 2
- 102100025748 Mothers against decapentaplegic homolog 3 Human genes 0.000 description 2
- 101710143111 Mothers against decapentaplegic homolog 3 Proteins 0.000 description 2
- 241000699660 Mus musculus Species 0.000 description 2
- 101100178955 Mus musculus Hoxd4 gene Proteins 0.000 description 2
- 101001067395 Mus musculus Phospholipid scramblase 1 Proteins 0.000 description 2
- 102100021148 Myocyte-specific enhancer factor 2A Human genes 0.000 description 2
- 108010018525 NFATC Transcription Factors Proteins 0.000 description 2
- 102000002673 NFATC Transcription Factors Human genes 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 208000009869 Neu-Laxova syndrome Diseases 0.000 description 2
- 102100022165 Nuclear factor 1 B-type Human genes 0.000 description 2
- 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 description 2
- 102100031700 Nuclear factor erythroid 2-related factor 3 Human genes 0.000 description 2
- 102100022673 Nuclear receptor subfamily 4 group A member 3 Human genes 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 2
- 102000007354 PAX6 Transcription Factor Human genes 0.000 description 2
- 108010032788 PAX6 Transcription Factor Proteins 0.000 description 2
- 102100035395 POU domain, class 4, transcription factor 1 Human genes 0.000 description 2
- 102100027584 Protein c-Fos Human genes 0.000 description 2
- 108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 description 2
- 108010001859 Proto-Oncogene Proteins c-rel Proteins 0.000 description 2
- 102000000850 Proto-Oncogene Proteins c-rel Human genes 0.000 description 2
- 102100026869 RNA-binding protein MEX3B Human genes 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 102100038242 Replication initiator 1 Human genes 0.000 description 2
- 102100034253 Retinoic acid receptor RXR-beta Human genes 0.000 description 2
- 102100033912 Retinoic acid receptor gamma Human genes 0.000 description 2
- 101150058731 STAT5A gene Proteins 0.000 description 2
- 102100024481 Signal transducer and activator of transcription 5A Human genes 0.000 description 2
- 108020004459 Small interfering RNA Proteins 0.000 description 2
- 108010074436 Sterol Regulatory Element Binding Protein 1 Proteins 0.000 description 2
- 108010014480 T-box transcription factor 5 Proteins 0.000 description 2
- 102100038409 T-box transcription factor TBX3 Human genes 0.000 description 2
- 102100024755 T-box transcription factor TBX5 Human genes 0.000 description 2
- 102100040296 TATA-box-binding protein Human genes 0.000 description 2
- 101001023030 Toxoplasma gondii Myosin-D Proteins 0.000 description 2
- 102000003929 Transaminases Human genes 0.000 description 2
- 108090000340 Transaminases Proteins 0.000 description 2
- 102100021783 Transcription factor E2F4 Human genes 0.000 description 2
- 102100037331 Transcription factor E4F1 Human genes 0.000 description 2
- 102100028438 Transcription factor HIVEP2 Human genes 0.000 description 2
- 102100022821 Transcription factor RFX3 Human genes 0.000 description 2
- 102100028604 Transcription initiation factor IIA subunit 2 Human genes 0.000 description 2
- 102100040105 Upstream stimulatory factor 1 Human genes 0.000 description 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
- 102100040827 Zinc finger protein 398 Human genes 0.000 description 2
- 102100028440 Zinc finger protein 40 Human genes 0.000 description 2
- 102100032570 Zinc finger protein PLAGL1 Human genes 0.000 description 2
- QWXOJIDBSHLIFI-UHFFFAOYSA-N [3-(1-chloro-3'-methoxyspiro[adamantane-4,4'-dioxetane]-3'-yl)phenyl] dihydrogen phosphate Chemical compound O1OC2(C3CC4CC2CC(Cl)(C4)C3)C1(OC)C1=CC=CC(OP(O)(O)=O)=C1 QWXOJIDBSHLIFI-UHFFFAOYSA-N 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 229960005305 adenosine Drugs 0.000 description 2
- 210000000577 adipose tissue Anatomy 0.000 description 2
- 239000011543 agarose gel Substances 0.000 description 2
- 230000033115 angiogenesis Effects 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- 208000035269 cancer or benign tumor Diseases 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 230000004656 cell transport Effects 0.000 description 2
- 230000019522 cellular metabolic process Effects 0.000 description 2
- 230000007541 cellular toxicity Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- WLNARFZDISHUGS-MIXBDBMTSA-N cholesteryl hemisuccinate Chemical compound C1C=C2C[C@@H](OC(=O)CCC(O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 WLNARFZDISHUGS-MIXBDBMTSA-N 0.000 description 2
- 210000003483 chromatin Anatomy 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 235000011180 diphosphates Nutrition 0.000 description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 238000012869 ethanol precipitation Methods 0.000 description 2
- 101150051296 foxj2 gene Proteins 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 238000001502 gel electrophoresis Methods 0.000 description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
- 210000002288 golgi apparatus Anatomy 0.000 description 2
- 101150003074 hoxa5 gene Proteins 0.000 description 2
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
- 230000007813 immunodeficiency Effects 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 108090000865 liver X receptors Proteins 0.000 description 2
- 102000004311 liver X receptors Human genes 0.000 description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 210000001161 mammalian embryo Anatomy 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- CGVLVOOFCGWBCS-RGDJUOJXSA-N n-octyl β-d-thioglucopyranoside Chemical compound CCCCCCCCS[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O CGVLVOOFCGWBCS-RGDJUOJXSA-N 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 210000005170 neoplastic cell Anatomy 0.000 description 2
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 2
- 239000002777 nucleoside Substances 0.000 description 2
- 238000011580 nude mouse model Methods 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 229960003104 ornithine Drugs 0.000 description 2
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 208000008443 pancreatic carcinoma Diseases 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 description 2
- 238000000053 physical method Methods 0.000 description 2
- 230000007505 plaque formation Effects 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 229920005643 polyisobutyl cyanoacrylate Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 238000010837 poor prognosis Methods 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 230000010837 receptor-mediated endocytosis Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 230000003252 repetitive effect Effects 0.000 description 2
- 108091008760 retinoic acid receptors γ Proteins 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 108010014677 transcription factor TFIIE Proteins 0.000 description 2
- 230000007723 transport mechanism Effects 0.000 description 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 2
- 230000001173 tumoral effect Effects 0.000 description 2
- 239000011534 wash buffer Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- ACLCWAROHDVHJU-UHFFFAOYSA-N (1-carboxy-2-hydroxyethoxy)-oxido-oxophosphanium phosphono dihydrogen phosphate Chemical compound OP(O)(=O)OP(O)(O)=O.OCC(C(O)=O)OP(=O)=O ACLCWAROHDVHJU-UHFFFAOYSA-N 0.000 description 1
- BQPPJGMMIYJVBR-UHFFFAOYSA-N (10S)-3c-Acetoxy-4.4.10r.13c.14t-pentamethyl-17c-((R)-1.5-dimethyl-hexen-(4)-yl)-(5tH)-Delta8-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C BQPPJGMMIYJVBR-UHFFFAOYSA-N 0.000 description 1
- FBVVGPMIPAZFAW-RZVRUWJTSA-N (2S)-pyrrolidine-2-carboxylic acid Chemical compound OC(=O)[C@@H]1CCCN1.OC(=O)[C@@H]1CCCN1 FBVVGPMIPAZFAW-RZVRUWJTSA-N 0.000 description 1
- TYBFYWFTPNZNIS-DKWTVANSSA-N (2s)-2-aminobutanedioic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)[C@@H](N)CC(O)=O TYBFYWFTPNZNIS-DKWTVANSSA-N 0.000 description 1
- CHGIKSSZNBCNDW-UHFFFAOYSA-N (3beta,5alpha)-4,4-Dimethylcholesta-8,24-dien-3-ol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21 CHGIKSSZNBCNDW-UHFFFAOYSA-N 0.000 description 1
- UTZAFOQPCXRRFF-RKBILKOESA-N (beta-D-glucosyl)-O-mycofactocinone Chemical compound CC1(C(NC(=O)C1=O)CC2=CC=C(C=C2)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)C UTZAFOQPCXRRFF-RKBILKOESA-N 0.000 description 1
- ZKSVYBRJSMBDMV-UHFFFAOYSA-N 1,3-diphenyl-2-benzofuran Chemical compound C1=CC=CC=C1C1=C2C=CC=CC2=C(C=2C=CC=CC=2)O1 ZKSVYBRJSMBDMV-UHFFFAOYSA-N 0.000 description 1
- GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 1
- VMNRNUNYBVFVQI-UHFFFAOYSA-N 10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one Chemical compound C1CC2CC(=O)CCC2(C)C2C1C1CCCC1(C)CC2 VMNRNUNYBVFVQI-UHFFFAOYSA-N 0.000 description 1
- KVUXYQHEESDGIJ-UHFFFAOYSA-N 10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-3,16-diol Chemical compound C1CC2CC(O)CCC2(C)C2C1C1CC(O)CC1(C)CC2 KVUXYQHEESDGIJ-UHFFFAOYSA-N 0.000 description 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- XYTLYKGXLMKYMV-UHFFFAOYSA-N 14alpha-methylzymosterol Natural products CC12CCC(O)CC1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C XYTLYKGXLMKYMV-UHFFFAOYSA-N 0.000 description 1
- LDGWQMRUWMSZIU-LQDDAWAPSA-M 2,3-bis[(z)-octadec-9-enoxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC\C=C/CCCCCCCC LDGWQMRUWMSZIU-LQDDAWAPSA-M 0.000 description 1
- KSXTUUUQYQYKCR-LQDDAWAPSA-M 2,3-bis[[(z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC KSXTUUUQYQYKCR-LQDDAWAPSA-M 0.000 description 1
- AKWUNZFZIXEOPV-UHFFFAOYSA-N 2-[4-[[3-[7-chloro-1-(oxan-4-ylmethyl)indol-3-yl]-1,2,4-oxadiazol-5-yl]methyl]piperazin-1-yl]acetamide Chemical compound C1CN(CC(=O)N)CCN1CC1=NC(C=2C3=CC=CC(Cl)=C3N(CC3CCOCC3)C=2)=NO1 AKWUNZFZIXEOPV-UHFFFAOYSA-N 0.000 description 1
- 108010030844 2-methylcitrate synthase Proteins 0.000 description 1
- 102100033747 39S ribosomal protein L15, mitochondrial Human genes 0.000 description 1
- FPTJELQXIUUCEY-UHFFFAOYSA-N 3beta-Hydroxy-lanostan Natural products C1CC2C(C)(C)C(O)CCC2(C)C2C1C1(C)CCC(C(C)CCCC(C)C)C1(C)CC2 FPTJELQXIUUCEY-UHFFFAOYSA-N 0.000 description 1
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 1
- 125000002124 5'-adenosyl group Chemical group N1=CN=C2N(C=NC2=C1N)[C@H]1[C@H](O)[C@H](O)[C@H](O1)C* 0.000 description 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 108010088547 ARNTL Transcription Factors Proteins 0.000 description 1
- 102100038511 AT-rich interactive domain-containing protein 3A Human genes 0.000 description 1
- 102100030835 AT-rich interactive domain-containing protein 5B Human genes 0.000 description 1
- 101710081716 AT-rich interactive domain-containing protein 5B Proteins 0.000 description 1
- 208000006678 Abdominal Neoplasms Diseases 0.000 description 1
- 108010000700 Acetolactate synthase Proteins 0.000 description 1
- 108010051457 Acid Phosphatase Proteins 0.000 description 1
- 102000013563 Acid Phosphatase Human genes 0.000 description 1
- 102100022900 Actin, cytoplasmic 1 Human genes 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 102100025976 Adenosine deaminase 2 Human genes 0.000 description 1
- 102100032534 Adenosine kinase Human genes 0.000 description 1
- 108020000543 Adenylate kinase Proteins 0.000 description 1
- NRCXNPKDOMYPPJ-HYORBCNSSA-N Aflatoxin P1 Chemical compound C=1([C@@H]2C=CO[C@@H]2OC=1C=C(C1=2)O)C=2OC(=O)C2=C1CCC2=O NRCXNPKDOMYPPJ-HYORBCNSSA-N 0.000 description 1
- 244000068687 Amelanchier alnifolia Species 0.000 description 1
- 235000009027 Amelanchier alnifolia Nutrition 0.000 description 1
- 208000031295 Animal disease Diseases 0.000 description 1
- 102000000412 Annexin Human genes 0.000 description 1
- 108050008874 Annexin Proteins 0.000 description 1
- 101710145634 Antigen 1 Proteins 0.000 description 1
- 108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
- 102100021987 Apoptosis-stimulating of p53 protein 1 Human genes 0.000 description 1
- 102100021986 Apoptosis-stimulating of p53 protein 2 Human genes 0.000 description 1
- 101100004644 Arabidopsis thaliana BAT1 gene Proteins 0.000 description 1
- 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 description 1
- 101000719121 Arabidopsis thaliana Protein MEI2-like 1 Proteins 0.000 description 1
- 101000797612 Arabidopsis thaliana Protein MEI2-like 3 Proteins 0.000 description 1
- 101710144814 Aromatase 1 Proteins 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 241001076939 Artines Species 0.000 description 1
- 102100027839 Aryl hydrocarbon receptor nuclear translocator 2 Human genes 0.000 description 1
- 102100037211 Aryl hydrocarbon receptor nuclear translocator-like protein 1 Human genes 0.000 description 1
- 102100021661 Aryl hydrocarbon receptor nuclear translocator-like protein 2 Human genes 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
- 102100021631 B-cell lymphoma 6 protein Human genes 0.000 description 1
- 102000036365 BRCA1 Human genes 0.000 description 1
- 108700020463 BRCA1 Proteins 0.000 description 1
- 101150072950 BRCA1 gene Proteins 0.000 description 1
- 108700020462 BRCA2 Proteins 0.000 description 1
- 102000052609 BRCA2 Human genes 0.000 description 1
- 101001074429 Bacillus subtilis (strain 168) Polyketide biosynthesis acyltransferase homolog PksD Proteins 0.000 description 1
- 101000936617 Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) Polyketide biosynthesis acyltransferase homolog BaeD Proteins 0.000 description 1
- 101150057523 Barhl2 gene Proteins 0.000 description 1
- 229940122361 Bisphosphonate Drugs 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 101150008921 Brca2 gene Proteins 0.000 description 1
- 102000019063 CCAAT-Binding Factor Human genes 0.000 description 1
- 108010026988 CCAAT-Binding Factor Proteins 0.000 description 1
- 102100034800 CCAAT/enhancer-binding protein epsilon Human genes 0.000 description 1
- 101710153441 CCAAT/enhancer-binding protein epsilon Proteins 0.000 description 1
- 108010014064 CCCTC-Binding Factor Proteins 0.000 description 1
- 102100033849 CCHC-type zinc finger nucleic acid binding protein Human genes 0.000 description 1
- 101710116319 CCHC-type zinc finger nucleic acid binding protein Proteins 0.000 description 1
- 101150017002 CD44 gene Proteins 0.000 description 1
- 101150035324 CDK9 gene Proteins 0.000 description 1
- 108010083123 CDX2 Transcription Factor Proteins 0.000 description 1
- 108010065376 COUP Transcription Factor I Proteins 0.000 description 1
- 102100028228 COUP transcription factor 1 Human genes 0.000 description 1
- 102100028226 COUP transcription factor 2 Human genes 0.000 description 1
- 108010018842 CTF-1 transcription factor Proteins 0.000 description 1
- 102100024156 Cadherin-12 Human genes 0.000 description 1
- 101710196882 Cadherin-12 Proteins 0.000 description 1
- 101100170001 Caenorhabditis elegans ddb-1 gene Proteins 0.000 description 1
- 101100227322 Caenorhabditis elegans fli-1 gene Proteins 0.000 description 1
- 101100454128 Caenorhabditis elegans ksr-1 gene Proteins 0.000 description 1
- 101100280477 Caenorhabditis elegans lbp-1 gene Proteins 0.000 description 1
- 101100129500 Caenorhabditis elegans max-2 gene Proteins 0.000 description 1
- 101100518995 Caenorhabditis elegans pax-3 gene Proteins 0.000 description 1
- 101100033032 Caenorhabditis elegans rbbp-5 gene Proteins 0.000 description 1
- 101100257372 Caenorhabditis elegans sox-3 gene Proteins 0.000 description 1
- 101100258233 Caenorhabditis elegans sun-1 gene Proteins 0.000 description 1
- 102000055006 Calcitonin Human genes 0.000 description 1
- 108060001064 Calcitonin Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 241001534961 Calicium Species 0.000 description 1
- 102000000584 Calmodulin Human genes 0.000 description 1
- 108010041952 Calmodulin Proteins 0.000 description 1
- 102100027313 Calsenilin Human genes 0.000 description 1
- 101100422204 Candida albicans (strain SC5314 / ATCC MYA-2876) CDC68 gene Proteins 0.000 description 1
- 101100341660 Canis lupus familiaris KRT1 gene Proteins 0.000 description 1
- 102000007132 Carboxyl and Carbamoyl Transferases Human genes 0.000 description 1
- 108010072957 Carboxyl and Carbamoyl Transferases Proteins 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 102000008122 Casein Kinase I Human genes 0.000 description 1
- 108010049812 Casein Kinase I Proteins 0.000 description 1
- 102000052052 Casein Kinase II Human genes 0.000 description 1
- 108010010919 Casein Kinase II Proteins 0.000 description 1
- 102100035882 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 102000004225 Cathepsin B Human genes 0.000 description 1
- 108090000712 Cathepsin B Proteins 0.000 description 1
- 102000004172 Cathepsin L Human genes 0.000 description 1
- 108090000624 Cathepsin L Proteins 0.000 description 1
- 101000850997 Cavia porcellus Eosinophil granule major basic protein 2 Proteins 0.000 description 1
- ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 description 1
- 101150096994 Cdx1 gene Proteins 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 108010086832 Chloride-Bicarbonate Antiporters Proteins 0.000 description 1
- 102100039095 Chromatin-remodeling ATPase INO80 Human genes 0.000 description 1
- 101150065749 Churc1 gene Proteins 0.000 description 1
- 102100032247 Cilium assembly protein DZIP1L Human genes 0.000 description 1
- 108010071536 Citrate (Si)-synthase Proteins 0.000 description 1
- 102000006732 Citrate synthase Human genes 0.000 description 1
- 102100026191 Class E basic helix-loop-helix protein 40 Human genes 0.000 description 1
- 101710130550 Class E basic helix-loop-helix protein 40 Proteins 0.000 description 1
- 102100026190 Class E basic helix-loop-helix protein 41 Human genes 0.000 description 1
- 102100023709 Coiled-coil domain-containing protein 71 Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 108010079362 Core Binding Factor Alpha 3 Subunit Proteins 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- 101001120236 Crotalus durissus cumanensis Basic phospholipase A2 10 Proteins 0.000 description 1
- 229920001651 Cyanoacrylate Polymers 0.000 description 1
- 101710095468 Cyclase Proteins 0.000 description 1
- 108010045171 Cyclic AMP Response Element-Binding Protein Proteins 0.000 description 1
- 102000005636 Cyclic AMP Response Element-Binding Protein Human genes 0.000 description 1
- 102100023580 Cyclic AMP-dependent transcription factor ATF-4 Human genes 0.000 description 1
- 102100023582 Cyclic AMP-dependent transcription factor ATF-5 Human genes 0.000 description 1
- 102100023583 Cyclic AMP-dependent transcription factor ATF-6 alpha Human genes 0.000 description 1
- 102100027309 Cyclic AMP-responsive element-binding protein 5 Human genes 0.000 description 1
- 101710128030 Cyclic AMP-responsive element-binding protein 5 Proteins 0.000 description 1
- 102000002427 Cyclin B Human genes 0.000 description 1
- 108010068150 Cyclin B Proteins 0.000 description 1
- 102000002435 Cyclin T Human genes 0.000 description 1
- 102100024112 Cyclin-T2 Human genes 0.000 description 1
- 102000001493 Cyclophilins Human genes 0.000 description 1
- 108010068682 Cyclophilins Proteins 0.000 description 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 1
- 102000003849 Cytochrome P450 Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 150000008574 D-amino acids Chemical class 0.000 description 1
- 230000005778 DNA damage Effects 0.000 description 1
- 231100000277 DNA damage Toxicity 0.000 description 1
- 102100029145 DNA damage-inducible transcript 3 protein Human genes 0.000 description 1
- 101710156077 DNA damage-inducible transcript 3 protein Proteins 0.000 description 1
- 102100021044 DNA-binding protein RFXANK Human genes 0.000 description 1
- 101100281017 Danio rerio fgf3 gene Proteins 0.000 description 1
- 101100480530 Danio rerio tal1 gene Proteins 0.000 description 1
- 102100028559 Death domain-associated protein 6 Human genes 0.000 description 1
- 101710085792 Defensin-like protein 1 Proteins 0.000 description 1
- 102000000541 Defensins Human genes 0.000 description 1
- 108010002069 Defensins Proteins 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 108010003661 Distal-less homeobox proteins Proteins 0.000 description 1
- 102000004648 Distal-less homeobox proteins Human genes 0.000 description 1
- 102100021212 Double homeobox protein 1 Human genes 0.000 description 1
- 102100021158 Double homeobox protein 4 Human genes 0.000 description 1
- 101000831686 Drosophila melanogaster Protein cycle Proteins 0.000 description 1
- 101000650113 Drosophila melanogaster Protein wingless Proteins 0.000 description 1
- 101100422210 Drosophila melanogaster dre4 gene Proteins 0.000 description 1
- 206010013883 Dwarfism Diseases 0.000 description 1
- 102100038913 E1A-binding protein p400 Human genes 0.000 description 1
- 102100034597 E3 ubiquitin-protein ligase TRIM22 Human genes 0.000 description 1
- 101150059079 EBNA1 gene Proteins 0.000 description 1
- 101150059401 EGR2 gene Proteins 0.000 description 1
- 101150000195 EGR3 gene Proteins 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 108010032363 ERRalpha estrogen-related receptor Proteins 0.000 description 1
- 101150033269 ESRRG gene Proteins 0.000 description 1
- 108700037623 ETS-related transcription factor Elf-3 Proteins 0.000 description 1
- 102100039247 ETS-related transcription factor Elf-4 Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 102100033167 Elastin Human genes 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 101710157062 Endoplasmic reticulum membrane sensor NFE2L1 Proteins 0.000 description 1
- 102100036448 Endothelial PAS domain-containing protein 1 Human genes 0.000 description 1
- 102100032450 Endothelial differentiation-related factor 1 Human genes 0.000 description 1
- 101710182961 Endothelial differentiation-related factor 1 Proteins 0.000 description 1
- 101000885147 Enterococcus avium D-arabitol-phosphate dehydrogenase Proteins 0.000 description 1
- 102100030751 Eomesodermin homolog Human genes 0.000 description 1
- 108010043942 Ephrin-A2 Proteins 0.000 description 1
- 102100033919 Ephrin-A2 Human genes 0.000 description 1
- 102100031690 Erythroid transcription factor Human genes 0.000 description 1
- 101710100588 Erythroid transcription factor Proteins 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 102100031855 Estrogen-related receptor gamma Human genes 0.000 description 1
- 102100028166 FACT complex subunit SSRP1 Human genes 0.000 description 1
- 101150043847 FOXD1 gene Proteins 0.000 description 1
- 102100034553 Fanconi anemia group J protein Human genes 0.000 description 1
- 102000008857 Ferritin Human genes 0.000 description 1
- 108050000784 Ferritin Proteins 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 description 1
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 description 1
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 description 1
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 description 1
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 description 1
- 108010010285 Forkhead Box Protein L2 Proteins 0.000 description 1
- 102100021109 Forkhead box protein B1 Human genes 0.000 description 1
- 102100021084 Forkhead box protein C1 Human genes 0.000 description 1
- 102100021083 Forkhead box protein C2 Human genes 0.000 description 1
- 102100037057 Forkhead box protein D1 Human genes 0.000 description 1
- 102100037062 Forkhead box protein D2 Human genes 0.000 description 1
- 102100037060 Forkhead box protein D3 Human genes 0.000 description 1
- 102100020856 Forkhead box protein F1 Human genes 0.000 description 1
- 102100020848 Forkhead box protein F2 Human genes 0.000 description 1
- 102100035130 Forkhead box protein K1 Human genes 0.000 description 1
- 102100035120 Forkhead box protein L1 Human genes 0.000 description 1
- 102100035137 Forkhead box protein L2 Human genes 0.000 description 1
- 102100023371 Forkhead box protein N1 Human genes 0.000 description 1
- 102100023360 Forkhead box protein N2 Human genes 0.000 description 1
- 102100023359 Forkhead box protein N3 Human genes 0.000 description 1
- 102100027581 Forkhead box protein P3 Human genes 0.000 description 1
- 102100027579 Forkhead box protein P4 Human genes 0.000 description 1
- 102100027570 Forkhead box protein Q1 Human genes 0.000 description 1
- 101710088110 Forkhead box protein Q1 Proteins 0.000 description 1
- 102100029346 Forkhead box protein S1 Human genes 0.000 description 1
- 102000003817 Fos-related antigen 1 Human genes 0.000 description 1
- 108090000123 Fos-related antigen 1 Proteins 0.000 description 1
- 108010045438 Frizzled receptors Proteins 0.000 description 1
- 102100039818 Frizzled-5 Human genes 0.000 description 1
- 101710140951 Frizzled-5 Proteins 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 230000010190 G1 phase Effects 0.000 description 1
- 102100035205 GA-binding protein subunit beta-1 Human genes 0.000 description 1
- 101710082961 GATA-binding factor 2 Proteins 0.000 description 1
- 102100029974 GTPase HRas Human genes 0.000 description 1
- 102100030708 GTPase KRas Human genes 0.000 description 1
- 101710113436 GTPase KRas Proteins 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 101000597041 Gallus gallus Transcriptional enhancer factor TEF-3 Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 102000013382 Gelatinases Human genes 0.000 description 1
- 108010026132 Gelatinases Proteins 0.000 description 1
- 102000004878 Gelsolin Human genes 0.000 description 1
- 108090001064 Gelsolin Proteins 0.000 description 1
- 102100038073 General transcription factor II-I Human genes 0.000 description 1
- 101710144827 General transcription factor II-I Proteins 0.000 description 1
- 101710202045 General transcription factor IIF subunit 1 Proteins 0.000 description 1
- 102100033842 General transcription factor IIF subunit 2 Human genes 0.000 description 1
- 101710202044 General transcription factor IIF subunit 2 Proteins 0.000 description 1
- 102100033299 Glia-derived nexin Human genes 0.000 description 1
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 description 1
- BKLIAINBCQPSOV-UHFFFAOYSA-N Gluanol Natural products CC(C)CC=CC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(O)C(C)(C)C4CC3 BKLIAINBCQPSOV-UHFFFAOYSA-N 0.000 description 1
- 102100041011 Glucocorticoid modulatory element-binding protein 1 Human genes 0.000 description 1
- 102000053187 Glucuronidase Human genes 0.000 description 1
- 108010060309 Glucuronidase Proteins 0.000 description 1
- 102000009127 Glutaminase Human genes 0.000 description 1
- 108010073324 Glutaminase Proteins 0.000 description 1
- XYZZKVRWGOWVGO-UHFFFAOYSA-N Glycerol-phosphate Chemical compound OP(O)(O)=O.OCC(O)CO XYZZKVRWGOWVGO-UHFFFAOYSA-N 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 102100034228 Grainyhead-like protein 1 homolog Human genes 0.000 description 1
- 108700010013 HMGB1 Proteins 0.000 description 1
- 108700010012 HMGN1 Proteins 0.000 description 1
- 101150004541 HOXC8 gene Proteins 0.000 description 1
- 108010081348 HRT1 protein Hairy Proteins 0.000 description 1
- 208000002927 Hamartoma Diseases 0.000 description 1
- 102100023855 Heart- and neural crest derivatives-expressed protein 1 Human genes 0.000 description 1
- 102100034049 Heat shock factor protein 2 Human genes 0.000 description 1
- 102100027529 Heat shock factor-binding protein 1 Human genes 0.000 description 1
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 description 1
- 102100039165 Heat shock protein beta-1 Human genes 0.000 description 1
- 101710100504 Heat shock protein beta-1 Proteins 0.000 description 1
- 102100031880 Helicase SRCAP Human genes 0.000 description 1
- 102100021889 Helix-loop-helix protein 2 Human genes 0.000 description 1
- 108010085682 Hemoglobin A Proteins 0.000 description 1
- 102000007513 Hemoglobin A Human genes 0.000 description 1
- 108091005880 Hemoglobin F Proteins 0.000 description 1
- 108010020382 Hepatocyte Nuclear Factor 1-alpha Proteins 0.000 description 1
- 108010038661 Hepatocyte Nuclear Factor 3-alpha Proteins 0.000 description 1
- 102000010818 Hepatocyte Nuclear Factor 3-alpha Human genes 0.000 description 1
- 108010087745 Hepatocyte Nuclear Factor 3-beta Proteins 0.000 description 1
- 102000009094 Hepatocyte Nuclear Factor 3-beta Human genes 0.000 description 1
- 108010055480 Hepatocyte Nuclear Factor 3-gamma Proteins 0.000 description 1
- 102000000155 Hepatocyte Nuclear Factor 3-gamma Human genes 0.000 description 1
- 102100022057 Hepatocyte nuclear factor 1-alpha Human genes 0.000 description 1
- 102000005646 Heterogeneous-Nuclear Ribonucleoprotein K Human genes 0.000 description 1
- 108010084680 Heterogeneous-Nuclear Ribonucleoprotein K Proteins 0.000 description 1
- 102000005548 Hexokinase Human genes 0.000 description 1
- 108700040460 Hexokinases Proteins 0.000 description 1
- 102100037907 High mobility group protein B1 Human genes 0.000 description 1
- 102100022128 High mobility group protein B2 Human genes 0.000 description 1
- 102100030445 Histone H4 transcription factor Human genes 0.000 description 1
- 101710189113 Histone H4 transcription factor Proteins 0.000 description 1
- 102100039996 Histone deacetylase 1 Human genes 0.000 description 1
- 102100039999 Histone deacetylase 2 Human genes 0.000 description 1
- 102100021454 Histone deacetylase 4 Human genes 0.000 description 1
- 102100021453 Histone deacetylase 5 Human genes 0.000 description 1
- 108010016918 Histone-Lysine N-Methyltransferase Proteins 0.000 description 1
- 108010033040 Histones Proteins 0.000 description 1
- 101150068639 Hnf4a gene Proteins 0.000 description 1
- 102100030941 Homeobox even-skipped homolog protein 1 Human genes 0.000 description 1
- 102100031671 Homeobox protein CDX-2 Human genes 0.000 description 1
- 102100029019 Homeobox protein HMX1 Human genes 0.000 description 1
- 102100030309 Homeobox protein Hox-A1 Human genes 0.000 description 1
- 102100030307 Homeobox protein Hox-A13 Human genes 0.000 description 1
- 102100039542 Homeobox protein Hox-A2 Human genes 0.000 description 1
- 102100039541 Homeobox protein Hox-A3 Human genes 0.000 description 1
- 102100025116 Homeobox protein Hox-A4 Human genes 0.000 description 1
- 102100025110 Homeobox protein Hox-A5 Human genes 0.000 description 1
- 102100022649 Homeobox protein Hox-A6 Human genes 0.000 description 1
- 102100022650 Homeobox protein Hox-A7 Human genes 0.000 description 1
- 102100034889 Homeobox protein Hox-B1 Human genes 0.000 description 1
- 102100021088 Homeobox protein Hox-B13 Human genes 0.000 description 1
- 102100034862 Homeobox protein Hox-B2 Human genes 0.000 description 1
- 102100028411 Homeobox protein Hox-B3 Human genes 0.000 description 1
- 102100028404 Homeobox protein Hox-B4 Human genes 0.000 description 1
- 102100025056 Homeobox protein Hox-B6 Human genes 0.000 description 1
- 102100025061 Homeobox protein Hox-B7 Human genes 0.000 description 1
- 102100029433 Homeobox protein Hox-B9 Human genes 0.000 description 1
- 102100029426 Homeobox protein Hox-C10 Human genes 0.000 description 1
- 102100020766 Homeobox protein Hox-C11 Human genes 0.000 description 1
- 102100020758 Homeobox protein Hox-C12 Human genes 0.000 description 1
- 102100020761 Homeobox protein Hox-C13 Human genes 0.000 description 1
- 102100020759 Homeobox protein Hox-C4 Human genes 0.000 description 1
- 102100022597 Homeobox protein Hox-C9 Human genes 0.000 description 1
- 102100039544 Homeobox protein Hox-D10 Human genes 0.000 description 1
- 102100039545 Homeobox protein Hox-D11 Human genes 0.000 description 1
- 102100021086 Homeobox protein Hox-D4 Human genes 0.000 description 1
- 102100034858 Homeobox protein Hox-D8 Human genes 0.000 description 1
- 102100034864 Homeobox protein Hox-D9 Human genes 0.000 description 1
- 102100024208 Homeobox protein MIXL1 Human genes 0.000 description 1
- 102100029330 Homeobox protein PKNOX2 Human genes 0.000 description 1
- 102100035081 Homeobox protein TGIF1 Human genes 0.000 description 1
- 102100039704 Homeobox protein VENTX Human genes 0.000 description 1
- 102100033791 Homeobox protein aristaless-like 3 Human genes 0.000 description 1
- 102100030234 Homeobox protein cut-like 1 Human genes 0.000 description 1
- 102100030231 Homeobox protein cut-like 2 Human genes 0.000 description 1
- 101000760079 Homo sapiens 14-3-3 protein epsilon Proteins 0.000 description 1
- 101000733945 Homo sapiens 39S ribosomal protein L15, mitochondrial Proteins 0.000 description 1
- 101000808887 Homo sapiens AT-rich interactive domain-containing protein 3A Proteins 0.000 description 1
- 101000720051 Homo sapiens Adenosine deaminase 2 Proteins 0.000 description 1
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 1
- 101000752722 Homo sapiens Apoptosis-stimulating of p53 protein 1 Proteins 0.000 description 1
- 101000752711 Homo sapiens Apoptosis-stimulating of p53 protein 2 Proteins 0.000 description 1
- 101000768838 Homo sapiens Aryl hydrocarbon receptor nuclear translocator 2 Proteins 0.000 description 1
- 101000740484 Homo sapiens Aryl hydrocarbon receptor nuclear translocator-like protein 1 Proteins 0.000 description 1
- 101000971234 Homo sapiens B-cell lymphoma 6 protein Proteins 0.000 description 1
- 101000860860 Homo sapiens COUP transcription factor 2 Proteins 0.000 description 1
- 101000726098 Homo sapiens Calsenilin Proteins 0.000 description 1
- 101001033682 Homo sapiens Chromatin-remodeling ATPase INO80 Proteins 0.000 description 1
- 101000980066 Homo sapiens Cilia- and flagella-associated protein 410 Proteins 0.000 description 1
- 101001016178 Homo sapiens Cilium assembly protein DZIP1L Proteins 0.000 description 1
- 101000765033 Homo sapiens Class E basic helix-loop-helix protein 41 Proteins 0.000 description 1
- 101000978332 Homo sapiens Coiled-coil domain-containing protein 71 Proteins 0.000 description 1
- 101000974934 Homo sapiens Cyclic AMP-dependent transcription factor ATF-2 Proteins 0.000 description 1
- 101000905743 Homo sapiens Cyclic AMP-dependent transcription factor ATF-4 Proteins 0.000 description 1
- 101000905746 Homo sapiens Cyclic AMP-dependent transcription factor ATF-5 Proteins 0.000 description 1
- 101000905751 Homo sapiens Cyclic AMP-dependent transcription factor ATF-6 alpha Proteins 0.000 description 1
- 101001132307 Homo sapiens DNA repair protein RAD51 homolog 2 Proteins 0.000 description 1
- 101001075464 Homo sapiens DNA-binding protein RFXANK Proteins 0.000 description 1
- 101000915428 Homo sapiens Death domain-associated protein 6 Proteins 0.000 description 1
- 101000968544 Homo sapiens Double homeobox protein 1 Proteins 0.000 description 1
- 101000968549 Homo sapiens Double homeobox protein 4 Proteins 0.000 description 1
- 101000636713 Homo sapiens E3 ubiquitin-protein ligase NEDD4 Proteins 0.000 description 1
- 101000848629 Homo sapiens E3 ubiquitin-protein ligase TRIM22 Proteins 0.000 description 1
- 101000813135 Homo sapiens ETS-related transcription factor Elf-4 Proteins 0.000 description 1
- 101001064167 Homo sapiens Eomesodermin homolog Proteins 0.000 description 1
- 101000697353 Homo sapiens FACT complex subunit SSRP1 Proteins 0.000 description 1
- 101000848171 Homo sapiens Fanconi anemia group J protein Proteins 0.000 description 1
- 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 description 1
- 101000818727 Homo sapiens Forkhead box protein B1 Proteins 0.000 description 1
- 101000818310 Homo sapiens Forkhead box protein C1 Proteins 0.000 description 1
- 101000818305 Homo sapiens Forkhead box protein C2 Proteins 0.000 description 1
- 101001029314 Homo sapiens Forkhead box protein D2 Proteins 0.000 description 1
- 101001029308 Homo sapiens Forkhead box protein D3 Proteins 0.000 description 1
- 101000931494 Homo sapiens Forkhead box protein F1 Proteins 0.000 description 1
- 101000931482 Homo sapiens Forkhead box protein F2 Proteins 0.000 description 1
- 101001023398 Homo sapiens Forkhead box protein K1 Proteins 0.000 description 1
- 101001023352 Homo sapiens Forkhead box protein L1 Proteins 0.000 description 1
- 101000907576 Homo sapiens Forkhead box protein N1 Proteins 0.000 description 1
- 101000907593 Homo sapiens Forkhead box protein N2 Proteins 0.000 description 1
- 101000907594 Homo sapiens Forkhead box protein N3 Proteins 0.000 description 1
- 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 description 1
- 101000861403 Homo sapiens Forkhead box protein P4 Proteins 0.000 description 1
- 101001062403 Homo sapiens Forkhead box protein S1 Proteins 0.000 description 1
- 101001022098 Homo sapiens GA-binding protein subunit beta-1 Proteins 0.000 description 1
- 101000584633 Homo sapiens GTPase HRas Proteins 0.000 description 1
- 101000926140 Homo sapiens Gem-associated protein 2 Proteins 0.000 description 1
- 101000997803 Homo sapiens Glia-derived nexin Proteins 0.000 description 1
- 101000997829 Homo sapiens Glial cell line-derived neurotrophic factor Proteins 0.000 description 1
- 101001069933 Homo sapiens Grainyhead-like protein 1 homolog Proteins 0.000 description 1
- 101000905239 Homo sapiens Heart- and neural crest derivatives-expressed protein 1 Proteins 0.000 description 1
- 101001016883 Homo sapiens Heat shock factor protein 2 Proteins 0.000 description 1
- 101001080298 Homo sapiens Heat shock factor-binding protein 1 Proteins 0.000 description 1
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 description 1
- 101000704158 Homo sapiens Helicase SRCAP Proteins 0.000 description 1
- 101000897691 Homo sapiens Helix-loop-helix protein 1 Proteins 0.000 description 1
- 101000897700 Homo sapiens Helix-loop-helix protein 2 Proteins 0.000 description 1
- 101001045791 Homo sapiens High mobility group protein B2 Proteins 0.000 description 1
- 101001046967 Homo sapiens Histone acetyltransferase KAT2A Proteins 0.000 description 1
- 101001035024 Homo sapiens Histone deacetylase 1 Proteins 0.000 description 1
- 101001035011 Homo sapiens Histone deacetylase 2 Proteins 0.000 description 1
- 101000899259 Homo sapiens Histone deacetylase 4 Proteins 0.000 description 1
- 101000899255 Homo sapiens Histone deacetylase 5 Proteins 0.000 description 1
- 101001028782 Homo sapiens Histone-lysine N-methyltransferase EZH1 Proteins 0.000 description 1
- 101000938552 Homo sapiens Homeobox even-skipped homolog protein 1 Proteins 0.000 description 1
- 101000986308 Homo sapiens Homeobox protein HMX1 Proteins 0.000 description 1
- 101001083156 Homo sapiens Homeobox protein Hox-A1 Proteins 0.000 description 1
- 101000962636 Homo sapiens Homeobox protein Hox-A2 Proteins 0.000 description 1
- 101000962622 Homo sapiens Homeobox protein Hox-A3 Proteins 0.000 description 1
- 101001077578 Homo sapiens Homeobox protein Hox-A4 Proteins 0.000 description 1
- 101001077568 Homo sapiens Homeobox protein Hox-A5 Proteins 0.000 description 1
- 101001045083 Homo sapiens Homeobox protein Hox-A6 Proteins 0.000 description 1
- 101001045116 Homo sapiens Homeobox protein Hox-A7 Proteins 0.000 description 1
- 101001019745 Homo sapiens Homeobox protein Hox-B1 Proteins 0.000 description 1
- 101001041145 Homo sapiens Homeobox protein Hox-B13 Proteins 0.000 description 1
- 101001019752 Homo sapiens Homeobox protein Hox-B2 Proteins 0.000 description 1
- 101000839775 Homo sapiens Homeobox protein Hox-B3 Proteins 0.000 description 1
- 101000839788 Homo sapiens Homeobox protein Hox-B4 Proteins 0.000 description 1
- 101001077542 Homo sapiens Homeobox protein Hox-B6 Proteins 0.000 description 1
- 101001077539 Homo sapiens Homeobox protein Hox-B7 Proteins 0.000 description 1
- 101000989000 Homo sapiens Homeobox protein Hox-B9 Proteins 0.000 description 1
- 101000989027 Homo sapiens Homeobox protein Hox-C10 Proteins 0.000 description 1
- 101001003015 Homo sapiens Homeobox protein Hox-C11 Proteins 0.000 description 1
- 101001002991 Homo sapiens Homeobox protein Hox-C12 Proteins 0.000 description 1
- 101001002988 Homo sapiens Homeobox protein Hox-C13 Proteins 0.000 description 1
- 101001002994 Homo sapiens Homeobox protein Hox-C4 Proteins 0.000 description 1
- 101001045140 Homo sapiens Homeobox protein Hox-C9 Proteins 0.000 description 1
- 101000962573 Homo sapiens Homeobox protein Hox-D10 Proteins 0.000 description 1
- 101000962591 Homo sapiens Homeobox protein Hox-D11 Proteins 0.000 description 1
- 101001041136 Homo sapiens Homeobox protein Hox-D4 Proteins 0.000 description 1
- 101001019776 Homo sapiens Homeobox protein Hox-D8 Proteins 0.000 description 1
- 101001019766 Homo sapiens Homeobox protein Hox-D9 Proteins 0.000 description 1
- 101001052462 Homo sapiens Homeobox protein MIXL1 Proteins 0.000 description 1
- 101001125949 Homo sapiens Homeobox protein PKNOX2 Proteins 0.000 description 1
- 101000596925 Homo sapiens Homeobox protein TGIF1 Proteins 0.000 description 1
- 101000667986 Homo sapiens Homeobox protein VENTX Proteins 0.000 description 1
- 101000779611 Homo sapiens Homeobox protein aristaless-like 3 Proteins 0.000 description 1
- 101000726740 Homo sapiens Homeobox protein cut-like 1 Proteins 0.000 description 1
- 101000726714 Homo sapiens Homeobox protein cut-like 2 Proteins 0.000 description 1
- 101001021527 Homo sapiens Huntingtin-interacting protein 1 Proteins 0.000 description 1
- 101000852539 Homo sapiens Importin-5 Proteins 0.000 description 1
- 101001033233 Homo sapiens Interleukin-10 Proteins 0.000 description 1
- 101001053430 Homo sapiens Iroquois-class homeodomain protein IRX-3 Proteins 0.000 description 1
- 101001046537 Homo sapiens Kinesin-like protein KIFC2 Proteins 0.000 description 1
- 101001006895 Homo sapiens Krueppel-like factor 11 Proteins 0.000 description 1
- 101001006886 Homo sapiens Krueppel-like factor 12 Proteins 0.000 description 1
- 101001046564 Homo sapiens Krueppel-like factor 13 Proteins 0.000 description 1
- 101001046593 Homo sapiens Krueppel-like factor 16 Proteins 0.000 description 1
- 101001139146 Homo sapiens Krueppel-like factor 2 Proteins 0.000 description 1
- 101001139134 Homo sapiens Krueppel-like factor 4 Proteins 0.000 description 1
- 101001139130 Homo sapiens Krueppel-like factor 5 Proteins 0.000 description 1
- 101001139117 Homo sapiens Krueppel-like factor 7 Proteins 0.000 description 1
- 101001139112 Homo sapiens Krueppel-like factor 9 Proteins 0.000 description 1
- 101001022957 Homo sapiens LIM domain-binding protein 1 Proteins 0.000 description 1
- 101001022948 Homo sapiens LIM domain-binding protein 2 Proteins 0.000 description 1
- 101001038339 Homo sapiens LIM homeobox transcription factor 1-alpha Proteins 0.000 description 1
- 101000984044 Homo sapiens LIM homeobox transcription factor 1-beta Proteins 0.000 description 1
- 101001020548 Homo sapiens LIM/homeobox protein Lhx1 Proteins 0.000 description 1
- 101000619914 Homo sapiens LIM/homeobox protein Lhx5 Proteins 0.000 description 1
- 101001044093 Homo sapiens Lipopolysaccharide-induced tumor necrosis factor-alpha factor Proteins 0.000 description 1
- 101100456961 Homo sapiens MEX3B gene Proteins 0.000 description 1
- 101001005664 Homo sapiens Mastermind-like protein 1 Proteins 0.000 description 1
- 101001028019 Homo sapiens Metastasis-associated protein MTA2 Proteins 0.000 description 1
- 101000928479 Homo sapiens Microtubule organization protein AKNA Proteins 0.000 description 1
- 101000958041 Homo sapiens Musculin Proteins 0.000 description 1
- 101001017254 Homo sapiens Myb-binding protein 1A Proteins 0.000 description 1
- 101001128495 Homo sapiens Myeloid zinc finger 1 Proteins 0.000 description 1
- 101001023043 Homo sapiens Myoblast determination protein 1 Proteins 0.000 description 1
- 101000589002 Homo sapiens Myogenin Proteins 0.000 description 1
- 101000979909 Homo sapiens NMDA receptor synaptonuclear signaling and neuronal migration factor Proteins 0.000 description 1
- 101000603702 Homo sapiens Neurogenin-3 Proteins 0.000 description 1
- 101000634538 Homo sapiens Neuronal PAS domain-containing protein 1 Proteins 0.000 description 1
- 101000634537 Homo sapiens Neuronal PAS domain-containing protein 2 Proteins 0.000 description 1
- 101001111328 Homo sapiens Nuclear factor 1 A-type Proteins 0.000 description 1
- 101000973211 Homo sapiens Nuclear factor 1 B-type Proteins 0.000 description 1
- 101000979347 Homo sapiens Nuclear factor 1 X-type Proteins 0.000 description 1
- 101000973177 Homo sapiens Nuclear factor interleukin-3-regulated protein Proteins 0.000 description 1
- 101000974340 Homo sapiens Nuclear receptor corepressor 1 Proteins 0.000 description 1
- 101000582254 Homo sapiens Nuclear receptor corepressor 2 Proteins 0.000 description 1
- 101000603323 Homo sapiens Nuclear receptor subfamily 0 group B member 1 Proteins 0.000 description 1
- 101000633516 Homo sapiens Nuclear receptor subfamily 2 group F member 6 Proteins 0.000 description 1
- 101001109698 Homo sapiens Nuclear receptor subfamily 4 group A member 2 Proteins 0.000 description 1
- 101000934489 Homo sapiens Nucleosome-remodeling factor subunit BPTF Proteins 0.000 description 1
- 101000734351 Homo sapiens PDZ and LIM domain protein 1 Proteins 0.000 description 1
- 101001000773 Homo sapiens POU domain, class 2, transcription factor 2 Proteins 0.000 description 1
- 101000572989 Homo sapiens POU domain, class 3, transcription factor 3 Proteins 0.000 description 1
- 101000572950 Homo sapiens POU domain, class 3, transcription factor 4 Proteins 0.000 description 1
- 101001094737 Homo sapiens POU domain, class 4, transcription factor 3 Proteins 0.000 description 1
- 101001094700 Homo sapiens POU domain, class 5, transcription factor 1 Proteins 0.000 description 1
- 101000738966 Homo sapiens POU domain, class 6, transcription factor 1 Proteins 0.000 description 1
- 101001072590 Homo sapiens POZ-, AT hook-, and zinc finger-containing protein 1 Proteins 0.000 description 1
- 101000595669 Homo sapiens Pituitary homeobox 2 Proteins 0.000 description 1
- 101000595674 Homo sapiens Pituitary homeobox 3 Proteins 0.000 description 1
- 101001096159 Homo sapiens Pituitary-specific positive transcription factor 1 Proteins 0.000 description 1
- 101001047090 Homo sapiens Potassium voltage-gated channel subfamily H member 2 Proteins 0.000 description 1
- 101000619116 Homo sapiens Proline-rich protein 12 Proteins 0.000 description 1
- 101000892360 Homo sapiens Protein AF-17 Proteins 0.000 description 1
- 101000761460 Homo sapiens Protein CASP Proteins 0.000 description 1
- 101000948324 Homo sapiens Protein CutA Proteins 0.000 description 1
- 101000721172 Homo sapiens Protein DBF4 homolog A Proteins 0.000 description 1
- 101000716750 Homo sapiens Protein SCAF11 Proteins 0.000 description 1
- 101000640050 Homo sapiens Protein strawberry notch homolog 1 Proteins 0.000 description 1
- 101001133957 Homo sapiens Putative POU domain, class 5, transcription factor 1B Proteins 0.000 description 1
- 101000968552 Homo sapiens Putative double homeobox protein 3 Proteins 0.000 description 1
- 101000629813 Homo sapiens RNA-binding protein MEX3B Proteins 0.000 description 1
- 101001075466 Homo sapiens Regulatory factor X-associated protein Proteins 0.000 description 1
- 101001077298 Homo sapiens Retinoblastoma-binding protein 5 Proteins 0.000 description 1
- 101000640882 Homo sapiens Retinoic acid receptor RXR-gamma Proteins 0.000 description 1
- 101000703463 Homo sapiens Rho GTPase-activating protein 35 Proteins 0.000 description 1
- 101000703439 Homo sapiens Rho GTPase-activating protein 42 Proteins 0.000 description 1
- 101000650547 Homo sapiens Ribosome production factor 1 Proteins 0.000 description 1
- 101000857677 Homo sapiens Runt-related transcription factor 1 Proteins 0.000 description 1
- 101000857682 Homo sapiens Runt-related transcription factor 2 Proteins 0.000 description 1
- 101000711466 Homo sapiens SAM pointed domain-containing Ets transcription factor Proteins 0.000 description 1
- 101000713317 Homo sapiens SLC2A4 regulator Proteins 0.000 description 1
- 101000785063 Homo sapiens Serine-protein kinase ATM Proteins 0.000 description 1
- 101000585484 Homo sapiens Signal transducer and activator of transcription 1-alpha/beta Proteins 0.000 description 1
- 101000616761 Homo sapiens Single-minded homolog 2 Proteins 0.000 description 1
- 101000688996 Homo sapiens Ski-like protein Proteins 0.000 description 1
- 101000897669 Homo sapiens Small RNA 2'-O-methyltransferase Proteins 0.000 description 1
- 101000851696 Homo sapiens Steroid hormone receptor ERR2 Proteins 0.000 description 1
- 101000713596 Homo sapiens T-box transcription factor TBX19 Proteins 0.000 description 1
- 101000713606 Homo sapiens T-box transcription factor TBX20 Proteins 0.000 description 1
- 101000713602 Homo sapiens T-box transcription factor TBX21 Proteins 0.000 description 1
- 101000625913 Homo sapiens T-box transcription factor TBX4 Proteins 0.000 description 1
- 101000625859 Homo sapiens T-box transcription factor TBX6 Proteins 0.000 description 1
- 101000800488 Homo sapiens T-cell leukemia homeobox protein 1 Proteins 0.000 description 1
- 101000596086 Homo sapiens TATA box-binding protein-associated factor RNA polymerase I subunit D Proteins 0.000 description 1
- 101000702545 Homo sapiens Transcription activator BRG1 Proteins 0.000 description 1
- 101000891371 Homo sapiens Transcription elongation regulator 1 Proteins 0.000 description 1
- 101000732345 Homo sapiens Transcription factor AP-2-beta Proteins 0.000 description 1
- 101000701142 Homo sapiens Transcription factor ATOH1 Proteins 0.000 description 1
- 101000655403 Homo sapiens Transcription factor CP2-like protein 1 Proteins 0.000 description 1
- 101000837845 Homo sapiens Transcription factor E3 Proteins 0.000 description 1
- 101000837841 Homo sapiens Transcription factor EB Proteins 0.000 description 1
- 101000843556 Homo sapiens Transcription factor HES-1 Proteins 0.000 description 1
- 101000946167 Homo sapiens Transcription factor LBX1 Proteins 0.000 description 1
- 101001023770 Homo sapiens Transcription factor NF-E2 45 kDa subunit Proteins 0.000 description 1
- 101001075434 Homo sapiens Transcription factor RFX4 Proteins 0.000 description 1
- 101000825079 Homo sapiens Transcription factor SOX-13 Proteins 0.000 description 1
- 101000800860 Homo sapiens Transcription initiation factor IIB Proteins 0.000 description 1
- 101000596093 Homo sapiens Transcription initiation factor TFIID subunit 1 Proteins 0.000 description 1
- 101001074042 Homo sapiens Transcriptional activator GLI3 Proteins 0.000 description 1
- 101000657352 Homo sapiens Transcriptional adapter 2-alpha Proteins 0.000 description 1
- 101000652684 Homo sapiens Transcriptional adapter 3 Proteins 0.000 description 1
- 101000653735 Homo sapiens Transcriptional enhancer factor TEF-1 Proteins 0.000 description 1
- 101000597045 Homo sapiens Transcriptional enhancer factor TEF-3 Proteins 0.000 description 1
- 101000597043 Homo sapiens Transcriptional enhancer factor TEF-5 Proteins 0.000 description 1
- 101000669432 Homo sapiens Transducin-like enhancer protein 1 Proteins 0.000 description 1
- 101000796673 Homo sapiens Transformation/transcription domain-associated protein Proteins 0.000 description 1
- 101000971144 Homo sapiens Tyrosine-protein kinase BAZ1B Proteins 0.000 description 1
- 101000671649 Homo sapiens Upstream stimulatory factor 2 Proteins 0.000 description 1
- 101000747867 Homo sapiens Upstream-binding protein 1 Proteins 0.000 description 1
- 101000791652 Homo sapiens YY1-associated factor 2 Proteins 0.000 description 1
- 101100377226 Homo sapiens ZBTB16 gene Proteins 0.000 description 1
- 101100489441 Homo sapiens ZNF281 gene Proteins 0.000 description 1
- 101000723833 Homo sapiens Zinc finger E-box-binding homeobox 2 Proteins 0.000 description 1
- 101000964478 Homo sapiens Zinc finger and BTB domain-containing protein 17 Proteins 0.000 description 1
- 101000785559 Homo sapiens Zinc finger and SCAN domain-containing protein 26 Proteins 0.000 description 1
- 101000976577 Homo sapiens Zinc finger protein 124 Proteins 0.000 description 1
- 101000976580 Homo sapiens Zinc finger protein 133 Proteins 0.000 description 1
- 101000759226 Homo sapiens Zinc finger protein 143 Proteins 0.000 description 1
- 101000964587 Homo sapiens Zinc finger protein 174 Proteins 0.000 description 1
- 101000760175 Homo sapiens Zinc finger protein 35 Proteins 0.000 description 1
- 101000964392 Homo sapiens Zinc finger protein 354A Proteins 0.000 description 1
- 101000760180 Homo sapiens Zinc finger protein 43 Proteins 0.000 description 1
- 101000760183 Homo sapiens Zinc finger protein 44 Proteins 0.000 description 1
- 101000782464 Homo sapiens Zinc finger protein 444 Proteins 0.000 description 1
- 101000760182 Homo sapiens Zinc finger protein 45 Proteins 0.000 description 1
- 101000782287 Homo sapiens Zinc finger protein 629 Proteins 0.000 description 1
- 101000964736 Homo sapiens Zinc finger protein 7 Proteins 0.000 description 1
- 101000964726 Homo sapiens Zinc finger protein 76 Proteins 0.000 description 1
- 101000599042 Homo sapiens Zinc finger protein Aiolos Proteins 0.000 description 1
- 101000857273 Homo sapiens Zinc finger protein GLIS2 Proteins 0.000 description 1
- 101000730644 Homo sapiens Zinc finger protein PLAGL2 Proteins 0.000 description 1
- 101000782089 Homo sapiens Zinc finger protein ZFAT Proteins 0.000 description 1
- 101000976643 Homo sapiens Zinc finger protein ZIC 2 Proteins 0.000 description 1
- 101000873785 Homo sapiens mRNA-decapping enzyme 1A Proteins 0.000 description 1
- 101000687642 Homo sapiens snRNA-activating protein complex subunit 1 Proteins 0.000 description 1
- 101000825856 Homo sapiens snRNA-activating protein complex subunit 3 Proteins 0.000 description 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
- 241001502974 Human gammaherpesvirus 8 Species 0.000 description 1
- 241000341655 Human papillomavirus type 16 Species 0.000 description 1
- 102100035957 Huntingtin-interacting protein 1 Human genes 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- 102100031612 Hypermethylated in cancer 1 protein Human genes 0.000 description 1
- 101710133850 Hypermethylated in cancer 1 protein Proteins 0.000 description 1
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
- 101150027427 ICP4 gene Proteins 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 108010087227 IMP Dehydrogenase Proteins 0.000 description 1
- 102000006674 IMP dehydrogenase Human genes 0.000 description 1
- 108010075418 Immunoglobulin J Recombination Signal Sequence Binding Protein Proteins 0.000 description 1
- 102000008047 Immunoglobulin J Recombination Signal Sequence Binding Protein Human genes 0.000 description 1
- 102100036340 Importin-5 Human genes 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 108090000191 Inhibitor of growth protein 1 Proteins 0.000 description 1
- 102000003781 Inhibitor of growth protein 1 Human genes 0.000 description 1
- 102100027636 Insulin-like growth factor-binding protein 1 Human genes 0.000 description 1
- 108090000957 Insulin-like growth factor-binding protein 1 Proteins 0.000 description 1
- 108010032038 Interferon Regulatory Factor-3 Proteins 0.000 description 1
- 108090000890 Interferon regulatory factor 1 Proteins 0.000 description 1
- 102000004289 Interferon regulatory factor 1 Human genes 0.000 description 1
- 102100029838 Interferon regulatory factor 2 Human genes 0.000 description 1
- 108090000908 Interferon regulatory factor 2 Proteins 0.000 description 1
- 102100029843 Interferon regulatory factor 3 Human genes 0.000 description 1
- 102100030126 Interferon regulatory factor 4 Human genes 0.000 description 1
- 102100030131 Interferon regulatory factor 5 Human genes 0.000 description 1
- 101710157897 Interferon regulatory factor 5 Proteins 0.000 description 1
- 102100030130 Interferon regulatory factor 6 Human genes 0.000 description 1
- 101710157822 Interferon regulatory factor 6 Proteins 0.000 description 1
- 102100038069 Interferon regulatory factor 8 Human genes 0.000 description 1
- 102100038251 Interferon regulatory factor 9 Human genes 0.000 description 1
- 101710157824 Interferon regulatory factor 9 Proteins 0.000 description 1
- 102000003815 Interleukin-11 Human genes 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 102000004310 Ion Channels Human genes 0.000 description 1
- 108090000862 Ion Channels Proteins 0.000 description 1
- 102100024374 Iroquois-class homeodomain protein IRX-3 Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 102000010638 Kinesin Human genes 0.000 description 1
- 108010063296 Kinesin Proteins 0.000 description 1
- 102100022251 Kinesin-like protein KIFC2 Human genes 0.000 description 1
- 108010093008 Kinins Proteins 0.000 description 1
- 102000002397 Kinins Human genes 0.000 description 1
- 102100022248 Krueppel-like factor 1 Human genes 0.000 description 1
- 102100027798 Krueppel-like factor 10 Human genes 0.000 description 1
- 101710166468 Krueppel-like factor 10 Proteins 0.000 description 1
- 102100027797 Krueppel-like factor 11 Human genes 0.000 description 1
- 102100027792 Krueppel-like factor 12 Human genes 0.000 description 1
- 102100022254 Krueppel-like factor 13 Human genes 0.000 description 1
- 102100022324 Krueppel-like factor 16 Human genes 0.000 description 1
- 102100020675 Krueppel-like factor 2 Human genes 0.000 description 1
- 102100020678 Krueppel-like factor 3 Human genes 0.000 description 1
- 101710116712 Krueppel-like factor 3 Proteins 0.000 description 1
- 102100020677 Krueppel-like factor 4 Human genes 0.000 description 1
- 102100020680 Krueppel-like factor 5 Human genes 0.000 description 1
- 102100020679 Krueppel-like factor 6 Human genes 0.000 description 1
- 102100020692 Krueppel-like factor 7 Human genes 0.000 description 1
- 102100020684 Krueppel-like factor 9 Human genes 0.000 description 1
- 108010049058 Kruppel-Like Factor 6 Proteins 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 150000008575 L-amino acids Chemical class 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- 102100035114 LIM domain-binding protein 1 Human genes 0.000 description 1
- 102100040290 LIM homeobox transcription factor 1-alpha Human genes 0.000 description 1
- 102100025457 LIM homeobox transcription factor 1-beta Human genes 0.000 description 1
- 102100036133 LIM/homeobox protein Lhx1 Human genes 0.000 description 1
- 102100022139 LIM/homeobox protein Lhx5 Human genes 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 102100032241 Lactotransferrin Human genes 0.000 description 1
- 241000550087 Lanium Species 0.000 description 1
- LOPKHWOTGJIQLC-UHFFFAOYSA-N Lanosterol Natural products CC(CCC=C(C)C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 LOPKHWOTGJIQLC-UHFFFAOYSA-N 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 108010028275 Leukocyte Elastase Proteins 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 102100021607 Lipopolysaccharide-induced tumor necrosis factor-alpha factor Human genes 0.000 description 1
- 102000003820 Lipoxygenases Human genes 0.000 description 1
- 108090000128 Lipoxygenases Proteins 0.000 description 1
- 102100022699 Lymphoid enhancer-binding factor 1 Human genes 0.000 description 1
- 108090001093 Lymphoid enhancer-binding factor 1 Proteins 0.000 description 1
- 101150022636 MAFB gene Proteins 0.000 description 1
- 101150083522 MECP2 gene Proteins 0.000 description 1
- 108010064699 MSH Release-Inhibiting Hormone Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010064912 Malignant transformation Diseases 0.000 description 1
- 241001446467 Mama Species 0.000 description 1
- 102000001696 Mannosidases Human genes 0.000 description 1
- 108010054377 Mannosidases Proteins 0.000 description 1
- 102100025129 Mastermind-like protein 1 Human genes 0.000 description 1
- 102100030200 Matrix metalloproteinase-16 Human genes 0.000 description 1
- 108090000561 Matrix metalloproteinase-16 Proteins 0.000 description 1
- NOOJLZTTWSNHOX-UWVGGRQHSA-N Melanostatin Chemical compound NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1 NOOJLZTTWSNHOX-UWVGGRQHSA-N 0.000 description 1
- 102000012750 Membrane Glycoproteins Human genes 0.000 description 1
- 108010090054 Membrane Glycoproteins Proteins 0.000 description 1
- 102100037511 Metastasis-associated protein MTA2 Human genes 0.000 description 1
- 108010061951 Methemoglobin Proteins 0.000 description 1
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical compound COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 description 1
- 102100039124 Methyl-CpG-binding protein 2 Human genes 0.000 description 1
- 108010050345 Microphthalmia-Associated Transcription Factor Proteins 0.000 description 1
- 102100030157 Microphthalmia-associated transcription factor Human genes 0.000 description 1
- 102100036470 Microtubule organization protein AKNA Human genes 0.000 description 1
- 102100030610 Mothers against decapentaplegic homolog 5 Human genes 0.000 description 1
- 101710143113 Mothers against decapentaplegic homolog 5 Proteins 0.000 description 1
- 102100030608 Mothers against decapentaplegic homolog 7 Human genes 0.000 description 1
- 101150118570 Msx2 gene Proteins 0.000 description 1
- 101100220214 Mus musculus Cdx4 gene Proteins 0.000 description 1
- 101100444898 Mus musculus Egr1 gene Proteins 0.000 description 1
- 101100445099 Mus musculus Emx1 gene Proteins 0.000 description 1
- 101100445103 Mus musculus Emx2 gene Proteins 0.000 description 1
- 101100446506 Mus musculus Fgf3 gene Proteins 0.000 description 1
- 101100281205 Mus musculus Fli1 gene Proteins 0.000 description 1
- 101100121434 Mus musculus Gcm1 gene Proteins 0.000 description 1
- 101100176745 Mus musculus Gsc2 gene Proteins 0.000 description 1
- 101100071843 Mus musculus Hoxb1 gene Proteins 0.000 description 1
- 101100018257 Mus musculus Hoxb3 gene Proteins 0.000 description 1
- 101100507933 Mus musculus Hoxc6 gene Proteins 0.000 description 1
- 101100289867 Mus musculus Lyl1 gene Proteins 0.000 description 1
- 101100024583 Mus musculus Mtf1 gene Proteins 0.000 description 1
- 101100405118 Mus musculus Nr4a1 gene Proteins 0.000 description 1
- 101100518987 Mus musculus Pax1 gene Proteins 0.000 description 1
- 101100518992 Mus musculus Pax2 gene Proteins 0.000 description 1
- 101100518997 Mus musculus Pax3 gene Proteins 0.000 description 1
- 101100351020 Mus musculus Pax5 gene Proteins 0.000 description 1
- 101100351033 Mus musculus Pax7 gene Proteins 0.000 description 1
- 101100519086 Mus musculus Pcgf2 gene Proteins 0.000 description 1
- 101100521345 Mus musculus Prop1 gene Proteins 0.000 description 1
- 101100310657 Mus musculus Sox1 gene Proteins 0.000 description 1
- 101100149887 Mus musculus Sox10 gene Proteins 0.000 description 1
- 101100366231 Mus musculus Sox12 gene Proteins 0.000 description 1
- 101100310650 Mus musculus Sox18 gene Proteins 0.000 description 1
- 101100257376 Mus musculus Sox3 gene Proteins 0.000 description 1
- 101100043050 Mus musculus Sox4 gene Proteins 0.000 description 1
- 101100043062 Mus musculus Sox7 gene Proteins 0.000 description 1
- 101100480538 Mus musculus Tal1 gene Proteins 0.000 description 1
- 102100038169 Musculin Human genes 0.000 description 1
- 102100034005 Myb-binding protein 1A Human genes 0.000 description 1
- 101710101468 Myb-binding protein 1A Proteins 0.000 description 1
- 102100034711 Myb-related protein A Human genes 0.000 description 1
- 101710115158 Myb-related protein A Proteins 0.000 description 1
- 102100034670 Myb-related protein B Human genes 0.000 description 1
- 101710115153 Myb-related protein B Proteins 0.000 description 1
- 102100038893 Myelin transcription factor 1 Human genes 0.000 description 1
- 101710104371 Myelin transcription factor 1 Proteins 0.000 description 1
- 108700041619 Myeloid Ecotropic Viral Integration Site 1 Proteins 0.000 description 1
- 102000047831 Myeloid Ecotropic Viral Integration Site 1 Human genes 0.000 description 1
- 102100031827 Myeloid zinc finger 1 Human genes 0.000 description 1
- 102100035077 Myoblast determination protein 1 Human genes 0.000 description 1
- 102100038380 Myogenic factor 5 Human genes 0.000 description 1
- 101710099061 Myogenic factor 5 Proteins 0.000 description 1
- 102100038379 Myogenic factor 6 Human genes 0.000 description 1
- 102100032970 Myogenin Human genes 0.000 description 1
- GUNURVWAJRRUAV-UHFFFAOYSA-N N(1)-acetylspermine Chemical compound CC(=O)NCCCNCCCCNCCCN GUNURVWAJRRUAV-UHFFFAOYSA-N 0.000 description 1
- 108700026495 N-Myc Proto-Oncogene Proteins 0.000 description 1
- 102100030124 N-myc proto-oncogene protein Human genes 0.000 description 1
- 102000002250 NAD+ Nucleosidase Human genes 0.000 description 1
- 108010000193 NAD+ Nucleosidase Proteins 0.000 description 1
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 1
- 108010071380 NF-E2-Related Factor 1 Proteins 0.000 description 1
- 102000018745 NF-KappaB Inhibitor alpha Human genes 0.000 description 1
- 108010052419 NF-KappaB Inhibitor alpha Proteins 0.000 description 1
- 108010057466 NF-kappa B Proteins 0.000 description 1
- 101150111110 NKX2-1 gene Proteins 0.000 description 1
- 102100024546 NMDA receptor synaptonuclear signaling and neuronal migration factor Human genes 0.000 description 1
- 102000048850 Neoplasm Genes Human genes 0.000 description 1
- 108700019961 Neoplasm Genes Proteins 0.000 description 1
- CAHGCLMLTWQZNJ-UHFFFAOYSA-N Nerifoliol Natural products CC12CCC(O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C CAHGCLMLTWQZNJ-UHFFFAOYSA-N 0.000 description 1
- 102100038553 Neurogenin-3 Human genes 0.000 description 1
- 102100029052 Neuronal PAS domain-containing protein 1 Human genes 0.000 description 1
- 102100029045 Neuronal PAS domain-containing protein 2 Human genes 0.000 description 1
- 101100043306 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) ctc-2 gene Proteins 0.000 description 1
- 101100445499 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) erg-1 gene Proteins 0.000 description 1
- 101100410801 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pxr-1 gene Proteins 0.000 description 1
- 102100033174 Neutrophil elastase Human genes 0.000 description 1
- 101150114527 Nkx2-5 gene Proteins 0.000 description 1
- 101150013760 Nkx6-1 gene Proteins 0.000 description 1
- 101150095442 Nr1h2 gene Proteins 0.000 description 1
- 108090001146 Nuclear Receptor Coactivator 1 Proteins 0.000 description 1
- 108090001145 Nuclear Receptor Coactivator 3 Proteins 0.000 description 1
- 108010016592 Nuclear Respiratory Factor 1 Proteins 0.000 description 1
- 101710205482 Nuclear factor 1 A-type Proteins 0.000 description 1
- 101710170464 Nuclear factor 1 B-type Proteins 0.000 description 1
- 102100023049 Nuclear factor 1 X-type Human genes 0.000 description 1
- 101710140810 Nuclear factor 1 X-type Proteins 0.000 description 1
- 102100022163 Nuclear factor interleukin-3-regulated protein Human genes 0.000 description 1
- 102100035413 Nuclear factor of activated T-cells 5 Human genes 0.000 description 1
- 108050006769 Nuclear factor of activated T-cells 5 Proteins 0.000 description 1
- 102100037223 Nuclear receptor coactivator 1 Human genes 0.000 description 1
- 102100022883 Nuclear receptor coactivator 3 Human genes 0.000 description 1
- 102100022929 Nuclear receptor coactivator 6 Human genes 0.000 description 1
- 101710115514 Nuclear receptor coactivator 6 Proteins 0.000 description 1
- 102100022935 Nuclear receptor corepressor 1 Human genes 0.000 description 1
- 102100030569 Nuclear receptor corepressor 2 Human genes 0.000 description 1
- 102100039019 Nuclear receptor subfamily 0 group B member 1 Human genes 0.000 description 1
- 102100023171 Nuclear receptor subfamily 1 group D member 2 Human genes 0.000 description 1
- 102100029528 Nuclear receptor subfamily 2 group F member 6 Human genes 0.000 description 1
- 102100022679 Nuclear receptor subfamily 4 group A member 1 Human genes 0.000 description 1
- 102100022676 Nuclear receptor subfamily 4 group A member 2 Human genes 0.000 description 1
- 102100034408 Nuclear transcription factor Y subunit alpha Human genes 0.000 description 1
- 101710115878 Nuclear transcription factor Y subunit alpha Proteins 0.000 description 1
- 108010025568 Nucleophosmin Proteins 0.000 description 1
- 102100025062 Nucleosome-remodeling factor subunit BPTF Human genes 0.000 description 1
- 241000795633 Olea <sea slug> Species 0.000 description 1
- 102000043276 Oncogene Human genes 0.000 description 1
- 108090000417 Oxygenases Proteins 0.000 description 1
- 102000004020 Oxygenases Human genes 0.000 description 1
- 102100034819 PDZ and LIM domain protein 1 Human genes 0.000 description 1
- 102000017946 PGC-1 Human genes 0.000 description 1
- 108700038399 PGC-1 Proteins 0.000 description 1
- 101150062967 PHOX2A gene Proteins 0.000 description 1
- 102100030476 POU domain class 2-associating factor 1 Human genes 0.000 description 1
- 101710114665 POU domain class 2-associating factor 1 Proteins 0.000 description 1
- 102100035591 POU domain, class 2, transcription factor 2 Human genes 0.000 description 1
- 102100026459 POU domain, class 3, transcription factor 2 Human genes 0.000 description 1
- 102100026456 POU domain, class 3, transcription factor 3 Human genes 0.000 description 1
- 102100026450 POU domain, class 3, transcription factor 4 Human genes 0.000 description 1
- 102100035394 POU domain, class 4, transcription factor 2 Human genes 0.000 description 1
- 102100035398 POU domain, class 4, transcription factor 3 Human genes 0.000 description 1
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 description 1
- 102100037483 POU domain, class 6, transcription factor 1 Human genes 0.000 description 1
- 102000025443 POZ domain binding proteins Human genes 0.000 description 1
- 108091014659 POZ domain binding proteins Proteins 0.000 description 1
- 102100036665 POZ-, AT hook-, and zinc finger-containing protein 1 Human genes 0.000 description 1
- 102100024894 PR domain zinc finger protein 1 Human genes 0.000 description 1
- 102100041030 Pancreas/duodenum homeobox protein 1 Human genes 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 101100312945 Pasteurella multocida (strain Pm70) talA gene Proteins 0.000 description 1
- 101100536300 Pasteurella multocida (strain Pm70) talB gene Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102100020739 Peptidyl-prolyl cis-trans isomerase FKBP4 Human genes 0.000 description 1
- 102100021698 Peregrin Human genes 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 102100038824 Peroxisome proliferator-activated receptor delta Human genes 0.000 description 1
- 102000009569 Phosphoglucomutase Human genes 0.000 description 1
- 102100026918 Phospholipase A2 Human genes 0.000 description 1
- 102000011420 Phospholipase D Human genes 0.000 description 1
- 108090000553 Phospholipase D Proteins 0.000 description 1
- 108010058864 Phospholipases A2 Proteins 0.000 description 1
- 102000007982 Phosphoproteins Human genes 0.000 description 1
- 108010089430 Phosphoproteins Proteins 0.000 description 1
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 1
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 1
- ZYFVNVRFVHJEIU-UHFFFAOYSA-N PicoGreen Chemical compound CN(C)CCCN(CCCN(C)C)C1=CC(=CC2=[N+](C3=CC=CC=C3S2)C)C2=CC=CC=C2N1C1=CC=CC=C1 ZYFVNVRFVHJEIU-UHFFFAOYSA-N 0.000 description 1
- 240000004760 Pimpinella anisum Species 0.000 description 1
- 102100036090 Pituitary homeobox 2 Human genes 0.000 description 1
- 102100036088 Pituitary homeobox 3 Human genes 0.000 description 1
- 102100037914 Pituitary-specific positive transcription factor 1 Human genes 0.000 description 1
- 102100038124 Plasminogen Human genes 0.000 description 1
- 108010051456 Plasminogen Proteins 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 108010021757 Polynucleotide 5'-Hydroxyl-Kinase Proteins 0.000 description 1
- 102000008422 Polynucleotide 5'-hydroxyl-kinase Human genes 0.000 description 1
- 108010009975 Positive Regulatory Domain I-Binding Factor 1 Proteins 0.000 description 1
- 102100022807 Potassium voltage-gated channel subfamily H member 2 Human genes 0.000 description 1
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
- 102100040659 Prolargin Human genes 0.000 description 1
- 102100022637 Proline-rich protein 12 Human genes 0.000 description 1
- 108700003766 Promyelocytic Leukemia Zinc Finger Proteins 0.000 description 1
- 108700017836 Prophet of Pit-1 Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100040638 Protein AF-17 Human genes 0.000 description 1
- 102100036046 Protein CutA Human genes 0.000 description 1
- 102100025198 Protein DBF4 homolog A Human genes 0.000 description 1
- 108090000315 Protein Kinase C Proteins 0.000 description 1
- 102000003923 Protein Kinase C Human genes 0.000 description 1
- 102100030128 Protein L-Myc Human genes 0.000 description 1
- 101710111380 Protein L-Myc Proteins 0.000 description 1
- 102100020876 Protein SCAF11 Human genes 0.000 description 1
- 102100027171 Protein SET Human genes 0.000 description 1
- 101710148582 Protein SET Proteins 0.000 description 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 1
- 108010014651 Proto-Oncogene Protein c-ets-1 Proteins 0.000 description 1
- 102000017012 Proto-Oncogene Protein c-ets-1 Human genes 0.000 description 1
- 102000009096 Proto-Oncogene Proteins c-myb Human genes 0.000 description 1
- 108010087776 Proto-Oncogene Proteins c-myb Proteins 0.000 description 1
- 102100034145 Putative POU domain, class 5, transcription factor 1B Human genes 0.000 description 1
- 102100021168 Putative double homeobox protein 3 Human genes 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- 102000013009 Pyruvate Kinase Human genes 0.000 description 1
- 108020005115 Pyruvate Kinase Proteins 0.000 description 1
- 108091008773 RAR-related orphan receptors γ Proteins 0.000 description 1
- 108091008103 RNA aptamers Proteins 0.000 description 1
- 102100023544 Ras-responsive element-binding protein 1 Human genes 0.000 description 1
- 101710132554 Ras-responsive element-binding protein 1 Proteins 0.000 description 1
- 101100065098 Rattus norvegicus Egr4 gene Proteins 0.000 description 1
- 101100016889 Rattus norvegicus Hes2 gene Proteins 0.000 description 1
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 description 1
- 101100533701 Rattus norvegicus Smad1 gene Proteins 0.000 description 1
- 101100480477 Rattus norvegicus Taar7d gene Proteins 0.000 description 1
- 101100431670 Rattus norvegicus Ybx3 gene Proteins 0.000 description 1
- 230000010799 Receptor Interactions Effects 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 102100021043 Regulatory factor X-associated protein Human genes 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 102100034262 Retinoic acid receptor RXR-gamma Human genes 0.000 description 1
- 102100033909 Retinoic acid receptor beta Human genes 0.000 description 1
- 108091008770 Rev-ErbAß Proteins 0.000 description 1
- 102100030676 Rho GTPase-activating protein 35 Human genes 0.000 description 1
- 102100030757 Rho GTPase-activating protein 42 Human genes 0.000 description 1
- 102000042463 Rho family Human genes 0.000 description 1
- 108091078243 Rho family Proteins 0.000 description 1
- 108091028664 Ribonucleotide Proteins 0.000 description 1
- 102100027482 Ribosome production factor 1 Human genes 0.000 description 1
- 108010039491 Ricin Proteins 0.000 description 1
- 102100025373 Runt-related transcription factor 1 Human genes 0.000 description 1
- 102100025368 Runt-related transcription factor 2 Human genes 0.000 description 1
- 102100025369 Runt-related transcription factor 3 Human genes 0.000 description 1
- 230000018199 S phase Effects 0.000 description 1
- 102100034018 SAM pointed domain-containing Ets transcription factor Human genes 0.000 description 1
- 102100036901 SLC2A4 regulator Human genes 0.000 description 1
- 101700026522 SMAD7 Proteins 0.000 description 1
- 101150020367 SOX11 gene Proteins 0.000 description 1
- 101150073471 SOX14 gene Proteins 0.000 description 1
- 101150106167 SOX9 gene Proteins 0.000 description 1
- 101150097243 SPT16 gene Proteins 0.000 description 1
- 102000004265 STAT2 Transcription Factor Human genes 0.000 description 1
- 108010081691 STAT2 Transcription Factor Proteins 0.000 description 1
- 102000005886 STAT4 Transcription Factor Human genes 0.000 description 1
- 108010019992 STAT4 Transcription Factor Proteins 0.000 description 1
- 102000013968 STAT6 Transcription Factor Human genes 0.000 description 1
- 108010011005 STAT6 Transcription Factor Proteins 0.000 description 1
- 102100024793 SWI/SNF complex subunit SMARCC1 Human genes 0.000 description 1
- 101710169053 SWI/SNF complex subunit SMARCC1 Proteins 0.000 description 1
- 102100025746 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Human genes 0.000 description 1
- 101710199691 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Proteins 0.000 description 1
- 102100024777 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 Human genes 0.000 description 1
- 101710188233 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 Proteins 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 101100333774 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ERR3 gene Proteins 0.000 description 1
- 101100122755 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) NPA3 gene Proteins 0.000 description 1
- 101100528938 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ker1 gene Proteins 0.000 description 1
- 102100020824 Serine-protein kinase ATM Human genes 0.000 description 1
- 108010016797 Sickle Hemoglobin Proteins 0.000 description 1
- 102100021825 Single-minded homolog 2 Human genes 0.000 description 1
- 102100024451 Ski-like protein Human genes 0.000 description 1
- 102100021887 Small RNA 2'-O-methyltransferase Human genes 0.000 description 1
- 101150117830 Sox5 gene Proteins 0.000 description 1
- 108010071698 Spermine synthase Proteins 0.000 description 1
- 102100037616 Spermine synthase Human genes 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 108010049356 Steroid 11-beta-Hydroxylase Proteins 0.000 description 1
- 102100036832 Steroid hormone receptor ERR1 Human genes 0.000 description 1
- 102100036831 Steroid hormone receptor ERR2 Human genes 0.000 description 1
- 102000008078 Sterol Regulatory Element Binding Protein 1 Human genes 0.000 description 1
- 108010074438 Sterol Regulatory Element Binding Protein 2 Proteins 0.000 description 1
- 102100026839 Sterol regulatory element-binding protein 1 Human genes 0.000 description 1
- 102100026841 Sterol regulatory element-binding protein 2 Human genes 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 108010029625 T-Box Domain Protein 2 Proteins 0.000 description 1
- 102100036773 T-box transcription factor TBX19 Human genes 0.000 description 1
- 102100038721 T-box transcription factor TBX2 Human genes 0.000 description 1
- 102100036833 T-box transcription factor TBX20 Human genes 0.000 description 1
- 102100036840 T-box transcription factor TBX21 Human genes 0.000 description 1
- 102100024754 T-box transcription factor TBX4 Human genes 0.000 description 1
- 102100024751 T-box transcription factor TBX6 Human genes 0.000 description 1
- 102100033111 T-cell leukemia homeobox protein 1 Human genes 0.000 description 1
- 102100035207 TATA box-binding protein-associated factor RNA polymerase I subunit D Human genes 0.000 description 1
- 102100036407 Thioredoxin Human genes 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 102000002938 Thrombospondin Human genes 0.000 description 1
- 108060008245 Thrombospondin Proteins 0.000 description 1
- 102100031224 Tonsoku-like protein Human genes 0.000 description 1
- 101710169241 Tonsoku-like protein Proteins 0.000 description 1
- 102100040396 Transcobalamin-1 Human genes 0.000 description 1
- 101710124861 Transcobalamin-1 Proteins 0.000 description 1
- 108010063400 Transcription Factor Brn-3B Proteins 0.000 description 1
- 108010083262 Transcription Factor TFIIA Proteins 0.000 description 1
- 108010083268 Transcription Factor TFIID Proteins 0.000 description 1
- 108010068068 Transcription Factor TFIIIA Proteins 0.000 description 1
- 102100031027 Transcription activator BRG1 Human genes 0.000 description 1
- 102100040393 Transcription elongation regulator 1 Human genes 0.000 description 1
- 102100033121 Transcription factor 21 Human genes 0.000 description 1
- 101710119687 Transcription factor 21 Proteins 0.000 description 1
- 108050005285 Transcription factor 7-like 1 Proteins 0.000 description 1
- 102100026155 Transcription factor A, mitochondrial Human genes 0.000 description 1
- 101710106416 Transcription factor A, mitochondrial Proteins 0.000 description 1
- 102100033348 Transcription factor AP-2-beta Human genes 0.000 description 1
- 102100029373 Transcription factor ATOH1 Human genes 0.000 description 1
- 102100032866 Transcription factor CP2-like protein 1 Human genes 0.000 description 1
- 102100038313 Transcription factor E2-alpha Human genes 0.000 description 1
- 108050002596 Transcription factor E2F5 Proteins 0.000 description 1
- 102100028507 Transcription factor E3 Human genes 0.000 description 1
- 102100028502 Transcription factor EB Human genes 0.000 description 1
- 102100030798 Transcription factor HES-1 Human genes 0.000 description 1
- 102100028336 Transcription factor HIVEP3 Human genes 0.000 description 1
- 101710177551 Transcription factor HIVEP3 Proteins 0.000 description 1
- 102100028509 Transcription factor IIIA Human genes 0.000 description 1
- 102100034738 Transcription factor LBX1 Human genes 0.000 description 1
- 102100035412 Transcription factor NF-E2 45 kDa subunit Human genes 0.000 description 1
- 102100020984 Transcription factor RFX4 Human genes 0.000 description 1
- 102100022435 Transcription factor SOX-13 Human genes 0.000 description 1
- 101710145409 Transcription initiation factor IIA subunit 2 Proteins 0.000 description 1
- 101710165271 Transcription initiation factor IIF subunit alpha Proteins 0.000 description 1
- 101710156229 Transcription initiation factor IIF subunit beta Proteins 0.000 description 1
- 102100035222 Transcription initiation factor TFIID subunit 1 Human genes 0.000 description 1
- 102100022011 Transcription intermediary factor 1-alpha Human genes 0.000 description 1
- 102100035559 Transcriptional activator GLI3 Human genes 0.000 description 1
- 102100030836 Transcriptional adapter 3 Human genes 0.000 description 1
- 102100029898 Transcriptional enhancer factor TEF-1 Human genes 0.000 description 1
- 102100035148 Transcriptional enhancer factor TEF-3 Human genes 0.000 description 1
- 102100035147 Transcriptional enhancer factor TEF-5 Human genes 0.000 description 1
- 102100027671 Transcriptional repressor CTCF Human genes 0.000 description 1
- 102100039362 Transducin-like enhancer protein 1 Human genes 0.000 description 1
- 102100032762 Transformation/transcription domain-associated protein Human genes 0.000 description 1
- 102100033459 Transforming growth factor beta-1-induced transcript 1 protein Human genes 0.000 description 1
- 101710188061 Transforming growth factor beta-1-induced transcript 1 protein Proteins 0.000 description 1
- 102100027172 Transposon Hsmar1 transposase Human genes 0.000 description 1
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 1
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 1
- 102000000504 Tumor Suppressor p53-Binding Protein 1 Human genes 0.000 description 1
- 208000035896 Twin-reversed arterial perfusion sequence Diseases 0.000 description 1
- 108010079194 Type C Phospholipases Proteins 0.000 description 1
- 102100021575 Tyrosine-protein kinase BAZ1B Human genes 0.000 description 1
- 102100040103 Upstream stimulatory factor 2 Human genes 0.000 description 1
- 102100040065 Upstream-binding protein 1 Human genes 0.000 description 1
- DJJCXFVJDGTHFX-UHFFFAOYSA-N Uridinemonophosphate Natural products OC1C(O)C(COP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-UHFFFAOYSA-N 0.000 description 1
- 108020005202 Viral DNA Proteins 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- 108010035430 X-Box Binding Protein 1 Proteins 0.000 description 1
- 102100038151 X-box-binding protein 1 Human genes 0.000 description 1
- 102100036973 X-ray repair cross-complementing protein 5 Human genes 0.000 description 1
- 101710124921 X-ray repair cross-complementing protein 5 Proteins 0.000 description 1
- 102100036976 X-ray repair cross-complementing protein 6 Human genes 0.000 description 1
- 101710124907 X-ray repair cross-complementing protein 6 Proteins 0.000 description 1
- LRFVTYWOQMYALW-UHFFFAOYSA-N Xanthine Natural products O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 1
- 101000988661 Xenopus laevis Hepatocyte nuclear factor 1-alpha-A Proteins 0.000 description 1
- 101000988662 Xenopus laevis Hepatocyte nuclear factor 1-alpha-B Proteins 0.000 description 1
- 101100460507 Xenopus laevis nkx-2.5 gene Proteins 0.000 description 1
- 101100405120 Xenopus laevis nr4a1 gene Proteins 0.000 description 1
- 101100351021 Xenopus laevis pax5 gene Proteins 0.000 description 1
- 102100027644 YY1-associated factor 2 Human genes 0.000 description 1
- 108010016200 Zinc Finger Protein GLI1 Proteins 0.000 description 1
- 108010088665 Zinc Finger Protein Gli2 Proteins 0.000 description 1
- 102100040314 Zinc finger and BTB domain-containing protein 16 Human genes 0.000 description 1
- 102100040761 Zinc finger and BTB domain-containing protein 17 Human genes 0.000 description 1
- 102100021129 Zinc finger and BTB domain-containing protein 24 Human genes 0.000 description 1
- 102100026583 Zinc finger and SCAN domain-containing protein 26 Human genes 0.000 description 1
- 101710185494 Zinc finger protein Proteins 0.000 description 1
- 102100023573 Zinc finger protein 124 Human genes 0.000 description 1
- 102100023575 Zinc finger protein 133 Human genes 0.000 description 1
- 102100023389 Zinc finger protein 143 Human genes 0.000 description 1
- 102100040812 Zinc finger protein 174 Human genes 0.000 description 1
- 102100026316 Zinc finger protein 281 Human genes 0.000 description 1
- 102100024672 Zinc finger protein 35 Human genes 0.000 description 1
- 102100040317 Zinc finger protein 354A Human genes 0.000 description 1
- 101710160586 Zinc finger protein 37 Proteins 0.000 description 1
- 102100023552 Zinc finger protein 37 homolog Human genes 0.000 description 1
- 102100024666 Zinc finger protein 43 Human genes 0.000 description 1
- 102100024660 Zinc finger protein 44 Human genes 0.000 description 1
- 102100035868 Zinc finger protein 444 Human genes 0.000 description 1
- 102100024670 Zinc finger protein 45 Human genes 0.000 description 1
- 102100035817 Zinc finger protein 629 Human genes 0.000 description 1
- 102100040726 Zinc finger protein 7 Human genes 0.000 description 1
- 102100040710 Zinc finger protein 76 Human genes 0.000 description 1
- 102100023597 Zinc finger protein 816 Human genes 0.000 description 1
- 102100037798 Zinc finger protein Aiolos Human genes 0.000 description 1
- 102100035535 Zinc finger protein GLI1 Human genes 0.000 description 1
- 102100035558 Zinc finger protein GLI2 Human genes 0.000 description 1
- 102100025884 Zinc finger protein GLIS2 Human genes 0.000 description 1
- 102100032571 Zinc finger protein PLAGL2 Human genes 0.000 description 1
- 102100036606 Zinc finger protein ZFAT Human genes 0.000 description 1
- 102100023492 Zinc finger protein ZIC 2 Human genes 0.000 description 1
- 102100025105 Zinc fingers and homeoboxes protein 1 Human genes 0.000 description 1
- INAPMGSXUVUWAF-GCVPSNMTSA-N [(2r,3s,5r,6r)-2,3,4,5,6-pentahydroxycyclohexyl] dihydrogen phosphate Chemical compound OC1[C@H](O)[C@@H](O)C(OP(O)(O)=O)[C@H](O)[C@@H]1O INAPMGSXUVUWAF-GCVPSNMTSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 210000005221 acidic domain Anatomy 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 1
- 108060000200 adenylate cyclase Proteins 0.000 description 1
- 102000030621 adenylate cyclase Human genes 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 238000011256 aggressive treatment Methods 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- PPQRONHOSHZGFQ-LMVFSUKVSA-N aldehydo-D-ribose 5-phosphate Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PPQRONHOSHZGFQ-LMVFSUKVSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 239000002870 angiogenesis inducing agent Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 239000000074 antisense oligonucleotide Substances 0.000 description 1
- 238000012230 antisense oligonucleotides Methods 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 101150024767 arnT gene Proteins 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 239000012131 assay buffer Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 150000004663 bisphosphonates Chemical class 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 201000007295 breast benign neoplasm Diseases 0.000 description 1
- 201000003149 breast fibroadenoma Diseases 0.000 description 1
- FPJLPVUJBKKQCI-UHFFFAOYSA-N c1cc[pH]c1.OCC(O)CO Chemical compound c1cc[pH]c1.OCC(O)CO FPJLPVUJBKKQCI-UHFFFAOYSA-N 0.000 description 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 1
- 229960004015 calcitonin Drugs 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 210000000234 capsid Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 101150073031 cdk2 gene Proteins 0.000 description 1
- 230000011712 cell development Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000007248 cellular mechanism Effects 0.000 description 1
- 230000004700 cellular uptake Effects 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 201000010989 colorectal carcinoma Diseases 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000009918 complex formation Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 229960004544 cortisone Drugs 0.000 description 1
- 239000007819 coupling partner Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- IERHLVCPSMICTF-XVFCMESISA-N cytidine 5'-monophosphate Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O1 IERHLVCPSMICTF-XVFCMESISA-N 0.000 description 1
- 230000002559 cytogenic effect Effects 0.000 description 1
- 229940104302 cytosine Drugs 0.000 description 1
- 230000003436 cytoskeletal effect Effects 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 230000001085 cytostatic effect Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000010511 deprotection reaction Methods 0.000 description 1
- 201000005620 dermis tumor Diseases 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- OZRNSSUDZOLUSN-LBPRGKRZSA-N dihydrofolic acid Chemical compound N=1C=2C(=O)NC(N)=NC=2NCC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OZRNSSUDZOLUSN-LBPRGKRZSA-N 0.000 description 1
- QBSJHOGDIUQWTH-UHFFFAOYSA-N dihydrolanosterol Natural products CC(C)CCCC(C)C1CCC2(C)C3=C(CCC12C)C4(C)CCC(C)(O)C(C)(C)C4CC3 QBSJHOGDIUQWTH-UHFFFAOYSA-N 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 230000002900 effect on cell Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000012149 elution buffer Substances 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 108010018033 endothelial PAS domain-containing protein 1 Proteins 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 108010017796 epoxidase Proteins 0.000 description 1
- 108010089558 erythroid Kruppel-like factor Proteins 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 208000021045 exocrine pancreatic carcinoma Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000001215 fluorescent labelling Methods 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 101150064107 fosB gene Proteins 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 230000008303 genetic mechanism Effects 0.000 description 1
- 230000004034 genetic regulation Effects 0.000 description 1
- 150000002305 glucosylceramides Chemical class 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 239000003630 growth substance Substances 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 108010072499 hemoglobin Barcelona Proteins 0.000 description 1
- 108010051149 hemoglobin Bart's Proteins 0.000 description 1
- 108010089521 hemoglobin Bunbury Proteins 0.000 description 1
- 108010047389 hemoglobin D Proteins 0.000 description 1
- 108010078059 hemoglobin D Punjab Proteins 0.000 description 1
- 108010011344 hemoglobin Gower Proteins 0.000 description 1
- 108010042919 hemoglobin Indianapolis Proteins 0.000 description 1
- 108010032553 hemoglobin Kempsey Proteins 0.000 description 1
- 108010022474 hemoglobin Kenya Proteins 0.000 description 1
- 108010057485 hemoglobin Lepore Proteins 0.000 description 1
- 108010041854 hemoglobin Seattle Proteins 0.000 description 1
- 108010079102 hemoglobin Torino Proteins 0.000 description 1
- 108010090136 hemoglobin Wayne Proteins 0.000 description 1
- 108010080975 hemoglobin York Proteins 0.000 description 1
- 108010059775 hemoglobin Zurich Proteins 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
- 108010021685 homeobox protein HOXA13 Proteins 0.000 description 1
- 101150118036 hoxa9a gene Proteins 0.000 description 1
- 101150019766 hoxa9b gene Proteins 0.000 description 1
- 102000051196 human CFAP410 Human genes 0.000 description 1
- 102000053413 human GT-IC Human genes 0.000 description 1
- 108700042383 human GT-IC Proteins 0.000 description 1
- 102000049285 human KMT2A Human genes 0.000 description 1
- 102000057381 human MYBBP1A Human genes 0.000 description 1
- 102000048703 human PRELP Human genes 0.000 description 1
- 102000043323 human PSIP1 Human genes 0.000 description 1
- 102000048577 human RAD51B Human genes 0.000 description 1
- 102000052029 human ZHX1 Human genes 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 238000009802 hysterectomy Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000002998 immunogenetic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000008611 intercellular interaction Effects 0.000 description 1
- 108010051920 interferon regulatory factor-4 Proteins 0.000 description 1
- 108010051621 interferon regulatory factor-8 Proteins 0.000 description 1
- 210000003963 intermediate filament Anatomy 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 238000011813 knockout mouse model Methods 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 229940058690 lanosterol Drugs 0.000 description 1
- 230000001795 light effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 201000005296 lung carcinoma Diseases 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 102100035856 mRNA-decapping enzyme 1A Human genes 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000036212 malign transformation Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 101150029117 meox2 gene Proteins 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- ONCZDRURRATYFI-QTCHDTBASA-N methyl (2z)-2-methoxyimino-2-[2-[[(e)-1-[3-(trifluoromethyl)phenyl]ethylideneamino]oxymethyl]phenyl]acetate Chemical compound CO\N=C(/C(=O)OC)C1=CC=CC=C1CO\N=C(/C)C1=CC=CC(C(F)(F)F)=C1 ONCZDRURRATYFI-QTCHDTBASA-N 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 210000002464 muscle smooth vascular Anatomy 0.000 description 1
- 101150094258 mxi1 gene Proteins 0.000 description 1
- 108010084677 myogenic factor 6 Proteins 0.000 description 1
- UPSFMJHZUCSEHU-JYGUBCOQSA-N n-[(2s,3r,4r,5s,6r)-2-[(2r,3s,4r,5r,6s)-5-acetamido-4-hydroxy-2-(hydroxymethyl)-6-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide Chemical compound CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](OC=2C=C3OC(=O)C=C(C)C3=CC=2)O[C@@H]1CO UPSFMJHZUCSEHU-JYGUBCOQSA-N 0.000 description 1
- MRWXACSTFXYYMV-FDDDBJFASA-N nebularine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC=C2N=C1 MRWXACSTFXYYMV-FDDDBJFASA-N 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 108010010765 nuclear factor-jun Proteins 0.000 description 1
- 229940127073 nucleoside analogue Drugs 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 231100000590 oncogenic Toxicity 0.000 description 1
- 230000002246 oncogenic effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 108010018738 parvovirus initiation factor p96 subunit Proteins 0.000 description 1
- 230000009589 pathological growth Effects 0.000 description 1
- 101150098999 pax8 gene Proteins 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 description 1
- 108091008765 peroxisome proliferator-activated receptors β/δ Proteins 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000004713 phosphodiesters Chemical class 0.000 description 1
- 108091000115 phosphomannomutase Proteins 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- QVLTXCYWHPZMCA-UHFFFAOYSA-N po4-po4 Chemical compound OP(O)(O)=O.OP(O)(O)=O QVLTXCYWHPZMCA-UHFFFAOYSA-N 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 108010008370 protein phosphatase 4 Proteins 0.000 description 1
- 230000012743 protein tagging Effects 0.000 description 1
- 239000002212 purine nucleoside Substances 0.000 description 1
- ZLIBICFPKPWGIZ-UHFFFAOYSA-N pyrimethanil Chemical compound CC1=CC(C)=NC(NC=2C=CC=CC=2)=N1 ZLIBICFPKPWGIZ-UHFFFAOYSA-N 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 239000011535 reaction buffer Substances 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 108091008761 retinoic acid receptors β Proteins 0.000 description 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000009291 secondary effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 230000009919 sequestration Effects 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 102000030938 small GTPase Human genes 0.000 description 1
- 108060007624 small GTPase Proteins 0.000 description 1
- 102100024840 snRNA-activating protein complex subunit 1 Human genes 0.000 description 1
- 102100022779 snRNA-activating protein complex subunit 3 Human genes 0.000 description 1
- 101150077014 sox10 gene Proteins 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 108010067247 tacrolimus binding protein 4 Proteins 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 101150115978 tbx5 gene Proteins 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 108020002982 thioesterase Proteins 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 108060008226 thioredoxin Proteins 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 108010014678 transcription factor TFIIF Proteins 0.000 description 1
- 108010071511 transcriptional intermediary factor 1 Proteins 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000000439 tumor marker Substances 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- DJJCXFVJDGTHFX-XVFCMESISA-N uridine 5'-monophosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-XVFCMESISA-N 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 230000007733 viral latency Effects 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 238000012982 x-ray structure analysis Methods 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005020874 | 2005-05-04 | ||
| PCT/EP2006/004180 WO2006117217A2 (de) | 2005-05-04 | 2006-05-04 | Neue verwendung von spiegelmeren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007013760A true MX2007013760A (es) | 2008-01-28 |
Family
ID=36928624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007013760A MX2007013760A (es) | 2005-05-04 | 2006-05-04 | Uso novedoso de spiegelmers. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8497250B2 (enExample) |
| EP (2) | EP1877069A2 (enExample) |
| JP (2) | JP2008540363A (enExample) |
| KR (2) | KR101418369B1 (enExample) |
| CN (2) | CN104293780A (enExample) |
| AU (1) | AU2006243334A1 (enExample) |
| BR (1) | BRPI0610367A2 (enExample) |
| CA (1) | CA2607185A1 (enExample) |
| MX (1) | MX2007013760A (enExample) |
| SG (1) | SG161311A1 (enExample) |
| WO (1) | WO2006117217A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
| WO2008105773A2 (en) | 2006-03-31 | 2008-09-04 | Massachusetts Institute Of Technology | System for targeted delivery of therapeutic agents |
| JP5630998B2 (ja) | 2006-05-15 | 2014-11-26 | マサチューセッツ インスティテュート オブ テクノロジー | 機能的粒子のためのポリマー |
| WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| US9217129B2 (en) | 2007-02-09 | 2015-12-22 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
| WO2008124639A2 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Poly (amino acid) targeting moieties |
| BRPI0817664A2 (pt) | 2007-10-12 | 2015-03-24 | Massachusetts Inst Technology | Nanopartículas, método para preparar nanopartículas e método para tratar terapeuticamente ou profilaticamente um indivíduo |
| US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| WO2010138193A2 (en) | 2009-05-27 | 2010-12-02 | Selecta Biosciences, Inc. | Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents |
| US20130149314A1 (en) * | 2010-02-09 | 2013-06-13 | Jörn Bullerdiek | p19Arf, HMGA2 and MDM2 For Use in the Diagnosis and Treatment of Aberrant Cell Growth |
| WO2011131371A1 (en) | 2010-04-21 | 2011-10-27 | Noxxon Pharma Ag | Lipid binding nucleic acids |
| US20110293700A1 (en) | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| CN102375064A (zh) * | 2010-08-26 | 2012-03-14 | 杭州华得森生物技术有限公司 | 用酶联免疫法检测人体中hmga2含量的体外诊断试剂盒 |
| DE102010056610A1 (de) * | 2010-12-31 | 2012-07-05 | Volker A. Erdmann | Pharmazeutische Zusammensetzung enthaltend L-DNA |
| CN109172819A (zh) | 2011-07-29 | 2019-01-11 | 西莱克塔生物科技公司 | 产生体液和细胞毒性t淋巴细胞(ctl)免疫应答的合成纳米载体 |
| JP2014533098A (ja) * | 2011-10-21 | 2014-12-11 | ノクソン・ファルマ・アクチエンゲゼルシャフト | グルカゴン結合核酸 |
| SG11201403769YA (en) * | 2012-01-10 | 2014-07-30 | Noxxon Pharma Ag | Nucleic acids specifically binding cgrp |
| CN103566377A (zh) | 2012-07-18 | 2014-02-12 | 上海博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| US9233119B2 (en) * | 2012-09-27 | 2016-01-12 | Miami University | Use of HGMA-targeted phosphorothioate DNA aptamers to suppress carcinogenic activity and increase sensitivity to chemotherapy agents in human cancer cells |
| WO2014193964A2 (en) * | 2013-05-28 | 2014-12-04 | Marsha Rosner | Prognostic and predictive breast cancer signature |
| US10679730B2 (en) | 2013-05-28 | 2020-06-09 | The University Of Chicago | Prognostic and predictive breast cancer signature |
| CA2936377A1 (en) | 2014-01-10 | 2015-07-16 | Shanghai Birdie Biotech, Inc. | Compounds and compositions for treating egfr expressing tumors |
| EP4001311B1 (en) | 2014-07-09 | 2025-11-05 | Birdie Biopharmaceuticals Inc. | Anti-pd-l1/pd-1 combinations for treating tumors |
| CN112546231A (zh) | 2014-07-09 | 2021-03-26 | 博笛生物科技有限公司 | 用于治疗癌症的联合治疗组合物和联合治疗方法 |
| KR101755617B1 (ko) | 2014-07-23 | 2017-07-10 | 한국과학기술연구원 | 삼차원 자기조립 핵산 나노입자 구조를 갖는 약물전달체 |
| CN112546238A (zh) | 2014-09-01 | 2021-03-26 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| EP3233174B1 (en) * | 2014-12-19 | 2021-03-31 | Kemin Industries, Inc. | Intraocular delivery of bioactive molecules using iontophoresis |
| CA2985818A1 (en) | 2015-05-31 | 2016-12-08 | Curegenix Corporation | Combination compositions comprising an antagonist of porcupine and a pd-l/pd-1 axis antagonist for immunotherapy |
| EP3347051A4 (en) | 2015-09-10 | 2019-04-24 | Affigen, Inc. | SEQUENCING SELECTING TUMOR THEROSTICAS |
| DE17829597T1 (de) * | 2016-11-30 | 2019-12-05 | Noxxon Pharma Ag | Verfahren zur polyalkoxylierung von nukleinsäuren zur rückgewinnung und wiederverwendung einer überschüssigen polyalkoxylierungsreagenz |
| US20220033813A1 (en) * | 2018-09-11 | 2022-02-03 | The Texas A&M University System | L-oligonucleotide inhibitors of polycomb repressive complex 2 (prc2) |
| CN115997124A (zh) * | 2020-04-30 | 2023-04-21 | 维兰尼迪科技有限责任公司 | 用于检测生物或化学实体或事件的分子导线 |
| CN112725438B (zh) * | 2021-02-05 | 2023-08-22 | 深圳市宝安区妇幼保健院 | 子宫内膜息肉甲基化标志物组合、检测试剂盒及应用 |
| CN114807183B (zh) * | 2021-12-06 | 2023-06-02 | 西藏自治区农牧科学院农业研究所 | 一种青稞矢车菊素氧甲基转移酶基因的新用途 |
| CN118311277B (zh) * | 2024-06-11 | 2024-12-31 | 北京卫未科学技术有限公司 | 一种用于癌症早筛和辅助诊断的试剂盒及其应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622828A (en) * | 1990-06-11 | 1997-04-22 | Nexstar Pharmaceuticals, Inc. | High-affinity oligonucleotide ligands to secretory phospholipase A2 (sPLA2) |
| EP1793006A3 (en) * | 1993-09-08 | 2007-08-22 | Gilead Sciences, Inc. | Nucleic acid ligands and improved methods for producing the same |
| DE69638099D1 (de) * | 1995-05-04 | 2010-01-28 | Gilead Sciences Inc | Nukleinsäureligand-komplexe |
| US5780611A (en) * | 1995-09-15 | 1998-07-14 | Ramareddy Venkata Guntaka | Oligomers which inhibit expression of collagen genes |
| US6171779B1 (en) | 1996-07-12 | 2001-01-09 | University Of Medicine & Dentistry Of New Jersey | HMGI proteins in cancer |
| JP2001504448A (ja) * | 1996-08-30 | 2001-04-03 | フュルステ,イェンス,ペーター | 核酸の鏡面対称選択および進化 |
| DE19726186A1 (de) * | 1997-06-20 | 1998-12-24 | Boehringer Ingelheim Int | Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen |
| JP2004510829A (ja) * | 2000-10-09 | 2004-04-08 | バイエル アクチェンゲゼルシャフト | 核酸を細胞内に転移させるための複合体 |
| DE10118452A1 (de) * | 2001-04-12 | 2002-10-31 | Joern Bullerdiek | Nukleinsäuresequenzen von Hyperplasien und Tumoren der Schilddrüse |
| ES2346640T4 (es) * | 2001-10-26 | 2011-04-26 | Noxxon Pharma Ag | Ácido l-nucleico modificado. |
| WO2003051383A2 (de) * | 2001-12-19 | 2003-06-26 | Alcedo Biotech Gmbh | Verwendung von hmgb-proteinen und dafür codierenden nukleinsäuren |
| DE10211558A1 (de) * | 2002-03-15 | 2003-10-09 | Noxxon Pharma Ag | Neue Formen RNAi |
| WO2003094973A1 (de) * | 2002-05-08 | 2003-11-20 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Mittel und verfahren zum transport von biologisch aktiven molekülen in zellen |
| US7250496B2 (en) * | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| WO2004061456A2 (de) * | 2003-01-03 | 2004-07-22 | Alcedo Biotech Gmbh | Verwendungen von hmgb, hmgn, hmga proteinen |
| KR20060015505A (ko) * | 2003-04-13 | 2006-02-17 | 엔존 파마슈티컬즈, 인코포레이티드 | 올리고뉴클레오타이드 전구약물 |
| EP1628636A1 (de) * | 2003-05-09 | 2006-03-01 | Novosom AG | Injizierbare liposomale depots zum wirkstoffdelivery |
| CA2526853A1 (en) * | 2003-05-23 | 2005-03-03 | Board Of Regents - The University Of Texas System | Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting ap-1 transcription factors |
| US7727969B2 (en) * | 2003-06-06 | 2010-06-01 | Massachusetts Institute Of Technology | Controlled release nanoparticle having bound oligonucleotide for targeted delivery |
| WO2005072703A2 (en) * | 2004-01-26 | 2005-08-11 | Control Delivery Systems, Inc. | Controlled and sustained delivery of nucleic acid-based therapeutic agents |
| WO2006069782A2 (en) * | 2004-12-27 | 2006-07-06 | Silence Therapeutics Ag. | Lipid complexes coated with peg and their use |
-
2006
- 2006-05-04 CA CA002607185A patent/CA2607185A1/en not_active Abandoned
- 2006-05-04 MX MX2007013760A patent/MX2007013760A/es unknown
- 2006-05-04 BR BRPI0610367-7A patent/BRPI0610367A2/pt not_active IP Right Cessation
- 2006-05-04 KR KR1020077025457A patent/KR101418369B1/ko not_active Expired - Fee Related
- 2006-05-04 EP EP06742799A patent/EP1877069A2/de not_active Ceased
- 2006-05-04 CN CN201410395203.5A patent/CN104293780A/zh active Pending
- 2006-05-04 SG SG201002837-1A patent/SG161311A1/en unknown
- 2006-05-04 JP JP2008509380A patent/JP2008540363A/ja active Pending
- 2006-05-04 CN CN200680024585.4A patent/CN101217967B/zh not_active Expired - Fee Related
- 2006-05-04 WO PCT/EP2006/004180 patent/WO2006117217A2/de not_active Ceased
- 2006-05-04 KR KR1020147008135A patent/KR101418367B1/ko not_active Expired - Fee Related
- 2006-05-04 US US11/913,526 patent/US8497250B2/en not_active Expired - Fee Related
- 2006-05-04 AU AU2006243334A patent/AU2006243334A1/en not_active Abandoned
- 2006-05-04 EP EP09016125A patent/EP2206501A3/de not_active Withdrawn
-
2013
- 2013-06-20 JP JP2013129800A patent/JP5766750B2/ja not_active Expired - Fee Related
- 2013-07-30 US US13/953,797 patent/US9074214B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1877069A2 (de) | 2008-01-16 |
| EP2206501A2 (de) | 2010-07-14 |
| US8497250B2 (en) | 2013-07-30 |
| WO2006117217A3 (de) | 2007-08-09 |
| CN101217967A (zh) | 2008-07-09 |
| KR101418369B1 (ko) | 2014-07-24 |
| CN101217967B (zh) | 2014-09-10 |
| JP2013224319A (ja) | 2013-10-31 |
| US20130337049A1 (en) | 2013-12-19 |
| WO2006117217A2 (de) | 2006-11-09 |
| US20090192100A1 (en) | 2009-07-30 |
| BRPI0610367A2 (pt) | 2010-06-15 |
| CN104293780A (zh) | 2015-01-21 |
| US9074214B2 (en) | 2015-07-07 |
| AU2006243334A1 (en) | 2006-11-09 |
| KR20080009276A (ko) | 2008-01-28 |
| CA2607185A1 (en) | 2006-11-09 |
| SG161311A1 (en) | 2010-05-27 |
| JP2008540363A (ja) | 2008-11-20 |
| KR101418367B1 (ko) | 2014-07-25 |
| EP2206501A3 (de) | 2010-09-29 |
| KR20140042941A (ko) | 2014-04-07 |
| JP5766750B2 (ja) | 2015-08-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9074214B2 (en) | Use of spiegelmers | |
| Baluapuri et al. | MYC recruits SPT5 to RNA polymerase II to promote processive transcription elongation | |
| Moonen et al. | KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress | |
| Hollensen et al. | circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation | |
| Wall et al. | Methylarginines within the RGG-motif region of hnRNP A1 affect its IRES trans-acting factor activity and are required for hnRNP A1 stress granule localization and formation | |
| Peng et al. | A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor α-dependent transcriptional activation and breast carcinogenesis | |
| Ma et al. | circACTA2 mediates Ang II-induced VSMC senescence by modulation of the interaction of ILF3 with CDK4 mRNA | |
| Li et al. | FMRP regulates miR196a-mediated repression of HOXB8 via interaction with the AGO2 MID domain | |
| US12410237B2 (en) | Methods for purifying proteins having a tubulin carboxypeptidase activity and peptidic based inhibitors thereof | |
| Shinji et al. | Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin | |
| Ni et al. | An inducible long noncoding RNA, LncZFHX2, facilitates DNA repair to mediate osteoarthritis pathology | |
| Lista et al. | DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence | |
| Wang et al. | PRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub | |
| AU2012241062A1 (en) | Novel use of spiegelmers | |
| HK1119388A (en) | Novel use of spiegelmers | |
| Barsoum et al. | Sequential deregulation of histone marks, chromatin accessibility and gene expression in response to PROTAC-induced degradation of ASH2L | |
| CN116970694B (zh) | miR-9及其类似物在制备诊断和/或治疗细胞炎症的药物中的应用 | |
| CN116769828B (zh) | 调控nrf2转录因子活性的方法 | |
| Ryu et al. | Reversible acetylation modulates p54nrb/NONO-mediated expression of the interleukin 8 gene | |
| Lett | Coilin: A Regulator of Post-Translational Modifications | |
| Martín García et al. | Alternative splicing regulation of cell-cycle genes by SPF45/SR140/CHERP complex controls cell proliferation | |
| Swahn | Role of Epithelial-Selective ETS Factors Mapping to Chr11p13 in Human Airway Epithelial Health | |
| Kinnunen | Transcription factor interactions and environment in wild type and pathogenic variants | |
| Lourenço | Role of SP1 and PADI2 during Oligodendocyte Diffferentiation Enhanced by Mechanotransduction | |
| O'Dwyer | Transcription factors induce different stem cell states through distinct pioneer, collaborative and competitive interactions |