MX2007012688A - Terapia de combinacion para el cancer con compuestos de bis(tiohidrazida) amida. - Google Patents
Terapia de combinacion para el cancer con compuestos de bis(tiohidrazida) amida.Info
- Publication number
- MX2007012688A MX2007012688A MX2007012688A MX2007012688A MX2007012688A MX 2007012688 A MX2007012688 A MX 2007012688A MX 2007012688 A MX2007012688 A MX 2007012688A MX 2007012688 A MX2007012688 A MX 2007012688A MX 2007012688 A MX2007012688 A MX 2007012688A
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- optionally substituted
- mol
- bis
- bonded
- Prior art date
Links
- -1 amide compounds Chemical class 0.000 title 1
- 238000011275 oncology therapy Methods 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 229940123237 Taxane Drugs 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67213905P | 2005-04-15 | 2005-04-15 | |
| PCT/US2006/014531 WO2006113695A1 (en) | 2005-04-15 | 2006-04-13 | Combination cancer therapy with bis(thiohydrazide) amide compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007012688A true MX2007012688A (es) | 2008-03-14 |
Family
ID=36694110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007012688A MX2007012688A (es) | 2005-04-15 | 2006-04-13 | Terapia de combinacion para el cancer con compuestos de bis(tiohidrazida) amida. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8017654B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1877048A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2008536875A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2006236378B2 (cg-RX-API-DMAC10.html) |
| BR (1) | BRPI0610219A2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2604907A1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL186662A (cg-RX-API-DMAC10.html) |
| MX (1) | MX2007012688A (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ562572A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2006113695A1 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA200708703B (cg-RX-API-DMAC10.html) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI252847B (en) * | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| TWI332943B (en) | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI330079B (en) | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
| US7385084B2 (en) * | 2004-06-23 | 2008-06-10 | Synta Pharmaceutical Corp. | Bis(thio-hydrazide amide) salts for treatment of cancers |
| AU2005306471B2 (en) | 2004-11-19 | 2009-12-17 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amides) for increasing Hsp70 expression |
| EP1877048A1 (en) | 2005-04-15 | 2008-01-16 | Synta Pharmaceuticals Corporation | Combination cancer therapy with bis(thiohydrazide) amide compounds |
| WO2006113493A2 (en) * | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of determining cancer prognosis via natural killer cell activity |
| MX2007014314A (es) | 2005-05-16 | 2008-02-11 | Synta Pharmaceuticals Corp | Sintesis de sales de bis(tio-hidrazida amida). |
| MX2008002152A (es) | 2005-08-16 | 2008-04-19 | Synta Pharmaceuticals Corp | Formulacion de bis(tio-hidrazida amida. |
| AU2007288336B2 (en) * | 2006-08-21 | 2011-04-21 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
| KR20090045354A (ko) | 2006-08-21 | 2009-05-07 | 신타 파마슈티칼스 코프. | 증식성 장애를 치료하기 위한 화합물 |
| US20100068174A1 (en) * | 2006-08-21 | 2010-03-18 | Synta Pharmaceuticals Corp. | Combination with bis (thiohydrazide amides) for treating cancer |
| AU2007288340A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) for treating melanoma |
| WO2008027445A2 (en) * | 2006-08-31 | 2008-03-06 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
| EP2061430A2 (en) * | 2006-09-11 | 2009-05-27 | Synta Pharmaceuticals Corporation | Bis (thiohydrazide amides) formulation |
| WO2008033494A2 (en) | 2006-09-15 | 2008-03-20 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
| US8482732B2 (en) * | 2007-10-01 | 2013-07-09 | Maskless Lithography, Inc. | Alignment system for various materials and material flows |
| US8618170B2 (en) | 2007-11-09 | 2013-12-31 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
| WO2009105257A1 (en) | 2008-02-21 | 2009-08-27 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US8633323B2 (en) * | 2008-03-31 | 2014-01-21 | Synta Pharmaceuticals Corp. | Process for preparing bis(thiohydrazide amides) |
| BRPI0919720A2 (pt) | 2008-10-22 | 2015-12-08 | Synta Pharmaceuticals Corp | complexos de metal de transição de compostos bis-[tio hidrazida amida |
| CN102256949B (zh) | 2008-10-22 | 2014-09-24 | 辛塔医药品有限公司 | 双[硫代酰肼酰胺]化合物的过渡金属络合物 |
| US8525776B2 (en) * | 2008-10-27 | 2013-09-03 | Lenovo (Singapore) Pte. Ltd | Techniques for controlling operation of a device with a virtual touchscreen |
| US8680100B2 (en) | 2008-12-01 | 2014-03-25 | Synta Pharmaceuticals Corp. | Sulfonylhydrazide compounds for treating proliferative disorders |
| WO2011069159A2 (en) | 2009-12-04 | 2011-06-09 | Synta Pharmaceuticals Corp. | Bis[thiohydrazide amide] compounds for treating leukemia |
| WO2011133673A1 (en) | 2010-04-20 | 2011-10-27 | Synta Pharmaceuticals Corp. | Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers |
| EP2776021A1 (en) * | 2011-11-10 | 2014-09-17 | Synta Pharmaceuticals Corp. | Administration of a bis(thiohydrazide amide) compound for treating cancers |
| WO2013103795A1 (en) | 2012-01-05 | 2013-07-11 | The Board Of Trustees Of The Leland Stanford Junior University | Bis (thiohydrazide amide) compounds for treating cancers |
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| JP2010503674A (ja) | 2006-09-14 | 2010-02-04 | シンタ ファーマシューティカルズ コーポレーション | 血管形成治療用化合物 |
| WO2008033494A2 (en) | 2006-09-15 | 2008-03-20 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
| WO2008060572A1 (en) * | 2006-11-14 | 2008-05-22 | Xenoport, Inc. | Use of gabapentin and pregabalin prodrugs for treating tinnitus |
| US20090093538A1 (en) | 2007-01-03 | 2009-04-09 | Synta Pharmaceuticals Corp | Method for treating cancer |
| US8093425B2 (en) | 2007-04-30 | 2012-01-10 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US8729111B2 (en) | 2007-08-07 | 2014-05-20 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US8618170B2 (en) | 2007-11-09 | 2013-12-31 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
| EP2225201A2 (en) | 2007-11-28 | 2010-09-08 | Synta Pharmaceuticals Corp. | Polymorphs of n-malonyl-bis(n'-methyl-n'-thiobenzoylhydrazide) |
| TW200940050A (en) | 2007-11-28 | 2009-10-01 | Synta Pharmaceuticals Corp | Polymorphs of N-malonyl-bis(N'-methyl-N'-thiobenzoylhydrazide) |
-
2006
- 2006-04-13 EP EP06750538A patent/EP1877048A1/en not_active Withdrawn
- 2006-04-13 AU AU2006236378A patent/AU2006236378B2/en not_active Ceased
- 2006-04-13 BR BRPI0610219-0A patent/BRPI0610219A2/pt not_active IP Right Cessation
- 2006-04-13 MX MX2007012688A patent/MX2007012688A/es active IP Right Grant
- 2006-04-13 US US11/918,357 patent/US8017654B2/en not_active Expired - Fee Related
- 2006-04-13 CA CA002604907A patent/CA2604907A1/en not_active Abandoned
- 2006-04-13 JP JP2008506821A patent/JP2008536875A/ja active Pending
- 2006-04-13 WO PCT/US2006/014531 patent/WO2006113695A1/en not_active Ceased
- 2006-04-13 NZ NZ562572A patent/NZ562572A/en not_active IP Right Cessation
-
2007
- 2007-10-11 ZA ZA200708703A patent/ZA200708703B/xx unknown
- 2007-10-15 IL IL186662A patent/IL186662A/en not_active IP Right Cessation
-
2011
- 2011-09-12 US US13/230,315 patent/US20120232134A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006236378B2 (en) | 2010-12-02 |
| EP1877048A1 (en) | 2008-01-16 |
| US8017654B2 (en) | 2011-09-13 |
| IL186662A (en) | 2014-01-30 |
| WO2006113695A1 (en) | 2006-10-26 |
| BRPI0610219A2 (pt) | 2010-06-08 |
| CA2604907A1 (en) | 2006-10-26 |
| NZ562572A (en) | 2011-01-28 |
| JP2008536875A (ja) | 2008-09-11 |
| ZA200708703B (en) | 2008-11-26 |
| US20120232134A1 (en) | 2012-09-13 |
| IL186662A0 (en) | 2008-06-05 |
| US20090137682A1 (en) | 2009-05-28 |
| AU2006236378A1 (en) | 2006-10-26 |
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