MX2007012570A - Terapia de anticuerpo anti-egfr basada en un numero de copia creciente del gen egfr en tejidos de tumor. - Google Patents

Terapia de anticuerpo anti-egfr basada en un numero de copia creciente del gen egfr en tejidos de tumor.

Info

Publication number
MX2007012570A
MX2007012570A MX2007012570A MX2007012570A MX2007012570A MX 2007012570 A MX2007012570 A MX 2007012570A MX 2007012570 A MX2007012570 A MX 2007012570A MX 2007012570 A MX2007012570 A MX 2007012570A MX 2007012570 A MX2007012570 A MX 2007012570A
Authority
MX
Mexico
Prior art keywords
egfr
cancer
copy number
gene
tumor
Prior art date
Application number
MX2007012570A
Other languages
English (en)
Spanish (es)
Inventor
Salvatore Siena
Mauro Moroni
Alberto Bardelli
Giovanna Marrapese
Andrea Sartore-Bianchi
Silvio Veronese
Marcello Gambacorta
Silvia Benvenuti
Federica Di Nicolantonio
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2007012570A publication Critical patent/MX2007012570A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
MX2007012570A 2005-04-14 2006-04-12 Terapia de anticuerpo anti-egfr basada en un numero de copia creciente del gen egfr en tejidos de tumor. MX2007012570A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05008156 2005-04-14
PCT/EP2006/003358 WO2006108627A1 (en) 2005-04-14 2006-04-12 Anti-egfr antibody therapy based on an increased copy number of the egfr gene in tumor tissues

Publications (1)

Publication Number Publication Date
MX2007012570A true MX2007012570A (es) 2007-11-16

Family

ID=36645327

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007012570A MX2007012570A (es) 2005-04-14 2006-04-12 Terapia de anticuerpo anti-egfr basada en un numero de copia creciente del gen egfr en tejidos de tumor.

Country Status (12)

Country Link
US (1) US20090269344A1 (zh)
EP (1) EP1869208A1 (zh)
JP (1) JP2008535508A (zh)
KR (1) KR20080003422A (zh)
CN (1) CN101155932A (zh)
AU (1) AU2006233675A1 (zh)
BR (1) BRPI0610440A2 (zh)
CA (1) CA2604300A1 (zh)
MX (1) MX2007012570A (zh)
RU (1) RU2007141067A (zh)
WO (1) WO2006108627A1 (zh)
ZA (1) ZA200709780B (zh)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1869220A2 (en) * 2005-04-01 2007-12-26 Amgen, Inc. Epidermal growth factor receptor gene copy number
US7908091B2 (en) 2006-03-17 2011-03-15 Prometheus Laboratories Inc. Methods of predicting and monitoring tyrosine kinase inhibitor therapy
NZ578943A (en) 2007-03-01 2012-09-28 Symphogen As Recombinant anti-epidermal growth factor receptor antibody compositions
CL2008000717A1 (es) 2007-03-13 2008-09-22 Amgen Inc Metodo para pronosticar si un paciente sera no respondedor al tratamiento con un agente de union especifica a un polipeptido de egfr que comprende determinar la presencia o ausencia de una mutacion de k-ras en un tumor del paciente.
EP2118322A2 (en) * 2007-03-13 2009-11-18 Amgen Inc. K-ras and b-raf mutations and anti-egfr antibody therapy
JP5719298B2 (ja) 2008-08-29 2015-05-13 シムフォゲン・アクティーゼルスカブSymphogen A/S 組換え抗上皮増殖因子受容体抗体組成物
EP3216874A1 (en) 2008-09-05 2017-09-13 TOMA Biosciences, Inc. Methods for stratifying and annotating cancer drug treatment options
KR101918004B1 (ko) * 2009-10-26 2018-11-13 애보트 모레큘러 인크. 비-소세포 폐암의 예후를 측정하기 위한 진단 방법
US8609354B2 (en) * 2010-03-04 2013-12-17 Olli CARPEN Method for selecting patients for treatment with an EGFR inhibitor
WO2011107664A1 (en) 2010-03-04 2011-09-09 Hospital District Of Southwest Finland Method for selecting patients for treatment with an egfr inhibitor
US20120045433A1 (en) * 2010-08-17 2012-02-23 Kapil Dhingra Combination therapy
US8709419B2 (en) 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
EP3572528A1 (en) 2010-09-24 2019-11-27 The Board of Trustees of the Leland Stanford Junior University Direct capture, amplification and sequencing of target dna using immobilized primers
DE102010060964A1 (de) * 2010-12-02 2012-06-06 Universitätsklinikum Hamburg-Eppendorf Verfahren zur Prädikation der therapeutischen Wirksamkeit von EGFR-Inhibitoren
US9295669B2 (en) 2010-12-14 2016-03-29 Hoffman La-Roche Inc. Combination therapy for proliferative disorders
CN102153648B (zh) * 2011-01-27 2012-07-04 中国人民解放军军事医学科学院生物工程研究所 一种抗egfr人源化抗体l4-h3及其编码基因与应用
CN103619881B (zh) 2011-04-07 2017-07-28 安姆根有限公司 新的egfr结合蛋白
CN104145027A (zh) * 2011-12-12 2014-11-12 塞雷公司 用于室温原位检测生物样品中的目标核酸的方法和试剂盒
AU2015205755C1 (en) 2014-01-10 2020-08-13 Birdie Biopharmaceuticals Inc. Compounds and compositions for immunotherapy
KR102462743B1 (ko) 2014-07-09 2022-11-02 버디 바이오파마슈티칼즈, 인크. 종양 치료용 항-pd-l1 조합
JP6782698B2 (ja) * 2014-12-12 2020-11-11 セルキュイティー インコーポレイテッド がん患者を診断および処置するためのerbbシグナル伝達経路活性の測定方法
CN115252792A (zh) * 2016-01-07 2022-11-01 博笛生物科技有限公司 用于治疗肿瘤的抗-egfr组合
CN115554406A (zh) 2016-01-07 2023-01-03 博笛生物科技有限公司 用于治疗肿瘤的抗-cd20组合
CN108794467A (zh) 2017-04-27 2018-11-13 博笛生物科技有限公司 2-氨基-喹啉衍生物
EP3641771A4 (en) 2017-06-23 2020-12-16 Birdie Biopharmaceuticals, Inc. PHARMACEUTICAL COMPOSITIONS
WO2019109086A1 (en) * 2017-12-01 2019-06-06 Illumina, Inc. Methods and systems for determining somatic mutation clonality
EP3591666A1 (en) * 2018-07-04 2020-01-08 Dassault Systèmes Simulating evolution of a tumor
CN112430646A (zh) * 2020-12-11 2021-03-02 南京求臻基因科技有限公司 一种基于数字pcr平台的egfr基因扩增的检测方法
CN112646893A (zh) * 2021-01-08 2021-04-13 北京泛生子基因科技有限公司 一种egfr基因拷贝数检测试剂盒及检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2331646T3 (es) * 2000-05-19 2010-01-12 Genentech, Inc. Ensayo para la deteccion de genes para mejorar la probabilidad de una respuesta eficaz a una terapia contra el cancer basada en antagonistas de erbb.
AU2004248140A1 (en) * 2003-05-30 2004-12-23 Cedars-Sinai Medical Center Gene expression markers for response to EGFR inhibitor drugs
EP1869220A2 (en) * 2005-04-01 2007-12-26 Amgen, Inc. Epidermal growth factor receptor gene copy number

Also Published As

Publication number Publication date
RU2007141067A (ru) 2009-05-20
WO2006108627A1 (en) 2006-10-19
CN101155932A (zh) 2008-04-02
ZA200709780B (en) 2008-11-26
US20090269344A1 (en) 2009-10-29
KR20080003422A (ko) 2008-01-07
JP2008535508A (ja) 2008-09-04
BRPI0610440A2 (pt) 2010-06-22
WO2006108627A9 (en) 2007-10-11
AU2006233675A1 (en) 2006-10-19
CA2604300A1 (en) 2006-10-19
EP1869208A1 (en) 2007-12-26

Similar Documents

Publication Publication Date Title
MX2007012570A (es) Terapia de anticuerpo anti-egfr basada en un numero de copia creciente del gen egfr en tejidos de tumor.
JP2022078021A (ja) 癌のための治療方法及び診断方法
Rabinowits et al. Overcoming resistance to EGFR inhibitor in head and neck cancer: a review of the literature
Yarden et al. Molecular approach to breast cancer treatment
US20160303127A1 (en) Combination therapy with c-met and egfr antagonists
JP2016105096A (ja) バイオマーカー及び治療の方法
US20110262436A1 (en) Treatment method
TW201837467A (zh) 用於癌症之診斷及治療方法
JP2018518483A (ja) 抗ox40抗体及びpd−1軸結合アンタゴニストを使用して癌を治療する方法
JP2018508183A (ja) 化学療法耐性癌を治療及び診断する組成物及び方法
JP2015514710A (ja) Her3阻害剤に関する診断及び治療
KR20190015408A (ko) 종양을 치료하는 방법에 사용하기 위한 항-pd-1 항체
TW201019961A (en) Combination therapy
JP2022512744A (ja) 肉腫様腎臓がんのための診断および治療方法
Drago et al. Beyond HER2: targeting the ErbB receptor family in breast cancer
US20220154296A1 (en) Use of anti-pd-1 antibody in preparation of medicament for treating solid tumors
WO2010120592A1 (en) Combination therapy using an anti-egfr agent(s) and igf-1r specific inhibitors
CN117321418A (zh) 癌症生物标志物及其使用方法
UZ et al. CORRECTED VERSION
JP2023549581A (ja) ツカチニブ及び抗pd-1/抗pd-l1抗体の組み合わせによりがんを治療する方法
KR20240045281A (ko) Her3 항원 결합 분자를 사용한 암 치료 및 예방
Parakh Novel Anti-ErbB Antibodies in the Treatment of Cancer
CA2860732A1 (en) Cyclon expression for the identification and control of cancer cells
Eskens Signal transduction inhibitors

Legal Events

Date Code Title Description
FA Abandonment or withdrawal