MX163480B - Sintesis de 7-halo-7-desoxilincomicinas - Google Patents

Sintesis de 7-halo-7-desoxilincomicinas

Info

Publication number
MX163480B
MX163480B MX205050A MX20505085A MX163480B MX 163480 B MX163480 B MX 163480B MX 205050 A MX205050 A MX 205050A MX 20505085 A MX20505085 A MX 20505085A MX 163480 B MX163480 B MX 163480B
Authority
MX
Mexico
Prior art keywords
halo
adduct
deoxy
desoxilincomicinas
synthesis
Prior art date
Application number
MX205050A
Other languages
English (en)
Spanish (es)
Inventor
Douglas Alan Livingston
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MX163480B publication Critical patent/MX163480B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MX205050A 1984-05-15 1985-04-22 Sintesis de 7-halo-7-desoxilincomicinas MX163480B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/610,364 US4568741A (en) 1984-05-15 1984-05-15 Synthesis of 7-halo-7-deoxylincomycins

Publications (1)

Publication Number Publication Date
MX163480B true MX163480B (es) 1992-05-19

Family

ID=24444721

Family Applications (1)

Application Number Title Priority Date Filing Date
MX205050A MX163480B (es) 1984-05-15 1985-04-22 Sintesis de 7-halo-7-desoxilincomicinas

Country Status (18)

Country Link
US (1) US4568741A (show.php)
EP (1) EP0161794B1 (show.php)
JP (1) JPS60260591A (show.php)
KR (1) KR910002224B1 (show.php)
AT (1) ATE54150T1 (show.php)
AU (1) AU574453B2 (show.php)
CA (1) CA1229592A (show.php)
DE (1) DE3578425D1 (show.php)
DK (1) DK166390C (show.php)
ES (1) ES8606877A1 (show.php)
FI (1) FI78108C (show.php)
GR (1) GR851150B (show.php)
HK (1) HK59293A (show.php)
HU (1) HU196820B (show.php)
IL (2) IL74971A (show.php)
MX (1) MX163480B (show.php)
PT (1) PT80463B (show.php)
ZA (1) ZA852592B (show.php)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1004002B (zh) * 1984-11-29 1989-04-26 厄普约翰公司 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法
TW282399B (show.php) * 1990-05-25 1996-08-01 Takeda Pharm Industry Co Ltd
DE4039750A1 (de) * 1990-12-13 1992-06-17 Basf Ag Verfahren zur entfernung von phosgen aus abgasen
JP3202960B2 (ja) * 1998-02-17 2001-08-27 大塚化学株式会社 ハロゲン化剤及び水酸基のハロゲン化方法
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) * 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
EP1421093B1 (en) * 2001-08-28 2005-06-29 Pharmacia Corporation Crystaline clindamycin free base
EP1529052A2 (en) * 2002-08-15 2005-05-11 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199105B2 (en) * 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
WO2004064833A1 (en) 2003-01-24 2004-08-05 Connetics Australia Pty Ltd. Clindamycin phosphate foam
US7199106B2 (en) 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
US7256177B2 (en) 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
JP2006528190A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
CA2533178C (en) * 2003-07-21 2014-03-11 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
JP2006528185A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質製剤、その使用法及び作成方法
WO2005016311A1 (en) 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
AU2004264356B2 (en) * 2003-08-12 2011-01-27 Shionogi, Inc. Antibiotic product, use and formulation thereof
JP5686494B2 (ja) * 2003-08-29 2015-03-18 シオノギ インコーポレイテッド 抗生物質製剤、その使用法及び作成方法
EP1663169A4 (en) * 2003-09-15 2010-11-24 Middlebrook Pharmaceuticals In ANTIBIOTICS, ITS USE AND FORMULATION
CA2550983C (en) * 2003-12-24 2013-09-17 Advancis Pharmaceutical Corporation Enhanced absorption of modified release dosage forms
US7361743B2 (en) * 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
WO2006014427A1 (en) * 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
GB0417401D0 (en) * 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en) * 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
BRPI0709674A2 (pt) 2006-03-31 2011-12-06 Stiefel Research Australia Pty Ltd. gel de suspensão espumante
US8299052B2 (en) * 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
GB0620685D0 (en) * 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
CN101205245B (zh) * 2007-12-06 2011-04-06 河南天方药业股份有限公司 盐酸克林霉素的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3435025A (en) * 1966-03-18 1969-03-25 Upjohn Co 7-deoxylincomycin and analogs and isomers thereof and process for making the same
US3475407A (en) * 1967-12-22 1969-10-28 Upjohn Co Process for preparing 7(r)- and 7(s)-halolincomycins
US3509127A (en) * 1968-04-30 1970-04-28 Upjohn Co Isologs of lincomycins and process for preparing the same
US3574186A (en) * 1969-10-08 1971-04-06 Upjohn Co Process for making 7-chloro-7-deoxylincomycin and related compounds and novel intermediates produced therein
US3714141A (en) * 1970-05-26 1973-01-30 Upjohn Co Process for making 7-halolincomycins
CA1138443A (en) * 1979-03-09 1982-12-28 Tate & Lyle Patent Holdings Limited Process for the preparation of chloro-deoxysugars
CN1004002B (zh) * 1984-11-29 1989-04-26 厄普约翰公司 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法

Also Published As

Publication number Publication date
JPS60260591A (ja) 1985-12-23
FI78108B (fi) 1989-02-28
ES542940A0 (es) 1986-05-16
JPH0533711B2 (show.php) 1993-05-20
ZA852592B (en) 1985-11-27
IL75175A0 (en) 1985-09-29
EP0161794A2 (en) 1985-11-21
US4568741A (en) 1986-02-04
KR910002224B1 (ko) 1991-04-08
IL74971A0 (en) 1985-08-30
AU574453B2 (en) 1988-07-07
IL74971A (en) 1991-07-18
EP0161794A3 (en) 1987-07-29
GR851150B (show.php) 1985-11-25
DK166390B (da) 1993-05-10
FI78108C (fi) 1989-06-12
DK196185A (da) 1985-11-16
ES8606877A1 (es) 1986-05-16
PT80463B (pt) 1987-08-19
PT80463A (en) 1985-06-01
EP0161794B1 (en) 1990-06-27
HUT40805A (en) 1987-02-27
ATE54150T1 (de) 1990-07-15
FI851941A0 (fi) 1985-05-15
AU4095085A (en) 1985-11-21
KR850008349A (ko) 1985-12-16
HU196820B (en) 1989-01-30
HK59293A (en) 1993-06-25
DE3578425D1 (de) 1990-08-02
DK196185D0 (da) 1985-05-01
FI851941L (fi) 1985-11-16
CA1229592A (en) 1987-11-24
DK166390C (da) 1993-09-27

Similar Documents

Publication Publication Date Title
AU574453B2 (en) Process for preparation of 7-halo-7-deoxylincomycins
ES2097583T3 (es) Procedimiento de preparacion de derivados de alcoxiiminoacetamida y un intermediario de este procedimiento.
AU562802B2 (en) Preparation of phosphorus-containing cyanohydrins
ES2005746A6 (es) Un procedimiento para la preparacion de un haluro de piridinio.
PT85035A (en) Process for preparing antiallergy and antiinflammatory agents of benzoxazolones of analogs
FI913067A0 (fi) Bisfosfonsyraderivat, deras framstaellning och anvaendning.
FI854596A0 (fi) Nytt foerfarande foer uppdelning av racemiska -naftylpropionsyror i optiska isomerer.
FI873443A7 (fi) Norfloxacinmellanprodukt.
DK0485204T3 (da) Fremgangsmåde til fremstilling af 3-alkoxymethyl-cephalosporin-derivater
ES532098A0 (es) Un procedimiento para preparar derivados sustituidos en posicion 1 de azetidin-3-ol
DE3173904D1 (en) Esters of n-(4'-hydroxyphenyl)acetamide with 5-benzoyl-1-methylpyrrole-2-acetic acids
MX7654E (es) Procedimiento para preparar derivados de carbonato de 2,5-dimetil-4-hidroxi-3(2h)-furanona
FI844186L (fi) Bis(substituerad metyl)metylisoki- nolinderivat och foerfarande foer framstaellning daerav.
DE3068679D1 (en) Process for the production of branched s-alkyl phosphonodithioic halide intermediates
ATE86629T1 (de) 4-piperidincarboxamid-derivate.
IT1224316B (it) Procedimento di preparazione della n,n'-bis-(2-idrossietil)-piperazina
ATE31404T1 (de) Verfahren zur herstellung von cycklopropanabkoemmlingen.
DK0379191T3 (da) 1,3-Dioxolan-benzoesyrer og derivater deraf
JPS5152123A (en) Chikan transs ehokishi ciss arukennoshinkinaseizoho