MEP1308A - Kompozicije i postupci za upotrebu antitijela dickkopf-1 i-ili -4 - Google Patents

Kompozicije i postupci za upotrebu antitijela dickkopf-1 i-ili -4

Info

Publication number
MEP1308A
MEP1308A MEP-13/08A MEP1308A MEP1308A ME P1308 A MEP1308 A ME P1308A ME P1308 A MEP1308 A ME P1308A ME P1308 A MEP1308 A ME P1308A
Authority
ME
Montenegro
Prior art keywords
dickkopf
antibodies
methods
compositions
target
Prior art date
Application number
MEP-13/08A
Other languages
Bosnian (bs)
English (en)
Inventor
Janine Shulok
Feng Cong
Mark Fishman
Seth Ettenberg
Michael Bardroff
Mariel Donzeau
Stefanie Urlinger
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MEP1308A publication Critical patent/MEP1308A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
MEP-13/08A 2006-01-13 2007-01-12 Kompozicije i postupci za upotrebu antitijela dickkopf-1 i-ili -4 MEP1308A (xx)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75921606P 2006-01-13 2006-01-13
PCT/US2007/000777 WO2007084344A2 (en) 2006-01-13 2007-01-12 Compositions and methods of use for antibodies of dickkopf-1 and/or -4

Publications (1)

Publication Number Publication Date
MEP1308A true MEP1308A (xx) 2010-02-10

Family

ID=38288117

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-13/08A MEP1308A (xx) 2006-01-13 2007-01-12 Kompozicije i postupci za upotrebu antitijela dickkopf-1 i-ili -4
MEP-2008-13A ME00010B (me) 2006-01-13 2007-01-12 Kompozicije i postupci za upotrebu antitijela dickkopf-1 i-ili -4

Family Applications After (1)

Application Number Title Priority Date Filing Date
MEP-2008-13A ME00010B (me) 2006-01-13 2007-01-12 Kompozicije i postupci za upotrebu antitijela dickkopf-1 i-ili -4

Country Status (31)

Country Link
US (3) US8673306B2 (ru)
EP (1) EP1976594B1 (ru)
JP (2) JP5552233B2 (ru)
KR (1) KR101413785B1 (ru)
CN (1) CN101400406B (ru)
AR (1) AR060017A1 (ru)
AU (1) AU2007207787B2 (ru)
BR (1) BRPI0706524A2 (ru)
CA (1) CA2636579A1 (ru)
CR (1) CR10128A (ru)
CU (1) CU23871B1 (ru)
EA (1) EA015538B1 (ru)
EC (1) ECSP088618A (ru)
GE (1) GEP20125476B (ru)
HK (1) HK1121420A1 (ru)
HN (1) HN2008001104A (ru)
IL (1) IL192631A (ru)
MA (1) MA30158B1 (ru)
ME (2) MEP1308A (ru)
MY (1) MY153573A (ru)
NO (1) NO20083477L (ru)
NZ (1) NZ569555A (ru)
PE (2) PE20071239A1 (ru)
SG (1) SG169327A1 (ru)
SM (1) SMP200800042B (ru)
SV (1) SV2008002980A (ru)
TN (1) TNSN08297A1 (ru)
TW (1) TWI432450B (ru)
UA (1) UA101944C2 (ru)
WO (1) WO2007084344A2 (ru)
ZA (1) ZA200805743B (ru)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
US8450274B2 (en) 2006-05-24 2013-05-28 Theragenetex Co., Ltd. DKK2 protein and use thereof
KR20110117601A (ko) * 2010-04-21 2011-10-27 주식회사 테라젠이텍스 혈관신생과 연관된 화합물을 탐색하는 방법
JP2009065938A (ja) * 2007-09-14 2009-04-02 Matsumoto Shika Univ タンパク質、破骨細胞分化阻害剤、炎症性骨破壊治療薬、遺伝子、組み替えベクター、及びタンパク質の製造方法
AR068767A1 (es) 2007-10-12 2009-12-02 Novartis Ag Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina
JP5320730B2 (ja) * 2007-12-26 2013-10-23 Ｊｎｃ株式会社 発光基質水溶液およびその製造方法
BRPI0919473A2 (pt) 2008-09-26 2017-08-29 Oncomed Pharm Inc Agentes de ligação frizzled e usos dos mesmos
WO2010100200A2 (en) * 2009-03-05 2010-09-10 Novartis Ag Lyophilised antibody formulation
AR075989A1 (es) * 2009-04-10 2011-05-11 Lilly Co Eli Anticuerpo dkk -1 (dickkopf-1) humano disenado por ingenieria
RU2011149358A (ru) * 2009-05-07 2013-06-20 Новартис Аг Композиции и способы применения молекул, связывающихся с белком dickkopf-1 или с белком dickkopf-4, или с обоими указанными белками
RU2548817C2 (ru) * 2009-05-12 2015-04-20 Пфайзер Инк. БЛОКИРУЮЩИЕ АНТИТЕЛА ПРОТИВ Dkk-1 И ИХ ПРИМЕНЕНИЯ
WO2010130832A2 (en) * 2009-05-15 2010-11-18 Ablynx N.V. Amino acid sequences directed against dickkopf-1 and polypeptides comprising the same for the treatment of diseases and disorders associated with bone loss and/or osteolytic lesions
EP2494354A1 (en) * 2009-10-30 2012-09-05 Merck Sharp & Dohme Corp. Pcsk9 immunoassay
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
KR20120138241A (ko) * 2010-03-11 2012-12-24 화이자 인코포레이티드 ｐＨ 의존성 항원 결합을 갖는 항체
MX347515B (es) 2010-04-01 2017-04-28 Oncomed Pharmaceuticals Inc * Agentes que se unen al receptor encrespado y usos de los mismos.
AR083740A1 (es) * 2010-10-27 2013-03-20 Amgen Inc Anticuerpos dkk1 (dickkopf-1) y metodos de uso
EP2670435B1 (en) * 2011-02-01 2017-08-23 The University of Hong Kong Use of anti-dkk1 monoclonal antibody for treatment of liver cancer
CA2828000A1 (en) 2011-03-01 2012-09-07 Amgen Inc. Bispecific binding agents
CN103487581A (zh) * 2012-06-08 2014-01-01 上海市肿瘤研究所 血清dkk1在制备甲胎蛋白阴性肝细胞癌的诊断试剂中的用途
CN103472226A (zh) * 2012-06-08 2013-12-25 上海市肿瘤研究所 血清dkk1在制备早期肝细胞癌或小肝细胞癌的诊断试剂中的用途
UY35148A (es) * 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
WO2014121196A1 (en) 2013-02-04 2014-08-07 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a wnt pathway inhibitor
CN103083686B (zh) * 2013-02-18 2014-09-10 上海交通大学医学院附属仁济医院 Dkk4基因及其编码蛋白在制备药物中的应用
WO2014144817A2 (en) 2013-03-15 2014-09-18 Amgen Inc. Inhibitory polypeptides specific to wnt inhibitors
EP3164194B1 (en) * 2014-07-03 2021-11-24 Yale University Dickkopf2 (dkk2) inhibition suppresses tumor formation
DE102016206820B4 (de) 2015-04-22 2017-07-27 BSH Hausgeräte GmbH Weiterentwicklung eines Induktionswasserkochers, einer Kaffeemaschine und einer Suppenmaschine
EP3913051A1 (en) * 2015-08-07 2021-11-24 ALX Oncology Inc. Constructs having a sirp-alpha domain or variant thereof
CN105203773A (zh) * 2015-09-28 2015-12-30 成都博奥新景医学科技有限公司 一种人Dickkopf-1蛋白（DKK-1）定量检测试剂盒
US11267875B2 (en) 2015-10-28 2022-03-08 Yale University Humanized anti-DKK2 antibody and uses thereof
RU2656160C2 (ru) * 2016-08-17 2018-05-31 Закрытое Акционерное Общество "Биокад" Антитело или его антигенсвязывающий фрагмент, способный связываться с рецептором интерлейкина-6 человека
KR102701695B1 (ko) * 2016-10-26 2024-08-30 리프 테라퓨틱스 인코포레이티드 항-dkk-1 항체를 사용하여 암을 치료하기 위한 바이오마커로서의 베타-카테닌의 용도
CN110799212A (zh) * 2017-05-10 2020-02-14 古德T细胞有限公司 特异性存在于调节性t细胞中的dkk1蛋白及其用途
CN113454223B (zh) * 2019-01-15 2024-09-13 柏业公司 靶向dkk1基因的双链寡核苷酸、包含其的构建体以及含有其的脱发预防或毛发生长组合物
AU2020216494A1 (en) * 2019-02-01 2021-08-12 Board Of Regents, The University Of Texas System Monoclonal antibodies against MHC-bound human Dickkopf-1 peptides and uses thereof
CA3141130A1 (en) 2019-05-31 2020-12-03 ALX Oncology Inc. Methods of treating cancer with sirp alpha fc fusion in combination with an immune checkpoint inhibitor
CN112121147B (zh) * 2019-06-24 2023-07-04 中国人民解放军海军特色医学中心 多肽在治疗或预防骨髓瘤药物中的应用、多肽、核酸、药物及重组表达载体
CN111632147A (zh) * 2020-06-07 2020-09-08 重庆医科大学 骨细胞Wnt激活剂在制备骨折加速愈合、防治骨不连及不运动或失重骨丢失药物中的应用
KR102494042B1 (ko) * 2020-11-20 2023-02-07 주식회사 하울바이오 인간모유두세포의 성장을 촉진하는 항-dkk-1 항체 및 이의 용도
CN112592402B (zh) * 2020-12-02 2022-04-26 杭州奕安济世生物药业有限公司 抗dkk2抗体、包含该抗dkk2抗体的组合物及其用途
WO2022140670A2 (en) * 2020-12-23 2022-06-30 Phenomic Ai Anti-activin antibodies and methods of using the same
CN117916377A (zh) * 2021-09-26 2024-04-19 安沛治疗有限公司 针对dkk1的适体及其用途
CN116514966A (zh) 2022-01-28 2023-08-01 上海君实生物医药科技股份有限公司 抗dkk1抗体、其药物组合物及用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5597710A (en) 1994-03-10 1997-01-28 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
CA2288430C (en) 1997-04-16 2013-04-09 Millennium Biotherapeutics, Inc. Crsp protein (cysteine-rich secreted proteins), nucleic acid molecules encoding them and uses therefor
US7057017B2 (en) 1997-04-16 2006-06-06 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor
DE19747418C1 (de) 1997-10-27 1999-07-15 Deutsches Krebsforsch Inhibitor-Protein des wnt-Signalwegs
US7446181B2 (en) 1998-01-15 2008-11-04 Millennium Pharmaceuticals, Inc. Antibodies that bind human Dickkopf-1 proteins
WO2000006714A1 (en) 1998-07-31 2000-02-10 Eli Lilly And Company DDKh-3 NUCLEIC ACIDS, POLYPEPTIDES, VECTORS, HOST CELLS, METHODS AND USES THEREOF
US6936697B2 (en) 1998-09-01 2005-08-30 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6344541B1 (en) 1998-09-25 2002-02-05 Amgen Inc. DKR polypeptides
US6682736B1 (en) 1998-12-23 2004-01-27 Abgenix, Inc. Human monoclonal antibodies to CTLA-4
EP1399483B1 (en) 2001-01-05 2010-04-14 Pfizer Inc. Antibodies to insulin-like growth factor i receptor
PL374006A1 (en) 2001-02-16 2005-09-19 Genentech, Inc. Treatment involving dkk-1 or antagonists thereof
WO2002086085A2 (en) 2001-04-24 2002-10-31 Bayer Corporation Human timp-1 antibodies
AU2002359357A1 (en) 2001-11-07 2003-07-09 The Board Of Trustees Of The University Of Arkansas Diagnosis prognosis and identification of potential therapeutic targets of multiple myeloma based on gene expression profiling
AR038568A1 (es) 2002-02-20 2005-01-19 Hoffmann La Roche Anticuerpos anti-a beta y su uso
WO2004053063A2 (en) 2002-12-05 2004-06-24 The Board Of Trustees Of The University Of Arkansas System Molecular determinants of myeloma bone disease and uses thereof
US20050084494A1 (en) 2003-05-21 2005-04-21 Darwin Prockop Inhibitors of Dkk-1
AU2005271523B2 (en) * 2004-08-03 2011-09-15 Dyax Corp. hk1-binding proteins
US7709611B2 (en) * 2004-08-04 2010-05-04 Amgen Inc. Antibodies to Dkk-1
GB0417487D0 (en) 2004-08-05 2004-09-08 Novartis Ag Organic compound
KR20070114324A (ko) * 2005-03-25 2007-11-30 글리카트 바이오테크놀로지 아게 Ｍｃｓｐ 에 향하며 증가된 ｆｃ 수용체 결합 친화도 및효과기 작용을 갖는 항원 결합 분자
US8716195B2 (en) * 2005-11-14 2014-05-06 Bioren, Inc. Antibody ultrahumanization by predicted mature CDR blasting and cohort library generation and screening

Also Published As

Publication number Publication date
JP2013099334A (ja) 2013-05-23
IL192631A0 (en) 2011-08-01
IL192631A (en) 2015-06-30
CN101400406B (zh) 2014-01-29
HK1121420A1 (en) 2009-04-24
ZA200805743B (en) 2009-08-26
TW200804417A (en) 2008-01-16
AR060017A1 (es) 2008-05-21
US20120023600A1 (en) 2012-01-26
KR20080085908A (ko) 2008-09-24
MA30158B1 (fr) 2009-01-02
SMAP200800042A (it) 2008-07-30
US20140170147A1 (en) 2014-06-19
US8673306B2 (en) 2014-03-18
KR101413785B1 (ko) 2014-07-09
WO2007084344A3 (en) 2008-02-14
TNSN08297A1 (en) 2009-12-29
AU2007207787A1 (en) 2007-07-26
CU20080133A7 (es) 2012-06-21
AU2007207787B2 (en) 2011-03-17
JP5552233B2 (ja) 2014-07-16
MY153573A (en) 2015-02-27
US9296813B2 (en) 2016-03-29
HN2008001104A (es) 2011-06-08
CR10128A (es) 2008-08-25
ECSP088618A (es) 2008-08-29
ME00010B (me) 2010-06-10
CA2636579A1 (en) 2007-07-26
EP1976594B1 (en) 2015-05-06
EA015538B1 (ru) 2011-08-30
TWI432450B (zh) 2014-04-01
BRPI0706524A2 (pt) 2011-03-29
EP1976594A2 (en) 2008-10-08
JP2009523421A (ja) 2009-06-25
PE20120816A1 (es) 2012-08-01
US20140341901A1 (en) 2014-11-20
WO2007084344A2 (en) 2007-07-26
CN101400406A (zh) 2009-04-01
SV2008002980A (es) 2010-05-21
NO20083477L (no) 2008-10-13
SG169327A1 (en) 2011-03-30
NZ569555A (en) 2011-12-22
PE20071239A1 (es) 2008-02-12
UA101944C2 (ru) 2013-05-27
EA200801679A1 (ru) 2009-02-27
CU23871B1 (es) 2013-03-27
SMP200800042B (it) 2009-07-14
GEP20125476B (en) 2012-04-25

Similar Documents

Publication Publication Date Title
MEP1308A (xx) Kompozicije i postupci za upotrebu antitijela dickkopf-1 i-ili -4
WO2007126799A3 (en) Compositions and methods of use for antibodies of c-met
PH12015500093A1 (en) Il-17 binding proteins
WO2008133722A3 (en) Anti human sclerostin antibodies
PH12016501691A1 (en) Antibodies to matrix metalloproteinase 9
AU2016204344A1 (en) Improved methods and compositions for wound healing
MX2011011768A (es) Composiciones y metodos de uso para moleculas de enlace a dickkopf-1 o dickkopf-4 o a ambos.
MX2010008206A (es) Metodos y composiciones que utilizan polipeptidos de fusion de klotho-fgf.
EA200870185A1 (ru) Комбинации ингибиторов ang2 и vegf
WO2011047087A3 (en) Protein detection via nanoreporters
JO3118B1 (ar) تراكيب وطرق لبروتين c5 المتمم يستهدف الأجسام المضادة
WO2010011944A3 (en) Protein screeing methods
TN2011000528A1 (en) Compositions and methods for antibodies targeting complement protein c3b
TW200716667A (en) Binding agents
MY174493A (en) Binding agents
EA201170242A1 (ru) Модифицированные бычьи полипептиды g-csf и их применение
EP2035015A4 (en) COMPOSITIONS, METHODS AND KITS FOR DRY EYE TREATMENT
WO2009009034A3 (en) Methods and compositions useful in the treatment of mucositis
SG156589A1 (en) Oven control system and methods
MX2010000979A (es) Metodos y composiciones para tratar enfermedad autoinmune.
MX2009003022A (es) Composiciones y metodos para tratar picaduras de medusa.