ME02621B - Postupak za proizvodnju naltreksona - Google Patents
Postupak za proizvodnju naltreksonaInfo
- Publication number
- ME02621B ME02621B MEP-2017-57A MEP5717A ME02621B ME 02621 B ME02621 B ME 02621B ME P5717 A MEP5717 A ME P5717A ME 02621 B ME02621 B ME 02621B
- Authority
- ME
- Montenegro
- Prior art keywords
- mixture
- noroxymorphone
- reaction
- mixing
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41040510P | 2010-11-05 | 2010-11-05 | |
| DKPA201001007 | 2010-11-05 | ||
| US201161489701P | 2011-05-25 | 2011-05-25 | |
| DKPA201100396 | 2011-05-25 | ||
| PCT/DK2011/000128 WO2012059103A1 (en) | 2010-11-05 | 2011-11-04 | Method for the manufacturing of naltrexone |
| EP11785301.0A EP2635586B1 (en) | 2010-11-05 | 2011-11-04 | Method for the manufacturing of naltrexone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02621B true ME02621B (me) | 2017-06-20 |
Family
ID=45001588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2017-57A ME02621B (me) | 2010-11-05 | 2011-11-04 | Postupak za proizvodnju naltreksona |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP2635586B1 (https=) |
| JP (2) | JP6246589B2 (https=) |
| AP (1) | AP3415A (https=) |
| AU (1) | AU2011325563B2 (https=) |
| CA (1) | CA2815093C (https=) |
| CY (1) | CY1118742T1 (https=) |
| DK (1) | DK2635586T3 (https=) |
| EA (1) | EA022266B1 (https=) |
| ES (1) | ES2620660T3 (https=) |
| HR (1) | HRP20170379T1 (https=) |
| HU (1) | HUE033596T2 (https=) |
| LT (1) | LT2635586T (https=) |
| ME (1) | ME02621B (https=) |
| MX (1) | MX2013005009A (https=) |
| PL (1) | PL2635586T3 (https=) |
| PT (1) | PT2635586T (https=) |
| RS (1) | RS55777B1 (https=) |
| SI (1) | SI2635586T1 (https=) |
| SM (1) | SMT201700177T1 (https=) |
| WO (1) | WO2012059103A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140005217A1 (en) | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
| AR096851A1 (es) | 2013-07-11 | 2016-02-03 | H Lundbeck As | Sales que no forman hidratos ni solvatos de nalmefeno |
| MX368870B (es) | 2013-12-20 | 2019-10-21 | H Lundbeck As | Uso de un antagonista de receptores de opioides con actividad kappa y vortioxetina para el tratamiento de trastorno depresivo con características melancólicas. |
| EP3134090B1 (en) | 2014-04-22 | 2019-06-05 | Otsuka Pharmaceutical Co., Ltd. | Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders |
| US9701688B2 (en) * | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
| US9701687B2 (en) * | 2014-05-05 | 2017-07-11 | Noramco, Inc. | Process for the preparation of opioid compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4535157A (en) | 1983-11-01 | 1985-08-13 | Key Pharmaceuticals, Inc. | Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone |
| US4751307A (en) | 1985-01-17 | 1988-06-14 | Mallinckrodt, Inc. | Wittig-reaction processes |
| CA2067200C (en) * | 1989-10-16 | 1998-06-30 | Kenner C. Rice | Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via n-nor intermediates |
| FR2906252B1 (fr) * | 2006-09-21 | 2008-11-28 | Sanofi Aventis Sa | Procede de preparation d'halogenures de n-aklyl naltrexone |
| WO2008138383A1 (de) * | 2007-05-16 | 2008-11-20 | Cilag Ag | Verfahren zur herstellung von n-methylnaltrexonbromid |
| CA2738246C (en) * | 2008-09-30 | 2017-09-05 | Mallinckrodt Inc. | Processes for the alkylation of secondary amine groups of morphinan derivatives |
| ES2564006T3 (es) | 2009-05-25 | 2016-03-17 | H. Lundbeck A/S | Preparación de hidrocloruro de nalmefeno a partir de naltrexona |
-
2011
- 2011-11-04 SM SM20170177T patent/SMT201700177T1/it unknown
- 2011-11-04 WO PCT/DK2011/000128 patent/WO2012059103A1/en not_active Ceased
- 2011-11-04 LT LTEP11785301.0T patent/LT2635586T/lt unknown
- 2011-11-04 RS RS20170244A patent/RS55777B1/sr unknown
- 2011-11-04 AP AP2013006897A patent/AP3415A/xx active
- 2011-11-04 PT PT117853010T patent/PT2635586T/pt unknown
- 2011-11-04 CA CA2815093A patent/CA2815093C/en active Active
- 2011-11-04 DK DK11785301.0T patent/DK2635586T3/en active
- 2011-11-04 SI SI201131131A patent/SI2635586T1/sl unknown
- 2011-11-04 ES ES11785301.0T patent/ES2620660T3/es active Active
- 2011-11-04 AU AU2011325563A patent/AU2011325563B2/en not_active Ceased
- 2011-11-04 HR HRP20170379TT patent/HRP20170379T1/hr unknown
- 2011-11-04 ME MEP-2017-57A patent/ME02621B/me unknown
- 2011-11-04 PL PL11785301T patent/PL2635586T3/pl unknown
- 2011-11-04 MX MX2013005009A patent/MX2013005009A/es active IP Right Grant
- 2011-11-04 JP JP2013537002A patent/JP6246589B2/ja active Active
- 2011-11-04 EA EA201390658A patent/EA022266B1/ru not_active IP Right Cessation
- 2011-11-04 EP EP11785301.0A patent/EP2635586B1/en active Active
- 2011-11-04 HU HUE11785301A patent/HUE033596T2/hu unknown
-
2016
- 2016-06-24 JP JP2016125389A patent/JP6215399B2/ja active Active
-
2017
- 2017-03-17 CY CY20171100341T patent/CY1118742T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016199566A (ja) | 2016-12-01 |
| PL2635586T3 (pl) | 2017-06-30 |
| EP2635586A1 (en) | 2013-09-11 |
| SMT201700177T1 (it) | 2017-05-08 |
| EA022266B1 (ru) | 2015-11-30 |
| CY1118742T1 (el) | 2017-07-12 |
| JP6246589B2 (ja) | 2017-12-13 |
| JP6215399B2 (ja) | 2017-10-18 |
| RS55777B1 (sr) | 2017-07-31 |
| AU2011325563B2 (en) | 2015-08-20 |
| ES2620660T3 (es) | 2017-06-29 |
| CA2815093A1 (en) | 2012-05-10 |
| CA2815093C (en) | 2019-08-06 |
| LT2635586T (lt) | 2017-04-10 |
| HRP20170379T1 (hr) | 2017-05-05 |
| AU2011325563A1 (en) | 2013-05-02 |
| EA201390658A1 (ru) | 2013-11-29 |
| AP2013006897A0 (en) | 2013-05-31 |
| PT2635586T (pt) | 2017-03-30 |
| MX2013005009A (es) | 2013-08-01 |
| JP2013541564A (ja) | 2013-11-14 |
| DK2635586T3 (en) | 2017-03-27 |
| WO2012059103A1 (en) | 2012-05-10 |
| HUE033596T2 (hu) | 2017-12-28 |
| SI2635586T1 (sl) | 2017-07-31 |
| AP3415A (en) | 2015-09-30 |
| EP2635586B1 (en) | 2017-02-08 |
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