ME02410B - Upotreba testosterona i 5-ht1a agonista za lečenje seksualne disfunkcije - Google Patents
Upotreba testosterona i 5-ht1a agonista za lečenje seksualne disfunkcijeInfo
- Publication number
- ME02410B ME02410B MEP-2016-33A MEP3316A ME02410B ME 02410 B ME02410 B ME 02410B ME P3316 A MEP3316 A ME P3316A ME 02410 B ME02410 B ME 02410B
- Authority
- ME
- Montenegro
- Prior art keywords
- testosterone
- metabolite
- precursor
- ht1a agonist
- ht1a
- Prior art date
Links
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 title claims 46
- 239000003723 serotonin 1A agonist Substances 0.000 title claims 24
- 229960003604 testosterone Drugs 0.000 title claims 23
- 201000001880 Sexual dysfunction Diseases 0.000 title claims 5
- 231100000872 sexual dysfunction Toxicity 0.000 title claims 5
- 239000002207 metabolite Substances 0.000 claims 22
- 239000002243 precursor Substances 0.000 claims 22
- -1 Dipropii-5 -CT Chemical compound 0.000 claims 9
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 claims 7
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 5
- QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 claims 3
- 229960002495 buspirone Drugs 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000001568 sexual effect Effects 0.000 claims 2
- IPRJDKMLMDPMBH-XFULWGLBSA-N (3r)-n-(1,3-benzodioxol-5-ylmethyl)-1,2,3,4-tetrahydro-[1]benzothiolo[2,3-c]pyridine-3-carboxamide;hydrochloride Chemical compound Cl.S1C2=CC=CC=C2C(C2)=C1CN[C@H]2C(=O)NCC1=CC=C(OCO2)C2=C1 IPRJDKMLMDPMBH-XFULWGLBSA-N 0.000 claims 1
- UXWBIYCPUVWKHP-KBPBESRZSA-N 1-[[(7s,9as)-2-pyrimidin-2-yl-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-7-yl]methyl]pyrrolidine-2,5-dione Chemical compound O=C1CCC(=O)N1C[C@@H]1CN2CCN(C=3N=CC=CN=3)C[C@@H]2CC1 UXWBIYCPUVWKHP-KBPBESRZSA-N 0.000 claims 1
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 claims 1
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 claims 1
- QYFHCFNBYQZGKW-BDQAORGHSA-N 8-[4-[[(3s)-5-methoxy-3,4-dihydro-2h-chromen-3-yl]-propylamino]butyl]-8-azaspiro[4.5]decane-7,9-dione;hydrochloride Chemical compound Cl.CCCN([C@H]1CC2=C(OC)C=CC=C2OC1)CCCCN(C(C1)=O)C(=O)CC21CCCC2 QYFHCFNBYQZGKW-BDQAORGHSA-N 0.000 claims 1
- 206010057671 Female sexual dysfunction Diseases 0.000 claims 1
- 206010057672 Male sexual dysfunction Diseases 0.000 claims 1
- ICMGLRUYEQNHPF-UHFFFAOYSA-N Uraprene Chemical compound COC1=CC=CC=C1N1CCN(CCCNC=2N(C(=O)N(C)C(=O)C=2)C)CC1 ICMGLRUYEQNHPF-UHFFFAOYSA-N 0.000 claims 1
- 229950000420 alnespirone Drugs 0.000 claims 1
- 229940015273 buspar Drugs 0.000 claims 1
- UEAKCKJAKUFIQP-OAHLLOKOSA-N ebalzotan Chemical compound C1=CC(C(=O)NC(C)C)=C2C[C@@H](N(C(C)C)CCC)COC2=C1 UEAKCKJAKUFIQP-OAHLLOKOSA-N 0.000 claims 1
- 229950007357 ebalzotan Drugs 0.000 claims 1
- NYSDRDDQELAVKP-SFHVURJKSA-N flesinoxan Chemical compound C([C@@H](O1)CO)OC2=C1C=CC=C2N(CC1)CCN1CCNC(=O)C1=CC=C(F)C=C1 NYSDRDDQELAVKP-SFHVURJKSA-N 0.000 claims 1
- 229950003678 flesinoxan Drugs 0.000 claims 1
- PPRRDFIXUUSXRA-UHFFFAOYSA-N flibanserin Chemical compound FC(F)(F)C1=CC=CC(N2CCN(CCN3C(NC4=CC=CC=C43)=O)CC2)=C1 PPRRDFIXUUSXRA-UHFFFAOYSA-N 0.000 claims 1
- 229960002053 flibanserin Drugs 0.000 claims 1
- AHCPKWJUALHOPH-UHFFFAOYSA-N lesopitron Chemical compound C1=C(Cl)C=NN1CCCCN1CCN(C=2N=CC=CN=2)CC1 AHCPKWJUALHOPH-UHFFFAOYSA-N 0.000 claims 1
- 229950001590 lesopitron Drugs 0.000 claims 1
- JITOKQVGRJSHHA-UHFFFAOYSA-M monosodium methyl arsenate Chemical compound [Na+].C[As](O)([O-])=O JITOKQVGRJSHHA-UHFFFAOYSA-M 0.000 claims 1
- MEEQBDCQPIZMLY-HNNXBMFYSA-N osemozotan Chemical compound C1=C2OCOC2=CC(OCCCNC[C@@H]2OC3=CC=CC=C3OC2)=C1 MEEQBDCQPIZMLY-HNNXBMFYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- URMTUEWUIGOJBW-UHFFFAOYSA-N piclozotan Chemical compound ClC1=COC2=CC=CC=C2C(=O)N1CCCCN(CC=1)CCC=1C1=CC=CC=N1 URMTUEWUIGOJBW-UHFFFAOYSA-N 0.000 claims 1
- YGYBFMRFXNDIPO-QGZVFWFLSA-N repinotan Chemical compound O=S1(=O)C2=CC=CC=C2C(=O)N1CCCCNC[C@@H]1OC2=CC=CC=C2CC1 YGYBFMRFXNDIPO-QGZVFWFLSA-N 0.000 claims 1
- 229950009693 repinotan Drugs 0.000 claims 1
- 229950011106 sunepitron Drugs 0.000 claims 1
- 229960001130 urapidil Drugs 0.000 claims 1
- AERLHOTUXIJQFV-RCPZPFRWSA-N zalospirone Chemical compound O=C([C@@H]1[C@@H]([C@@H]2C=C[C@H]1[C@H]1C=C[C@H]12)C1=O)N1CCCCN(CC1)CCN1C1=NC=CC=N1 AERLHOTUXIJQFV-RCPZPFRWSA-N 0.000 claims 1
- 229950005255 zalospirone Drugs 0.000 claims 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 claims 1
- 229960000607 ziprasidone Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Claims (9)
1. Testosteron ili metabolit ili njegov prekurzor i 5-HT1A agonist za upotrebu u liječenju seksualne disfunkcije, pri čemu se pomenuti 5-HT1A agonist u suštini otpušta između jednog sata i jednog i po sata pre početka i pomenuti testosteron ili njegov metabolit ili prekurzor 3,5-5,5 sati pre seksualne aktivnosti tako da se maksimalno dejstvo 5-HT1A agonista i testosterona ili njegovog metabolita ili prekurzora delimično prepliće.
2. Testosteron ili njegov metabolit ili prekurzor i 5-HT1 A agonist za upotrebu prema patentnom zahtjevu 1, još obuhvata PDE5 inhibitor za upotrebu za liječenje seksualne disfunkcije, pri čemu se pomenuti 5-HT1A u suštini otpušta između jednog sata i jednog i po sata pre početka, pomenuti PDE5 inhibitor 1-2 sata i pomenuti testosteron ili njegov metabolit ili prekurzor 3,5-5,5 sati pre seksualne aktivnosti tako da se maksimalno dejstvo 5-HT1A agonista, PDE5 inhibitora i testosterona ili njegovog metabolita ili prekurzora delimično prepliće.
3. Testosteron ili njegov metabolit ili prekurzor i 5-HT1A agonist za upotrebu prema patentnom zahtjevu 1, pri čemu su pomenuti testosteron ili njegov metabolit ili prekurzor i 5-HT1A agonist obezbeđeni kao farmaceutsko jedinjenje koje obuhvata testosteron ili njegov metabolit ili prekurzor i 5- HT1 A agonist.
4. Testosteron ili njegov metabolit ili prekurzor i 5-HT1A agonist za upotrebu prema patentnom zahtjevu 2, pri čemu su pomenuti testosteron ili njegov metabolit ili prekurzor, 5-HT1A agonist, i PDE5 inhibitor obezbeđeni kao farmaceutsko jedinjenje koje obuhvata testosteron ili njegov metabolit ili prekurzor, PDE5 inhibitor i 5-HT1A agonist.
5. Testosteron ili njegov metabolit ili prekurzor i 5-HT1A agonist za upotrebu prema patentnom zahtevu 1, pri čemu su pomenuti testosteron ili njegov metabolit ili prekurzor i 5-HT1A agonist obezbeđeni kao komplet delova koji obuhvata najmanje jedno farmaceutsko jedinjenje koje obuhvata testosteron ili njegov metabolit ili prekurzor koji obuhvata 5- HT1A agonist. EP 2 086 544 61
6. Testosteron ili njegov metabolit ili prekurzor i 5-HT1A agonist za upotrebu prema patentnom zahtjevu 2, pri čemu su pomenuti testosteron ili njegov metabolit ili prekurzor, 5-HT1A agonist i PDE5 ihibitor obezbeđeni kao komplet delova koji obuhvata najmanje jedno farmaceutsko jedinjenje koje obuhvata testosteron ili njegov metabolit ili prekurzor, najmanje jedno jedinjenje koje obuhvata PDE5 inhibitor i najmanje jedno jedinjenje koje obuhvata 5-HT1A agonist.
7. Testosteron ili njegov metabolit ili prekurzor i 5-HT1A agonist za upotrebu prema jednom od patentnih zahtjeva 1-6, pri čemu je pomenuta seksualana disfunkcija ženska seksualna disfunkcija.
8. Testosteron ili njegov metabolit ili prekurzor i 5-HT1A agonist za upotrebu prema jednom od patentnih zahtjeva 1-6, pri čemu je pomenuta seksualana disfunkcija muška seksualna disfunkcija.
9. Testosteron ili njegov metabolit ili prekurzor i 5-HT1A agonist za upotrebu prema jednom od patentnih zahtjeva 1-8, pri čemu je 5-HT1A agonist 8-0H- OPAT, Alnespiron, AP-521, Buspar, Buspiron, Dipropii-5-CT, DU-125530, E6265, Ebalzotan, Eptapiron, Flesinoksan, Flibanserin, Gepiron, lpsapiron, Lesopitron, LY293284, LY301317, MKC242, R(+)-ZTH-301, Repinotan, SR57746A, Sunepitron, SUN-N4057, Tandosporin, U-92016A, Urapidil, VML-670, Zalospiron ili Zaprasidon.
1O. Testosteron ili njegov metabolit ili prekurzor i 5-HT1A agonist za upotrebu prema za upotrebu prema patentnom zahtevu 9, pri čemu je 5-HT1A agonist buspiron.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06076976A EP1925307A1 (en) | 2006-11-03 | 2006-11-03 | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
| EP07834663.2A EP2086544B1 (en) | 2006-11-03 | 2007-11-02 | Use of testosterone and a 5-ht1a agonist in the treatment of sexual dysfunction |
| PCT/NL2007/050533 WO2008054213A2 (en) | 2006-11-03 | 2007-11-02 | Use of testosterone and a 5-ht1a agonist in the treatment of sexual dysfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02410B true ME02410B (me) | 2016-09-20 |
Family
ID=37846101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2016-33A ME02410B (me) | 2006-11-03 | 2007-02-11 | Upotreba testosterona i 5-ht1a agonista za lečenje seksualne disfunkcije |
Country Status (27)
| Country | Link |
|---|---|
| US (10) | US8575139B2 (me) |
| EP (5) | EP1925307A1 (me) |
| JP (8) | JP2010509212A (me) |
| KR (6) | KR20090115113A (me) |
| CN (6) | CN103381270A (me) |
| AU (3) | AU2007314736B2 (me) |
| BR (3) | BRPI0717963A2 (me) |
| CA (3) | CA2668320C (me) |
| CY (1) | CY1117191T1 (me) |
| DK (1) | DK2086544T3 (me) |
| ES (1) | ES2561946T3 (me) |
| HR (1) | HRP20160108T1 (me) |
| HU (1) | HUE026752T2 (me) |
| IL (5) | IL198461A (me) |
| ME (1) | ME02410B (me) |
| MX (3) | MX2009004696A (me) |
| NO (3) | NO343597B1 (me) |
| NZ (3) | NZ577390A (me) |
| PH (2) | PH12014501440A1 (me) |
| PL (1) | PL2086544T3 (me) |
| PT (1) | PT2086544E (me) |
| RS (1) | RS54541B1 (me) |
| RU (4) | RU2463054C2 (me) |
| SI (1) | SI2086544T1 (me) |
| UA (4) | UA103592C2 (me) |
| WO (3) | WO2008054214A2 (me) |
| ZA (3) | ZA200903836B (me) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1750766T3 (pl) | 2004-05-11 | 2013-12-31 | Eb Ip Lybrido B V | Preparaty farmaceutyczne i ich zastosowania do leczenia zaburzeń seksualnych u kobiet |
| EP1790343A1 (en) * | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| EP1925307A1 (en) * | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
| EP2266568A1 (en) | 2009-05-26 | 2010-12-29 | Æterna Zentaris GmbH | Use of LHRH antagonists in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders |
| EP2266567A1 (en) | 2009-05-26 | 2010-12-29 | Æterna Zentaris GmbH | Use of cetrorelix in combination with PDE V inhibitors for the treatment of sex hormone dependent disorders |
| JP6121990B2 (ja) * | 2011-05-13 | 2017-04-26 | イービー アイピー ハイブリタブス ビー．ブイ． | 薬物送達システム |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| JP5828923B2 (ja) | 2014-01-30 | 2015-12-09 | 国立大学法人高知大学 | ニッケル粉の製造方法 |
| CA2939809C (en) | 2014-02-21 | 2017-08-22 | Kochi University, National University Corporation | Method for producing nickel powder |
| JP6406613B2 (ja) | 2014-04-15 | 2018-10-17 | 住友金属鉱山株式会社 | 含有する炭素及び硫黄の濃度を低減するニッケル粉の製造方法 |
| CN103947533B (zh) * | 2014-05-15 | 2015-12-16 | 青岛理工大学 | 生长环境可控的磁化水工厂化豆芽菜生产系统 |
| RU2600845C2 (ru) | 2014-07-04 | 2016-10-27 | Общество С Ограниченной Ответственностью "Консорциум-Пик" | Применение производных оксатриазолий-5-олата для лечения сексуальных расстройств |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
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|---|---|---|---|---|
| US3251436A (en) * | 1965-03-16 | 1966-05-17 | Dayton Steel Foundry Co | Spot-type disk brake |
| US3976776A (en) | 1972-12-06 | 1976-08-24 | Mead Johnson & Company | Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones |
| US4521421A (en) | 1983-09-26 | 1985-06-04 | Eli Lilly And Company | Treatment of sexual dysfunction |
| ZA848005B (en) | 1983-10-17 | 1985-05-29 | Duphar Int Res | Blood-pressure lowering piperazine derivatives |
| US4596795A (en) | 1984-04-25 | 1986-06-24 | The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services | Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives |
| US4640921A (en) | 1986-02-04 | 1987-02-03 | Bristol-Myers | Treatment of sexual dysfunction with buspirone |
| US5015646A (en) | 1987-08-28 | 1991-05-14 | Bristol-Myers Squibb Co. | Pharmaceutically useful polymorphic modification of buspirone |
| US4877774A (en) | 1987-09-09 | 1989-10-31 | The United States Of America As Represented By The Department Of Health And Human Services | Administration of steroid hormones |
| CA1335106C (en) | 1989-02-27 | 1995-04-04 | John Mehnert Schaus | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes |
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| US5250534A (en) | 1990-06-20 | 1993-10-05 | Pfizer Inc. | Pyrazolopyrimidinone antianginal agents |
| US5431922A (en) * | 1991-03-05 | 1995-07-11 | Bristol-Myers Squibb Company | Method for administration of buspirone |
| GB9301192D0 (en) | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
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