MD940402A - Eteri noi, procedeu de obţinere a lor, compoziţie farmaceutică, metodă de tratament - Google Patents

Eteri noi, procedeu de obţinere a lor, compoziţie farmaceutică, metodă de tratament

Info

Publication number
MD940402A
MD940402A MD94-0402A MD940402A MD940402A MD 940402 A MD940402 A MD 940402A MD 940402 A MD940402 A MD 940402A MD 940402 A MD940402 A MD 940402A
Authority
MD
Moldova
Prior art keywords
obtaining
treatment
pharmaceutical composition
new
general formula
Prior art date
Application number
MD94-0402A
Other languages
English (en)
Russian (ru)
Inventor
Bertil Valdemar Hansen
Per-Olov Gunnar Gunnarsson
Henri Rene Mollberg
Sven-Ake Johansson
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of MD940402A publication Critical patent/MD940402A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/46—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Invenţia se referă la eteri noi cu activitate anticancer, în special la eterii estramastinei.Compuşii noi au formula generală (I):Procedeul de obţinere a compuşilor cu formula (I) include eterificarea estramastinei cu acid, care posedă substituenţi capabili de reacţie, sau cu aminoacid cu formula generală HOOC-CHR'-(CH')-(CH2)n-NR2R5, formând substanţa intermediară cu formula (II):Apoi ea intră în reacţie formând compuşi noi cu formula (I).
MD94-0402A 1988-06-28 1994-07-14 Eteri noi, procedeu de obţinere a lor, compoziţie farmaceutică, metodă de tratament MD940402A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8802402A SE8802402D0 (sv) 1988-06-28 1988-06-28 Novel esters

Publications (1)

Publication Number Publication Date
MD940402A true MD940402A (ro) 1996-01-31

Family

ID=20372746

Family Applications (1)

Application Number Title Priority Date Filing Date
MD94-0402A MD940402A (ro) 1988-06-28 1994-07-14 Eteri noi, procedeu de obţinere a lor, compoziţie farmaceutică, metodă de tratament

Country Status (25)

Country Link
US (1) US5036062A (ro)
EP (1) EP0351561B1 (ro)
JP (1) JP2563587B2 (ro)
KR (1) KR910000607A (ro)
CN (1) CN1031060C (ro)
AT (1) ATE96446T1 (ro)
CA (1) CA1317587C (ro)
DD (1) DD284026A5 (ro)
DE (1) DE68910211T2 (ro)
DK (1) DK318989A (ro)
ES (1) ES2059626T3 (ro)
FI (1) FI92707C (ro)
HU (1) HU203766B (ro)
IE (1) IE62462B1 (ro)
IL (1) IL90724A0 (ro)
LT (1) LT3548B (ro)
LV (1) LV10235B (ro)
MD (1) MD940402A (ro)
NO (1) NO172939C (ro)
NZ (1) NZ229649A (ro)
PH (1) PH30437A (ro)
PT (1) PT90986B (ro)
RU (1) RU2036929C1 (ro)
SE (1) SE8802402D0 (ro)
ZA (1) ZA894716B (ro)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5209926A (en) * 1990-06-12 1993-05-11 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5256408A (en) * 1990-06-12 1993-10-26 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5124154A (en) * 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5252319A (en) * 1990-06-12 1993-10-12 Insite Vision Incorporated Aminosteroids for ophthalmic use
JP2520074B2 (ja) * 1992-06-11 1996-07-31 呉羽化学工業株式会社 新規なエストラジオ―ル誘導体−クロラムブチル結合体、その製造方法、及び医薬製剤
JPH07101977A (ja) * 1993-10-05 1995-04-18 Kureha Chem Ind Co Ltd ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤
FR2717690B1 (fr) * 1994-03-24 1996-04-26 Roussel Uclaf Application de stéroïdes aromatiques 3 substitués par un aminoalcoxy substitué à l'obtention d'un médicament pour contrôler la stérilité, notamment masculine.
GB9419153D0 (en) * 1994-09-22 1994-11-09 Erba Carlo Spa Estramustine formulations with improved pharmaceutical properties
US20030108764A1 (en) * 2001-12-04 2003-06-12 Neill John Thomas Method for improving bonding of circuit board substrates to metal surfaces and the articles formed thereby
CN101463295B (zh) * 2008-11-28 2011-08-17 江苏海迅实业集团股份有限公司 半导体工业用清洗剂
CN105636592A (zh) 2013-07-11 2016-06-01 伊万斯彻有限公司 形成前药的化合物
BR112020007673A2 (pt) 2017-10-19 2020-10-13 Evestra, Inc. contraceptivos pró-fármaco de progestina de ação prolongada
CN112979744B (zh) * 2021-02-18 2022-02-15 齐齐哈尔医学院 具有抗肿瘤活性的薯蓣皂苷元拼合氮芥衍生物及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1126386B (de) * 1959-11-14 1962-03-29 Hoechst Ag Verfahren zur Herstellung von Steroid-21-aminosaeureestern
US3299104A (en) * 1963-04-09 1967-01-17 Leo Ab Certain steroid nu-bis-(haloethyl)-carbamates
US4443440A (en) * 1982-08-30 1984-04-17 The Upjohn Company Amine containing ester prodrugs of corticosteroids
US4615835A (en) * 1983-11-17 1986-10-07 Stiftung Deutsches Krebsforschungs Zentrum Steroid esters of N-(2-halogenethyl)-N-nitroso-carbamoylamino and acids and peptides therefore, as well as method for preparing them
JPS617292A (ja) * 1984-06-20 1986-01-13 Japan Atom Energy Res Inst 制癌剤を結合させたエストラサイト系化合物を製造する方法

Also Published As

Publication number Publication date
US5036062A (en) 1991-07-30
FI893130A (fi) 1989-12-29
NO892672L (no) 1989-12-29
LV10235A (lv) 1994-10-20
FI92707B (fi) 1994-09-15
DK318989A (da) 1989-12-29
JP2563587B2 (ja) 1996-12-11
PT90986B (pt) 1994-11-30
CA1317587C (en) 1993-05-11
IE62462B1 (en) 1995-02-08
DE68910211T2 (de) 1994-05-11
DK318989D0 (da) 1989-06-27
ATE96446T1 (de) 1993-11-15
PH30437A (en) 1997-05-09
LTIP603A (en) 1995-01-31
FI92707C (fi) 1994-12-27
NO172939B (no) 1993-06-21
LV10235B (en) 1995-04-20
SE8802402D0 (sv) 1988-06-28
ZA894716B (en) 1990-03-28
HU203766B (en) 1991-09-30
JPH0253795A (ja) 1990-02-22
AU607621B2 (en) 1991-03-07
KR910000607A (ko) 1991-01-29
IE891908L (en) 1989-12-28
RU2036929C1 (ru) 1995-06-09
FI893130A0 (fi) 1989-06-27
CN1045792A (zh) 1990-10-03
HUT52521A (en) 1990-07-28
ES2059626T3 (es) 1994-11-16
AU3668289A (en) 1990-01-04
NO172939C (no) 1993-09-29
NZ229649A (en) 1991-12-23
EP0351561B1 (en) 1993-10-27
CN1031060C (zh) 1996-02-21
DE68910211D1 (de) 1993-12-02
EP0351561A1 (en) 1990-01-24
DD284026A5 (de) 1990-10-31
NO892672D0 (no) 1989-06-27
PT90986A (pt) 1989-12-29
IL90724A0 (en) 1990-01-18
LT3548B (en) 1995-11-27

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