MD4440B1 - Procedeu de sinteză enzimatică a acidului (7S)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-carboxilic şi aplicarea acestuia în sinteza ivabradinei şi a sărurilor sale - Google Patents
Procedeu de sinteză enzimatică a acidului (7S)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-carboxilic şi aplicarea acestuia în sinteza ivabradinei şi a sărurilor saleInfo
- Publication number
- MD4440B1 MD4440B1 MDA20140015A MD20140015A MD4440B1 MD 4440 B1 MD4440 B1 MD 4440B1 MD A20140015 A MDA20140015 A MD A20140015A MD 20140015 A MD20140015 A MD 20140015A MD 4440 B1 MD4440 B1 MD 4440B1
- Authority
- MD
- Moldova
- Prior art keywords
- synthesis
- ivabradine
- salts
- dimethoxybicyclo
- triene
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/05—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in nitriles (3.5.5)
- C12Y305/05001—Nitrilase (3.5.5.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Vascular Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Urology & Nephrology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Saccharide Compounds (AREA)
Abstract
Invenţia se referă la un procedeu de sinteză enzimatică a compusului cu formula (I):prin hidroliza enzimatică enantioselectivă a nitrilului racemic sau non optic pur cu formula (IV):cu ajutorul nitrilazei Rhodococcus rhodochrous NCIMB 11216 cu supraexpresie într-un alt organism care are un sistem biologic competent, într-un amestec de solvent organic şi soluţie apoasă.Invenţia se referă, de asemenea, la un procedeu de sinteză a ivabradinei, a sărurilor sale acceptabile farmaceutic sub formă anhidră sau de hidrat, cu utilizarea compusului cu formula (I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1351785A FR3002542B1 (fr) | 2013-02-28 | 2013-02-28 | Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique et application a la synthese de l'ivabradine et de ses sels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| MD20140015A2 MD20140015A2 (ro) | 2014-08-31 |
| MD4440B1 true MD4440B1 (ro) | 2016-10-31 |
| MD4440C1 MD4440C1 (ro) | 2017-05-31 |
Family
ID=48468557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20140015A MD4440C1 (ro) | 2013-02-28 | 2014-02-24 | Procedeu de sinteză enzimatică a acidului (7S)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-carboxilic şi aplicarea acestuia în sinteza ivabradinei şi a sărurilor sale |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US9476071B2 (ro) |
| EP (1) | EP2772547B1 (ro) |
| JP (1) | JP5837114B2 (ro) |
| KR (1) | KR101570727B1 (ro) |
| CN (1) | CN104017832B (ro) |
| AR (1) | AR094883A1 (ro) |
| AU (1) | AU2014200700B2 (ro) |
| BR (1) | BR102014004349A2 (ro) |
| CA (1) | CA2843985C (ro) |
| CY (1) | CY1116826T1 (ro) |
| DK (1) | DK2772547T3 (ro) |
| EA (1) | EA023883B1 (ro) |
| ES (1) | ES2549226T3 (ro) |
| FR (1) | FR3002542B1 (ro) |
| GE (1) | GEP201606578B (ro) |
| HK (2) | HK1198372A1 (ro) |
| HR (1) | HRP20150950T1 (ro) |
| HU (1) | HUE027809T2 (ro) |
| MA (1) | MA35612B1 (ro) |
| MD (1) | MD4440C1 (ro) |
| ME (1) | ME02217B (ro) |
| MX (1) | MX347536B (ro) |
| NZ (1) | NZ620915A (ro) |
| PL (1) | PL2772547T3 (ro) |
| PT (1) | PT2772547E (ro) |
| RS (1) | RS54167B1 (ro) |
| SG (1) | SG2014010854A (ro) |
| SI (1) | SI2772547T1 (ro) |
| WO (1) | WO2014131996A1 (ro) |
| ZA (1) | ZA201401224B (ro) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3101010A1 (en) | 2015-06-03 | 2016-12-07 | Urquima S.A. | New method for the preparation of highly pure ivabradine base and salts thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX169933B (es) * | 1987-09-18 | 1993-08-02 | Hideaki Yamada | Procedimiento para la produccion biologica de amidas |
| CZ280901B6 (cs) * | 1988-10-06 | 1996-05-15 | Hideaki Yamada | Způsob kultivace bakterií |
| AU627648B2 (en) * | 1990-02-28 | 1992-08-27 | Teruhiko Beppu | Dna fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant |
| FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
| JP3218133B2 (ja) * | 1993-02-03 | 2001-10-15 | 三菱レイヨン株式会社 | フェニル基を有する光学活性α−ヒドロキシカルボン酸の製造法 |
| DE10010149A1 (de) * | 2000-03-03 | 2001-09-06 | Basf Ag | Nitrilase aus Rhodococcus rhodochrous NCIMB 11216 |
| WO2007035161A1 (en) * | 2005-09-22 | 2007-03-29 | Astrazeneca Ab | New process for converting aromatic halo-substituted dinitriles into halo-substituted cyanocarboxylic acids |
| CA2626763A1 (en) | 2005-12-20 | 2007-06-28 | Basf Se | Method for producing 5-norbornen-2-carboxylic acid from 5-norbornen-2-carbonitrile using an arylacetonitrilase |
| CN101284813B (zh) * | 2007-04-12 | 2012-08-15 | 上海优拓医药科技有限公司 | 伊伐布雷定的制备方法 |
| FR2935381B1 (fr) * | 2008-08-29 | 2010-12-17 | Servier Lab | Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine |
| CN101671265B (zh) * | 2008-09-12 | 2012-08-15 | 中国科学院上海药物研究所 | 一种苯并环丁烷类化合物及其制备方法与用途 |
| HUP1000245A2 (en) * | 2010-05-07 | 2011-11-28 | Richter Gedeon Nyrt | Industrial process for the production ivabradin salts |
| CN102249937A (zh) * | 2010-05-18 | 2011-11-23 | 上海京新生物医药有限公司 | 1-(s)-4,5-二甲氧基-1-甲胺基甲基-苯并环丁烷的制备方法 |
-
2013
- 2013-02-28 FR FR1351785A patent/FR3002542B1/fr not_active Expired - Fee Related
-
2014
- 2014-02-07 NZ NZ620915A patent/NZ620915A/en not_active IP Right Cessation
- 2014-02-10 AU AU2014200700A patent/AU2014200700B2/en not_active Ceased
- 2014-02-11 SG SG2014010854A patent/SG2014010854A/en unknown
- 2014-02-14 MX MX2014001785A patent/MX347536B/es active IP Right Grant
- 2014-02-18 ZA ZA2014/01224A patent/ZA201401224B/en unknown
- 2014-02-18 CN CN201410054182.0A patent/CN104017832B/zh not_active Expired - Fee Related
- 2014-02-24 MA MA36779A patent/MA35612B1/fr unknown
- 2014-02-24 CA CA2843985A patent/CA2843985C/fr not_active Expired - Fee Related
- 2014-02-24 MD MDA20140015A patent/MD4440C1/ro not_active IP Right Cessation
- 2014-02-25 BR BR102014004349A patent/BR102014004349A2/pt not_active Application Discontinuation
- 2014-02-26 US US14/190,702 patent/US9476071B2/en not_active Expired - Fee Related
- 2014-02-26 GE GEAP201413399A patent/GEP201606578B/en unknown
- 2014-02-26 AR ARP140100591A patent/AR094883A1/es unknown
- 2014-02-27 KR KR1020140023556A patent/KR101570727B1/ko active IP Right Grant
- 2014-02-27 EA EA201400171A patent/EA023883B1/ru not_active IP Right Cessation
- 2014-02-27 SI SI201430006T patent/SI2772547T1/sl unknown
- 2014-02-27 PL PL14156910T patent/PL2772547T3/pl unknown
- 2014-02-27 JP JP2014036219A patent/JP5837114B2/ja active Active
- 2014-02-27 DK DK14156910.3T patent/DK2772547T3/en active
- 2014-02-27 ME MEP-2015-153A patent/ME02217B/me unknown
- 2014-02-27 ES ES14156910.3T patent/ES2549226T3/es active Active
- 2014-02-27 RS RS20150519A patent/RS54167B1/en unknown
- 2014-02-27 WO PCT/FR2014/050423 patent/WO2014131996A1/fr active Application Filing
- 2014-02-27 PT PT141569103T patent/PT2772547E/pt unknown
- 2014-02-27 HU HUE14156910A patent/HUE027809T2/en unknown
- 2014-02-27 EP EP14156910.3A patent/EP2772547B1/fr active Active
- 2014-11-24 HK HK14111867A patent/HK1198372A1/xx not_active IP Right Cessation
-
2015
- 2015-03-02 HK HK15102081.9A patent/HK1201564A1/xx unknown
- 2015-09-08 HR HRP20150950TT patent/HRP20150950T1/hr unknown
- 2015-09-16 CY CY20151100811T patent/CY1116826T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |