MX347536B - Procedimiento de sintesis enzimatica del acido (7s)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-carboxilico y aplicacion en la sintesis de ivabradina y de sus sales. - Google Patents

Procedimiento de sintesis enzimatica del acido (7s)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-carboxilico y aplicacion en la sintesis de ivabradina y de sus sales.

Info

Publication number
MX347536B
MX347536B MX2014001785A MX2014001785A MX347536B MX 347536 B MX347536 B MX 347536B MX 2014001785 A MX2014001785 A MX 2014001785A MX 2014001785 A MX2014001785 A MX 2014001785A MX 347536 B MX347536 B MX 347536B
Authority
MX
Mexico
Prior art keywords
synthesis
ivabradine
application
salts
dimethoxybicyclo
Prior art date
Application number
MX2014001785A
Other languages
English (en)
Other versions
MX2014001785A (es
Inventor
Pedragosa Moreau Sandrine
Lefoulon François
Original Assignee
Les Laboratories Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratories Servier filed Critical Les Laboratories Servier
Publication of MX2014001785A publication Critical patent/MX2014001785A/es
Publication of MX347536B publication Critical patent/MX347536B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/05—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in nitriles (3.5.5)
    • C12Y305/05001—Nitrilase (3.5.5.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/06—One of the condensed rings being a six-membered aromatic ring the other ring being four-membered
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Abstract

Procedimiento de síntesis enzimática del compuesto de fórmula (I): (ver Fórmula) Aplicación a la síntesis de la ivabradina y de sus sales de adición a un ácido farmacéuticamente aceptable.
MX2014001785A 2013-02-28 2014-02-14 Procedimiento de sintesis enzimatica del acido (7s)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-carboxilico y aplicacion en la sintesis de ivabradina y de sus sales. MX347536B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1351785A FR3002542B1 (fr) 2013-02-28 2013-02-28 Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique et application a la synthese de l'ivabradine et de ses sels

Publications (2)

Publication Number Publication Date
MX2014001785A MX2014001785A (es) 2014-09-08
MX347536B true MX347536B (es) 2017-05-02

Family

ID=48468557

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014001785A MX347536B (es) 2013-02-28 2014-02-14 Procedimiento de sintesis enzimatica del acido (7s)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-carboxilico y aplicacion en la sintesis de ivabradina y de sus sales.

Country Status (30)

Country Link
US (1) US9476071B2 (es)
EP (1) EP2772547B1 (es)
JP (1) JP5837114B2 (es)
KR (1) KR101570727B1 (es)
CN (1) CN104017832B (es)
AR (1) AR094883A1 (es)
AU (1) AU2014200700B2 (es)
BR (1) BR102014004349A2 (es)
CA (1) CA2843985C (es)
CY (1) CY1116826T1 (es)
DK (1) DK2772547T3 (es)
EA (1) EA023883B1 (es)
ES (1) ES2549226T3 (es)
FR (1) FR3002542B1 (es)
GE (1) GEP201606578B (es)
HK (2) HK1198372A1 (es)
HR (1) HRP20150950T1 (es)
HU (1) HUE027809T2 (es)
MA (1) MA35612B1 (es)
MD (1) MD4440C1 (es)
ME (1) ME02217B (es)
MX (1) MX347536B (es)
NZ (1) NZ620915A (es)
PL (1) PL2772547T3 (es)
PT (1) PT2772547E (es)
RS (1) RS54167B1 (es)
SG (1) SG2014010854A (es)
SI (1) SI2772547T1 (es)
WO (1) WO2014131996A1 (es)
ZA (1) ZA201401224B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD274631A5 (de) * 1987-09-18 1989-12-27 Kk Verfahren zur biologischen herstellung von amiden
CZ280901B6 (cs) * 1988-10-06 1996-05-15 Hideaki Yamada Způsob kultivace bakterií
AU627648B2 (en) * 1990-02-28 1992-08-27 Teruhiko Beppu Dna fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
JP3218133B2 (ja) * 1993-02-03 2001-10-15 三菱レイヨン株式会社 フェニル基を有する光学活性α−ヒドロキシカルボン酸の製造法
DE10010149A1 (de) 2000-03-03 2001-09-06 Basf Ag Nitrilase aus Rhodococcus rhodochrous NCIMB 11216
JP2009508522A (ja) * 2005-09-22 2009-03-05 アストラゼネカ・アクチエボラーグ 芳香族ハロ−置換ジニトリルをハロ−置換シアノカルボン酸に変換する新規な方法
EP1966381A2 (de) 2005-12-20 2008-09-10 Basf Se Verfahren zur herstellung von 5-norbornen-2-carbonsäure aus 5-norbornen-2-carbonitril unter verwendung einer arylacetonitrilase
CN101284813B (zh) * 2007-04-12 2012-08-15 上海优拓医药科技有限公司 伊伐布雷定的制备方法
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
CN101671265B (zh) * 2008-09-12 2012-08-15 中国科学院上海药物研究所 一种苯并环丁烷类化合物及其制备方法与用途
HUP1000245A2 (en) * 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
CN102249937A (zh) * 2010-05-18 2011-11-23 上海京新生物医药有限公司 1-(s)-4,5-二甲氧基-1-甲胺基甲基-苯并环丁烷的制备方法

Also Published As

Publication number Publication date
ES2549226T3 (es) 2015-10-26
US9476071B2 (en) 2016-10-25
ZA201401224B (en) 2015-12-23
PT2772547E (pt) 2015-08-05
CA2843985C (fr) 2018-03-20
EP2772547A1 (fr) 2014-09-03
US20140242644A1 (en) 2014-08-28
MD20140015A2 (ro) 2014-08-31
AR094883A1 (es) 2015-09-02
HUE027809T2 (en) 2016-11-28
AU2014200700B2 (en) 2017-06-22
FR3002542A1 (fr) 2014-08-29
NZ620915A (en) 2015-02-27
CN104017832B (zh) 2017-04-12
EA023883B1 (ru) 2016-07-29
AU2014200700A1 (en) 2014-09-11
KR20140108163A (ko) 2014-09-05
FR3002542B1 (fr) 2016-01-22
HRP20150950T1 (en) 2015-10-09
HK1201564A1 (en) 2015-09-04
MX2014001785A (es) 2014-09-08
MA35612B1 (fr) 2014-11-01
JP5837114B2 (ja) 2015-12-24
JP2014168461A (ja) 2014-09-18
HK1198372A1 (en) 2015-04-10
RS54167B1 (en) 2015-12-31
PL2772547T3 (pl) 2015-12-31
KR101570727B1 (ko) 2015-11-23
EP2772547B1 (fr) 2015-07-08
CY1116826T1 (el) 2017-03-15
SG2014010854A (en) 2014-09-26
DK2772547T3 (en) 2015-10-19
SI2772547T1 (sl) 2015-10-30
MD4440C1 (ro) 2017-05-31
BR102014004349A2 (pt) 2015-10-20
WO2014131996A1 (fr) 2014-09-04
MD4440B1 (ro) 2016-10-31
ME02217B (me) 2016-02-20
EA201400171A1 (ru) 2014-08-29
CN104017832A (zh) 2014-09-03
CA2843985A1 (fr) 2014-08-28
GEP201606578B (en) 2016-11-25

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