MD3846810T2 - Dozare cronică nocturnă a lasmiditanului pentru prevenirea migrenei - Google Patents
Dozare cronică nocturnă a lasmiditanului pentru prevenirea migreneiInfo
- Publication number
- MD3846810T2 MD3846810T2 MDE20210640T MDE20210640T MD3846810T2 MD 3846810 T2 MD3846810 T2 MD 3846810T2 MD E20210640 T MDE20210640 T MD E20210640T MD E20210640 T MDE20210640 T MD E20210640T MD 3846810 T2 MD3846810 T2 MD 3846810T2
- Authority
- MD
- Moldova
- Prior art keywords
- lasmiditan
- migraine
- prevention
- migraine prevention
- chronic
- Prior art date
Links
- 208000019695 Migraine disease Diseases 0.000 title abstract 4
- 206010027599 migraine Diseases 0.000 title abstract 4
- 230000002265 prevention Effects 0.000 title abstract 3
- 230000001684 chronic effect Effects 0.000 title abstract 2
- XEDHVZKDSYZQBF-UHFFFAOYSA-N lasmiditan Chemical compound C1CN(C)CCC1C(=O)C1=CC=CC(NC(=O)C=2C(=CC(F)=CC=2F)F)=N1 XEDHVZKDSYZQBF-UHFFFAOYSA-N 0.000 title abstract 2
- 229950009142 lasmiditan Drugs 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 230000009977 dual effect Effects 0.000 abstract 1
- 230000000422 nocturnal effect Effects 0.000 abstract 1
- 238000009097 single-agent therapy Methods 0.000 abstract 1
- 238000011285 therapeutic regimen Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
Abstract
Prezenta invenţie se referă la utilizarea nocturnă cronică de lasmiditan pentru prevenirea migrenei, în special a migrenei rezistente la terapie care este definită în acest document ca migrenă refractară la două sau mai multe regimuri terapeutice anterioare de tratament sau de prevenire cu monoterapie şi/sau terapie dublă.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862726585P | 2018-09-04 | 2018-09-04 | |
| PCT/US2019/049340 WO2020051137A1 (en) | 2018-09-04 | 2019-09-03 | Chronic nightly dosing of lasmiditan for migraine prevention |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD3846810T2 true MD3846810T2 (ro) | 2024-04-30 |
Family
ID=68051892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDE20210640T MD3846810T2 (ro) | 2018-09-04 | 2019-09-03 | Dozare cronică nocturnă a lasmiditanului pentru prevenirea migrenei |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US20210338655A1 (ro) |
| EP (2) | EP4279132A3 (ro) |
| JP (2) | JP7321256B2 (ro) |
| KR (1) | KR102649644B1 (ro) |
| CN (1) | CN112638383A (ro) |
| AU (2) | AU2019336667B2 (ro) |
| BR (1) | BR112021002945A2 (ro) |
| CA (1) | CA3111205A1 (ro) |
| CL (1) | CL2021000529A1 (ro) |
| CO (1) | CO2021002766A2 (ro) |
| CR (1) | CR20210126A (ro) |
| DK (1) | DK3846810T3 (ro) |
| DO (1) | DOP2021000039A (ro) |
| EA (1) | EA202190440A1 (ro) |
| EC (1) | ECSP21015491A (ro) |
| ES (1) | ES2967665T3 (ro) |
| FI (1) | FI3846810T3 (ro) |
| HR (1) | HRP20231587T1 (ro) |
| HU (1) | HUE064519T2 (ro) |
| IL (1) | IL281208B1 (ro) |
| JO (1) | JOP20210033A1 (ro) |
| LT (1) | LT3846810T (ro) |
| MA (1) | MA53551B1 (ro) |
| MD (1) | MD3846810T2 (ro) |
| MX (1) | MX2021002474A (ro) |
| PE (1) | PE20211599A1 (ro) |
| PH (1) | PH12021550448A1 (ro) |
| PL (1) | PL3846810T3 (ro) |
| PT (1) | PT3846810T (ro) |
| RS (1) | RS64857B1 (ro) |
| SG (1) | SG11202101530PA (ro) |
| SI (1) | SI3846810T1 (ro) |
| TW (1) | TWI826514B (ro) |
| WO (1) | WO2020051137A1 (ro) |
| ZA (1) | ZA202100666B (ro) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102448369B1 (ko) | 2014-02-05 | 2022-09-28 | 머크 샤프 앤드 돔 엘엘씨 | Cgrp-활성 화합물에 대한 정제 제제 |
| EP4188375A4 (en) | 2020-07-29 | 2024-07-24 | Allergan Pharmaceuticals Int Ltd | TREATMENT OF MIGRAINE |
| AU2021409718A1 (en) | 2020-12-22 | 2023-07-13 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698571A (en) * | 1994-10-05 | 1997-12-16 | Eli Lilly And Company | 5-HT1F mediated inhibition of neurogenic meningeal extravasation: a method for the treatment of migraine |
| TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
| CA2757019C (en) | 2009-04-02 | 2018-05-15 | Colucid Pharmaceuticals, Inc. | Composition of 2,4,6-trifluoro-n-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamide |
| WO2011123654A1 (en) | 2010-04-02 | 2011-10-06 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinoylpiperidine 5-ht1f agonists |
-
2019
- 2019-09-02 TW TW108131567A patent/TWI826514B/zh active
- 2019-09-03 LT LTEPPCT/US2019/049340T patent/LT3846810T/lt unknown
- 2019-09-03 JP JP2021512380A patent/JP7321256B2/ja active Active
- 2019-09-03 PE PE2021000286A patent/PE20211599A1/es unknown
- 2019-09-03 HR HRP20231587TT patent/HRP20231587T1/hr unknown
- 2019-09-03 EA EA202190440A patent/EA202190440A1/ru unknown
- 2019-09-03 IL IL281208A patent/IL281208B1/en unknown
- 2019-09-03 MX MX2021002474A patent/MX2021002474A/es unknown
- 2019-09-03 ES ES19773583T patent/ES2967665T3/es active Active
- 2019-09-03 PT PT197735830T patent/PT3846810T/pt unknown
- 2019-09-03 KR KR1020217005977A patent/KR102649644B1/ko active IP Right Grant
- 2019-09-03 US US17/271,950 patent/US20210338655A1/en active Pending
- 2019-09-03 AU AU2019336667A patent/AU2019336667B2/en active Active
- 2019-09-03 BR BR112021002945-1A patent/BR112021002945A2/pt unknown
- 2019-09-03 HU HUE19773583A patent/HUE064519T2/hu unknown
- 2019-09-03 EP EP23195738.2A patent/EP4279132A3/en active Pending
- 2019-09-03 PL PL19773583.0T patent/PL3846810T3/pl unknown
- 2019-09-03 FI FIEP19773583.0T patent/FI3846810T3/fi active
- 2019-09-03 DK DK19773583.0T patent/DK3846810T3/da active
- 2019-09-03 MA MA53551A patent/MA53551B1/fr unknown
- 2019-09-03 CA CA3111205A patent/CA3111205A1/en active Pending
- 2019-09-03 SG SG11202101530PA patent/SG11202101530PA/en unknown
- 2019-09-03 WO PCT/US2019/049340 patent/WO2020051137A1/en active Application Filing
- 2019-09-03 CR CR20210126A patent/CR20210126A/es unknown
- 2019-09-03 RS RS20231107A patent/RS64857B1/sr unknown
- 2019-09-03 JO JOP/2021/0033A patent/JOP20210033A1/ar unknown
- 2019-09-03 CN CN201980055464.3A patent/CN112638383A/zh active Pending
- 2019-09-03 EP EP19773583.0A patent/EP3846810B1/en active Active
- 2019-09-03 MD MDE20210640T patent/MD3846810T2/ro unknown
- 2019-09-03 SI SI201930647T patent/SI3846810T1/sl unknown
-
2021
- 2021-01-29 ZA ZA2021/00666A patent/ZA202100666B/en unknown
- 2021-03-01 CO CONC2021/0002766A patent/CO2021002766A2/es unknown
- 2021-03-02 PH PH12021550448A patent/PH12021550448A1/en unknown
- 2021-03-02 DO DO2021000039A patent/DOP2021000039A/es unknown
- 2021-03-03 CL CL2021000529A patent/CL2021000529A1/es unknown
- 2021-03-04 EC ECSENADI202115491A patent/ECSP21015491A/es unknown
-
2022
- 2022-12-22 AU AU2022291568A patent/AU2022291568A1/en active Pending
-
2023
- 2023-07-25 JP JP2023120471A patent/JP7543497B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12017502103A1 (en) | Methods and kits for treating depression | |
| MD3846810T2 (ro) | Dozare cronică nocturnă a lasmiditanului pentru prevenirea migrenei | |
| MX2018004947A (es) | Metodos para el tratamiento de sindrome de angelman y de los trastornos relacionados. | |
| MX2023008760A (es) | Terapia combinada de lasmiditan y un antagonista de cgrp para el uso en el tratamiento de la migra?a. | |
| EA202090510A1 (ru) | Способ лечения бокового амиотрофического склероза придопидином | |
| EA201390060A1 (ru) | Аннелированные пиримидины и триазины и их применение для лечения и/или профилактики сердечно-сосудистых заболеваний | |
| MX2019001814A (es) | Tratamiento y remision virologica sostenida de infeccion de vih mediante anticuerpos a cd4 en pacientes estabilizados con haart. | |
| MX2017003211A (es) | Anticuerpos anti-met y composiciones. | |
| EA201791696A1 (ru) | Композиция для лечения веноокклюзионной болезни печени | |
| MX2017014396A (es) | Tratamiento de mieloma multiple. | |
| PH12021550122A1 (en) | Solubilized apyrases, methods and use | |
| NZ743344A (en) | Il-8 inhibitors for use in the treatment of chemotherapy-induced peripheral neuropathy | |
| EA201892631A1 (ru) | Дигидротестостерон и производные и промоторы дигидротестостерона в лечении рака | |
| EA201791525A3 (ru) | Соединения для лечения блокады ремиелинизации при заболеваниях, связанных с экспрессией белка оболочки herv-w | |
| EA202090266A1 (ru) | Ингибиторы mpo для применения в медицине | |
| SA515360377B1 (ar) | نظائر خيمرية من سوماتوستاتين- دوبامين | |
| ES2482342A1 (es) | TRATAMIENTO TERAPÉUTICO DE LEUCEMIAS LINFOBLÁSTICAS AGUDAS T y B Y LINFOMAS HUMANOS POR INHIBICIÓN DEL RECEPTOR DE INTERLEUQUINA-7 (IL-7R) | |
| MX2017002093A (es) | Terapia con anticuerpos para vih como sustituto de tratamiento. | |
| MD3638370T2 (ro) | Tratamentul migrenei cu acetil-leucină | |
| MD3322438T2 (ro) | Inhibitori ai IL-8 pentru utilizare în tratamentul anumitor tulburări urologice | |
| MX2021003302A (es) | Uso de gaboxadol para el tratamiento del sindrome de tourette, los tics y la tartamudez. | |
| EA201692564A1 (ru) | Комбинированная терапия | |
| EA201790537A1 (ru) | Дипептидилкетоамидные соединения и их применение для лечения и/или предотвращения накопления жира | |
| EA202091524A1 (ru) | Ингибиторы рецептора, активируемого протеазой 2 | |
| PH12015502304A1 (en) | Use of pidotimod to treat irritable bowel syndrome |