EA202090510A1 - Способ лечения бокового амиотрофического склероза придопидином - Google Patents
Способ лечения бокового амиотрофического склероза придопидиномInfo
- Publication number
- EA202090510A1 EA202090510A1 EA202090510A EA202090510A EA202090510A1 EA 202090510 A1 EA202090510 A1 EA 202090510A1 EA 202090510 A EA202090510 A EA 202090510A EA 202090510 A EA202090510 A EA 202090510A EA 202090510 A1 EA202090510 A1 EA 202090510A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pridopidin
- treatment
- amyotrophic sclerosis
- lateral amyotrophic
- lateral
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 208000034189 Sclerosis Diseases 0.000 title 1
- FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 abstract 1
- 238000011360 adjunctive therapy Methods 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 229940037876 dextromethorphan / quinidine Drugs 0.000 abstract 1
- QELUYTUMUWHWMC-UHFFFAOYSA-N edaravone Chemical compound O=C1CC(C)=NN1C1=CC=CC=C1 QELUYTUMUWHWMC-UHFFFAOYSA-N 0.000 abstract 1
- 229950009041 edaravone Drugs 0.000 abstract 1
- MRUNQKQTAMUPRF-PUTLROBFSA-N nuedexta Chemical compound Br.OS(O)(=O)=O.C([C@@H]12)CCC[C@]11CCN(C)[C@H]2CC2=CC=C(OC)C=C21.C1C([C@H](C2)C=C)CCN2[C@H]1[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21.C1C([C@H](C2)C=C)CCN2[C@H]1[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 MRUNQKQTAMUPRF-PUTLROBFSA-N 0.000 abstract 1
- YGKUEOZJFIXDGI-UHFFFAOYSA-N pridopidine Chemical compound C1CN(CCC)CCC1C1=CC=CC(S(C)(=O)=O)=C1 YGKUEOZJFIXDGI-UHFFFAOYSA-N 0.000 abstract 1
- 229950003764 pridopidine Drugs 0.000 abstract 1
- 229960004181 riluzole Drugs 0.000 abstract 1
- 238000009097 single-agent therapy Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
В настоящем документе представлен способ лечения человеческого субъекта, страдающего БАС, путем введения субъекту терапевтически эффективного количества придопидина в качестве монотерапии или вместе с рилузолом, эдаравоном или декстрометорфаном/хинидином в качестве комбинированной или дополнительной терапии.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762545315P | 2017-08-14 | 2017-08-14 | |
PCT/US2018/046481 WO2019036358A1 (en) | 2017-08-14 | 2018-08-13 | METHODS OF TREATING AMYOTROPHIC LATERAL SCLEROSIS WITH PRIDOPIDINE |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202090510A1 true EA202090510A1 (ru) | 2020-06-08 |
Family
ID=63405481
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202090510A EA202090510A1 (ru) | 2017-08-14 | 2018-08-13 | Способ лечения бокового амиотрофического склероза придопидином |
Country Status (16)
Country | Link |
---|---|
US (1) | US11406625B2 (ru) |
EP (2) | EP4154882A1 (ru) |
JP (1) | JP7082186B2 (ru) |
CN (2) | CN111278440B (ru) |
AU (1) | AU2018317346B2 (ru) |
BR (1) | BR112020003119A2 (ru) |
CA (1) | CA3072882C (ru) |
DK (1) | DK3668509T3 (ru) |
EA (1) | EA202090510A1 (ru) |
ES (1) | ES2938546T3 (ru) |
FI (1) | FI3668509T3 (ru) |
HU (1) | HUE061505T2 (ru) |
IL (1) | IL272596B2 (ru) |
MX (1) | MX2020001836A (ru) |
PL (1) | PL3668509T3 (ru) |
WO (1) | WO2019036358A1 (ru) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130197031A1 (en) | 2010-09-03 | 2013-08-01 | IVAX International GmbH | Deuterated analogs of pridopidine useful as dopaminergic stabilizers |
US11090297B2 (en) | 2013-06-21 | 2021-08-17 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating huntington's disease |
CA3035099C (en) | 2016-08-24 | 2023-01-17 | Prilenia Therapeutics Development Ltd. | Use of pridopidine for treating dystonias |
CA3151507C (en) | 2016-08-24 | 2024-05-28 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine for treating functional decline |
US12102627B2 (en) | 2016-09-16 | 2024-10-01 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine for treating rett syndrome |
FI3668509T3 (fi) | 2017-08-14 | 2023-03-14 | Prilenia Neurotherapeutics Ltd | Menetelmä hoitaa amyotrofista lateraaliskleroosia pridopidiinilla |
EP3678664A1 (en) | 2017-09-08 | 2020-07-15 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating drug induced dyskinesias |
US12036213B2 (en) | 2017-09-08 | 2024-07-16 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating drug induced dyskinesias |
AU2021219072B2 (en) * | 2020-02-13 | 2024-10-03 | Prilenia Neurotherapeutics Ltd. | Combination therapy for treating amyotrophic lateral using pridopidine and another active agent |
CN112972480A (zh) * | 2021-03-09 | 2021-06-18 | 兆科药业(广州)有限公司 | 一种含牛磺熊去氧胆酸、苯丁酸钠的复方散剂/颗粒剂、制备方法、用途以及其药物组合物 |
WO2022188029A1 (zh) * | 2021-03-09 | 2022-09-15 | 兆科药业(广州)有限公司 | 一种含牛磺熊去氧胆酸、苯丁酸钠的复方散剂/颗粒剂、制备方法、用途以及其药物组合物 |
US20230277630A1 (en) * | 2022-03-02 | 2023-09-07 | Amylyx Pharmaceuticals, Inc. | Methods and compositions for treating amyotrophic lateral sclerosis |
CN117603982B (zh) * | 2024-01-22 | 2024-04-19 | 中国医学科学院北京协和医院 | 肌萎缩侧索硬化症的SQSTM1的p.P374TfsTer18突变致病基因及其应用 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9904724D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
US20040063751A1 (en) | 2002-05-31 | 2004-04-01 | Pharmacia Corporation | Combination therapy for the treatment of amyotrophic lateral sclerosis (ALS) with cyclooxygenase-2 (COX-2) inhibitor(s) and a second drug |
HUE029790T2 (hu) | 2004-10-13 | 2017-04-28 | Teva Pharmaceuticals Int Gmbh | Eljárás 4-(3-metánszulfonil-fenil)-l-N-propil-piperidin elõállítására |
WO2008127188A1 (en) | 2007-04-12 | 2008-10-23 | Allbay Ab | N-oxide and/or di-n-oxide derivatives of dopamine receptor stabilizers/modulators displaying improved cardiovascular side-effects profiles |
TW200848063A (en) | 2007-04-23 | 2008-12-16 | Combinatorx Inc | Methods and compositions for the treatment of neurodegenerative disorders |
US20130197031A1 (en) | 2010-09-03 | 2013-08-01 | IVAX International GmbH | Deuterated analogs of pridopidine useful as dopaminergic stabilizers |
EP2753603B1 (en) | 2011-09-07 | 2017-06-21 | Teva Pharmaceuticals International GmbH | Polymorphic form of pridopidine hydrochloride |
UY34503A (es) | 2011-12-08 | 2013-07-31 | Ivax Int Gmbh | ?sal de bromhidrato de pridopidina? |
AU2013243461A1 (en) | 2012-04-04 | 2014-11-06 | Teva Pharmaceuticals International Gmbh | Pharmaceutical compositions for combination therapy |
WO2014052935A2 (en) | 2012-09-27 | 2014-04-03 | Teva Pharmaceutical Industries Ltd. | Combination of rasagiline and pridopidine for treating neurodegenerative disorders, in particular huntington's disease |
MX2015003608A (es) * | 2012-09-27 | 2015-06-05 | Teva Pharma | Combinacion de laquinimod y pridopidina para tratar trastornos neurodegenerativos. |
EP2994145B1 (en) | 2013-05-07 | 2023-01-04 | Bio Blast Pharma Ltd. | Treatment of oculopharyngeal muscular dystrophy by intravenous administration of trehalose |
ES2879631T3 (es) * | 2013-06-21 | 2021-11-22 | Prilenia Neurotherapeutics Ltd | Pridopidina para el tratamiento de la enfermedad de Huntington |
EP4049657A1 (en) | 2014-01-22 | 2022-08-31 | Prilenia Neurotherapeutics Ltd. | Modified release formulations of pridopidine |
TW201613859A (en) | 2014-06-30 | 2016-04-16 | Teva Pharma | Analogs of PRIDOPIDINE, their preparation and use |
US9796673B2 (en) | 2014-12-22 | 2017-10-24 | Teva Pharmaceuticals International Gmbh | L-tartrate salt of pridopidine |
HUE060353T2 (hu) | 2015-02-25 | 2023-02-28 | Prilenia Neurotherapeutics Ltd | Pridopidin alkalmazása memória javítására |
WO2016138135A1 (en) | 2015-02-25 | 2016-09-01 | Teva Pharmaceuticals International Gmbh | Sigma-1 receptor modulators for treating huntington's disease |
AR105434A1 (es) | 2015-07-22 | 2017-10-04 | Teva Pharmaceuticals Int Gmbh | Proceso para preparar pridopidina |
US20170020854A1 (en) | 2015-07-22 | 2017-01-26 | Teva Pharmaceuticals International Gmbh | Pridopidine base formulations and their use |
FI3668509T3 (fi) | 2017-08-14 | 2023-03-14 | Prilenia Neurotherapeutics Ltd | Menetelmä hoitaa amyotrofista lateraaliskleroosia pridopidiinilla |
-
2018
- 2018-08-13 FI FIEP18760219.8T patent/FI3668509T3/fi active
- 2018-08-13 CN CN201880065983.3A patent/CN111278440B/zh active Active
- 2018-08-13 WO PCT/US2018/046481 patent/WO2019036358A1/en unknown
- 2018-08-13 EA EA202090510A patent/EA202090510A1/ru unknown
- 2018-08-13 BR BR112020003119-4A patent/BR112020003119A2/pt active Search and Examination
- 2018-08-13 IL IL272596A patent/IL272596B2/en unknown
- 2018-08-13 EP EP22205384.5A patent/EP4154882A1/en active Pending
- 2018-08-13 EP EP18760219.8A patent/EP3668509B1/en active Active
- 2018-08-13 JP JP2020508347A patent/JP7082186B2/ja active Active
- 2018-08-13 PL PL18760219.8T patent/PL3668509T3/pl unknown
- 2018-08-13 CA CA3072882A patent/CA3072882C/en active Active
- 2018-08-13 HU HUE18760219A patent/HUE061505T2/hu unknown
- 2018-08-13 ES ES18760219T patent/ES2938546T3/es active Active
- 2018-08-13 DK DK18760219.8T patent/DK3668509T3/da active
- 2018-08-13 MX MX2020001836A patent/MX2020001836A/es unknown
- 2018-08-13 AU AU2018317346A patent/AU2018317346B2/en active Active
- 2018-08-13 CN CN202310491754.0A patent/CN116370473A/zh active Pending
-
2020
- 2020-02-13 US US16/789,564 patent/US11406625B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
HUE061505T2 (hu) | 2023-07-28 |
JP7082186B2 (ja) | 2022-06-07 |
FI3668509T3 (fi) | 2023-03-14 |
WO2019036358A1 (en) | 2019-02-21 |
EP3668509B1 (en) | 2022-11-16 |
EP4154882A1 (en) | 2023-03-29 |
US20200179355A1 (en) | 2020-06-11 |
CA3072882A1 (en) | 2019-02-21 |
CN116370473A (zh) | 2023-07-04 |
CA3072882C (en) | 2023-03-21 |
US11406625B2 (en) | 2022-08-09 |
CN111278440A (zh) | 2020-06-12 |
EP3668509A1 (en) | 2020-06-24 |
IL272596B1 (en) | 2024-01-01 |
BR112020003119A2 (pt) | 2020-10-13 |
AU2018317346A1 (en) | 2020-02-27 |
PL3668509T3 (pl) | 2023-03-20 |
MX2020001836A (es) | 2020-08-10 |
CN111278440B (zh) | 2023-04-25 |
DK3668509T3 (da) | 2023-02-20 |
ES2938546T3 (es) | 2023-04-12 |
AU2018317346B2 (en) | 2021-08-26 |
IL272596A (en) | 2020-03-31 |
JP2020530847A (ja) | 2020-10-29 |
IL272596B2 (en) | 2024-05-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA202090510A1 (ru) | Способ лечения бокового амиотрофического склероза придопидином | |
MX2020001732A (es) | Tratamiento de las afecciones del sistema nervioso central. | |
PH12017500493A1 (en) | Combination therapy | |
MX2022001778A (es) | Metodos para tratar esquizofrenia. | |
PH12015501858A1 (en) | Use of agonists of formyl peptide receptor 2 for treating ocular inflammatory diseases | |
BR112022002609A2 (pt) | Métodos de tratamento de tumores estromais gastrointestinais | |
MY177740A (en) | Treatment of cataplexy | |
EA201891925A1 (ru) | Антитела к cd40 с усиленной агонистической активностью | |
NZ739392A (en) | Methods for treating hepcidin-mediated disorders | |
EA202091640A1 (ru) | Способы лечения опосредованного il-6 воспаления без иммунодепрессии | |
NZ767902A (en) | Methods of treating ulcerative colitis | |
EA202192122A1 (ru) | Соединения, обладающие активностью индуцирования ферроптоза, и способы их применения | |
EP4279127A3 (en) | Growth differentiation factor 15 as biomarker for metformin | |
MX2019001958A (es) | Metodos para tratar la enfermedad de crohn con un anticuerpo anti-nkg2d. | |
BR112019005539A2 (pt) | métodos de tratamento de lesão renal aguda | |
MX2021007330A (es) | Composiciones y métodos terapéuticos para tratar cáncer usando ácido 6, 8-bis-benciltio-octanoico y un inhibidor de autofagia. | |
MX2017014396A (es) | Tratamiento de mieloma multiple. | |
WO2015126930A3 (en) | Booster drug therapy for mycobacterium infections | |
MA38369B1 (fr) | Peptides et compositions pour le traitement d'une lesion de l'articulation | |
BR112019004791A2 (pt) | tratamento de esclerose múltipla com chs-131 | |
MX2020003243A (es) | Métodos para tratar la insuficiencia cardíaca con fracción de eyección preservada. | |
BR112018002763A2 (pt) | método para cicatrização de ferimentos | |
MX2017002093A (es) | Terapia con anticuerpos para vih como sustituto de tratamiento. | |
BR112017002449A2 (pt) | tratamento de sintomas associados com terapia de privação androgênica | |
EA201990559A1 (ru) | Комбинированная терапия |