MD3277677T2 - Compuși de 1-ciano-pirolidină utilizați ca inhibitori de USP30 - Google Patents

Compuși de 1-ciano-pirolidină utilizați ca inhibitori de USP30

Info

Publication number
MD3277677T2
MD3277677T2 MDE20180120T MDE20180120T MD3277677T2 MD 3277677 T2 MD3277677 T2 MD 3277677T2 MD E20180120 T MDE20180120 T MD E20180120T MD E20180120 T MDE20180120 T MD E20180120T MD 3277677 T2 MD3277677 T2 MD 3277677T2
Authority
MD
Moldova
Prior art keywords
cyano
compounds
inhibitors
usp30
relates
Prior art date
Application number
MDE20180120T
Other languages
English (en)
Inventor
Alison Jones
Mark KEMP
Martin Stockley
Karl Gibson
Gavin WHITLOCK
Original Assignee
Mission Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1505429.9A external-priority patent/GB201505429D0/en
Priority claimed from GBGB1512829.1A external-priority patent/GB201512829D0/en
Application filed by Mission Therapeutics Ltd filed Critical Mission Therapeutics Ltd
Publication of MD3277677T2 publication Critical patent/MD3277677T2/ro

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Prezenta invenţie se referă la noi compuşi şi metode pentru fabricarea inhibitorilor enzimelor de dezubiquitilare (DUB). În particular, invenţia se referă la inhibarea ubiquitin C-terminal hidrolazei 30 (USP30). Invenţia se referă, în plus, la utilizarea inhibitorilor de DUB în tratamentul afecţiunilor care implică disfuncţii mitocondriale şi în tratamentul cancerului. Compuşii invenţiei includ compuşi cu formula (II) sau o sare acceptabilă farmaceutic a acestora, în care R1, R2, R3, R4, R5, R8, R9, R10, R12, Z, Y şi m sunt aşa cum sunt definiţi în invenţie.
MDE20180120T 2015-03-30 2016-03-24 Compuși de 1-ciano-pirolidină utilizați ca inhibitori de USP30 MD3277677T2 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1505429.9A GB201505429D0 (en) 2015-03-30 2015-03-30 Novel compounds
GBGB1512829.1A GB201512829D0 (en) 2015-07-21 2015-07-21 Novel compounds
PCT/GB2016/050851 WO2016156816A1 (en) 2015-03-30 2016-03-24 1-cyano-pyrrolidine compounds as usp30 inhibitors

Publications (1)

Publication Number Publication Date
MD3277677T2 true MD3277677T2 (ro) 2021-07-31

Family

ID=55646790

Family Applications (1)

Application Number Title Priority Date Filing Date
MDE20180120T MD3277677T2 (ro) 2015-03-30 2016-03-24 Compuși de 1-ciano-pirolidină utilizați ca inhibitori de USP30

Country Status (29)

Country Link
US (6) US10343992B2 (ro)
EP (3) EP3842427A1 (ro)
JP (3) JP6708661B2 (ro)
KR (1) KR102578325B1 (ro)
CN (2) CN112707893B (ro)
AU (1) AU2016240033B2 (ro)
BR (1) BR112017020900B1 (ro)
CA (1) CA2976741C (ro)
CO (1) CO2017011172A2 (ro)
CY (1) CY1124170T1 (ro)
DK (1) DK3277677T3 (ro)
ES (1) ES2864950T3 (ro)
HK (1) HK1245266A1 (ro)
HR (1) HRP20210791T2 (ro)
HU (1) HUE054474T2 (ro)
IL (1) IL254721B (ro)
LT (1) LT3277677T (ro)
MD (1) MD3277677T2 (ro)
MX (1) MX2017012566A (ro)
MY (1) MY188957A (ro)
NZ (1) NZ736450A (ro)
PL (1) PL3277677T3 (ro)
PT (1) PT3277677T (ro)
RS (1) RS61759B9 (ro)
RU (1) RU2717238C2 (ro)
SG (1) SG11201706542TA (ro)
SI (1) SI3277677T1 (ro)
WO (1) WO2016156816A1 (ro)
ZA (1) ZA201705717B (ro)

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SG11201706542TA (en) 2017-10-30
PT3277677T (pt) 2021-04-20
KR20170131654A (ko) 2017-11-29
HK1245266A1 (zh) 2018-08-24
MY188957A (en) 2022-01-14
EP3943490A1 (en) 2022-01-26
HRP20210791T1 (hr) 2021-06-25
EP3277677A1 (en) 2018-02-07
RS61759B1 (sr) 2021-05-31
HRP20210791T2 (hr) 2021-12-10
RU2717238C2 (ru) 2020-03-19
RU2017134901A (ru) 2019-04-30
AU2016240033B2 (en) 2020-04-16
IL254721B (en) 2019-12-31
NZ736450A (en) 2022-04-29
EP3277677B1 (en) 2021-02-24
CA2976741A1 (en) 2016-10-06
CN112707893A (zh) 2021-04-27
PL3277677T3 (pl) 2021-08-30
DK3277677T3 (da) 2021-05-25
ES2864950T3 (es) 2021-10-14
CN107484415B (zh) 2021-01-29
AU2016240033A1 (en) 2017-11-09
BR112017020900B1 (pt) 2023-02-23
US10689345B2 (en) 2020-06-23
JP2018510183A (ja) 2018-04-12
SI3277677T1 (sl) 2021-08-31
RU2017134901A3 (ro) 2019-06-25
US20220251041A1 (en) 2022-08-11
IL254721A0 (en) 2017-11-30
LT3277677T (lt) 2021-05-25
US10343992B2 (en) 2019-07-09
US20190270708A1 (en) 2019-09-05
WO2016156816A1 (en) 2016-10-06
US11066365B2 (en) 2021-07-20
MX2017012566A (es) 2018-01-25
BR112017020900A2 (pt) 2018-07-10
US20190284138A1 (en) 2019-09-19
US20190322624A1 (en) 2019-10-24
JP6708661B2 (ja) 2020-06-10
US11053198B2 (en) 2021-07-06
CO2017011172A2 (es) 2018-01-16
EP3277677B9 (en) 2021-07-14
ES2864950T9 (es) 2021-11-18
RS61759B9 (sr) 2021-11-30
JP7389856B2 (ja) 2023-11-30
CN112707893B (zh) 2023-10-31
US11390584B2 (en) 2022-07-19
KR102578325B1 (ko) 2023-09-15
CY1124170T1 (el) 2022-05-27
CN107484415A (zh) 2017-12-15
CA2976741C (en) 2023-01-17
JP2020143124A (ja) 2020-09-10
US20180086708A1 (en) 2018-03-29
HUE054474T2 (hu) 2021-09-28
JP7216682B2 (ja) 2023-02-01
ZA201705717B (en) 2019-09-25
US20200181086A1 (en) 2020-06-11
EP3842427A1 (en) 2021-06-30

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