MD2353C2 - Preparat antibiotic, procedeu de obţinere şi utilizările acestuia - Google Patents

Preparat antibiotic, procedeu de obţinere şi utilizările acestuia

Info

Publication number
MD2353C2
MD2353C2 MDA20020073A MD20020073A MD2353C2 MD 2353 C2 MD2353 C2 MD 2353C2 MD A20020073 A MDA20020073 A MD A20020073A MD 20020073 A MD20020073 A MD 20020073A MD 2353 C2 MD2353 C2 MD 2353C2
Authority
MD
Moldova
Prior art keywords
obtaining
antibiotic preparation
component
preparation
medicine
Prior art date
Application number
MDA20020073A
Other languages
English (en)
Russian (ru)
Other versions
MD2353B2 (ro
MD20020073A (ro
Inventor
Себастьян ВОГТ
Маттиас ШНАБЕЛЬРАУХ
Клаус-Дитер КУН
Original Assignee
ХЕРАУС КУЛЦЕР ГмбХ и Ко. КГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ХЕРАУС КУЛЦЕР ГмбХ и Ко. КГ filed Critical ХЕРАУС КУЛЦЕР ГмбХ и Ко. КГ
Publication of MD20020073A publication Critical patent/MD20020073A/ro
Publication of MD2353B2 publication Critical patent/MD2353B2/ro
Publication of MD2353C2 publication Critical patent/MD2353C2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Invenţia se referă la un preparat antibiotic, la un procedeu de obţinere a lui, care poate fi utilizat în medicină şi medicina veterinară pentru tratamentul infecţiilor microbiene locale în ţesuturile tari şi în cele moi.Esenţa procedeului constă în aceea că se amestecă cu apă un component amfifilic dintre sulfaţi, sulfamaţi sau sulfonaţi, unul sau mai multe antibiotice din grupa aminoglicozidelor, lincosamidelor sau tetraciclinelor, un component auxiliar organic şi/sau anorganic şi, eventual, cel puţin un component biologic activ.Preparatul obţinut poate fi utilizat ca implant resorbabil sau neresorbabil.
MDA20020073A 2001-03-22 2002-02-13 Preparat antibiotic, procedeu de obţinere şi utilizările acestuia MD2353C2 (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10114245A DE10114245A1 (de) 2001-03-22 2001-03-22 Herstellung und Verwendung einer Antibiotikum-/Antibiotika-Zubereitung

Publications (3)

Publication Number Publication Date
MD20020073A MD20020073A (ro) 2002-11-30
MD2353B2 MD2353B2 (ro) 2004-01-31
MD2353C2 true MD2353C2 (ro) 2004-08-31

Family

ID=7678692

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20020073A MD2353C2 (ro) 2001-03-22 2002-02-13 Preparat antibiotic, procedeu de obţinere şi utilizările acestuia

Country Status (32)

Country Link
US (1) US20020183265A1 (ro)
EP (1) EP1243258B1 (ro)
JP (1) JP2002275098A (ro)
CN (1) CN1286467C (ro)
AT (1) ATE259636T1 (ro)
AU (1) AU772160B2 (ro)
BG (1) BG65505B1 (ro)
BR (1) BR0201099A (ro)
CA (1) CA2378503C (ro)
CZ (1) CZ2002868A3 (ro)
DE (2) DE10114245A1 (ro)
DK (1) DK1243258T3 (ro)
EE (1) EE200200155A (ro)
ES (1) ES2213718T3 (ro)
GE (1) GEP20053450B (ro)
HR (1) HRP20020242B1 (ro)
HU (1) HUP0201043A2 (ro)
IL (1) IL148705A (ro)
IS (1) IS2499B (ro)
MD (1) MD2353C2 (ro)
MX (1) MXPA02003006A (ro)
NO (1) NO20021389L (ro)
NZ (1) NZ517920A (ro)
PL (1) PL204985B1 (ro)
PT (1) PT1243258E (ro)
RU (1) RU2212880C1 (ro)
SA (1) SA02230036B1 (ro)
SK (1) SK3952002A3 (ro)
TR (1) TR200400363T4 (ro)
UA (1) UA71993C2 (ro)
YU (1) YU11702A (ro)
ZA (1) ZA200202255B (ro)

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IS6390A (is) 2001-08-31 2003-03-03 Heraeus Kulzer Gmbh & Co. Kg Reynsla af sýklalyfjahúðun skrokka sem í eru örholrými, þannig húðuðum skrokkum og einnig af notkunþeirra
IS6389A (is) 2001-08-31 2003-03-03 Heraeus Kulzer Gmbh & Co. Kg Reynsla af sýklalyfjahúðun skrokka, sem í eru örholrými, og einnig af þannig húðuðum skrokkum og notkun þeirra
DE10262176B4 (de) * 2002-06-21 2007-10-04 Heraeus Kulzer Gmbh Verfahren zur Herstellung von antibiotisch beschichteten porösen Körpern sowie Verwendung
DE10318991A1 (de) * 2003-04-25 2004-11-18 Heraeus Kulzer Gmbh & Co. Kg Poröser Körper mit antibiotischer Beschichtung, Verfahren zur Herstellung sowie Verwendung
ZA200604869B (en) 2003-12-04 2007-11-28 Univ Utah Res Found Modified macromolecules and methods of making and using thereof
DE102004060666B3 (de) 2004-12-15 2006-03-30 Heraeus Kulzer Gmbh Antibiotikum/Antibiotika enthaltendes Knochenersatzmaterial mit retardierender Wirkstofffreisetzung
DE102005002703C5 (de) 2005-01-19 2013-07-04 Heraeus Kulzer Gmbh Antibiotische Beschichtung von Implantaten sowie Verfahren zur antibiotischen Beschichtung
WO2008006083A2 (en) 2006-07-07 2008-01-10 Surmodics, Inc. Beaded wound spacer device
WO2008100262A1 (en) * 2007-02-16 2008-08-21 Alpharma, Inc. Medicated feed premix comprising chlortetracycline hydrochloride
DE102007063613B4 (de) * 2007-04-24 2010-01-07 Heraeus Kulzer Gmbh Verwendung eines Spacer-Polymethylmethacrylat-Knochenzement
DE102007039871A1 (de) 2007-08-21 2009-02-26 Friedrich-Baur-Gmbh Weichgewebe-Implantat mit antibakterieller Wirkung
CN101225125B (zh) * 2008-01-18 2012-12-05 中国科学院烟台海岸带研究所 一种吸湿保湿剂及其制备方法
US8167836B2 (en) * 2009-12-08 2012-05-01 Taris Biomedical, Inc. Tissue expander configured for drug delivery
DE102010020940B4 (de) * 2010-05-19 2014-09-25 Heraeus Medical Gmbh Antibiotische Beschichtung
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
CN102391954B (zh) * 2011-10-26 2014-12-10 厦门大学 球形棕囊藻培养液的除菌方法
CN102552885A (zh) * 2011-12-16 2012-07-11 青岛海芬海洋生物科技有限公司 海洋生物痔疮及肛内上皮和直肠粘膜上皮细胞消炎修护液
CA2888241C (en) 2012-10-16 2020-12-29 Surmodics, Inc. Wound packing device and methods
RU2540468C2 (ru) * 2012-11-06 2015-02-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Нижегородский государственный университет им. Н.И. Лобачевского"Российская Федерация Способ получения композиционных рассасывающихся материалов на основе хитозана и полилактида
MX2015012367A (es) 2013-03-15 2016-05-31 Taris Biomedical Llc Dispositivos de suministro de farmacos con un componente permeable al farmaco y metodos.
US10201457B2 (en) 2014-08-01 2019-02-12 Surmodics, Inc. Wound packing device with nanotextured surface
US10894150B2 (en) 2015-04-23 2021-01-19 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods
CN105999401B (zh) * 2016-07-22 2019-03-08 武汉理工大学 一种基于羟基磷灰石的牙科抑菌修复材料及其制备方法
CN107459654B (zh) * 2017-08-03 2020-05-26 天津大学 一种模拟抗菌肽共聚物及其制备方法
CN109674806B (zh) * 2019-01-14 2021-10-26 福州奥尼多生物科技有限公司 春雷霉素在制备抗菌药物中的用途

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BE821600A (fr) * 1974-05-29 1975-02-17 Nouveaux derives de la gentamicine
US4291013A (en) * 1978-10-09 1981-09-22 Merck Patent Gesellschaft Mit Beschrankter Haftung Medicinally useful, shaped mass of collagen resorbable in the body
DE3248328A1 (de) * 1982-12-28 1984-06-28 Bayer Ag, 5090 Leverkusen Schwerloesliche salze von aminoglykosiden sowie diese enthaltende formulierungen mit verzoegerter wirkstoff-freigabe
US4617293A (en) * 1981-05-13 1986-10-14 Merck Patent Gesellschaft Mit Beschraenkter Haftung Flavonoid phosphate salts of aminoglycoside antibiotics

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ES315101A1 (es) * 1965-07-08 1966-01-01 Folch Vazquez Conrado Procedimiento de preparaciën de nuevos derivados de tetraciclina
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DE10114364A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Verfahren zur Herstellung von antibiotischen Kompositen
DE10114244A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE821600A (fr) * 1974-05-29 1975-02-17 Nouveaux derives de la gentamicine
US4291013A (en) * 1978-10-09 1981-09-22 Merck Patent Gesellschaft Mit Beschrankter Haftung Medicinally useful, shaped mass of collagen resorbable in the body
US4617293A (en) * 1981-05-13 1986-10-14 Merck Patent Gesellschaft Mit Beschraenkter Haftung Flavonoid phosphate salts of aminoglycoside antibiotics
DE3248328A1 (de) * 1982-12-28 1984-06-28 Bayer Ag, 5090 Leverkusen Schwerloesliche salze von aminoglykosiden sowie diese enthaltende formulierungen mit verzoegerter wirkstoff-freigabe

Also Published As

Publication number Publication date
HRP20020242B1 (en) 2005-02-28
BR0201099A (pt) 2002-11-05
EP1243258B1 (de) 2004-02-18
YU11702A (sh) 2004-12-31
PL352922A1 (en) 2002-09-23
GEP20053450B (en) 2005-02-25
NO20021389L (no) 2002-09-23
SK3952002A3 (en) 2002-10-08
MXPA02003006A (es) 2003-08-20
NZ517920A (en) 2003-02-28
BG106456A (en) 2002-10-31
IL148705A (en) 2006-12-10
HUP0201043A2 (hu) 2003-02-28
MD2353B2 (ro) 2004-01-31
PT1243258E (pt) 2004-07-30
HRP20020242A2 (en) 2002-12-31
ZA200202255B (en) 2002-10-10
DE10114245A1 (de) 2002-10-02
CN1286467C (zh) 2006-11-29
RU2212880C1 (ru) 2003-09-27
CA2378503A1 (en) 2002-09-22
IS6271A (is) 2002-09-22
UA71993C2 (en) 2005-01-17
AU2756202A (en) 2002-09-26
US20020183265A1 (en) 2002-12-05
ES2213718T3 (es) 2004-09-01
NO20021389D0 (no) 2002-03-20
IS2499B (is) 2009-03-15
PL204985B1 (pl) 2010-02-26
ATE259636T1 (de) 2004-03-15
CN1380064A (zh) 2002-11-20
CA2378503C (en) 2008-09-16
DE50200244D1 (de) 2004-03-25
MD20020073A (ro) 2002-11-30
BG65505B1 (bg) 2008-10-31
EE200200155A (et) 2002-12-16
DK1243258T3 (da) 2004-06-21
TR200400363T4 (tr) 2004-03-22
EP1243258A1 (de) 2002-09-25
SA02230036B1 (ar) 2007-02-27
CZ2002868A3 (cs) 2002-11-13
IL148705A0 (en) 2002-09-12
AU772160B2 (en) 2004-04-08
JP2002275098A (ja) 2002-09-25
HU0201043D0 (ro) 2002-05-29

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Legal Events

Date Code Title Description
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees