MD123C2 - Procedeu de obţinere a compuşilor macrolizi - Google Patents
Procedeu de obţinere a compuşilor macroliziInfo
- Publication number
- MD123C2 MD123C2 MD94-0129A MD940129A MD123C2 MD 123 C2 MD123 C2 MD 123C2 MD 940129 A MD940129 A MD 940129A MD 123 C2 MD123 C2 MD 123C2
- Authority
- MD
- Moldova
- Prior art keywords
- hydroxyl
- obtaining
- group
- macrolidine
- protected
- Prior art date
Links
- SXKCXUIPCXTZBS-UHFFFAOYSA-N macrolidine Chemical compound N1C2CC(C3C=C)C(C(=O)OC)=COC3OC(C(C(O)C3O)O)OC3COC(=O)C1CC1=C2NC2=CC=CC=C12 SXKCXUIPCXTZBS-UHFFFAOYSA-N 0.000 title abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000008030 elimination Effects 0.000 abstract 2
- 238000003379 elimination reaction Methods 0.000 abstract 2
- HNUALPPJLMYHDK-UHFFFAOYSA-N C[CH]C Chemical compound C[CH]C HNUALPPJLMYHDK-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000000507 anthelmentic effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000006266 etherification reaction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 238000006146 oximation reaction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000001012 protector Effects 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Insects & Arthropods (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Invenţia se referă la macrolide, în particular la obţinerea compuşilor cu formula generală:în care R1 reprezintă CH3, C2H5 sau izo-C3H7;R2 reprezintă alchil inferior şi grupa “NOR2” este amplasată în configuraţia E;OR3 reprezintă hidroxil care posedă o activitate antihelmintică, ceea cei face utili în medicină. Scopul constă în crearea unor noi preparate mai active din clasa indicată.Sinteza se efectuează prin oximarea cetonei respective, în care grupa OR'3 poate fi hidroxil sau hidroxil protejat de un compus cu formula II: R2 reprezintă H sau alchil inferior: R'2O-NH2, cu separarea ulterioară a produsului cu destinaţie specială sau, în caz de necesitate cu eliminarea grupei de protecţie de la hidroxil - OR'3. În alt caz, când R'2 = H şi OR3 reprezintă hidroxil protejat, atunci se supune eterificării cu o halogenură cu formula III:R2-Y, în care Y reprezintă halogen, cu eliminarea ulterioară a protecţiei de la hidroxil. Preparatele noi reduc până la 98% afectarea cu helminţi, manifestând o toxicitate joasă.Tabele: 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868613790A GB8613790D0 (en) | 1986-06-06 | 1986-06-06 | Chemical compounds |
| SU874203050A RU1831483C (ru) | 1986-06-06 | 1987-06-05 | Способ получени макролидных соединений |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD123B1 MD123B1 (ro) | 1994-12-31 |
| MD123C2 true MD123C2 (ro) | 1995-06-30 |
Family
ID=10599054
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0087A MD20C2 (ro) | 1986-06-06 | 1994-04-27 | Procedeu de obţinere a compuşilor macrolidici |
| MD94-0129A MD123C2 (ro) | 1986-06-06 | 1994-05-31 | Procedeu de obţinere a compuşilor macrolizi |
| MD94-0360A MD1026G2 (ro) | 1986-06-06 | 1994-07-14 | Compuşi macrolidici |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0087A MD20C2 (ro) | 1986-06-06 | 1994-04-27 | Procedeu de obţinere a compuşilor macrolidici |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0360A MD1026G2 (ro) | 1986-06-06 | 1994-07-14 | Compuşi macrolidici |
Country Status (10)
| Country | Link |
|---|---|
| AP (1) | AP38A (ro) |
| GB (1) | GB8613790D0 (ro) |
| GE (1) | GEP19970660B (ro) |
| LT (3) | LT3676B (ro) |
| LV (1) | LV5678A3 (ro) |
| MD (3) | MD20C2 (ro) |
| RU (1) | RU1831483C (ro) |
| SU (1) | SU1731060A3 (ro) |
| UA (2) | UA12797A (ro) |
| ZA (1) | ZA874052B (ro) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB216646A (en) | 1923-04-17 | 1924-06-05 | Reginald Arthur Angier | Improvements in feeding troughs for pigs and other animals |
| GR852232B (ro) * | 1984-09-14 | 1986-01-14 | American Cyanamid Co | |
| DE3446134A1 (de) * | 1984-12-18 | 1986-06-26 | G. Düsterloh GmbH, 4322 Sprockhövel | Reversierbare hydraulische maschine |
| ES8802229A1 (es) * | 1985-04-30 | 1988-04-16 | Glaxo Group Ltd | Un procedimiento para preparar nuevos derivados lactonicos macrociclicos. |
-
1986
- 1986-06-06 GB GB868613790A patent/GB8613790D0/en active Pending
-
1987
- 1987-06-05 UA UA4203050A patent/UA12797A/uk unknown
- 1987-06-05 ZA ZA874052A patent/ZA874052B/xx unknown
- 1987-06-05 AP APAP/P/1987/000065A patent/AP38A/en active
- 1987-06-05 UA UA4613245A patent/UA18587A/uk unknown
- 1987-06-05 RU SU874203050A patent/RU1831483C/ru active
-
1989
- 1989-01-13 SU SU894613245A patent/SU1731060A3/ru active
-
1993
- 1993-09-22 LT LTIP1076A patent/LT3676B/lt not_active IP Right Cessation
- 1993-09-29 LT LTRP1260A patent/LT2643B/xx not_active IP Right Cessation
- 1993-10-08 LV LV931144A patent/LV5678A3/xx unknown
- 1993-12-21 LT LTIP1649A patent/LTIP1649A/xx not_active Application Discontinuation
-
1994
- 1994-04-27 MD MD94-0087A patent/MD20C2/ro active IP Right Grant
- 1994-05-16 GE GEAP19941921A patent/GEP19970660B/en unknown
- 1994-05-31 MD MD94-0129A patent/MD123C2/ro active IP Right Grant
- 1994-07-14 MD MD94-0360A patent/MD1026G2/ro not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| Brevet nr. 2166436, GB, Int. cl. C 07 D 493/22, 1986. * |
Also Published As
| Publication number | Publication date |
|---|---|
| LV5678A3 (lv) | 1994-10-20 |
| GB8613790D0 (en) | 1986-07-09 |
| LT2643B (lt) | 1994-04-25 |
| LTIP1649A (en) | 1995-07-25 |
| LTIP1076A (en) | 1995-04-25 |
| ZA874052B (en) | 1988-02-24 |
| UA18587A (uk) | 1997-12-25 |
| GEP19970660B (en) | 1997-01-04 |
| RU1831483C (ru) | 1993-07-30 |
| MD1026G2 (ro) | 1999-06-30 |
| MD940360A (ro) | 1996-04-30 |
| SU1731060A3 (ru) | 1992-04-30 |
| UA12797A (uk) | 1997-02-28 |
| MD20B1 (ro) | 1994-05-31 |
| AP38A (en) | 1989-04-13 |
| AP8700065A0 (en) | 1987-05-01 |
| MD20C2 (ro) | 1994-05-31 |
| LT3676B (en) | 1996-01-25 |
| MD123B1 (ro) | 1994-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20070604 |
|
| MK4A | Patent for invention expired |