MD123C2 - Method of obtaining of macrolidine derivers - Google Patents

Method of obtaining of macrolidine derivers

Info

Publication number
MD123C2
MD123C2 MD94-0129A MD940129A MD123C2 MD 123 C2 MD123 C2 MD 123C2 MD 940129 A MD940129 A MD 940129A MD 123 C2 MD123 C2 MD 123C2
Authority
MD
Moldova
Prior art keywords
hydroxyl
obtaining
group
macrolidine
protected
Prior art date
Application number
MD94-0129A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD123B1 (en
Inventor
Derek R. Sutherland
L. Pereira Oswy
Hazel M Noble
Michael V.J RAMSAY
John B. Ward
Richard A Fletton
Edward P. Tiley
Neil Porter
David Noble
Original Assignee
Эмерикэн Сайенэмид Компэни
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмерикэн Сайенэмид Компэни filed Critical Эмерикэн Сайенэмид Компэни
Publication of MD123B1 publication Critical patent/MD123B1/en
Publication of MD123C2 publication Critical patent/MD123C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Insects & Arthropods (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention relates to macrolidine, especially to the obtaining of compounds with general formula:in which R1 represents CH3C2H5 or iso-C3H7;R2 represents inferior alkyl and “NOR2” group is placed in E configurationOR3 - represents hydroxyl which possess an antihelminthic activity, which might be used in medicine. The purpose consists in the obtaining of new more active substances from this class.The synthesis is done through the oximation of respective Retone in which OR'3 group might be hydroxyl or hydroxyl protected by a compound with formula II; R2 represents H or inferior alkyl: R2O-NH2, with subsequent separation of product with special destination or in case of necessity with the elimination of protector group from hydroxyl-OR. In other case, when R=H and OR3 represents protected hydroxyl than is submitted to etherification with a halogenid of formula III R2-Y, in which Y represents halogen with subsequent elimination of protection from hydroxyl. New preparation reduces with 98% the affectation with helmints, manifesting a low toxicity.Tab.: 2
MD94-0129A 1986-06-06 1994-05-31 Method of obtaining of macrolidine derivers MD123C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868613790A GB8613790D0 (en) 1986-06-06 1986-06-06 Chemical compounds
SU874203050A RU1831483C (en) 1986-06-06 1987-06-05 Method of preparing macarlide compounds

Publications (2)

Publication Number Publication Date
MD123B1 MD123B1 (en) 1994-12-31
MD123C2 true MD123C2 (en) 1995-06-30

Family

ID=10599054

Family Applications (3)

Application Number Title Priority Date Filing Date
MD940087A MD20B1 (en) 1986-06-06 1994-04-27 Process for obtaining macrolide compounds
MD94-0129A MD123C2 (en) 1986-06-06 1994-05-31 Method of obtaining of macrolidine derivers
MD94-0360A MD1026G2 (en) 1986-06-06 1994-07-14 Macrolide compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MD940087A MD20B1 (en) 1986-06-06 1994-04-27 Process for obtaining macrolide compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
MD94-0360A MD1026G2 (en) 1986-06-06 1994-07-14 Macrolide compounds

Country Status (10)

Country Link
AP (1) AP38A (en)
GB (1) GB8613790D0 (en)
GE (1) GEP19970660B (en)
LT (3) LT3676B (en)
LV (1) LV5678A3 (en)
MD (3) MD20B1 (en)
RU (1) RU1831483C (en)
SU (1) SU1731060A3 (en)
UA (2) UA18587A (en)
ZA (1) ZA874052B (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB216646A (en) 1923-04-17 1924-06-05 Reginald Arthur Angier Improvements in feeding troughs for pigs and other animals
AU596565B2 (en) * 1984-09-14 1990-05-10 American Cyanamid Company Antibiotic compounds and their preparation
DE3446134A1 (en) * 1984-12-18 1986-06-26 G. Düsterloh GmbH, 4322 Sprockhövel REVERSIBLE HYDRAULIC MACHINE
ES8802229A1 (en) * 1985-04-30 1988-04-16 Glaxo Group Ltd Macrolide antibiotics and their preparation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Brevet nr. 2166436, GB, Int. cl. C 07 D 493/22, 1986. *

Also Published As

Publication number Publication date
LTIP1649A (en) 1995-07-25
GB8613790D0 (en) 1986-07-09
UA12797A (en) 1997-02-28
MD20C2 (en) 1994-05-31
MD20B1 (en) 1994-05-31
UA18587A (en) 1997-12-25
AP8700065A0 (en) 1987-05-01
MD940360A (en) 1996-04-30
MD123B1 (en) 1994-12-31
MD1026G2 (en) 1999-06-30
GEP19970660B (en) 1997-01-04
AP38A (en) 1989-04-13
SU1731060A3 (en) 1992-04-30
LV5678A3 (en) 1994-10-20
LT2643B (en) 1994-04-25
LTIP1076A (en) 1995-04-25
LT3676B (en) 1996-01-25
RU1831483C (en) 1993-07-30
ZA874052B (en) 1988-02-24

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20070604

MK4A Patent for invention expired