MD123C2 - Способ получения макролидных соединений - Google Patents
Способ получения макролидных соединенийInfo
- Publication number
- MD123C2 MD123C2 MD94-0129A MD940129A MD123C2 MD 123 C2 MD123 C2 MD 123C2 MD 940129 A MD940129 A MD 940129A MD 123 C2 MD123 C2 MD 123C2
- Authority
- MD
- Moldova
- Prior art keywords
- hydroxyl
- obtaining
- group
- macrolidine
- protected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Insects & Arthropods (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Изобретение касается макролидов, в частности получения соединения общей ф-лыгде R1-CH3, C2H5 или изо-C3H7; R2-низший алкил и группа “NOR2” находится в Е-конфигурации: OR3 - гидроксил, обладающих антигельминтовой активностью, что может быть использовано в медицине. Цель - создание новых более активных веществ указанного класса. Синтез ведут оксимированием соответствующего кетона, в котором группа OR3-может быть гидроксилом или защищенным гидроксилом с помощью соединения ф-лы II: R2 - H или низший алкил: R'2O-NH2, с последующим выделением целевого продукта или при необходимости, снятием защитной группы с гидроксила -OR'3. В другом случае, когда R2 1=H и OR3 - защищенный гидроксил, то подвергают этерификации галогенидом ф-лы III: R2-Y, где Y - галоген, с последующим снятием защиты с гидроксила. новые вещества снижают до 98% поражение гельминтами при низкой токсичности.Табл.: 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868613790A GB8613790D0 (en) | 1986-06-06 | 1986-06-06 | Chemical compounds |
| SU874203050A RU1831483C (ru) | 1986-06-06 | 1987-06-05 | Способ получени макролидных соединений |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD123B1 MD123B1 (ro) | 1994-12-31 |
| MD123C2 true MD123C2 (ru) | 1995-06-30 |
Family
ID=10599054
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0087A MD20C2 (ru) | 1986-06-06 | 1994-04-27 | Способ получения макролидных соединений |
| MD94-0129A MD123C2 (ru) | 1986-06-06 | 1994-05-31 | Способ получения макролидных соединений |
| MD94-0360A MD1026G2 (ru) | 1986-06-06 | 1994-07-14 | Макролидные соединения |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0087A MD20C2 (ru) | 1986-06-06 | 1994-04-27 | Способ получения макролидных соединений |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0360A MD1026G2 (ru) | 1986-06-06 | 1994-07-14 | Макролидные соединения |
Country Status (10)
| Country | Link |
|---|---|
| AP (1) | AP38A (ru) |
| GB (1) | GB8613790D0 (ru) |
| GE (1) | GEP19970660B (ru) |
| LT (3) | LT3676B (ru) |
| LV (1) | LV5678A3 (ru) |
| MD (3) | MD20C2 (ru) |
| RU (1) | RU1831483C (ru) |
| SU (1) | SU1731060A3 (ru) |
| UA (2) | UA12797A (ru) |
| ZA (1) | ZA874052B (ru) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB216646A (en) | 1923-04-17 | 1924-06-05 | Reginald Arthur Angier | Improvements in feeding troughs for pigs and other animals |
| IT1182857B (it) * | 1984-09-14 | 1987-10-05 | Glaxo Group Ltd | Composti antibiotici, composizioni antiparassitarie che li contengono e procedimento per prepararli ed applicarli |
| DE3446134A1 (de) * | 1984-12-18 | 1986-06-26 | G. Düsterloh GmbH, 4322 Sprockhövel | Reversierbare hydraulische maschine |
| ES8802229A1 (es) * | 1985-04-30 | 1988-04-16 | Glaxo Group Ltd | Un procedimiento para preparar nuevos derivados lactonicos macrociclicos. |
-
1986
- 1986-06-06 GB GB868613790A patent/GB8613790D0/en active Pending
-
1987
- 1987-06-05 ZA ZA874052A patent/ZA874052B/xx unknown
- 1987-06-05 UA UA4203050A patent/UA12797A/uk unknown
- 1987-06-05 UA UA4613245A patent/UA18587A/ru unknown
- 1987-06-05 RU SU874203050A patent/RU1831483C/ru active
- 1987-06-05 AP APAP/P/1987/000065A patent/AP38A/en active
-
1989
- 1989-01-13 SU SU894613245A patent/SU1731060A3/ru active
-
1993
- 1993-09-22 LT LTIP1076A patent/LT3676B/lt not_active IP Right Cessation
- 1993-09-29 LT LTRP1260A patent/LT2643B/xx not_active IP Right Cessation
- 1993-10-08 LV LV931144A patent/LV5678A3/xx unknown
- 1993-12-21 LT LTIP1649A patent/LTIP1649A/xx not_active Application Discontinuation
-
1994
- 1994-04-27 MD MD94-0087A patent/MD20C2/ru active IP Right Grant
- 1994-05-16 GE GEAP19941921A patent/GEP19970660B/en unknown
- 1994-05-31 MD MD94-0129A patent/MD123C2/ru active IP Right Grant
- 1994-07-14 MD MD94-0360A patent/MD1026G2/ru not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| Brevet nr. 2166436, GB, Int. cl. C 07 D 493/22, 1986. * |
Also Published As
| Publication number | Publication date |
|---|---|
| SU1731060A3 (ru) | 1992-04-30 |
| RU1831483C (ru) | 1993-07-30 |
| LT2643B (lt) | 1994-04-25 |
| UA18587A (ru) | 1997-12-25 |
| LTIP1649A (en) | 1995-07-25 |
| MD1026G2 (ru) | 1999-06-30 |
| LV5678A3 (lv) | 1994-10-20 |
| LTIP1076A (en) | 1995-04-25 |
| GB8613790D0 (en) | 1986-07-09 |
| MD20B1 (ro) | 1994-05-31 |
| MD940360A (en) | 1996-04-30 |
| AP38A (en) | 1989-04-13 |
| LT3676B (en) | 1996-01-25 |
| MD123B1 (ro) | 1994-12-31 |
| ZA874052B (en) | 1988-02-24 |
| AP8700065A0 (en) | 1987-05-01 |
| UA12797A (uk) | 1997-02-28 |
| GEP19970660B (en) | 1997-01-04 |
| MD20C2 (ru) | 1994-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20070604 |
|
| MK4A | Patent for invention expired |