MD122C2 - Procedeu de obţinere a derivaţilor oxadiazolilalchilpurinei sau a sărurilor ei acide aditive farmacologic acceptabile - Google Patents
Procedeu de obţinere a derivaţilor oxadiazolilalchilpurinei sau a sărurilor ei acide aditive farmacologic acceptabileInfo
- Publication number
- MD122C2 MD122C2 MD94-0131A MD940131A MD122C2 MD 122 C2 MD122 C2 MD 122C2 MD 940131 A MD940131 A MD 940131A MD 122 C2 MD122 C2 MD 122C2
- Authority
- MD
- Moldova
- Prior art keywords
- obtaining
- alkyl
- nr2r3
- substances
- possess
- Prior art date
Links
- 150000008043 acidic salts Chemical class 0.000 title 1
- 239000000654 additive Substances 0.000 title 1
- 230000000996 additive effect Effects 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 3
- 206010011224 Cough Diseases 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 oxyphenil Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- WJKWZEQHHHGYTH-UHFFFAOYSA-N 1-(2,3-dimethoxyphenyl)-2-phenylethane-1,2-dione Chemical group COC1=CC=CC(C(=O)C(=O)C=2C=CC=CC=2)=C1OC WJKWZEQHHHGYTH-UHFFFAOYSA-N 0.000 abstract 1
- GMSNIKWWOQHZGF-UHFFFAOYSA-N 3MX Natural products O=C1NC(=O)N(C)C2=C1N=CN2 GMSNIKWWOQHZGF-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- WURBFLDFSFBTLW-UHFFFAOYSA-N benzil Chemical group C=1C=CC=CC=1C(=O)C(=O)C1=CC=CC=C1 WURBFLDFSFBTLW-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229960004126 codeine Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Invenţia se referă la substanţele heterociclice, în particular la obţinerea derivaţilor oxadiazolilalchilpurinei cu formula generală(I)în care A reprezintă C1-C4-alchilen; R1 reprezintă C1-C6-alchil, oxialchil-C1-C6, alchil halogenic-C1-C6, alchil carboxilic-C1-C4, ciclohexil, alchilaminic-(CH2)n-NR2R3, când n=1-3, R2 şi R3 reprezintă C1-C4-alchil sau NR2R3 formează ciclul piperidinic sau morfolinic, sau R1 reprezintă fenil, oxifenil; carboxifenil, benzil sau dimetoxibenzil, sau sărurile ei cu acizii farmacologic acceptabili care posedă o acţiune contra tusei, ceea ce poate fi utilizat în medicină. Scopul constă în obţinerea substanţelor noi din clasa aceasta, mai active. Sinteza are loc prin reacţia compuşilor cu formulele II şi IIIîn care X reprezintă halogen, în prezenţa bazei în mediul dizolvantului organic. În afară de aceasta, în loc de 3-metilxantină (compusul cu formula III) poate fi folosită sarea ei de Na sau K. Separarea substanţei finale se efectuează sau sub formă de bază, sau sub formă de sare necesară. Substanţele noi posedă o acţiune mai puternică contra tusei, în comparaţie cu codeina, fiind mai puţin toxice.Tabele: 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU864230A HU197574B (en) | 1986-10-09 | 1986-10-09 | Process for production of derivatives of 3,7-dihydro-3-methil-7-//1,2,4-oxadiasole/-3-il/alkylenil/-1h-purin-2,6-dion and medical compositions containing these substances |
| SU874203547A RU2007404C1 (ru) | 1986-10-09 | 1987-10-09 | Способ получения производных оксадиазолалкилпурина или их фармацевтически приемлемых кислотно-аддитивных солей (его варианты) |
| SU884356424A SU1635901A3 (ru) | 1986-10-09 | 1988-09-19 | Способ получени производных оксадиазолилалкилпурина или их фармацевтически приемлемых кислых аддитивных солей |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD122B1 MD122B1 (ro) | 1994-12-31 |
| MD122C2 true MD122C2 (ro) | 1995-05-31 |
Family
ID=27270039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0131A MD122C2 (ro) | 1986-10-09 | 1994-04-21 | Procedeu de obţinere a derivaţilor oxadiazolilalchilpurinei sau a sărurilor ei acide aditive farmacologic acceptabile |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD122C2 (ro) |
-
1994
- 1994-04-21 MD MD94-0131A patent/MD122C2/ro active IP Right Grant
Non-Patent Citations (2)
| Title |
|---|
| Arzneimittel-Forschung, 617-621 (1966), * |
| Мошковский М.Д. Лекарственные травы. М.: Медицина, 1987, ч.1, с.171. * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD122B1 (ro) | 1994-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20071008 |