MD122C2 - Method of obtaining of oxadiaxolelalkylpurin derivers or of its acidic salts additive pharmaceutical useful - Google Patents
Method of obtaining of oxadiaxolelalkylpurin derivers or of its acidic salts additive pharmaceutical usefulInfo
- Publication number
- MD122C2 MD122C2 MD94-0131A MD940131A MD122C2 MD 122 C2 MD122 C2 MD 122C2 MD 940131 A MD940131 A MD 940131A MD 122 C2 MD122 C2 MD 122C2
- Authority
- MD
- Moldova
- Prior art keywords
- obtaining
- alkyl
- nr2r3
- substances
- possess
- Prior art date
Links
Abstract
The invention relates to the heterocyclic substances, especially to the obtaining of oxadiazolelalkylpurin with general formula 1: in which A represents C1-C4-alkylen; R1 represents C1-C6-alkyl oxyalkyl-C1-C6 ,halogenic alkyl-C1-C6, alkylcarboxylic-C1-C4, cyclohexil, alkylamine-(CH2)n-NR2R3 when n=1-3, R2 and R3 represent C1-C4-alkyl or NR2R3 form the piperidine or morpholine cycle or R1 represents phenyl, oxyphenil, carboxyphenyl, benzil or dimethoxybenzil, or it's salts with the acides pharmaceutical useful, which possess an action against cough, which might be used in medicine. The purpose consists in the obtaining of new more active substances from this class. The synthesis takes place through the reaction of compounds with formulas II and III in which X represents halogen, in the presence of base in the organic dissolvent's medium. Moreover, in place of 3 methyl xantine (compound with formula III) might be used its salt of Na or K-. The separation of final substance is done or under base form, or under the necessary salt. New substances possess a more powerful action against the cough in compairing with codeine, being a little toxic.Tab.: 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU864230A HU197574B (en) | 1986-10-09 | 1986-10-09 | Process for production of derivatives of 3,7-dihydro-3-methil-7-//1,2,4-oxadiasole/-3-il/alkylenil/-1h-purin-2,6-dion and medical compositions containing these substances |
| SU874203547A RU2007404C1 (en) | 1986-10-09 | 1987-10-09 | Method of producing derivatives of oxadiazolalkylpurine or its pharmaceutically available acid additive salts ( and variants of this method ) |
| SU884356424A SU1635901A3 (en) | 1986-10-09 | 1988-09-19 | Process for preparing oxadiazolylalkylpurine derivatives or pharmaceutically acceptable acid addition salts thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD122B1 MD122B1 (en) | 1994-12-31 |
| MD122C2 true MD122C2 (en) | 1995-05-31 |
Family
ID=27270039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0131A MD122C2 (en) | 1986-10-09 | 1994-04-21 | Method of obtaining of oxadiaxolelalkylpurin derivers or of its acidic salts additive pharmaceutical useful |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD122C2 (en) |
-
1994
- 1994-04-21 MD MD94-0131A patent/MD122C2/en active IP Right Grant
Non-Patent Citations (2)
| Title |
|---|
| Arzneimittel-Forschung, 617-621 (1966), * |
| Мошковский М.Д. Лекарственные травы. М.: Медицина, 1987, ч.1, с.171. * |
Also Published As
| Publication number | Publication date |
|---|---|
| MD122B1 (en) | 1994-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20071008 |