MD122C2 - Method of obtaining of oxadiaxolelalkylpurin derivers or of its acidic salts additive pharmaceutical useful - Google Patents

Method of obtaining of oxadiaxolelalkylpurin derivers or of its acidic salts additive pharmaceutical useful

Info

Publication number
MD122C2
MD122C2 MD94-0131A MD940131A MD122C2 MD 122 C2 MD122 C2 MD 122C2 MD 940131 A MD940131 A MD 940131A MD 122 C2 MD122 C2 MD 122C2
Authority
MD
Moldova
Prior art keywords
obtaining
alkyl
nr2r3
substances
possess
Prior art date
Application number
MD94-0131A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD122B1 (en
Inventor
Emil Minker
Zoltan Vargai
Gergely Heja
Gabor Kovacs
Agnes Gottsegen
Sandor Antus
Sandor Virag
Andrea Bolehovszky
Jeno Marton
Marmarosine Kellner Katalin
Lorand Debreczeni
Laszlo Tardos
Peter Kormoczy
Vera Gergely
Gabor Horvath
Dr.Korbonita DEZSO
Original Assignee
Chinoin Gyogyszer -Es Vegyeszeti Termekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU864230A external-priority patent/HU197574B/en
Application filed by Chinoin Gyogyszer -Es Vegyeszeti Termekek Gyara Rt. filed Critical Chinoin Gyogyszer -Es Vegyeszeti Termekek Gyara Rt.
Publication of MD122B1 publication Critical patent/MD122B1/en
Publication of MD122C2 publication Critical patent/MD122C2/en

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to the heterocyclic substances, especially to the obtaining of oxadiazolelalkylpurin with general formula 1: in which A represents C1-C4-alkylen; R1 represents C1-C6-alkyl oxyalkyl-C1-C6 ,halogenic alkyl-C1-C6, alkylcarboxylic-C1-C4, cyclohexil, alkylamine-(CH2)n-NR2R3 when n=1-3, R2 and R3 represent C1-C4-alkyl or NR2R3 form the piperidine or morpholine cycle or R1 represents phenyl, oxyphenil, carboxyphenyl, benzil or dimethoxybenzil, or it's salts with the acides pharmaceutical useful, which possess an action against cough, which might be used in medicine. The purpose consists in the obtaining of new more active substances from this class. The synthesis takes place through the reaction of compounds with formulas II and III in which X represents halogen, in the presence of base in the organic dissolvent's medium. Moreover, in place of 3 methyl xantine (compound with formula III) might be used its salt of Na or K-. The separation of final substance is done or under base form, or under the necessary salt. New substances possess a more powerful action against the cough in compairing with codeine, being a little toxic.Tab.: 1
MD94-0131A 1986-10-09 1994-04-21 Method of obtaining of oxadiaxolelalkylpurin derivers or of its acidic salts additive pharmaceutical useful MD122C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU864230A HU197574B (en) 1986-10-09 1986-10-09 Process for production of derivatives of 3,7-dihydro-3-methil-7-//1,2,4-oxadiasole/-3-il/alkylenil/-1h-purin-2,6-dion and medical compositions containing these substances
SU874203547A RU2007404C1 (en) 1986-10-09 1987-10-09 Method of producing derivatives of oxadiazolalkylpurine or its pharmaceutically available acid additive salts ( and variants of this method )
SU884356424A SU1635901A3 (en) 1986-10-09 1988-09-19 Process for preparing oxadiazolylalkylpurine derivatives or pharmaceutically acceptable acid addition salts thereof

Publications (2)

Publication Number Publication Date
MD122B1 MD122B1 (en) 1994-12-31
MD122C2 true MD122C2 (en) 1995-05-31

Family

ID=27270039

Family Applications (1)

Application Number Title Priority Date Filing Date
MD94-0131A MD122C2 (en) 1986-10-09 1994-04-21 Method of obtaining of oxadiaxolelalkylpurin derivers or of its acidic salts additive pharmaceutical useful

Country Status (1)

Country Link
MD (1) MD122C2 (en)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Arzneimittel-Forschung, 617-621 (1966), *
Мошковский М.Д. Лекарственные травы. М.: Медицина, 1987, ч.1, с.171. *

Also Published As

Publication number Publication date
MD122B1 (en) 1994-12-31

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20071008