MA64323B1 - Inhibiteurs de nlrp3 - Google Patents

Inhibiteurs de nlrp3

Info

Publication number
MA64323B1
MA64323B1 MA64323A MA64323A MA64323B1 MA 64323 B1 MA64323 B1 MA 64323B1 MA 64323 A MA64323 A MA 64323A MA 64323 A MA64323 A MA 64323A MA 64323 B1 MA64323 B1 MA 64323B1
Authority
MA
Morocco
Prior art keywords
nlrp3 inhibitors
compounds
nlrp3
inhibitors
composition
Prior art date
Application number
MA64323A
Other languages
English (en)
Inventor
Georg Jaeschke
Wolfgang Guba
Lea Aurelie BOUCHE
Stefanie Katharina MESCH
Andreas Michael TOSSTORFF
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of MA64323B1 publication Critical patent/MA64323B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

L'invention concerne de nouveaux composés représentés par la formule générale Ib Ib, dans laquelle R1, R2, R3, R4, R5 et Z sont tels que décrits dans la description, une composition comprenant lesdits composés et des procédés d'utilisation desdits composés.
MA64323A 2021-05-12 2022-05-10 Inhibiteurs de nlrp3 MA64323B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP21173452 2021-05-12
EP21209447 2021-11-22
EP21215859 2021-12-20
PCT/EP2022/062525 WO2022238347A1 (fr) 2021-05-12 2022-05-10 Inhibiteurs de nlrp3
EP22728228.2A EP4337652B1 (fr) 2021-05-12 2022-05-10 Inhibiteurs de nlrp3

Publications (1)

Publication Number Publication Date
MA64323B1 true MA64323B1 (fr) 2025-06-30

Family

ID=81941106

Family Applications (1)

Application Number Title Priority Date Filing Date
MA64323A MA64323B1 (fr) 2021-05-12 2022-05-10 Inhibiteurs de nlrp3

Country Status (26)

Country Link
US (1) US20240208928A1 (fr)
EP (2) EP4609865A3 (fr)
JP (1) JP7869248B2 (fr)
KR (1) KR20240007152A (fr)
AR (1) AR125818A1 (fr)
AU (1) AU2022275300A1 (fr)
BR (1) BR112023023527A2 (fr)
CA (1) CA3214626A1 (fr)
CL (1) CL2023003312A1 (fr)
CO (1) CO2023016204A2 (fr)
CR (1) CR20230529A (fr)
DK (1) DK4337652T3 (fr)
ES (1) ES3031704T3 (fr)
FI (1) FI4337652T3 (fr)
HR (1) HRP20250632T1 (fr)
HU (1) HUE071498T2 (fr)
IL (1) IL307188A (fr)
LT (1) LT4337652T (fr)
MA (1) MA64323B1 (fr)
MX (1) MX2023012907A (fr)
PE (1) PE20240126A1 (fr)
PL (1) PL4337652T3 (fr)
RS (1) RS66893B1 (fr)
SI (1) SI4337652T1 (fr)
TW (1) TWI915553B (fr)
WO (1) WO2022238347A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
US11319319B1 (en) 2021-04-07 2022-05-03 Ventus Therapeutics U.S., Inc. Compounds for inhibiting NLRP3 and uses thereof
WO2022230912A1 (fr) 2021-04-28 2022-11-03 アステラス製薬株式会社 Composé triazine substitué
MX2024008548A (es) * 2022-01-07 2024-07-19 Transthera Sciences Nanjing Inc Inhibidor del inflamosoma nlrp3 y uso del mismo.
US12331048B2 (en) 2022-10-31 2025-06-17 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors
US20260167637A1 (en) * 2022-11-04 2026-06-18 Transthera Sciences (Nanjing), Inc. Nlrp3 inflammasome inhibitor and use thereof
JP2025540202A (ja) * 2022-12-07 2025-12-11 エフ． ホフマン－ラ ロシュ アーゲー Ｎｌｒｐ３阻害のモジュレーターとしての新規化合物
US20260234123A1 (en) * 2023-01-27 2026-08-13 Mwyngil Therapeutics, Inc. Inhibitors of NLRP3
EP4683918A1 (fr) * 2023-03-20 2026-01-28 Insilico Medicine IP Limited Inhibiteurs de l'inflammasome nlrp3 et leurs utilisations
JP2026509587A (ja) 2023-03-23 2026-03-19 成都▲ざ▼▲霊▼生物医▲薬▼科技有限公司 トリアジン化合物およびその使用
AU2024280075A1 (en) 2023-06-02 2025-12-11 Merck Sharp & Dohme Llc 5,6-Unsaturated Bicyclic Heterocycles Useful as Inhibitors of Nod-Like Receptor Protein 3
KR20260029291A (ko) 2023-06-29 2026-03-04 에프. 호프만-라 로슈 아게 Nlrp3 억제제로서의 트리아진 유도체
CN121586712A (zh) 2023-07-28 2026-02-27 豪夫迈·罗氏有限公司 新颖化合物
EP4777504A1 (fr) * 2023-09-12 2026-07-22 Zomagen Biosciences Ltd Modulateurs de nlrp3
TW202545527A (zh) 2024-01-16 2025-12-01 英商諾得瑟拉公司 Ｎｌｒｐ３及ｇｌｐ－１ａ組合療法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653316B1 (en) * 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
WO2022230912A1 (fr) 2021-04-28 2022-11-03 アステラス製薬株式会社 Composé triazine substitué

Also Published As

Publication number Publication date
EP4337652B1 (fr) 2025-04-09
BR112023023527A2 (pt) 2024-01-30
DK4337652T3 (da) 2025-06-10
PE20240126A1 (es) 2024-01-22
FI4337652T3 (fi) 2025-06-20
CO2023016204A2 (es) 2023-12-11
WO2022238347A1 (fr) 2022-11-17
SI4337652T1 (sl) 2025-07-31
EP4337652A1 (fr) 2024-03-20
EP4609865A3 (fr) 2025-10-29
JP2024517917A (ja) 2024-04-23
PL4337652T3 (pl) 2025-07-14
HRP20250632T1 (hr) 2025-07-18
AR125818A1 (es) 2023-08-16
TWI915553B (zh) 2026-02-21
EP4609865A2 (fr) 2025-09-03
KR20240007152A (ko) 2024-01-16
JP7869248B2 (ja) 2026-06-02
TW202311245A (zh) 2023-03-16
ES3031704T3 (en) 2025-07-10
CA3214626A1 (fr) 2022-11-17
RS66893B1 (sr) 2025-07-31
US20240208928A1 (en) 2024-06-27
MX2023012907A (es) 2023-11-08
CR20230529A (es) 2023-12-04
LT4337652T (lt) 2025-06-25
IL307188A (en) 2023-11-01
AU2022275300A1 (en) 2023-09-21
CL2023003312A1 (es) 2024-06-21
HUE071498T2 (hu) 2025-09-28

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