MA58208B1 - Acides nucléiques pour inhiber l'expression de lpa dans une cellule - Google Patents
Acides nucléiques pour inhiber l'expression de lpa dans une celluleInfo
- Publication number
- MA58208B1 MA58208B1 MA58208A MA58208A MA58208B1 MA 58208 B1 MA58208 B1 MA 58208B1 MA 58208 A MA58208 A MA 58208A MA 58208 A MA58208 A MA 58208A MA 58208 B1 MA58208 B1 MA 58208B1
- Authority
- MA
- Morocco
- Prior art keywords
- expression
- lpa
- inhibiting
- cell
- nucleic acids
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/532—Closed or circular
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne des produits et des compositions ainsi que leurs utilisations. En particulier, l'invention concerne des produits d'acide nucléique qui interfèrent avec l'expression du gène lpa ou inhibent son expression, de préférence pour une utilisation en tant que traitement, prévention ou réduction du risque de souffrir d'une maladie cardiovasculaire telle qu'une coronaropathie, une sténose aortique ou un accident vasculaire cérébral, ou tout autre trouble, pathologie ou syndrome lié à des taux élevés de particules de lp(a).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2018/081106 WO2019092283A1 (fr) | 2017-11-13 | 2018-11-13 | Acides nucléiques permettant d'inhiber l'expression de lpa dans une cellule |
EP19174466 | 2019-05-14 | ||
PCT/EP2019/081158 WO2020099476A1 (fr) | 2018-11-13 | 2019-11-13 | Acides nucléiques permettant d'inhiber l'expression de lpa dans une cellule |
Publications (1)
Publication Number | Publication Date |
---|---|
MA58208B1 true MA58208B1 (fr) | 2022-12-30 |
Family
ID=66554180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA58208A MA58208B1 (fr) | 2018-11-13 | 2019-11-13 | Acides nucléiques pour inhiber l'expression de lpa dans une cellule |
Country Status (29)
Country | Link |
---|---|
US (2) | US20220002722A1 (fr) |
EP (2) | EP4219712A3 (fr) |
JP (1) | JP7245328B2 (fr) |
KR (1) | KR102553386B1 (fr) |
CN (1) | CN113227372A (fr) |
AU (1) | AU2019380628A1 (fr) |
BR (1) | BR112021009213A2 (fr) |
CA (1) | CA3119239A1 (fr) |
CL (1) | CL2021001225A1 (fr) |
CO (1) | CO2021007372A2 (fr) |
CR (1) | CR20210301A (fr) |
DK (1) | DK3880818T3 (fr) |
EA (1) | EA202190895A1 (fr) |
ES (1) | ES2932295T3 (fr) |
FI (1) | FI3880818T3 (fr) |
HR (1) | HRP20221358T1 (fr) |
HU (1) | HUE060703T2 (fr) |
IL (1) | IL283159A (fr) |
LT (1) | LT3880818T (fr) |
MA (1) | MA58208B1 (fr) |
MX (1) | MX2021005590A (fr) |
PE (1) | PE20211282A1 (fr) |
PH (1) | PH12021550801A1 (fr) |
PL (1) | PL3880818T3 (fr) |
PT (1) | PT3880818T (fr) |
RS (1) | RS63778B1 (fr) |
SG (1) | SG11202103882QA (fr) |
SI (1) | SI3880818T1 (fr) |
WO (1) | WO2020099476A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110520531A (zh) * | 2017-04-05 | 2019-11-29 | 赛伦斯治疗有限责任公司 | 产品和组合物 |
EP4219716A3 (fr) | 2017-11-13 | 2024-03-27 | Silence Therapeutics GmbH | Acides nucléiques pour inhiber l'expression de lpa dans une cellule |
DK3880818T3 (da) | 2018-11-13 | 2022-12-05 | Silence Therapeutics Gmbh | Nukleinsyrer til inhibering af ekspression af LPA i en celle |
JP2023545502A (ja) | 2020-10-16 | 2023-10-30 | サノフイ | リポタンパク質(a)を阻害するためのrna組成物および方法 |
WO2023041508A2 (fr) * | 2021-09-14 | 2023-03-23 | Argonaute RNA Limited | Traitement d'une maladie cardiovasculaire |
WO2023152194A1 (fr) | 2022-02-09 | 2023-08-17 | Silence Therapeutics Gmbh | Inhibition thérapeutique de l'expression de lpa |
CN114703184A (zh) * | 2022-03-11 | 2022-07-05 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
WO2024013334A1 (fr) * | 2022-07-15 | 2024-01-18 | Silence Therapeutics Gmbh | Acides nucléiques pour inhiber l'expression de l'agt dans une cellule |
CN115851723B (zh) * | 2022-10-24 | 2023-10-03 | 厦门甘宝利生物医药有限公司 | 一种抑制lpa基因表达的rna抑制剂及其应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL9201440A (nl) | 1992-08-11 | 1994-03-01 | Univ Leiden | Triantennaire clusterglycosiden, hun bereiding en toepassing. |
US7259150B2 (en) * | 2001-08-07 | 2007-08-21 | Isis Pharmaceuticals, Inc. | Modulation of apolipoprotein (a) expression |
US7227014B2 (en) | 2001-08-07 | 2007-06-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein (a) expression |
US20060160759A1 (en) | 2002-09-28 | 2006-07-20 | Jianzhu Chen | Influenza therapeutic |
CN101278059A (zh) * | 2005-07-28 | 2008-10-01 | 肿瘤疗法科学股份有限公司 | 诊断和治疗肾细胞癌的方法 |
US20110110886A1 (en) | 2008-06-13 | 2011-05-12 | Yale University | Small molecule inhibitors of autotaxin and methods of use |
WO2016149020A1 (fr) * | 2015-03-17 | 2016-09-22 | Arrowhead Research Corporation | Agents d'interférence arn |
JOP20210043A1 (ar) * | 2015-10-01 | 2017-06-16 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
EP3228326A1 (fr) * | 2016-04-05 | 2017-10-11 | Silence Therapeutics GmbH | Acide nucléique lié à un glycoconjugué trivalent |
CN110520531A (zh) | 2017-04-05 | 2019-11-29 | 赛伦斯治疗有限责任公司 | 产品和组合物 |
EP3735461A1 (fr) * | 2017-11-13 | 2020-11-11 | Silence Therapeutics GmbH | Acides nucléiques permettant d'inhiber l'expression de l'aldh2 dans une céllule |
EP4219716A3 (fr) * | 2017-11-13 | 2024-03-27 | Silence Therapeutics GmbH | Acides nucléiques pour inhiber l'expression de lpa dans une cellule |
DK3880818T3 (da) | 2018-11-13 | 2022-12-05 | Silence Therapeutics Gmbh | Nukleinsyrer til inhibering af ekspression af LPA i en celle |
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2019
- 2019-11-13 DK DK19801033.2T patent/DK3880818T3/da active
- 2019-11-13 EA EA202190895A patent/EA202190895A1/ru unknown
- 2019-11-13 PL PL19801033.2T patent/PL3880818T3/pl unknown
- 2019-11-13 CR CR20210301A patent/CR20210301A/es unknown
- 2019-11-13 CN CN201980074785.8A patent/CN113227372A/zh active Pending
- 2019-11-13 HU HUE19801033A patent/HUE060703T2/hu unknown
- 2019-11-13 ES ES19801033T patent/ES2932295T3/es active Active
- 2019-11-13 WO PCT/EP2019/081158 patent/WO2020099476A1/fr active Application Filing
- 2019-11-13 RS RS20221119A patent/RS63778B1/sr unknown
- 2019-11-13 MX MX2021005590A patent/MX2021005590A/es unknown
- 2019-11-13 AU AU2019380628A patent/AU2019380628A1/en active Pending
- 2019-11-13 CA CA3119239A patent/CA3119239A1/fr active Pending
- 2019-11-13 PT PT198010332T patent/PT3880818T/pt unknown
- 2019-11-13 EP EP22197500.6A patent/EP4219712A3/fr active Pending
- 2019-11-13 BR BR112021009213-7A patent/BR112021009213A2/pt not_active Application Discontinuation
- 2019-11-13 LT LTEPPCT/EP2019/081158T patent/LT3880818T/lt unknown
- 2019-11-13 EP EP19801033.2A patent/EP3880818B1/fr active Active
- 2019-11-13 JP JP2021525771A patent/JP7245328B2/ja active Active
- 2019-11-13 FI FIEP19801033.2T patent/FI3880818T3/fi active
- 2019-11-13 MA MA58208A patent/MA58208B1/fr unknown
- 2019-11-13 SI SI201930387T patent/SI3880818T1/sl unknown
- 2019-11-13 US US17/293,303 patent/US20220002722A1/en active Pending
- 2019-11-13 SG SG11202103882QA patent/SG11202103882QA/en unknown
- 2019-11-13 PE PE2021000650A patent/PE20211282A1/es unknown
- 2019-11-13 HR HRP20221358TT patent/HRP20221358T1/hr unknown
- 2019-11-13 KR KR1020217017471A patent/KR102553386B1/ko active IP Right Grant
-
2021
- 2021-04-12 PH PH12021550801A patent/PH12021550801A1/en unknown
- 2021-05-10 CL CL2021001225A patent/CL2021001225A1/es unknown
- 2021-05-12 IL IL283159A patent/IL283159A/en unknown
- 2021-06-04 CO CONC2021/0007372A patent/CO2021007372A2/es unknown
- 2021-12-22 US US17/559,479 patent/US11499153B2/en active Active
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