HRP20221358T1 - Nukleinske kiseline za inhibiranje ekspresije lpa u stanici - Google Patents
Nukleinske kiseline za inhibiranje ekspresije lpa u stanici Download PDFInfo
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- HRP20221358T1 HRP20221358T1 HRP20221358TT HRP20221358T HRP20221358T1 HR P20221358 T1 HRP20221358 T1 HR P20221358T1 HR P20221358T T HRP20221358T T HR P20221358TT HR P20221358 T HRP20221358 T HR P20221358T HR P20221358 T1 HRP20221358 T1 HR P20221358T1
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- 108020004707 nucleic acids Proteins 0.000 title claims 19
- 150000007523 nucleic acids Chemical class 0.000 title claims 19
- 102000039446 nucleic acids Human genes 0.000 title claims 19
- 230000002401 inhibitory effect Effects 0.000 title claims 2
- 108091028664 Ribonucleotide Proteins 0.000 claims 10
- 239000002336 ribonucleotide Substances 0.000 claims 10
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000007170 pathology Effects 0.000 claims 3
- 102100040214 Apolipoprotein(a) Human genes 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 2
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 2
- OVRNDRQMDRJTHS-KEWYIRBNSA-N N-acetyl-D-galactosamine Chemical group CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-KEWYIRBNSA-N 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 239000012752 auxiliary agent Substances 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 101710115418 Apolipoprotein(a) Proteins 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- -1 alkylene ether Chemical group 0.000 claims 1
- 206010002906 aortic stenosis Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 101150091521 lpa gene Proteins 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
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Claims (13)
1. Nukleinska kiselina za inhibiranje ekspresije LPA u stanici, naznačena time, da sadrži najmanje jednu dupleks regiju koja sadrži barem dio prve niti i barem dio druge niti koja je barem djelomično komplementarna prvoj niti, pri čemu navedena prva nit je barem djelomično komplementarna barem dijelu RNA koja je transkribirana iz LPA gena, gdje navedena prva nit sadrži nukleotidni slijed:
5' mA (ps) fU (ps) mA fA mC fU mC fU mG fU mC fC mA fU mU fA mC (ps) fC (ps) mG 3' (SEQ ID NO: 165),
i gdje navedena druga nit sadrži nukleotidni slijed:
5' mC mG mG mU mA mA fU fG fG mA mC mA mG mA mG mU mU (ps) mA (ps) mU 3' (SEQ ID NO: 163);
pri čemu fA, fC, fG i fU označavaju 2'-deoksi-2'-fluoro ribonukleotide;
mA, mC, mG i mU označavaju 2'-O-metil ribonukleotide; i
(ps) označava fosforotioatni poveznik.
2. Nukleinska kiselina prema patentnom zahtjevu 1, naznačena time, da se prva nit sastoji od nukleotidnog slijeda:
5' mA (ps) fU (ps) mA fA mC fU mC fU mG fU mC fC mA fU mU fA mC (ps) fC (ps) mG 3' (SEQ ID NO: 165);
pri čemu fA, fC, fG i fU označavaju 2'-deoksi-2'-fluoro ribonukleotide;
mA, mC, mG i mU označavaju 2'-O-metil ribonukleotide; i
(ps) označava fosforotioatni poveznik.
3. Nukleinska kiselina prema patentnom zahtjevu 1 ili zahtjevu 2, naznačena time, da se druga nit sastoji od nukleotidnog slijeda:
5' mC mG mG mU mA mA fU fG fG mA mC mA mG mA mG mU mU (ps) mA (ps) mU 3' (SEQ ID NO: 163);
pri čemu fA, fC, fG i fU označavaju 2'-deoksi-2'-fluoro ribonukleotide;
mA, mC, mG i mU označavaju 2'-O-metil ribonukleotide; i
(ps) označava fosforotioatni poveznik.
4. Nukleinska kiselina prema bilo kojem od prethodnih patentnih zahtjeva, naznačena time, da je nukleinska kiselina konjugirana na ligand.
5. Nukleinska kiselina prema patentnom zahtjevu 4, naznačena time, da ligand sadrži (i) jedan ili više ostataka N-acetil galaktozamin (GalNAc) skupine ili njihovih derivata, i (ii) poveznik, gdje poveznik konjugira najmanje jedan ostatak GalNAc skupine ili njegov derivat na nukleinsku kiselinu.
6. Nukleinska kiselina prema bilo kojem od prethodnih patentnih zahtjeva, naznačena time, da nukleinska kiselina koja je konjugirana na ligand, sadrži spoj formule (I):
[S-X1-P-X2]3-A-X3- (I)
u kojoj:
S predstavlja saharid, poželjno gdje saharid je N-acetil galaktozamin;
X1 predstavlja C3-C6 alkilen ili (-CH2-CH2-O)m(-CH2)2- gdje m je 1, 2 ili 3;
P je fosfat ili modificirani fosfat, poželjno tiofosfat;
X2 je alkilen ili alkilen eter formule (-CH2)n-O-CH2- gdje n = 1-6;
A je jedinica grananja;
X3 predstavlja jedinicu premoštenja;
pri čemu je nukleinska kiselina koja je definirana u bilo kojem od patentnih zahtjeva 1 do 5, konjugirana na X3 preko fosfata ili modificiranog fosfata, poželjno tiofosfata, i nukleinska kiselina je poželjno konjugirana na X3 preko 5' kraja druge niti.
7. Nukleinska kiselina prema bilo kojem od prethodnih patentnih zahtjeva, naznačena time, da je nukleinska kiselina konjugirana na ligand i posjeduje sljedeću strukturu:
[image]
pri čemu Z je nukleinska kiselina prema bilo kojem od prethodnih patentnih zahtjeva i ligand je poželjno konjugiran na 5' kraj druge niti.
8. Nukleinska kiselina prema bilo kojem od patentnih zahtjeva 4 do 7, naznačena time, da druga nit sadrži nukleotidni slijed:
5' [ST23 (ps)]3 C6XLT (ps) mC mG mG mU mA mA fU fG fG mA mC mA mG mA mG mU mU (ps) mA (ps) mU 3' (SEQ ID NO: 164);
pri čemu fA, fC, fG i fU označavaju 2'-deoksi-2'-fluoro ribonukleotide;
mA, mC, mG i mU označavaju 2'-O-metil ribonukleotide; i
(ps) označava fosforotioatni poveznik; i
[ST23 (ps)]3 C6XLT (ps) označava:
[image]
9. Nukleinska kiselina prema patentnom zahtjevu 8, naznačena time, da se druga nit sastoji od nukleotidnog slijeda:
5' [ST23 (ps)]3 C6XLT (ps) mC mG mG mU mA mA fU fG fG mA mC mA mG mA mG mU mU (ps) mA (ps) mU 3' (SEQ ID NO: 164);
pri čemu fA, fC, fG i fU označavaju 2'-deoksi-2'-fluoro ribonukleotide;
mA, mC, mG i mU označavaju 2'-O-metil ribonukleotide; i
(ps) označava fosforotioatni poveznik; i
[ST23 (ps)]3 C6XLT (ps) označava:
[image]
10. Pripravak, naznačen time, da sadrži nukleinsku kiselinu prema bilo kojem od patentnih zahtjeva 1 do 9, i opcionalno, prijenosno sredstvo za raspodjelu i/ili fiziološki prihvatljivo pomoćno sredstvo i/ili nosač i/ili razrjeđivač i/ili pufer i/ili konzervans, pri čemu je za uporabu kao medikament.
11. Pripravak za uporabu prema patentnom zahtjevu 10, naznačen time, da je navedeni pripravak za uporabu u prevenciji ili liječenju ili smanjenju rizika bolesti ili patologije, pri čemu bolest ili patologija je kardiovaskularna bolest.
12. Pripravak za uporabu prema patentnom zahtjevu 11, naznačen time, da kardiovaskularna bolest je moždani udar, ateroskleroza, tromboza, koronarna srčana bolest ili stenoza aorte i/ili bilo koja druga bolest ili patologija koja je povezana s povišenim razinama Lp(a) čestica.
13. Farmaceutski pripravak, naznačen time, da sadrži nukleinsku kiselinu prema bilo kojem od patentnih zahtjeva 1 do 9, i nadalje sadrži prijenosno sredstvo za raspodjelu i/ili fiziološki prihvatljivo pomoćno sredstvo i/ili nosač i/ili razrjeđivač.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2018/081106 WO2019092283A1 (en) | 2017-11-13 | 2018-11-13 | Nucleic acids for inhibiting expression of lpa in a cell |
EP19174466 | 2019-05-14 | ||
EP19801033.2A EP3880818B1 (en) | 2018-11-13 | 2019-11-13 | Nucleic acids for inhibiting expression of lpa in a cell |
PCT/EP2019/081158 WO2020099476A1 (en) | 2018-11-13 | 2019-11-13 | Nucleic acids for inhibiting expression of lpa in a cell |
Publications (1)
Publication Number | Publication Date |
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HRP20221358T1 true HRP20221358T1 (hr) | 2022-12-23 |
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Application Number | Title | Priority Date | Filing Date |
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HRP20221358TT HRP20221358T1 (hr) | 2018-11-13 | 2019-11-13 | Nukleinske kiseline za inhibiranje ekspresije lpa u stanici |
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US (2) | US20220002722A1 (hr) |
EP (2) | EP3880818B1 (hr) |
JP (1) | JP7245328B2 (hr) |
KR (1) | KR102553386B1 (hr) |
CN (1) | CN113227372A (hr) |
AU (1) | AU2019380628A1 (hr) |
BR (1) | BR112021009213A2 (hr) |
CA (1) | CA3119239C (hr) |
CL (1) | CL2021001225A1 (hr) |
CO (1) | CO2021007372A2 (hr) |
CR (1) | CR20210301A (hr) |
DK (1) | DK3880818T3 (hr) |
EA (1) | EA202190895A1 (hr) |
ES (1) | ES2932295T3 (hr) |
FI (1) | FI3880818T3 (hr) |
HR (1) | HRP20221358T1 (hr) |
HU (1) | HUE060703T2 (hr) |
IL (1) | IL283159A (hr) |
LT (1) | LT3880818T (hr) |
MA (1) | MA58208B1 (hr) |
MX (1) | MX2021005590A (hr) |
PE (1) | PE20211282A1 (hr) |
PH (1) | PH12021550801A1 (hr) |
PL (1) | PL3880818T3 (hr) |
PT (1) | PT3880818T (hr) |
RS (1) | RS63778B1 (hr) |
SA (1) | SA521421963B1 (hr) |
SG (1) | SG11202103882QA (hr) |
SI (1) | SI3880818T1 (hr) |
WO (1) | WO2020099476A1 (hr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3607069T1 (sl) * | 2017-04-05 | 2023-02-28 | Silence Therapeutics Gmbh | Produkti in sestavki |
IL274503B1 (en) | 2017-11-13 | 2024-06-01 | Silence Therapeutics Gmbh | Nucleic acids to inhibit LPA expression in the cell |
PT3880818T (pt) | 2019-05-14 | 2022-12-06 | Silence Therapeutics Gmbh | Ácidos nucleicos para inibir a expressão de lpa numa célula |
US20240035029A1 (en) | 2020-10-16 | 2024-02-01 | Sanofi | Rna compositions and methods for inhibiting lipoprotein(a) |
EP4402263A2 (en) * | 2021-09-14 | 2024-07-24 | Argonaute Rna Limited | Treatment of cardiovascular disease |
WO2023152194A1 (en) | 2022-02-09 | 2023-08-17 | Silence Therapeutics Gmbh | Therapeutic inhibition of lpa expression |
CN114703184B (zh) * | 2022-03-11 | 2024-06-18 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
WO2024013334A1 (en) * | 2022-07-15 | 2024-01-18 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of agt in a cell |
CN115851723B (zh) * | 2022-10-24 | 2023-10-03 | 厦门甘宝利生物医药有限公司 | 一种抑制lpa基因表达的rna抑制剂及其应用 |
WO2024151937A1 (en) * | 2023-01-13 | 2024-07-18 | Eli Lilly And Company | Therapeutic oligonucleotide-containing pharmaceutical compositions and dosing regimens using the same |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL9201440A (nl) | 1992-08-11 | 1994-03-01 | Univ Leiden | Triantennaire clusterglycosiden, hun bereiding en toepassing. |
US7227014B2 (en) | 2001-08-07 | 2007-06-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein (a) expression |
US7259150B2 (en) * | 2001-08-07 | 2007-08-21 | Isis Pharmaceuticals, Inc. | Modulation of apolipoprotein (a) expression |
US20060160759A1 (en) | 2002-09-28 | 2006-07-20 | Jianzhu Chen | Influenza therapeutic |
CN101278059A (zh) * | 2005-07-28 | 2008-10-01 | 肿瘤疗法科学股份有限公司 | 诊断和治疗肾细胞癌的方法 |
WO2009151644A2 (en) | 2008-06-13 | 2009-12-17 | Yale University | Small molecule inhibitors of autotaxin methods of use |
AU2014284152B2 (en) * | 2013-06-21 | 2020-01-23 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulation of target nucleic acids |
US20160272970A1 (en) | 2015-03-17 | 2016-09-22 | Arrowhead Madison Inc. | RNA Interference Agents |
JOP20210043A1 (ar) * | 2015-10-01 | 2017-06-16 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
EP3228326A1 (en) * | 2016-04-05 | 2017-10-11 | Silence Therapeutics GmbH | Nucleic acid linked to a trivalent glycoconjugate |
SI3607069T1 (sl) | 2017-04-05 | 2023-02-28 | Silence Therapeutics Gmbh | Produkti in sestavki |
IL274503B1 (en) * | 2017-11-13 | 2024-06-01 | Silence Therapeutics Gmbh | Nucleic acids to inhibit LPA expression in the cell |
CA3118327A1 (en) * | 2017-11-13 | 2019-05-16 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of aldh2 in a cell |
PT3880818T (pt) | 2019-05-14 | 2022-12-06 | Silence Therapeutics Gmbh | Ácidos nucleicos para inibir a expressão de lpa numa célula |
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