MA54447A - Dérivés de 7-phénoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amine et composés apparentés en tant que modulateurs de gamma-sécrétase pour le traitement de la maladie d'alzheimer - Google Patents

Dérivés de 7-phénoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amine et composés apparentés en tant que modulateurs de gamma-sécrétase pour le traitement de la maladie d'alzheimer

Info

Publication number
MA54447A
MA54447A MA054447A MA54447A MA54447A MA 54447 A MA54447 A MA 54447A MA 054447 A MA054447 A MA 054447A MA 54447 A MA54447 A MA 54447A MA 54447 A MA54447 A MA 54447A
Authority
MA
Morocco
Prior art keywords
octan
azabicyclo
pyrrolo
triazol
alzheimer
Prior art date
Application number
MA054447A
Other languages
English (en)
Inventor
Beat Frei
Hasane Ratni
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA54447A publication Critical patent/MA54447A/fr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MA054447A 2018-12-13 2019-12-11 Dérivés de 7-phénoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amine et composés apparentés en tant que modulateurs de gamma-sécrétase pour le traitement de la maladie d'alzheimer MA54447A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18212199 2018-12-13

Publications (1)

Publication Number Publication Date
MA54447A true MA54447A (fr) 2022-03-23

Family

ID=64665266

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054447A MA54447A (fr) 2018-12-13 2019-12-11 Dérivés de 7-phénoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amine et composés apparentés en tant que modulateurs de gamma-sécrétase pour le traitement de la maladie d'alzheimer

Country Status (19)

Country Link
US (1) US20220056036A1 (fr)
EP (1) EP3894411B1 (fr)
JP (1) JP2022513466A (fr)
KR (1) KR20210102900A (fr)
CN (2) CN113179641B (fr)
AR (1) AR116906A1 (fr)
AU (1) AU2019395774A1 (fr)
BR (1) BR112021009443A2 (fr)
CA (1) CA3117870A1 (fr)
CL (1) CL2021001547A1 (fr)
CO (1) CO2021006837A2 (fr)
CR (1) CR20210305A (fr)
IL (2) IL310081A (fr)
MA (1) MA54447A (fr)
MX (1) MX2021006761A (fr)
PE (1) PE20211776A1 (fr)
SG (1) SG11202103340PA (fr)
TW (1) TWI831892B (fr)
WO (1) WO2020120521A1 (fr)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703763B2 (en) * 2011-03-02 2014-04-22 Hoffmann-La Roche Inc. Bridged piperidine derivatives
CN107922437B (zh) * 2015-09-09 2021-12-10 豪夫迈·罗氏有限公司 桥连哌啶衍生物
EP3386978B1 (fr) * 2015-12-10 2021-01-27 H. Hoffnabb-La Roche Ag Dérivés de pipéridine pontés
CN109311878B (zh) * 2016-06-27 2022-05-24 豪夫迈·罗氏有限公司 作为γ-分泌酶调节剂的三唑并吡啶类化合物
WO2018083050A1 (fr) * 2016-11-01 2018-05-11 F. Hoffmann-La Roche Ag Dérivés hétéroaryle bicycliques
AR110122A1 (es) * 2016-11-08 2019-02-27 Hoffmann La Roche Fenoxitriazoles
KR20190098998A (ko) 2016-12-16 2019-08-23 파이프라인 테라퓨틱스, 아이엔씨. 달팽이관 시냅스질환의 치료 방법

Also Published As

Publication number Publication date
PE20211776A1 (es) 2021-09-08
MX2021006761A (es) 2021-07-15
CN117946116A (zh) 2024-04-30
CA3117870A1 (fr) 2020-06-18
CN113179641B (zh) 2024-01-02
WO2020120521A1 (fr) 2020-06-18
BR112021009443A2 (pt) 2021-08-17
CR20210305A (es) 2021-07-20
JP2022513466A (ja) 2022-02-08
KR20210102900A (ko) 2021-08-20
SG11202103340PA (en) 2021-04-29
IL283823A (en) 2021-07-29
CO2021006837A2 (es) 2021-06-10
IL283823B2 (en) 2024-07-01
EP3894411A1 (fr) 2021-10-20
AU2019395774A1 (en) 2021-04-08
CN113179641A (zh) 2021-07-27
TW202039499A (zh) 2020-11-01
IL283823B1 (en) 2024-03-01
IL310081A (en) 2024-03-01
CL2021001547A1 (es) 2021-12-24
TWI831892B (zh) 2024-02-11
EP3894411B1 (fr) 2024-06-19
AR116906A1 (es) 2021-06-23
US20220056036A1 (en) 2022-02-24

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