MA53074A - Dérivés d'oxadiazolopyridine à substitution hétérocyclyle utilisés en tant qu'inhibiteurs de la ghréline o-acyltransférase (goat) - Google Patents
Dérivés d'oxadiazolopyridine à substitution hétérocyclyle utilisés en tant qu'inhibiteurs de la ghréline o-acyltransférase (goat)Info
- Publication number
- MA53074A MA53074A MA053074A MA53074A MA53074A MA 53074 A MA53074 A MA 53074A MA 053074 A MA053074 A MA 053074A MA 53074 A MA53074 A MA 53074A MA 53074 A MA53074 A MA 53074A
- Authority
- MA
- Morocco
- Prior art keywords
- ghrelin
- acyltransferase
- goat
- inhibitors
- derivatives used
- Prior art date
Links
- 102100038752 Ghrelin O-acyltransferase Human genes 0.000 title 2
- 101710205760 Ghrelin O-acyltransferase Proteins 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
- RWXCVESEMJNNMF-UHFFFAOYSA-N oxadiazolo[5,4-b]pyridine Chemical class C1=CN=C2ON=NC2=C1 RWXCVESEMJNNMF-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18154828 | 2018-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA53074A true MA53074A (fr) | 2021-05-12 |
Family
ID=61157053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA053074A MA53074A (fr) | 2018-02-02 | 2019-01-28 | Dérivés d'oxadiazolopyridine à substitution hétérocyclyle utilisés en tant qu'inhibiteurs de la ghréline o-acyltransférase (goat) |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US11319310B2 (fr) |
| EP (1) | EP3746450B1 (fr) |
| JP (1) | JP7150032B2 (fr) |
| KR (1) | KR20200118124A (fr) |
| CN (1) | CN111655699B (fr) |
| AU (1) | AU2019215709A1 (fr) |
| BR (1) | BR112020014320A2 (fr) |
| CA (1) | CA3087827A1 (fr) |
| CL (1) | CL2020001908A1 (fr) |
| CO (1) | CO2020009179A2 (fr) |
| CR (1) | CR20200331A (fr) |
| EA (1) | EA202091804A1 (fr) |
| EC (1) | ECSP20050791A (fr) |
| IL (1) | IL276137A (fr) |
| JO (1) | JOP20200191A1 (fr) |
| MA (1) | MA53074A (fr) |
| MX (1) | MX2020008116A (fr) |
| PE (1) | PE20210175A1 (fr) |
| PH (1) | PH12020551169A1 (fr) |
| SG (1) | SG11202006300XA (fr) |
| WO (1) | WO2019149659A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2874587T3 (es) | 2016-08-05 | 2021-11-05 | Boehringer Ingelheim Int | Derivados de oxadiazolopiridina para su uso como inhibidores de la grelina O-aciltransferasa (GOAT) |
| PE20210658A1 (es) | 2018-02-02 | 2021-03-31 | Boehringer Ingelheim Int | Derivados de triazolopirimidina para usar como inhibidores de ghrelin o-aciltransferasa (goat) |
| US11136337B2 (en) * | 2018-02-02 | 2021-10-05 | Boehringer Ingelheim International Gmbh | Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors |
| JOP20200190A1 (ar) | 2018-02-02 | 2020-07-29 | Boehringer Ingelheim Int | مشتقات أوكسادايازولو بيريدين بها استبدال ببنزيل -، (بيريدين -3- يل) ميثيل - أو (بيريدين -4- يل) ميثيل كمثبطات جريلين o- أسيل ترانسفيراز (goat) |
| EP4153600B1 (fr) | 2020-05-22 | 2024-08-07 | Boehringer Ingelheim International GmbH | Procédé continu de fabrication de 7-amino-5-méthyl-[1,2,5] oxadiazolo [3,4-b] pyridine-carboxylate d'alkyle |
| JP2023526351A (ja) * | 2020-05-22 | 2023-06-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルキル７－アミノ－５－メチル－［１，２，５］オキサジアゾロ［３，４－ｂ］ピリジンカルボキシレートの製造方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004082383A1 (fr) | 2003-03-17 | 2004-09-30 | Basf Aktiengesellschaft | Utilisation de triazolopyrimidines pour combattre les nematodoses de vegetaux |
| CA2677932A1 (fr) | 2007-02-15 | 2008-08-21 | Indiana University Research And Technology Corporation | Co-agonistes des recepteurs du glucagon/glp-1 |
| US7994122B2 (en) | 2007-06-15 | 2011-08-09 | Zealand Pharma A/S | Glucagon analogues |
| JP5635529B2 (ja) | 2008-12-15 | 2014-12-03 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン類似体 |
| KR20110126591A (ko) | 2008-12-15 | 2011-11-23 | 질랜드 파마 에이/에스 | 글루카곤 유사체 |
| KR101593406B1 (ko) | 2008-12-15 | 2016-02-12 | 질랜드 파마 에이/에스 | 글루카곤 유사체 |
| CA2747112A1 (fr) | 2008-12-15 | 2010-06-24 | Zealand Pharma A/S | Analogues du glucagon |
| ES2537287T3 (es) | 2009-07-13 | 2015-06-05 | Zealand Pharma A/S | Análogos de glucagón acilados |
| AR081975A1 (es) | 2010-06-23 | 2012-10-31 | Zealand Pharma As | Analogos de glucagon |
| MX2012014961A (es) | 2010-06-24 | 2013-02-26 | Zealand Pharma As | Analogos de glucagon. |
| AU2012357739A1 (en) | 2011-12-23 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Glucagon analogues |
| CA2864990C (fr) | 2012-02-24 | 2021-03-02 | Nobuyuki Takakura | Composes de benzofurane et de benzothiophene pour l'inhibition de la ghreline o-acyltransferase (goat) |
| ES2784223T3 (es) * | 2012-06-20 | 2020-09-23 | Univ Virginia Patent Foundation | Composiciones y procedimientos para regular la homeostasis de glucosa y la acción de insulina |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| UA118034C2 (uk) | 2013-11-14 | 2018-11-12 | Елі Ліллі Енд Компані | Заміщений піперидилетилпіримідин як інгібітор грелін-o-ацилтрансферази |
| US20170275249A1 (en) | 2014-09-17 | 2017-09-28 | The Regents Of The University Of California | Small lipopeptidomimetic inhibitors of ghrelin o-acyl transferase |
| JP6615896B2 (ja) | 2015-01-30 | 2019-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルドステロン合成酵素阻害剤 |
| AR104673A1 (es) | 2015-04-15 | 2017-08-09 | Lilly Co Eli | Inhibidores de grelina o-aciltransferasa |
| AR104672A1 (es) | 2015-04-15 | 2017-08-09 | Lilly Co Eli | Inhibidores de grelina o-aciltransferasa |
| ES2874587T3 (es) * | 2016-08-05 | 2021-11-05 | Boehringer Ingelheim Int | Derivados de oxadiazolopiridina para su uso como inhibidores de la grelina O-aciltransferasa (GOAT) |
-
2019
- 2019-01-28 CN CN201980010384.6A patent/CN111655699B/zh active Active
- 2019-01-28 EP EP19702085.2A patent/EP3746450B1/fr active Active
- 2019-01-28 JP JP2020541870A patent/JP7150032B2/ja active Active
- 2019-01-28 CR CR20200331A patent/CR20200331A/es unknown
- 2019-01-28 SG SG11202006300XA patent/SG11202006300XA/en unknown
- 2019-01-28 PE PE2020001163A patent/PE20210175A1/es unknown
- 2019-01-28 CA CA3087827A patent/CA3087827A1/fr not_active Abandoned
- 2019-01-28 JO JOP/2020/0191A patent/JOP20200191A1/ar unknown
- 2019-01-28 BR BR112020014320-0A patent/BR112020014320A2/pt not_active Application Discontinuation
- 2019-01-28 KR KR1020207025418A patent/KR20200118124A/ko unknown
- 2019-01-28 AU AU2019215709A patent/AU2019215709A1/en not_active Abandoned
- 2019-01-28 EA EA202091804A patent/EA202091804A1/ru unknown
- 2019-01-28 WO PCT/EP2019/051993 patent/WO2019149659A1/fr unknown
- 2019-01-28 MX MX2020008116A patent/MX2020008116A/es unknown
- 2019-01-28 US US16/966,489 patent/US11319310B2/en active Active
- 2019-01-28 MA MA053074A patent/MA53074A/fr unknown
-
2020
- 2020-07-19 IL IL276137A patent/IL276137A/en unknown
- 2020-07-21 CL CL2020001908A patent/CL2020001908A1/es unknown
- 2020-07-24 CO CONC2020/0009179A patent/CO2020009179A2/es unknown
- 2020-07-31 PH PH12020551169A patent/PH12020551169A1/en unknown
- 2020-08-24 EC ECSENADI202050791A patent/ECSP20050791A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP20050791A (es) | 2020-09-30 |
| WO2019149659A1 (fr) | 2019-08-08 |
| JP7150032B2 (ja) | 2022-10-07 |
| KR20200118124A (ko) | 2020-10-14 |
| US11319310B2 (en) | 2022-05-03 |
| JOP20200191A1 (ar) | 2020-07-29 |
| EP3746450A1 (fr) | 2020-12-09 |
| MX2020008116A (es) | 2020-09-25 |
| SG11202006300XA (en) | 2020-07-29 |
| AU2019215709A1 (en) | 2020-07-16 |
| EA202091804A1 (ru) | 2020-12-24 |
| CO2020009179A2 (es) | 2020-07-31 |
| CR20200331A (es) | 2020-09-03 |
| JP2021512112A (ja) | 2021-05-13 |
| CA3087827A1 (fr) | 2019-08-08 |
| BR112020014320A2 (pt) | 2020-12-08 |
| PH12020551169A1 (en) | 2021-05-31 |
| EP3746450B1 (fr) | 2022-03-16 |
| CN111655699B (zh) | 2023-07-14 |
| US20210040077A1 (en) | 2021-02-11 |
| CN111655699A (zh) | 2020-09-11 |
| IL276137A (en) | 2020-09-30 |
| CL2020001908A1 (es) | 2020-10-30 |
| PE20210175A1 (es) | 2021-01-29 |
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