MA45543B1 - Anticorps anti-peptide bêta-amyloïde n3pglu et leurs utilisations - Google Patents

Anticorps anti-peptide bêta-amyloïde n3pglu et leurs utilisations

Info

Publication number
MA45543B1
MA45543B1 MA45543A MA45543A MA45543B1 MA 45543 B1 MA45543 B1 MA 45543B1 MA 45543 A MA45543 A MA 45543A MA 45543 A MA45543 A MA 45543A MA 45543 B1 MA45543 B1 MA 45543B1
Authority
MA
Morocco
Prior art keywords
beta
n3pglu
amyloid peptide
antibodies
n3pglu antibodies
Prior art date
Application number
MA45543A
Other languages
English (en)
Other versions
MA45543A (fr
Inventor
Ronald Bradley Demattos
Michael Carl Irizarry
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA45543A publication Critical patent/MA45543A/fr
Publication of MA45543B1 publication Critical patent/MA45543B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un traitement par induction à court terme avec des anticorps anti-n3pglu aß d'une maladie caractérisée par le dépôt de aß dans la tête, qui inclus la maladie d'alzheimer (ad), le syndrome de down et l'angiopathie amyloïde cérébrale (caa). Dans certains modes d'emploi, une dose d'induction de 10 à 60 mg/kg d'un anticorps anti-n3pglu aß est administrée à des patients pendant une période inférieure ou égale à 6 mois.
MA45543A 2016-07-01 2017-06-23 Anticorps anti-peptide bêta-amyloïde n3pglu et leurs utilisations MA45543B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662357579P 2016-07-01 2016-07-01
PCT/US2017/038999 WO2018005282A1 (fr) 2016-07-01 2017-06-23 Anticorps anti-peptides n3pglu amyloïdes bêta et utilisations associées

Publications (2)

Publication Number Publication Date
MA45543A MA45543A (fr) 2019-05-08
MA45543B1 true MA45543B1 (fr) 2023-08-31

Family

ID=59295341

Family Applications (1)

Application Number Title Priority Date Filing Date
MA45543A MA45543B1 (fr) 2016-07-01 2017-06-23 Anticorps anti-peptide bêta-amyloïde n3pglu et leurs utilisations

Country Status (28)

Country Link
US (2) US11312763B2 (fr)
EP (2) EP3478712B1 (fr)
JP (4) JP7165588B2 (fr)
KR (3) KR20210024213A (fr)
CN (3) CN114917338A (fr)
AU (1) AU2017291414B2 (fr)
BR (1) BR112018073843A2 (fr)
CA (1) CA3029550C (fr)
DK (1) DK3478712T5 (fr)
EA (1) EA201892690A1 (fr)
ES (1) ES2958508T3 (fr)
FI (1) FI3478712T3 (fr)
HR (1) HRP20230861T1 (fr)
HU (1) HUE062980T2 (fr)
IL (1) IL263788B2 (fr)
LT (1) LT3478712T (fr)
MA (1) MA45543B1 (fr)
MD (1) MD3478712T2 (fr)
MX (2) MX2018016066A (fr)
PL (1) PL3478712T3 (fr)
PT (1) PT3478712T (fr)
RS (1) RS64386B1 (fr)
SG (1) SG11201810371XA (fr)
SI (1) SI3478712T1 (fr)
TW (2) TWI798751B (fr)
UA (1) UA127101C2 (fr)
WO (1) WO2018005282A1 (fr)
ZA (1) ZA201807633B (fr)

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TWI798751B (zh) 2016-07-01 2023-04-11 美商美國禮來大藥廠 抗－N3pGlu類澱粉β肽抗體及其用途
JOP20190247A1 (ar) * 2017-04-20 2019-10-20 Lilly Co Eli أجسام بيتا ببتيد النشوانية المضادة لـ N3pGlu واستخداماتها
EP3521308B1 (fr) * 2018-01-31 2024-03-13 Vivoryon Therapeutics N.V. Anticorps humanisés et dé-immunisés
WO2019169448A1 (fr) * 2018-03-09 2019-09-12 St Vincent's Institute Of Medical Research Anticorps multi-spécifiques
IL280315B2 (en) * 2018-07-24 2024-06-01 Eisai R&D Man Co Ltd Methods for treating and preventing Alzheimer's disease
CN111184725B (zh) * 2020-02-27 2020-12-01 慈溪市人民医院医疗健康集团(慈溪市人民医院) 一种防治脑梗塞的药物制剂及其制备方法
TWI843040B (zh) * 2021-01-11 2024-05-21 美商美國禮來大藥廠 抗N3pGlu類澱粉β抗體及其用途
WO2022251048A1 (fr) 2021-05-24 2022-12-01 Eli Lilly And Company Anticorps anti-amyloïde bêta et leurs utilisations
IL312380A (en) * 2021-10-29 2024-06-01 Lilly Co Eli Compounds and methods targeting interleukin-34
CN118475609A (zh) * 2021-10-29 2024-08-09 伊莱利利公司 靶向白细胞介素-34的化合物和方法
WO2023146818A2 (fr) * 2022-01-26 2023-08-03 T3D Therapeutics, Inc. Procédés de traitement de troubles cérébraux liés à l'amyloïde à l'aide de nouveaux composés et d'anticorps
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TWI798751B (zh) 2016-07-01 2023-04-11 美商美國禮來大藥廠 抗－N3pGlu類澱粉β肽抗體及其用途

Also Published As

Publication number Publication date
EP3478712B1 (fr) 2023-07-19
KR20230021773A (ko) 2023-02-14
EP4272828A2 (fr) 2023-11-08
PT3478712T (pt) 2023-08-21
KR20190012208A (ko) 2019-02-08
WO2018005282A1 (fr) 2018-01-04
EA201892690A1 (ru) 2019-05-31
NZ748496A (en) 2021-02-26
KR20210024213A (ko) 2021-03-04
SI3478712T1 (sl) 2023-10-30
DK3478712T5 (da) 2024-09-09
CN109415433A (zh) 2019-03-01
JP2021059546A (ja) 2021-04-15
HUE062980T2 (hu) 2023-12-28
MA45543A (fr) 2019-05-08
IL263788B1 (en) 2024-06-01
EP4272828A3 (fr) 2024-01-10
CN114917338A (zh) 2022-08-19
CA3029550C (fr) 2023-08-22
ES2958508T3 (es) 2024-02-09
UA127101C2 (uk) 2023-04-19
DK3478712T3 (da) 2023-09-04
HRP20230861T1 (hr) 2023-11-10
JP2019518783A (ja) 2019-07-04
IL263788B2 (en) 2024-10-01
JP2021059547A (ja) 2021-04-15
CN114887054A (zh) 2022-08-12
MX2023001299A (es) 2023-02-22
CA3029550A1 (fr) 2018-01-04
KR102221402B1 (ko) 2021-03-02
EP3478712A1 (fr) 2019-05-08
AU2017291414A1 (en) 2018-12-13
JP7165588B2 (ja) 2022-11-04
AU2017291414B2 (en) 2019-11-21
BR112018073843A2 (pt) 2019-02-26
SG11201810371XA (en) 2018-12-28
MX2018016066A (es) 2019-04-24
US20220235122A1 (en) 2022-07-28
US11312763B2 (en) 2022-04-26
US20190382471A1 (en) 2019-12-19
IL263788A (en) 2019-01-31
TW201811363A (zh) 2018-04-01
RS64386B1 (sr) 2023-08-31
TWI735600B (zh) 2021-08-11
ZA201807633B (en) 2021-05-26
LT3478712T (lt) 2023-08-25
TW202140544A (zh) 2021-11-01
PL3478712T3 (pl) 2023-11-06
FI3478712T3 (fi) 2023-10-02
JP2023123503A (ja) 2023-09-05
MD3478712T2 (ro) 2024-01-31
TWI798751B (zh) 2023-04-11
JP7241058B2 (ja) 2023-03-16

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